Research graph
References from A hypothesis-driven perspective on GLP-1R-β-catenin pathway crosstalk in astrocyte plasticity and endogenous neural repair. Local targets link to admitted publications; unresolved targets remain external evidence.
Cell biology of astrocyte-synapse interactions
10.1016/j.neuron.2017.09.056 · 2017 · External reference
The molecular basis of water transport in the brain
10.1038/nrn1252 · 2003 · External reference
Astrocyte scar formation aids central nervous system axon regeneration
10.1038/nature17623 · 2016 · External reference
The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
10.1016/j.drudis.2016.01.013 · 2016 · External reference
Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
10.1016/s0140-6736(17)31585-4 · 2017 · External reference
Alzheimer's disease
10.1016/s0140-6736(10)61349-9 · 2011 · External reference
Identification of region-specific astrocyte subtypes at single cell resolution
10.1038/s41467-019-14198-8 · 2020 · External reference
Astrocyte development and heterogeneity
10.1101/cshperspect.a020362 · 2014 · External reference
NF-kappaB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells
10.3390/cells10040840 · 2021 · External reference
Signaling Mechanisms Underlying the Glioprotective Effects of Guanosine Against Glucose Deprivation-Induced Glial Dysfunction
10.1007/s11064-025-04498-5 · 2025 · External reference
Notch signaling in development and cancer
10.1210/er.2006-0046 · 2007 · External reference
Mechanisms and models of somatic cell reprogramming
10.1038/nrg3473 · 2013 · External reference
Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss
10.1152/ajpendo.00250.2023 · 2024 · External reference
Reactive gliosis and the multicellular response to CNS damage and disease
10.1016/j.neuron.2013.12.034 · 2014 · External reference
Structural and functional diversity among agonist-bound states of the GLP-1 receptor
10.1038/s41589-021-00945-w · 2022 · External reference
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
10.1038/nbt.1529 · 2009 · External reference
Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway
10.1002/jcb.24425 · 2013 · External reference
Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases
10.1016/j.ejphar.2022.175439 · 2023 · External reference
A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion
10.1016/j.ymthe.2019.09.003 · 2020 · External reference
Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain
10.1054/npep.1999.0757 · 1999 · External reference
WNTs in the vertebrate nervous system: from patterning to neuronal connectivity
10.1038/nrn1665 · 2005 · External reference
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain
10.1016/j.molmet.2015.07.008 · 2015 · External reference
Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail
10.1155/2019/7627148 · 2019 · External reference
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
10.1038/nsmb912 · 2005 · External reference
Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
10.1042/cs20110374 · 2012 · External reference
Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
10.2337/diab.44.9.1126 · 1995 · External reference
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
10.1016/s0140-6736(06)69705-5 · 2006 · External reference
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
10.1016/s0021-9258(18)42531-8 · 1992 · External reference
Reactive astrocyte nomenclature, definitions, and future directions
10.1038/s41593-020-00783-4 · 2021 · External reference
Signaling mechanisms regulating adult neural stem cells and neurogenesis
10.1016/j.bbagen.2012.09.002 · 2013 · External reference
IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
10.1038/s41536-022-00248-1 · 2022 · External reference
Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer
10.1038/nn.3676 · 2014 · External reference
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
10.1016/s1097-2765(01)00253-2 · 2001 · External reference
Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination
10.1523/jneurosci.4267-13.2014 · 2014 · External reference
Semaglutide lowers body weight in rodents via distributed neural pathways
10.1172/jci.insight.133429 · 2020 · External reference
Glial development: the crossroads of regeneration and repair in the CNS
10.1016/j.neuron.2014.06.010 · 2014 · External reference
A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain
10.1002/cne.24905 · 2020 · External reference
vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
10.1016/j.stem.2013.12.001 · 2014 · External reference
Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling
10.1016/s0092-8674(00)80689-3 · 2000 · External reference
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
10.1186/1742-2094-5-19 · 2008 · External reference
Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models
10.1016/j.neuropharm.2018.01.040 · 2018 · External reference
Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization
10.1210/en.2017-00812 · 2018 · External reference
Entry of exendin-4 into brain is rapid but may be limited at high doses
10.1038/sj.ijo.0802206 · 2003 · External reference
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist
10.1073/pnas.2014879117 · 2020 · External reference
Diversity of astrocyte functions and phenotypes in neural circuits
10.1038/nn.4043 · 2015 · External reference
Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway
10.3390/genes11070804 · 2020 · External reference
Directed differentiation of functional astroglial subtypes from human pluripotent stem cells
10.1038/nprot.2011.405 · 2011 · External reference
The glial nature of embryonic and adult neural stem cells
10.1146/annurev.neuro.051508.135600 · 2009 · External reference
Wnt/beta-Catenin Signaling Promotes Differentiation of Ischemia-Activated Adult Neural Stem/Progenitor Cells to Neuronal Precursors
10.3389/fnins.2021.628983 · 2021 · External reference
A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
10.1186/1750-1326-6-49 · 2011 · External reference
Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications
10.3389/fnmol.2024.1427054 · 2024 · External reference
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons
10.1016/j.stem.2015.06.003 · 2015 · External reference
Wnt signalling regulates adult hippocampal neurogenesis
10.1038/nature04108 · 2005 · External reference
Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/beta-catenin pathway
10.1016/j.phymed.2023.154857 · 2023 · External reference
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
10.1074/jbc.m706105200 · 2008 · External reference
Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex
10.2337/dbi21-0003 · 2021 · External reference
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFkappaB signaling pathway in the mouse hippocampus
10.1016/j.pnpbp.2020.110109 · 2021 · External reference
Lactate in the brain: from metabolic end-product to signalling molecule
10.1038/nrn.2018.19 · 2018 · External reference
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
10.1126/science.346.6206.237 · 2014 · External reference
Pathophysiology of stroke: lessons from animal models
10.1023/b:mebr.0000043966.46964.e6 · 2004 · External reference
Astrocyte epigenetics as a priority area in neuroscience research
2025 · External reference
Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions
10.1186/s12929-019-0538-5 · 2019 · External reference
Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
10.1016/j.cell.2017.05.016 · 2017 · External reference
Uniquely hominid features of adult human astrocytes
10.1523/jneurosci.4707-08.2009 · 2009 · External reference
Wnt/beta-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration
10.1038/s41467-023-35937-y · 2023 · External reference
NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
10.15252/embj.201591206 · 2016 · External reference
Glucagon-like Peptide-1 Receptor in the Human Hypothalamus Is Associated with Body Mass Index and Colocalizes with the Anorexigenic Neuropeptide Nucleobindin-2/Nesfatin-1
10.3390/ijms232314899 · 2022 · External reference
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion
10.3389/fcell.2020.591883 · 2020 · External reference
Insulin on hydrogen peroxide-induced oxidative stress involves ROS/Ca2+ and Akt/Bcl-2 signaling pathways
10.3109/10715762.2013.869588 · 2014 · External reference
Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance
10.1523/jneurosci.3579-15.2016 · 2016 · External reference
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
10.1016/s0896-6273(00)80086-0 · 1996 · External reference
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics
10.1016/j.bcp.2020.114187 · 2020 · External reference
Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish
10.1002/glia.23311 · 2018 · External reference
Regeneration beyond the glial scar
10.1038/nrn1326 · 2004 · External reference
The neurobiology of glia in the context of water and ion homeostasis
10.1016/j.neuroscience.2004.09.053 · 2004 · External reference
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]
