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References from Sunitinib induces senolysis associated with modulation of platelet-derived growth factor receptor beta. Local targets link to admitted publications; unresolved targets remain external evidence.
Cellular Senescence: Defining a Path Forward
10.1016/j.cell.2019.10.005 · 2019 · External reference
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
10.3389/fcell.2021.645593 · 2021 · External reference
BCL-2 proteins in senescence: beyond a simple target for senolysis?
10.1038/s41580-023-00594-y · 2023 · External reference
Anti-apoptosis and cell survival: a review
10.1016/j.bbamcr.2010.10.010 · 2011 · External reference
Regulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions
10.1016/j.jmb.2019.05.036 · 2019 · External reference
Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span
10.1146/annurev-pharmtox-050120-105018 · 2021 · External reference
Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL
10.1158/0008-5472.can-10-4336 · 2011 · External reference
Regulation of cellular senescence via the FOXO4-p53 axis
10.1002/1873-3468.13057 · 2018 · External reference
Targeting HSP90 as a Novel Therapy for Cancer: Mechanistic Insights and Translational Relevance
10.3390/cells11182778 · 2022 · External reference
Identification of SYK inhibitor, R406 as a novel senolytic agent
10.18632/aging.103135 · 2020 · External reference
What matters in aging is signaling for responsiveness
10.1016/j.pharmthera.2023.108560 · 2023 · External reference
From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes
10.5483/bmbrep.2015.48.10.122 · 2015 · External reference
Mechanisms of activation of receptor tyrosine kinases: monomers or dimers
10.3390/cells3020304 · 2014 · External reference
Tyrosine kinase - Role and significance in Cancer
10.7150/ijms.1.101 · 2004 · External reference
Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor
10.1093/gerona/55.3.b125 · 2000 · External reference
Senescence as biologic endpoint following pharmacological targeting of receptor tyrosine kinases in cancer
10.1016/j.bcp.2016.08.022 · 2017 · External reference
Inhibition of VEGF induces cellular senescence in colorectal cancer cells
10.1002/ijc.26179 · 2011 · External reference
Prognostic significance of VEGF expression evaluated by quantitative immunohistochemical analysis in colorectal cancer
10.1016/j.jss.2007.05.041 · 2008 · External reference
Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) delays and induces escape from senescence in human dermal microvascular endothelial cells
10.1038/sj.onc.1201033 · 1997 · External reference
Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
10.1073/pnas.0405775102 · 2005 · External reference
Molecular evolution and functional characterization of Drosophila insulin-like peptides
10.1371/journal.pgen.1000857 · 2010 · External reference
Radiation-induced senescence in securin-deficient cancer cells promotes cell invasion involving the IL-6/STAT3 and PDGF-BB/PDGFR pathways
10.1038/srep01675 · 2013 · External reference
Platelet-derived growth factor receptor-alpha is essential for cardiac fibroblast survival
10.1152/ajpheart.00054.2019 · 2019 · External reference
PDGFR-beta Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration
10.1016/j.celrep.2019.06.065 · 2019 · External reference
Chemical screening identifies ATM as a target for alleviating senescence
10.1038/nchembio.2342 · 2017 · External reference
Brief guide to senescence assays using cultured mammalian cells
10.1016/j.mocell.2024.100102 · 2024 · External reference
Cellular senescence mediates fibrotic pulmonary disease
10.1038/ncomms14532 · 2017 · External reference
Further exploration of the Penh parameter
10.1016/j.etp.2006.02.014 · 2006 · External reference
Role of tetrahydrobiopterin in pulmonary vascular remodelling associated with pulmonary fibrosis
10.1136/thoraxjnl-2013-203408 · 2013 · External reference
Chop Deficiency Protects Mice Against Bleomycin-induced Pulmonary Fibrosis by Attenuating M2 Macrophage Production
10.1038/mt.2016.36 · 2016 · External reference
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production
10.1038/sj.onc.1209281 · 2006 · External reference
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling
10.1038/nm1282 · 2005 · External reference
Caspase activation cascades in apoptosis
10.1042/bst0360001 · 2008 · External reference
Caspases in apoptosis and beyond
10.1038/onc.2008.297 · 2008 · External reference
The Beclin 1 network regulates autophagy and apoptosis
10.1038/cdd.2010.191 · 2011 · External reference
LC3 and Autophagy
10.1007/978-1-59745-157-4_4 · 2008 · External reference
The autophagy initiating kinase ULK1 is regulated via opposing phosphorylation by AMPK and mTOR
10.4161/auto.7.6.15123 · 2011 · External reference
p62 links the autophagy pathway and the ubiqutin-proteasome system upon ubiquitinated protein degradation
10.1186/s11658-016-0031-z · 2016 · External reference
The molecular mechanisms of MLKL-dependent and MLKL-independent necrosis
10.1093/jmcb/mjaa055 · 2021 · External reference
