Research graph
References from Ogremorphin induces ferroptosis in primary human glioblastoma neurospheres. Local targets link to admitted publications; unresolved targets remain external evidence.
CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013-2017
10.1093/neuonc/noaa200 · 2020 · External reference
The 2016 World Health Organization classification of tumors of the central nervous system: a summary
10.1007/s00401-016-1545-1 · 2016 · External reference
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
10.1056/nejmoa043330 · 2005 · External reference
Recurrent Glioblastoma: a Review of the Treatment Options
10.3390/cancers15174279 · 2023 · External reference
Glioblastoma at the crossroads: current understanding and future therapeutic horizons
10.1038/s41392-025-02299-4 · 2025 · External reference
Tumor microenvironment in glioblastoma: current and emerging concepts
2023 · External reference
Proton sensing GPCR’s: the missing link to Warburg’s oncogenic legacy?
10.46439/cancerbiology.5.066 · 2024 · External reference
Targeting metabolic reprogramming in glioblastoma as a new strategy to overcome therapy resistance
10.3389/fcell.2025.1535073 · 2025 · External reference
Extracellular acidic pH activates the sterol regulatory element-binding protein 2 to promote tumor progression
10.1016/j.celrep.2017.02.006 · 2017 · External reference
Adaptation to chronic acidic extracellular pH elicits a sustained increase in lung cancer cell invasion and metastasis
10.1007/s10585-019-09990-1 · 2020 · External reference
Tumor microenvironment acidosis favors pancreatic cancer stem cell properties and in vivo metastasis
10.1016/j.isci.2025.111956 · 2025 · External reference
GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
10.1186/s40164-023-00468-1 · 2024 · External reference
Ferroptosis: Mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Iron Metabolism in Ferroptosis
10.3389/fcell.2020.590226 · 2020 · External reference
Iron homeostasis and ferroptosis in human diseases: Mechanisms and therapeutic prospects
10.1038/s41392-024-01969-z · 2024 · External reference
Targeting Ferroptosis to Iron Out Cancer
10.1016/j.ccell.2019.04.002 · 2019 · External reference
Understanding the unique mechanism of ferroptosis: A promising therapeutic target
2023 · External reference
Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies
10.1016/j.omtn.2025.102649 · 2025 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
System Xc -/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy
2022 · External reference
RSL3 Drives Ferroptosis through NF-κB Pathway Activation and GPX4 Depletion in Glioblastoma
10.1155/2021/2915019 · 2021 · External reference
Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells
10.1007/s11011-022-00983-w · 2023 · External reference
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
10.1038/s41467-023-36630-w · 2023 · External reference
Dual inhibition of xCT and GGCT induces ferroptosis in glioblastoma cells by depleting cysteine and disrupting redox homeostasis
10.1038/s41420-026-03108-9 · 2026 · External reference
Boric Acid Increases Susceptibility to Chemotherapy by Targeting the Ferritinophagy Signaling Pathway in TMZ Resistant Glioblastoma Cells
10.1007/s12011-023-03930-7 · 2024 · External reference
Dysregulation of Iron Homeostasis Mediated by FTH Increases Ferroptosis Sensitivity in TP53-Mutant Glioblastoma
10.1007/s12264-024-01322-y · 2025 · External reference
Stress granules restrain ferroptosis by sequestering ferritin
10.1038/s41556-026-01953-5 · 2026 · External reference
Inhibition of GPR68 kills glioblastoma in zebrafish xenograft models
10.1186/s13104-024-06900-x · 2024 · External reference
Patient-derived glioblastoma cultures as a tool for small-molecule drug discovery
10.18632/oncotarget.27457 · 2020 · External reference
High-Throughput Screening of Patient-Derived Cultures Reveals Potential for Precision Medicine in Glioblastoma
10.1021/acsmedchemlett.5b00128 · 2015 · External reference
Discordant inheritance of chromosomal and extrachromosomal DNA elements contributes to dynamic disease evolution in glioblastoma
10.1038/s41588-018-0105-0 · 2018 · External reference
Optimization of high grade glioma cell culture from surgical specimens for use in clinically relevant animal models and 3D immunochemistry