10.1016/j.stem.2013.01.019 · 2013 · External reference
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells
10.1016/j.neuron.2017.07.035 · 2017 · External reference
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron
10.1126/scitranslmed.adp5765 · 2024 · External reference
Molecular dissection of reactive astrogliosis and glial scar formation
10.1016/j.tins.2009.08.002 · 2009 · External reference
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
10.1016/j.it.2020.07.004 · 2020 · External reference
Astrocytes: biology and pathology
10.1007/s00401-009-0619-8 · 2010 · External reference
TGF-beta1/SMAD signaling induces astrocyte fate commitment in vitro: implications for radial glia development
10.1002/glia.20522 · 2007 · External reference
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
10.1016/j.cmet.2020.05.001 · 2020 · External reference
Generation of induced neurons via direct conversion in vivo
10.1073/pnas.1303829110 · 2013 · External reference
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
10.3389/fnmol.2012.00001 · 2012 · External reference
Molecular roadblocks for cellular reprogramming
10.1016/j.molcel.2012.09.008 · 2012 · External reference
Revisiting astrocyte to neuron conversion with lineage tracing in vivo
10.1016/j.cell.2021.09.005 · 2021 · External reference
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
10.1056/nejmoa2302392 · 2023 · External reference
Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
10.1016/j.stem.2017.06.012 · 2017 · External reference
GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway
10.1016/j.bcp.2021.114578 · 2021 · External reference
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes
10.1097/jim.0000000000000129 · 2015 · External reference
Transient activation of Wnt/beta-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice
10.1016/j.bbrc.2018.02.004 · 2018 · External reference
The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders
10.3390/ijms18091861 · 2017 · External reference
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
10.7150/thno.15993 · 2016 · External reference
The Neurotrophic Function of Glucagon-Like Peptide-1 Promotes Human Neuroblastoma Differentiation via the PI3K-AKT Axis
2020 · External reference
Chemical Conversion of Human Fetal Astrocytes into Neurons through Modulation of Multiple Signaling Pathways
10.1016/j.stemcr.2019.01.003 · 2019 · External reference
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
10.1038/s41591-018-0051-5 · 2018 · External reference
Differential GLP-1R binding and activation by peptide and non-peptide agonists
10.1016/j.molcel.2020.09.020 · 2020 · External reference
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse
10.1016/j.neuron.2015.11.013 · 2016 · External reference
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
10.1038/nature22394 · 2017 · External reference
Weight loss blockbuster development: a role for unimolecular polypharmacology
10.1146/annurev-pharmtox-061324-011832 · 2025 · External reference
Structural pharmacology and mechanisms of GLP-1R signaling
10.1016/j.tips.2025.03.003 · 2025 · External reference
Molecular mechanisms and potential therapeutical targets in Huntington's disease
10.1152/physrev.00041.2009 · 2010 · External reference
A novel mouse model of glucagon-like peptide-1 receptor expression: A look at the brain
10.1002/cne.24905 · ExternalCitation · doi-reference
TGF-beta1/SMAD signaling induces astrocyte fate commitment in vitro: implications for radial glia development
10.1002/glia.20522 · ExternalCitation · doi-reference
Wnt signaling regulates proliferation and differentiation of radial glia in regenerative processes after stab injury in the optic tectum of adult zebrafish
10.1002/glia.23311 · ExternalCitation · doi-reference
Exendin-4 inhibits iNOS expression at the protein level in LPS-stimulated Raw264.7 macrophage by the activation of cAMP/PKA pathway
10.1002/jcb.24425 · ExternalCitation · doi-reference
Astrocytes: biology and pathology
10.1007/s00401-009-0619-8 · ExternalCitation · doi-reference
Signaling Mechanisms Underlying the Glioprotective Effects of Guanosine Against Glucose Deprivation-Induced Glial Dysfunction
10.1007/s11064-025-04498-5 · ExternalCitation · doi-reference
Signaling mechanisms regulating adult neural stem cells and neurogenesis
10.1016/j.bbagen.2012.09.002 · ExternalCitation · doi-reference
Transient activation of Wnt/beta-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice
10.1016/j.bbrc.2018.02.004 · ExternalCitation · doi-reference
