Research graph
References from Cyclic nucleotide signaling through phosphodiesterase 1 inhibition and its interaction with the competing endogenous RNA network regulates cognition. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyloid-beta and tau protein beyond Alzheimer's disease
10.4103/1673-5374.386406 · 2024 · External reference
Amyloid-beta and Tau in Alzheimer's disease: pathogenesis, mechanisms, and interplay
10.1038/s41419-025-08186-8 · 2026 · External reference
KIF2A downregulation links amyloid-beta to Tau phosphorylation in Alzheimer's disease
10.1093/brain/awaf382 · 2026 · External reference
Recent advances in Alzheimer's disease: Mechanisms, clinical trials and new drug development strategies
10.1038/s41392-024-01911-3 · 2024 · External reference
Treatment of Alzheimer's Disease: Beyond Symptomatic Therapies
10.3390/ijms241813900 · 2023 · External reference
Anti-Amyloid Immunotherapies for Alzheimer's Disease: A 2023 Clinical Update
10.1007/s13311-023-01405-0 · 2023 · External reference
Unresolved reference
External reference
Fluorinated and iodinated (Z)-2-(4-(2-fluoroethoxy)benzylidene)-5-iodobenzofuran-3(2H)-one
2004 · External reference
Current Anti-Amyloid-beta Therapy for Alzheimer's Disease Treatment: From Clinical Research to Nanomedicine
10.2147/ijn.s444115 · 2023 · External reference
Lecanemab (Leqembi) is not the right drug for patients with Alzheimer's disease
10.17219/acem/171379 · 2023 · External reference
Lecanemab in Early Alzheimer's Disease
10.1056/nejmoa2212948 · 2023 · External reference
Approved drugs and natural products at clinical stages for treating Alzheimer's disease
2024 · External reference
Bioenergetic failure and oxidative stress: mitochondrial contributions to Alzheimer's disease
10.1007/s10787-025-01916-6 · 2025 · External reference
Promoting proteostasis by cAMP/PKA and cGMP/PKG
10.1016/j.molmed.2024.10.006 · 2025 · External reference
The protective and therapeutic effects of vinpocetine, a PDE1 inhibitor, on oxidative stress and learning and memory impairment induced by an intracerebroventricular (ICV) injection of amyloid beta (abeta) peptide
10.1016/j.bbr.2020.112512 · 2020 · External reference
Amelioration of intracerebroventricular streptozotocin induced cognitive dysfunction and oxidative stress by vinpocetine -- a PDE1 inhibitor
10.1016/j.ejphar.2009.08.027 · 2009 · External reference
Cyclic nucleotide phosphodiesterase 1 and cognitive impairment: Mechanistic insights and therapeutic implications
10.1016/j.biopha.2025.118796 · 2025 · External reference
PDE1 isozymes, key regulators of pathological vascular remodeling
10.1016/j.coph.2011.09.002 · 2011 · External reference
The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4
10.1016/j.toxlet.2006.10.016 · 2007 · External reference
The role of Phosphodiesterase-1 and its natural product inhibitors in Alzheimer's disease: A review
10.3389/fphar.2022.1070677 · 2022 · External reference
Phosphodiesterase inhibitors say NO to Alzheimer's disease
10.1016/j.fct.2019.110822 · 2019 · External reference
PDE1 inhibitors: a review of the recent patent literature (2008-present)
10.1080/13543776.2022.2027910 · 2022 · External reference
Inhibition of calcium-calmodulin-dependent phosphodiesterase (PDE1) suppresses inflammatory responses
10.1016/j.mcn.2019.103449 · 2020 · External reference
Genomic regulation of transcription and RNA processing by the multitasking Integrator complex
10.1038/s41580-022-00534-2 · 2023 · External reference
Identification of a lncRNA/circRNA-miRNA-mRNA ceRNA Network in Alzheimer's Disease
10.31083/j.jin2206136 · 2023 · External reference
Construction of lncRNA-ceRNA Networks to Reveal the Potential Role of Lfng/Notch1 Signaling Pathway in Alzheimer's Disease
10.2174/1567205020666221130090103 · 2022 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Ceria-nanocluster based therapy for Alzheimer's disease through the modulation of activated microglia and attenuation of amyloid-beta deposition
10.1016/j.celbio.2025.100158 · 2025 · External reference
Memory enhancing effects of BPN14770, an allosteric inhibitor of phosphodiesterase-4D, in wild-type and humanized mice
10.1038/s41386-018-0178-6 · 2018 · External reference