10.3791/51088-v · 2014 · External reference
Cytotoxicity enhancement in MDA-MB-231 cells by the combination treatment of tetrahydropalmatine and berberine derived from Corydalis yanhusuo
10.5455/jice.20140123040224 · 2014 · External reference
Proton-sensing G-protein-coupled receptors
10.1038/nature01905 · 2003 · External reference
Proton-Sensing GPCRs in Health and Disease
10.3390/cells10082050 · 2021 · External reference
Characterization of the Intracellular Acidity Regulation of Brain Tumor Cells and Consequences for Therapeutic Optimization of Temozolomide
2023 · External reference
Inhibition of GPR68 induces ferroptosis and radiosensitivity in diverse cancer cell types
10.1038/s41598-025-88357-x · 2025 · External reference
Mechanisms of ferroptosis
10.1007/s00018-016-2194-1 · 2016 · External reference
The ferroptotic effect of NRF2-GCLM signaling axis derived by radiotherapy of esophageal squamous cell cancer: The vivo study
10.1038/s41598-025-10414-2 · 2025 · External reference
NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8
10.1126/sciadv.ade9585 · 2023 · External reference
Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis
10.7554/elife.02523 · 2014 · External reference
Lipid Composition Alters Ferroptosis Sensitivity
10.1158/0008-5472.can-24-4207 · 2025 · External reference
NRF2 Is a Major Target of ARF in p53-Independent Tumor Suppression
10.1016/j.molcel.2017.09.009 · 2017 · External reference
Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis
10.1016/j.canlet.2017.12.025 · 2018 · External reference
Artesunate activates the ATF4-CHOP-CHAC1 pathway and affects ferroptosis in Burkitt’s Lymphoma
10.1016/j.bbrc.2019.09.023 · 2019 · External reference
Transferrin Receptor Is a Specific Ferroptosis Marker
10.1016/j.celrep.2020.02.049 · 2020 · External reference
Characteristics and Biomarkers of Ferroptosis
2021 · External reference
Ferroptosis: An iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models
10.1021/ja411006a · 2014 · External reference
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65
10.1038/nature15699 · 2015 · External reference
Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
10.1158/1078-0432.ccr-23-0547 · 2023 · External reference
Long-term lorazepam use may be associated with worse long-term outcomes among patients with pancreatic adenocarcinoma
10.1016/j.surg.2024.08.027 · 2025 · External reference
Impact of developmental state, p53 status, and interferon signaling on glioblastoma cell response to radiation and temozolomide treatment
10.1371/journal.pone.0315171 · 2025 · External reference
Inhibition of GPR68 induces ferroptosis in diffuse intrinsic pontine gliomas
10.3389/fonc.2026.1808752 · 2026 · External reference
Extrachromosomal oncogene amplification drives tumour evolution and genetic heterogeneity
10.1038/nature21356 · 2017 · External reference
Extrachromosomal DNA in cancer
10.1038/s41568-024-00669-8 · 2024 · External reference
Extrachromosomal circular DNA in cancer drug resistance and its potential clinical implications
10.3389/fonc.2022.1092705 · 2023 · External reference
Cancer Spheroids and Organoids as Novel Tools for Research and Therapy: State of the Art and Challenges to Guide Precision Medicine
10.3390/cells12071001 · 2023 · External reference
Neurosphere formation is an independent predictor of clinical outcome in malignant glioma
10.1002/stem.15 · 2009 · External reference
Identification of a set of genes potentially responsible for resistance to ferroptosis in lung adenocarcinoma cancer stem cells
10.1038/s41419-024-06667-w · 2024 · External reference
Ioning out glioblastoma: Ferroptosis mechanisms and therapeutic frontiers
10.1038/s41420-025-02711-6 · 2025 · External reference
Dihydrotanshinone I inhibits human glioma cell proliferation via the activation of ferroptosis
10.3892/ol.2020.11980 · 2020 · External reference
Dihydroartemisinin initiates ferroptosis in glioblastoma through GPX4 inhibition
10.1042/bsr20193314 · 2020 · External reference
Capsaicin Enhances Temozolomide-Resistant Glioblastoma Cells’ Chemosensitivity and Ferroptosis through FHOD1/IRF2 Downregulation
10.1155/2024/8464817 · 2024 · External reference
Boric Acid Suppresses Glioblastoma Cellular Survival by Regulating Ferroptosis via SOX10/GPx4/ACSL4 Signalling and Iron Metabolism