Brain uptake pharmacokinetics of incretin receptor agonists showing promise as Alzheimer's and Parkinson's disease therapeutics
10.1016/j.bcp.2020.114187 · ExternalCitation · doi-reference
GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway
10.1016/j.bcp.2021.114578 · ExternalCitation · doi-reference
Wnt/beta-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
10.1016/j.cell.2017.05.016 · ExternalCitation · doi-reference
Revisiting astrocyte to neuron conversion with lineage tracing in vivo
10.1016/j.cell.2021.09.005 · ExternalCitation · doi-reference
GLP-1 Receptor Signaling in Astrocytes Regulates Fatty Acid Oxidation, Mitochondrial Integrity, and Function
10.1016/j.cmet.2020.05.001 · ExternalCitation · doi-reference
The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action
10.1016/j.drudis.2016.01.013 · ExternalCitation · doi-reference
Alternative role of glucagon-like Peptide-1 receptor agonists in neurodegenerative diseases
10.1016/j.ejphar.2022.175439 · ExternalCitation · doi-reference
Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity
10.1016/j.it.2020.07.004 · ExternalCitation · doi-reference
Molecular roadblocks for cellular reprogramming
10.1016/j.molcel.2012.09.008 · ExternalCitation · doi-reference
Differential GLP-1R binding and activation by peptide and non-peptide agonists
10.1016/j.molcel.2020.09.020 · ExternalCitation · doi-reference
Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain
10.1016/j.molmet.2015.07.008 · ExternalCitation · doi-reference
Reactive gliosis and the multicellular response to CNS damage and disease
10.1016/j.neuron.2013.12.034 · ExternalCitation · doi-reference
Glial development: the crossroads of regeneration and repair in the CNS
10.1016/j.neuron.2014.06.010 · ExternalCitation · doi-reference
Purification and characterization of progenitor and mature human astrocytes reveals transcriptional and functional differences with mouse
10.1016/j.neuron.2015.11.013 · ExternalCitation · doi-reference
Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells
10.1016/j.neuron.2017.07.035 · ExternalCitation · doi-reference
Cell biology of astrocyte-synapse interactions
10.1016/j.neuron.2017.09.056 · ExternalCitation · doi-reference
Novel dual GLP-1/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models
10.1016/j.neuropharm.2018.01.040 · ExternalCitation · doi-reference
The neurobiology of glia in the context of water and ion homeostasis
10.1016/j.neuroscience.2004.09.053 · ExternalCitation · doi-reference
Therapeutic effects of shikonin on adjuvant-induced arthritis in rats and cellular inflammation, migration and invasion of rheumatoid fibroblast-like synoviocytes via blocking the activation of Wnt/beta-catenin pathway
10.1016/j.phymed.2023.154857 · ExternalCitation · doi-reference
Melatonin ameliorates methamphetamine-induced cognitive impairments by inhibiting neuroinflammation via suppression of the TLR4/MyD88/NFkappaB signaling pathway in the mouse hippocampus
10.1016/j.pnpbp.2020.110109 · ExternalCitation · doi-reference
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]
10.1016/j.stem.2013.01.019 · ExternalCitation · doi-reference
vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer's disease model
10.1016/j.stem.2013.12.001 · ExternalCitation · doi-reference
Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons
10.1016/j.stem.2015.06.003 · ExternalCitation · doi-reference
Human iPSC Glial Mouse Chimeras Reveal Glial Contributions to Schizophrenia
10.1016/j.stem.2017.06.012 · ExternalCitation · doi-reference
Chemical Conversion of Human Fetal Astrocytes into Neurons through Modulation of Multiple Signaling Pathways
10.1016/j.stemcr.2019.01.003 · ExternalCitation · doi-reference
Molecular dissection of reactive astrogliosis and glial scar formation
10.1016/j.tins.2009.08.002 · ExternalCitation · doi-reference
Structural pharmacology and mechanisms of GLP-1R signaling
10.1016/j.tips.2025.03.003 · ExternalCitation · doi-reference
A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion
10.1016/j.ymthe.2019.09.003 · ExternalCitation · doi-reference
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
10.1016/s0021-9258(18)42531-8 · ExternalCitation · doi-reference
Axonal remodeling and synaptic differentiation in the cerebellum is regulated by WNT-7a signaling
10.1016/s0092-8674(00)80689-3 · ExternalCitation · doi-reference
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
10.1016/s0140-6736(06)69705-5 · ExternalCitation · doi-reference
