Research graph
References from Discovery of natural product antagonists for the P2X7 receptor through virtual screening. Local targets link to admitted publications; unresolved targets remain external evidence.
Nomenclature and classification of purinoceptors
10.1016/s0031-6997(25)06782-1 · 1994 · External reference
The P2X7 purinergic receptor: from physiology to neurological disorders
10.1096/fj.09-138883 · 2010 · External reference
Receptors for purines and pyrimidines
10.1016/s0031-6997(24)01373-5 · 1998 · External reference
The role of the purinergic P2X7 receptor in inflammation
10.1186/1476-9255-4-5 · 2007 · External reference
The P2X7 receptor: shifting from a low- to a high-conductance channel — An enigmatic phenomenon?
10.1016/j.bbamem.2014.05.015 · 2014 · External reference
Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation
10.2174/157488910789753530 · 2010 · External reference
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
10.1124/pr.113.008003 · 2014 · External reference
ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation
10.1038/cddis.2012.144 · 2012 · External reference
Activation and regulation of the inflammasomes
10.1038/nri3452 · 2013 · External reference
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
10.1124/jpet.106.111559 · 2006 · External reference
Human rheumatoid synoviocytes express functional P2X7 receptors
10.1007/s00109-008-0365-8 · 2008 · External reference
In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer’s disease through GSK3B and secretases
10.1016/j.neurobiolaging.2011.09.040 · 2012 · External reference
Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
10.1073/pnas.1500656112 · 2015 · External reference
Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain
10.3390/molecules180910953 · 2013 · External reference
Virtual screening: a fast tool for drug design
10.3797/scipharm.0803-03 · 2008 · External reference
Natural products and drug discovery
10.1038/embor.2009.12 · 2009 · External reference
The role of natural products in modern drug discovery
10.1590/0001-3765201920190105 · 2019 · External reference
Natural product databases for drug discovery: Features and applications
2024 · External reference
Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization
10.1016/j.cell.2019.09.017 · 2019 · External reference
Cloning and pharmacological characterization of the dog P2X7 receptor
10.1111/j.1476-5381.2009.00425.x · 2009 · External reference
P2X7 receptors exhibit at least three modes of allosteric antagonism
10.1126/sciadv.ado5084 · 2024 · External reference
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
10.1038/s41467-025-62643-8 · 2025 · External reference
C. Förster, α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies
10.2147/ijn.s31373 · 2012 · External reference
PLIP: fully automated protein–ligand interaction profiler
10.1093/nar/gkv315 · 2015 · External reference
Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages
10.1016/j.bcp.2004.11.012 · 2005 · External reference
Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding
10.1038/sj.bjp.0707196 · 2007 · External reference
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373
10.1038/sj.bjp.0706933 · 2006 · External reference
Thesis, University of Manchester
2012 · External reference
Functional evidence of distinct ATP activation sites at the human P2X7 receptor
10.1111/j.1469-7793.2001.00025.x · 2001 · External reference
P2X7 in cancer: From molecular mechanisms to therapeutics
10.3389/fphar.2020.00793 · 2020 · External reference
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
10.1038/s41419-019-2110-3 · 2019 · External reference
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
10.1007/s00204-023-03474-8 · 2023 · External reference
Identification of new human P2X7 antagonists using ligand- and structure-based virtual screening
10.1021/acs.jcim.5c00552 · 2025 · External reference
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
10.1007/s11302-024-10055-6 · 2025 · External reference
P2X7 receptor as a key player in pathological pain: insights into neuropathic, inflammatory, and cancer pain
2025 · External reference
Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors
10.3390/ph6050650 · 2013 · External reference
Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists
10.1016/j.bcp.2016.07.020 · 2016 · External reference
In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response
10.1016/j.biopha.2023.114608 · 2023 · External reference
Natural phytochemicals as P2X7 receptor inhibitors for the treatment of inflammation-related diseases
10.15586/ijfs.v35i2.2288 · 2023 · External reference
Gallic acid alleviates visceral pain and depression via inhibition of P2X7 receptor
10.3390/ijms23116159 · 2022 · External reference
A hybrid approach combining shape-based and docking methods to identify novel potential P2X7 antagonists from natural product databases
10.3390/ph17050592 · 2024 · External reference
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
10.1038/s41598-017-00732-5 · 2017 · External reference
Structural basis for subtype-specific inhibition of the P2X7 receptor
10.7554/elife.22153 · 2016 · External reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(96)00423-1 · 1997 · External reference
Drug discovery beyond the rule of 5 - opportunities and challenges
10.1080/17460441.2017.1264385 · 2017 · External reference
BDDCS, the rule of 5 and drugability
10.1016/j.addr.2016.05.007 · 2016 · External reference
Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury
10.1021/acs.jmedchem.3c00837 · 2023 · External reference
Effects of new P2X7R antagonists on retinal inflammatory degenerative conditions
10.1007/s10753-026-02513-7 · 2026 · External reference
Human rheumatoid synoviocytes express functional P2X7 receptors
10.1007/s00109-008-0365-8 · ExternalCitation · doi-reference
Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved
10.1007/s00204-023-03474-8 · ExternalCitation · doi-reference
Effects of new P2X7R antagonists on retinal inflammatory degenerative conditions
10.1007/s10753-026-02513-7 · ExternalCitation · doi-reference
Screening herbal and natural product libraries to aid discovery of novel allosteric modulators of human P2X7
10.1007/s11302-024-10055-6 · ExternalCitation · doi-reference
BDDCS, the rule of 5 and drugability
10.1016/j.addr.2016.05.007 · ExternalCitation · doi-reference
The P2X7 receptor: shifting from a low- to a high-conductance channel — An enigmatic phenomenon?