Antiamnesic Effects of Novel Phthalimide Derivatives in Scopolamine-Induced Memory Impairment in Mice: A Useful Therapy for Alzheimer's Disease
10.1021/acsomega.2c07951 · 2023 · External reference
Different effects of scopolamine on the retrieval of spatial memory and fear memory
10.1016/j.bbr.2010.05.032 · 2011 · External reference
The Y-Maze for Assessment of Spatial Working and Reference Memory in Mice
10.1007/978-1-4939-8994-2_10 · 2019 · External reference
Assessing Spatial Working Memory Using the Spontaneous Alternation Y-maze Test in Aged Male Mice
10.21769/bioprotoc.3162 · 2019 · External reference
Use of the Open Field Maze to measure locomotor and anxiety-like behavior in mice
10.3791/52434-v · 2015 · External reference
Morris water maze test for learning and memory deficits in Alzheimer's disease model mice
10.3791/2920-v · 2011 · External reference
Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice
10.1093/brain/awae127 · 2024 · External reference
Beyond the blur: Scopolamine's utility and limits in modeling cognitive disorders across sexes - Narrative review
10.1016/j.arr.2024.102635 · 2025 · External reference
Mitochondrial dysfunction in Alzheimer's disease
2025 · External reference
Identification of mitochondrial related signature associated with immune microenvironment in Alzheimer's disease
10.1186/s12967-023-04254-9 · 2023 · External reference
Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease
10.1038/s41598-022-10554-9 · 2022 · External reference
Down-regulated expression of microRNA-338-5p contributes to neuropathology in Alzheimer's disease
10.1096/fj.201801846r · 2019 · External reference
Synaptic and cognitive improvements by inhibition of 2-AG metabolism are through upregulation of microRNA-188-3p in a mouse model of Alzheimer's disease
10.1523/jneurosci.1165-14.2014 · 2014 · External reference
The landscape of programmed cell death-related lncRNAs in Alzheimer's disease and Parkinson's disease
10.1007/s10495-024-01984-z · 2024 · External reference
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer's disease
10.1007/s00401-024-02787-x · 2024 · External reference
LncRNA NKILA Exacerbates Alzheimer's Disease Progression by Regulating the FOXA1-Mediated Transcription of TNFAIP1
10.1007/s11064-023-03944-6 · 2023 · External reference
Apelin-13-Mediated Upregulation of METTL3 Ameliorates Alzheimer's Disease via Inhibiting Neuroinflammation Through m6A-Dependent Regulation of lncRNA BDNF-AS
10.3390/biom15081188 · 2025 · External reference
Identification of key regulatory molecules in the early development stage of Alzheimer's disease
10.1111/jcmm.18151 · 2024 · External reference
LncRNA Xist, X-chromosome Instability and Alzheimer's Disease
10.2174/1567205017666200807185624 · 2020 · External reference
The maternal X chromosome affects cognition and brain ageing in female mice
10.1038/s41586-024-08457-y · 2025 · External reference
lncRNA Xist regulates sevoflurane-induced social and emotional impairment by modulating miR-98-5p/EDEM1 signaling axis in neonatal mice
10.1016/j.omtn.2021.04.010 · 2021 · External reference
Xist in X chromosome inactivation: mechanisms and disease relevance
10.1186/s12964-025-02534-z · 2025 · External reference
Silencing of long noncoding RNA XIST attenuated Alzheimer's disease-related BACE1 alteration through miR-124
10.1002/cbin.11263 · 2020 · External reference
LncRNA XIST knockdown attenuates Abeta(25-35)-induced toxicity, oxidative stress, and apoptosis in primary cultured rat hippocampal neurons by targeting miR-132
2018 · External reference
lncRNA XIST induces Abeta accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease
10.1080/01677063.2022.2028784 · 2022 · External reference
Vinpocetine restores cognitive and motor functions in Traumatic brain injury challenged rats
10.1007/s10787-022-01059-y · 2022 · External reference
The protective effect of taurine, piracetam and vinpocetine on etoposide-induced inflammation and brain injury in the serum of female albino rats
2023 · External reference
Vinpocetine, a PDE1 modulator, regulates markers of cerebral health, inflammation, and oxidative stress in a rat model of prenatal alcohol-induced experimental attention deficit hyperactivity disorder
10.1016/j.alcohol.2022.08.005 · 2022 · External reference