Alzheimer's disease
10.1016/s0140-6736(10)61349-9 · ExternalCitation · doi-reference
Exenatide once weekly versus placebo in Parkinson's disease: a randomised, double-blind, placebo-controlled trial
10.1016/s0140-6736(17)31585-4 · ExternalCitation · doi-reference
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
10.1016/s0896-6273(00)80086-0 · ExternalCitation · doi-reference
A Common Phosphate Binding Site Explains the Unique Substrate Specificity of GSK3 and Its Inactivation by Phosphorylation
10.1016/s1097-2765(01)00253-2 · ExternalCitation · doi-reference
Pathophysiology of stroke: lessons from animal models
10.1023/b:mebr.0000043966.46964.e6 · ExternalCitation · doi-reference
Wnt signalling regulates adult hippocampal neurogenesis
10.1038/nature04108 · ExternalCitation · doi-reference
Astrocyte scar formation aids central nervous system axon regeneration
10.1038/nature17623 · ExternalCitation · doi-reference
Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein
10.1038/nature22394 · ExternalCitation · doi-reference
Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling
10.1038/nbt.1529 · ExternalCitation · doi-reference
Parallel states of pathological Wnt signaling in neonatal brain injury and colon cancer
10.1038/nn.3676 · ExternalCitation · doi-reference
Diversity of astrocyte functions and phenotypes in neural circuits
10.1038/nn.4043 · ExternalCitation · doi-reference
Directed differentiation of functional astroglial subtypes from human pluripotent stem cells
10.1038/nprot.2011.405 · ExternalCitation · doi-reference
Mechanisms and models of somatic cell reprogramming
10.1038/nrg3473 · ExternalCitation · doi-reference
Lactate in the brain: from metabolic end-product to signalling molecule
10.1038/nrn.2018.19 · ExternalCitation · doi-reference
The molecular basis of water transport in the brain
10.1038/nrn1252 · ExternalCitation · doi-reference
Regeneration beyond the glial scar
10.1038/nrn1326 · ExternalCitation · doi-reference
WNTs in the vertebrate nervous system: from patterning to neuronal connectivity
10.1038/nrn1665 · ExternalCitation · doi-reference
Beta-catenin directly displaces Groucho/TLE repressors from Tcf/Lef in Wnt-mediated transcription activation
10.1038/nsmb912 · ExternalCitation · doi-reference
Identification of region-specific astrocyte subtypes at single cell resolution
10.1038/s41467-019-14198-8 · ExternalCitation · doi-reference
Wnt/beta-catenin signalling is required for pole-specific chromatin remodeling during planarian regeneration
10.1038/s41467-023-35937-y · ExternalCitation · doi-reference
IRES-mediated Wnt2 translation in apoptotic neurons triggers astrocyte dedifferentiation
10.1038/s41536-022-00248-1 · ExternalCitation · doi-reference
Structural and functional diversity among agonist-bound states of the GLP-1 receptor
10.1038/s41589-021-00945-w · ExternalCitation · doi-reference
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson's disease
10.1038/s41591-018-0051-5 · ExternalCitation · doi-reference
Reactive astrocyte nomenclature, definitions, and future directions
10.1038/s41593-020-00783-4 · ExternalCitation · doi-reference
Entry of exendin-4 into brain is rapid but may be limited at high doses
10.1038/sj.ijo.0802206 · ExternalCitation · doi-reference
Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats
10.1042/cs20110374 · ExternalCitation · doi-reference
Increased glucagon-like peptide-1 receptor expression in glia after mechanical lesion of the rat brain
10.1054/npep.1999.0757 · ExternalCitation · doi-reference
Daily Oral GLP-1 Receptor Agonist Orforglipron for Adults with Obesity
10.1056/nejmoa2302392 · ExternalCitation · doi-reference
Generation of induced neurons via direct conversion in vivo
10.1073/pnas.1303829110 · ExternalCitation · doi-reference
Structural basis for GLP-1 receptor activation by LY3502970, an orally active nonpeptide agonist
10.1073/pnas.2014879117 · ExternalCitation · doi-reference
Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation
10.1074/jbc.m706105200 · ExternalCitation · doi-reference
Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces Alzheimer disease-associated tau hyperphosphorylation in the hippocampus of rats with type 2 diabetes
10.1097/jim.0000000000000129 · ExternalCitation · doi-reference
Astrocyte development and heterogeneity
10.1101/cshperspect.a020362 · ExternalCitation · doi-reference
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse
10.1126/science.346.6206.237 · ExternalCitation · doi-reference