10.1016/j.bbamem.2014.05.015 · ExternalCitation · doi-reference
Multiple P2X and P2Y receptor subtypes in mouse J774, spleen and peritoneal macrophages
10.1016/j.bcp.2004.11.012 · ExternalCitation · doi-reference
Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists
10.1016/j.bcp.2016.07.020 · ExternalCitation · doi-reference
In silico and pharmacological study of N,S-acetal juglone derivatives as inhibitors of the P2X7 receptor-promoted in vitro and in vivo inflammatory response
10.1016/j.biopha.2023.114608 · ExternalCitation · doi-reference
Full-length P2X7 structures reveal how palmitoylation prevents channel desensitization
10.1016/j.cell.2019.09.017 · ExternalCitation · doi-reference
In vivo P2X7 inhibition reduces amyloid plaques in Alzheimer’s disease through GSK3B and secretases
10.1016/j.neurobiolaging.2011.09.040 · ExternalCitation · doi-reference
Receptors for purines and pyrimidines
10.1016/s0031-6997(24)01373-5 · ExternalCitation · doi-reference
Nomenclature and classification of purinoceptors
10.1016/s0031-6997(25)06782-1 · ExternalCitation · doi-reference
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
10.1016/s0169-409x(96)00423-1 · ExternalCitation · doi-reference
Identification of new human P2X7 antagonists using ligand- and structure-based virtual screening
10.1021/acs.jcim.5c00552 · ExternalCitation · doi-reference
Design, synthesis, and biological evaluation of novel P2X7 receptor antagonists for the treatment of septic acute kidney injury
10.1021/acs.jmedchem.3c00837 · ExternalCitation · doi-reference
ATP release and purinergic signaling: a common pathway for particle-mediated inflammasome activation
10.1038/cddis.2012.144 · ExternalCitation · doi-reference
Natural products and drug discovery
10.1038/embor.2009.12 · ExternalCitation · doi-reference
Activation and regulation of the inflammasomes
10.1038/nri3452 · ExternalCitation · doi-reference
Positive allosteric modulation of P2X7 promotes apoptotic cell death over lytic cell death responses in macrophages
10.1038/s41419-019-2110-3 · ExternalCitation · doi-reference
A polycyclic scaffold identified by structure-based drug design effectively inhibits the human P2X7 receptor
10.1038/s41467-025-62643-8 · ExternalCitation · doi-reference
Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120
10.1038/s41598-017-00732-5 · ExternalCitation · doi-reference
Characterization of a selective and potent antagonist of human P2X(7) receptors, AZ11645373
10.1038/sj.bjp.0706933 · ExternalCitation · doi-reference
Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding
10.1038/sj.bjp.0707196 · ExternalCitation · doi-reference
Extracellular ATP induces the rapid release of HIV-1 from virus containing compartments of human macrophages
10.1073/pnas.1500656112 · ExternalCitation · doi-reference
Drug discovery beyond the rule of 5 - opportunities and challenges
10.1080/17460441.2017.1264385 · ExternalCitation · doi-reference
PLIP: fully automated protein–ligand interaction profiler
10.1093/nar/gkv315 · ExternalCitation · doi-reference
The P2X7 purinergic receptor: from physiology to neurological disorders
10.1096/fj.09-138883 · ExternalCitation · doi-reference
Functional evidence of distinct ATP activation sites at the human P2X7 receptor
10.1111/j.1469-7793.2001.00025.x · ExternalCitation · doi-reference
Cloning and pharmacological characterization of the dog P2X7 receptor
10.1111/j.1476-5381.2009.00425.x · ExternalCitation · doi-reference
A-740003 [N-(1-{[(cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective P2X7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat
10.1124/jpet.106.111559 · ExternalCitation · doi-reference
The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease
10.1124/pr.113.008003 · ExternalCitation · doi-reference
P2X7 receptors exhibit at least three modes of allosteric antagonism
10.1126/sciadv.ado5084 · ExternalCitation · doi-reference
The role of the purinergic P2X7 receptor in inflammation
10.1186/1476-9255-4-5 · ExternalCitation · doi-reference
Natural phytochemicals as P2X7 receptor inhibitors for the treatment of inflammation-related diseases
10.15586/ijfs.v35i2.2288 · ExternalCitation · doi-reference
The role of natural products in modern drug discovery
10.1590/0001-3765201920190105 · ExternalCitation · doi-reference
C. Förster, α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies
10.2147/ijn.s31373 · ExternalCitation · doi-reference
Recent patents on novel P2X(7) receptor antagonists and their potential for reducing central nervous system inflammation
10.2174/157488910789753530 · ExternalCitation · doi-reference
P2X7 in cancer: From molecular mechanisms to therapeutics
10.3389/fphar.2020.00793 · ExternalCitation · doi-reference
Gallic acid alleviates visceral pain and depression via inhibition of P2X7 receptor
10.3390/ijms23116159 · ExternalCitation · doi-reference
Physiological roles and potential therapeutic applications of the P2X7 receptor in inflammation and pain
10.3390/molecules180910953 · ExternalCitation · doi-reference
A hybrid approach combining shape-based and docking methods to identify novel potential P2X7 antagonists from natural product databases
10.3390/ph17050592 · ExternalCitation · doi-reference
Natural products as a source for new anti-inflammatory and analgesic compounds through the inhibition of purinergic P2X receptors
10.3390/ph6050650 · ExternalCitation · doi-reference
Virtual screening: a fast tool for drug design
10.3797/scipharm.0803-03 · ExternalCitation · doi-reference
Structural basis for subtype-specific inhibition of the P2X7 receptor
10.7554/elife.22153 · ExternalCitation · doi-reference