10.1111/jcmm.70529 · 2025 · External reference
Targeting NQO1/GPX4-mediated ferroptosis by plumbagin suppresses in vitro and in vivo glioma growth
10.1038/s41416-022-01800-y · 2022 · External reference
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
10.1038/nchembio.2079 · 2016 · External reference
FIN56, a novel ferroptosis inducer, triggers lysosomal membrane permeabilization in a TFEB-dependent manner in glioblastoma
10.7150/jca.58500 · 2021 · External reference
Ferroptosis Modulation: Potential Therapeutic Target for Glioblastoma Treatment
10.3390/ijms23136879 · 2022 · External reference
The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin’s cytotoxicity in cancer cells
2018 · External reference
Sulfasalazine impacts on ferroptotic cell death and alleviates the tumor microenvironment and glioma-induced brain edema
10.18632/oncotarget.8651 · 2016 · External reference
NIR-promoted ferrous ion regeneration enhances ferroptosis for glioblastoma treatment
10.1016/j.jconrel.2024.01.004 · 2024 · External reference
Fucoxanthin triggers ferroptosis in glioblastoma cells by stabilizing the transferrin receptor
10.1007/s12032-023-02095-6 · 2023 · External reference
Artesunate induces ferroptosis via modulation of p38 and ERK signaling pathway in glioblastoma cells
10.1016/j.jphs.2022.01.007 · 2022 · External reference
Repurposing flubendazole for glioblastoma ferroptosis by affecting xCT and TFRC proteins
10.1111/jcmm.70188 · 2024 · External reference
Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells
10.3349/ymj.2021.62.9.843 · 2021 · External reference
The DRD2 Antagonist Haloperidol Mediates Autophagy-Induced Ferroptosis to Increase Temozolomide Sensitivity by Promoting Endoplasmic Reticulum Stress in Glioblastoma
10.1158/1078-0432.ccr-22-3971 · 2023 · External reference
Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4
10.1016/j.phymed.2024.155631 · 2024 · External reference
Ferroptosis-inducing effects of cromolyn in microglia through NCOA4-mediated ferritinophagy
10.1007/s11011-025-01729-0 · 2025 · External reference
Ferritinophagy: Research advance and clinical significance in cancers
10.1038/s41420-023-01753-y · 2023 · External reference
Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth
10.1016/j.celrep.2021.109024 · 2021 · External reference
Targeting glioblastoma mitochondrial metabolism with S-Gboxin induces cytotoxicity under conditions of the tumor microenvironment
10.1038/s41420-026-03072-4 · 2026 · External reference
MitoQ Triggers Mitochondrial Collapse and Apoptotic Death in Glioblastoma Associated with KATP Channel Expression Changes
10.1007/s11064-026-04742-6 · 2026 · External reference
KATP Channel Expression Determines ONC212 Sensitivity via Mitochondrial Dysfunction and PERK/ATF4/CHOP Activation in Glioblastoma
10.1111/jcmm.71301 · 2026 · External reference
ER stress and UPR activation in glioblastoma: Identification of a noncanonical PERK mechanism regulating GBM stem cells through SOX2 modulation
10.1038/s41419-019-1934-1 · 2019 · External reference
Targeting XBP1 mRNA splicing sensitizes glioblastoma to chemotherapy
10.1096/fba.2022-00141 · 2023 · External reference
Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy
10.1016/j.biopha.2023.115867 · 2024 · External reference
The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells
10.3390/ph17081089 · 2024 · External reference
Vulnerability of invasive glioblastoma cells to lysosomal membrane destabilization
10.15252/emmm.201809034 · 2019 · External reference
Lys05 induces lysosomal membrane permeabilization and increases radiosensitivity in glioblastoma
10.1002/jcb.29437 · 2020 · External reference
Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis
10.15252/embj.2019102030 · 2020 · External reference
Combinatorial targeting of glutamine metabolism and lysosomal-based lipid metabolism effectively suppresses glioblastoma
2024 · External reference
Lysine-arginine imbalance overcomes therapeutic tolerance governed by the transcription factor E3-lysosome axis in glioblastoma
10.1038/s41467-025-56946-z · 2025 · External reference
Identification of radiation responsive genes and transcriptome profiling via complete RNA sequencing in a stable radioresistant U87 glioblastoma model
10.18632/oncotarget.25247 · 2018 · External reference
