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References from A validated IL1β-induced caprine ex vivo early osteoarthritis model reveals disease-modifying efficacy of TC-S 7009 via HIF-2α inhibition. Local targets link to admitted publications; unresolved targets remain external evidence.
Osteoarthritis year in review 2025: Epidemiology and therapy
10.1016/j.joca.2025.08.015 · 2025 · External reference
Global, regional, and national burden of osteoarthritis, 1990–2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s2665-9913(23)00163-7 · 2023 · External reference
Osteoarthritis: molecular pathogenesis and potential therapeutic options
10.1038/s41392-025-02556-6 · 2026 · External reference
Update on clinical trials of intra-articular disease-modifying osteoarthritis drugs inducing cartilage regeneration
2025 · External reference
Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future
10.1016/j.joca.2016.07.017 · 2016 · External reference
Next-generation osteoarthritis models: integrating biological, computational, and engineering approaches
10.1186/s13287-025-04790-9 · 2025 · External reference
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols
10.1016/j.biopha.2020.110452 · 2020 · External reference
Osteoarthritis: pathogenic signaling pathways and therapeutic targets
10.1038/s41392-023-01330-w · 2023 · External reference
Is osteoarthritis one disease or a collection of many?
2018 · External reference
Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction
10.1038/nm.2153 · 2010 · External reference
Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
10.1038/nm.2146 · 2010 · External reference
Allosteric inhibition of hypoxia inducible factor-2 with small molecules
10.1038/nchembio.1185 · 2013 · External reference
The concept of early osteoarthritis and its significance in regenerative medicine
10.1007/s13770-022-00436-6 · 2022 · External reference
Models of osteoarthritis: the good, the bad and the promising
10.1016/j.joca.2018.09.016 · 2019 · External reference
A human osteoarthritis mimicking goat cartilage explant-based disease model for drug screening
2022 · External reference
Comparison of the effects of interleukin-1 on equine articular cartilage explants and cocultures of osteochondral and synovial explants
10.3389/fvets.2017.00152 · 2017 · External reference
Development of an in vitro model of injury-induced osteoarthritis in cartilage explants from adult horses through application of single-impact compressive overload
10.2460/ajvr.74.1.40 · 2013 · External reference
Clinical and omics biomarkers in osteoarthritis diagnosis and treatment
2025 · External reference
Pericellular plasma clot negates the influence of scaffold stiffness on chondrogenic differentiation
10.1016/j.actbio.2016.09.038 · 2016 · External reference
Hypoxia induces pulmonary fibroblast proliferation through NFAT signaling
10.1038/s41598-018-21073-x · 2018 · External reference
Piperlongumine mediates amelioration of osteoarthritis via inhibition of chondrocyte senescence and inflammation in a goat ex vivo model
10.1016/j.ejphar.2023.176136 · 2023 · External reference
Comparison of early-stage changes of osteoarthritis in cartilage and subchondral bone between two different rat models
2020 · External reference
Role of proinflammatory cytokines in the pathophysiology of osteoarthritis
10.1038/nrrheum.2010.196 · 2011 · External reference
Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator
10.1016/j.gene.2008.03.003 · 2008 · External reference
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
10.1038/nm.4324 · 2017 · External reference
NF-κB signaling in inflammation
2017 · External reference
The Effect of HIF-2α on the Development of Inflammation
2025 · External reference
On the dependency of cellular protein levels on mRNA abundance
10.1016/j.cell.2016.03.014 · 2016 · External reference
Targeting miR-18a sensitizes chondrocytes to anticytokine therapy to prevent osteoarthritis progression
10.1038/s41419-020-03155-9 · 2020 · External reference
Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg
10.1002/art.39243 · 2015 · External reference
Osteoarthritis: molecular pathogenesis and potential therapeutic options
10.1038/s41392-025-02556-6 · 2026 · External reference
Phospholipase A2 inhibitor–loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression
10.1126/sciadv.abe6374 · 2021 · External reference
Biphasic dose responses in biology, toxicology and medicine: accounting for their generalizability and quantitative features
10.1016/j.envpol.2013.07.046 · 2013 · External reference
Celecoxib inhibits production of MMP and NO via down-regulation of NF-κB and JNK in a PGE2 independent manner in human articular chondrocytes
10.1007/s00296-007-0511-6 · 2008 · External reference
Biphasic rapamycin effects in lymphoma and carcinoma treatment
10.1158/0008-5472.can-16-1140 · 2017 · External reference
Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice
10.1111/acel.12882 · 2019 · External reference
Targeting mTOR with rapamycin: one dose does not fit all
10.4161/cc.8.7.8044 · 2009 · External reference
Advancing drug delivery to articular cartilage: From single to multiple strategies
10.1016/j.apsb.2022.11.021 · 2023 · External reference
Intra-articular delivery of anti-Hif-2α siRNA by chondrocyte-homing nanoparticles to prevent cartilage degeneration in arthritic mice
10.1038/gt.2015.16 · 2015 · External reference