The pharmacological basis for nonpeptide agonism of the GLP-1 receptor by orforglipron
10.1126/scitranslmed.adp5765 · ExternalCitation · doi-reference
Weight loss blockbuster development: a role for unimolecular polypharmacology
10.1146/annurev-pharmtox-061324-011832 · ExternalCitation · doi-reference
The glial nature of embryonic and adult neural stem cells
10.1146/annurev.neuro.051508.135600 · ExternalCitation · doi-reference
Brain access of incretins and incretin receptor agonists to their central targets relevant for appetite suppression and weight loss
10.1152/ajpendo.00250.2023 · ExternalCitation · doi-reference
Molecular mechanisms and potential therapeutical targets in Huntington's disease
10.1152/physrev.00041.2009 · ExternalCitation · doi-reference
Neuronal Transdifferentiation Potential of Human Mesenchymal Stem Cells from Neonatal and Adult Sources by a Small Molecule Cocktail
10.1155/2019/7627148 · ExternalCitation · doi-reference
Semaglutide lowers body weight in rodents via distributed neural pathways
10.1172/jci.insight.133429 · ExternalCitation · doi-reference
Glucagon-like peptide 1 receptor stimulation reverses key deficits in distinct rodent models of Parkinson's disease
10.1186/1742-2094-5-19 · ExternalCitation · doi-reference
A Wnt1 regulated Frizzled-1/beta-Catenin signaling pathway as a candidate regulatory circuit controlling mesencephalic dopaminergic neuron-astrocyte crosstalk: Therapeutical relevance for neuron survival and neuroprotection
10.1186/1750-1326-6-49 · ExternalCitation · doi-reference
Pinin protects astrocytes from cell death after acute ischemic stroke via maintenance of mitochondrial anti-apoptotic and bioenergetics functions
10.1186/s12929-019-0538-5 · ExternalCitation · doi-reference
Characterization of the Glucagonlike Peptide-1 Receptor in Male Mouse Brain Using a Novel Antibody and In Situ Hybridization
10.1210/en.2017-00812 · ExternalCitation · doi-reference
Notch signaling in development and cancer
10.1210/er.2006-0046 · ExternalCitation · doi-reference
Astrocytes Regulate GLP-1 Receptor-Mediated Effects on Energy Balance
10.1523/jneurosci.3579-15.2016 · ExternalCitation · doi-reference
Astrocyte-derived BDNF supports myelin protein synthesis after cuprizone-induced demyelination
10.1523/jneurosci.4267-13.2014 · ExternalCitation · doi-reference
Uniquely hominid features of adult human astrocytes
10.1523/jneurosci.4707-08.2009 · ExternalCitation · doi-reference
NeuroD1 reprograms chromatin and transcription factor landscapes to induce the neuronal program
10.15252/embj.201591206 · ExternalCitation · doi-reference
Single-Cell Mapping of GLP-1 and GIP Receptor Expression in the Dorsal Vagal Complex
10.2337/dbi21-0003 · ExternalCitation · doi-reference
Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
10.2337/diab.44.9.1126 · ExternalCitation · doi-reference
Insulin on hydrogen peroxide-induced oxidative stress involves ROS/Ca2+ and Akt/Bcl-2 signaling pathways
10.3109/10715762.2013.869588 · ExternalCitation · doi-reference
Regeneration of Functional Neurons After Spinal Cord Injury via in situ NeuroD1-Mediated Astrocyte-to-Neuron Conversion
10.3389/fcell.2020.591883 · ExternalCitation · doi-reference
Wnt/beta-Catenin Signaling Promotes Differentiation of Ischemia-Activated Adult Neural Stem/Progenitor Cells to Neuronal Precursors
10.3389/fnins.2021.628983 · ExternalCitation · doi-reference
GSK-3 and Wnt Signaling in Neurogenesis and Bipolar Disorder
10.3389/fnmol.2012.00001 · ExternalCitation · doi-reference
Wnt signaling pathway in spinal cord injury: from mechanisms to potential applications
10.3389/fnmol.2024.1427054 · ExternalCitation · doi-reference
NF-kappaB and TNF Affect the Astrocytic Differentiation from Neural Stem Cells
10.3390/cells10040840 · ExternalCitation · doi-reference
Glia and Neural Stem and Progenitor Cells of the Healthy and Ischemic Brain: The Workplace for the Wnt Signaling Pathway
10.3390/genes11070804 · ExternalCitation · doi-reference
The Emerging Role of GLP-1 Receptors in DNA Repair: Implications in Neurological Disorders
10.3390/ijms18091861 · ExternalCitation · doi-reference
Glucagon-like Peptide-1 Receptor in the Human Hypothalamus Is Associated with Body Mass Index and Colocalizes with the Anorexigenic Neuropeptide Nucleobindin-2/Nesfatin-1
10.3390/ijms232314899 · ExternalCitation · doi-reference
Activation of GLP-1 Receptor Enhances Neuronal Base Excision Repair via PI3K-AKT-Induced Expression of Apurinic/Apyrimidinic Endonuclease 1
10.7150/thno.15993 · ExternalCitation · doi-reference