Short telomere length in IPF lung associates with fibrotic lesions and predicts survival
10.1371/journal.pone.0189467 · 2017 · External reference
Molecular programs of fibrotic change in aging human lung
10.1038/s41467-021-26603-2 · 2021 · External reference
The Aging Lung and Idiopathic Pulmonary Fibrosis
10.1016/j.amjms.2019.02.008 · 2019 · External reference
Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
10.1016/j.ebiom.2018.12.052 · 2019 · External reference
Fisetin Alleviated Bleomycin-Induced Pulmonary Fibrosis Partly by Rescuing Alveolar Epithelial Cells From Senescence
10.3389/fphar.2020.553690 · 2020 · External reference
Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging
10.1016/j.cell.2018.10.012 · 2018 · External reference
PDGF signalling controls age-dependent proliferation in pancreatic beta-cells
10.1038/nature10502 · 2011 · External reference
Therapeutic effects of PDGF-AB/BB against cellular senescence in human intervertebral disc
2025 · External reference
PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis
10.1002/dvdy.1225 · 2002 · External reference
PDGF-Ralpha gene expression predicts proliferation, but PDGF-A suppresses transdifferentiation of neonatal mouse lung myofibroblasts
10.1186/1465-9921-10-119 · 2009 · External reference
Use of multitarget tyrosine kinase inhibitors to attenuate platelet-derived growth factor signalling in lung disease
10.1183/16000617.0061-2017 · 2017 · External reference
New insights about the PDGF/PDGFR signaling pathway as a promising target to develop cancer therapeutic strategies
10.1016/j.biopha.2023.114491 · 2023 · External reference
PDGFRalpha/PDGFRbeta signaling balance modulates progenitor cell differentiation into white and beige adipocytes
10.1242/dev.155861 · 2018 · External reference
vitro and in vivo effects of PDGF-BB delivery strategies on tendon healing: a review
10.22203/ecm.v034a02 · 2017 · External reference
Mechanism of PI3K/Akt‑mediated mitochondrial pathway in obesity‑induced apoptosis (Review)
10.3892/br.2024.1918 · 2025 · External reference
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
10.18632/aging.100296 · 2011 · External reference
PDGFRbeta and oncogenic mutant PDGFRalpha D842V promote disassembly of primary cilia through a PLCgamma- and AURKA-dependent mechanism
2015 · External reference
Genetic Ablation of PDGF-Dependent Signaling Pathways Abolishes Vascular Remodeling and Experimental Pulmonary Hypertension
10.1161/atvbaha.114.304864 · 2015 · External reference
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3
10.1093/emboj/20.10.2487 · 2001 · External reference
Stat6 and Jak1 are common elements in platelet-derived growth factor and interleukin-4 signal transduction pathways in NIH 3T3 fibroblasts
10.1074/jbc.271.36.22175 · 1996 · External reference
PDGF stimulates tyrosine phosphorylation of JAK 1 protein tyrosine kinase in human mesangial cells
10.1038/ki.1996.3 · 1996 · External reference
Distinct mechanisms of activation of Stat1 and Stat3 by platelet-derived growth factor receptor in a cell-free system
10.1128/mcb.19.5.3727 · 1999 · External reference
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL-6 in human liver cancer cells
10.1074/jbc.m110.142752 · 2010 · External reference
The role of STATs in apoptosis
10.2174/1566524023362456 · 2002 · External reference
Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway
10.1007/s00432-011-1037-6 · 2011 · External reference
Janus Kinase 1 Plays a Critical Role in Mammary Cancer Progression
10.1016/j.celrep.2018.10.063 · 2018 · External reference
The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells
10.18632/aging.102172 · 2019 · External reference
The role of BCL-2 family proteins in regulating apoptosis and cancer therapy
10.3389/fonc.2022.985363 · 2022 · External reference
Glutamine reliance in cell metabolism
10.1038/s12276-020-00504-8 · 2020 · External reference
Identification of senescent cell surface targetable protein DPP4
10.1101/gad.302570.117 · 2017 · External reference
Sunitinib: a multitargeted receptor tyrosine kinase inhibitor in the era of molecular cancer therapies
10.2165/11318860-000000000-00000 · 2009 · External reference
Anlotinib Suppressed Ovarian Cancer Progression via Inducing G2/M Phase Arrest and Apoptosis
10.3390/jcm12010162 · 2022 · External reference
Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors
10.1016/j.clinthera.2007.07.022 · 2007 · External reference
Sunitinib: a novel tyrosine kinase inhibitor. A brief review of its therapeutic potential in the treatment of renal carcinoma and gastrointestinal stromal tumors (GIST)
10.2147/tcrm.2007.3.2.341 · 2007 · External reference
A. Alshamsan, Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-kappaB Signaling Pathways
2017 · External reference
Sunitinib promotes apoptosis via p38 MAPK activation and STAT3 downregulation in oral keratinocytes
10.1111/odi.14457 · 2024 · External reference
Sunitinib induces apoptosis and growth arrest of medulloblastoma tumor cells by inhibiting STAT3 and AKT signaling pathways
10.1158/1541-7786.mcr-09-0220 · 2010 · External reference
The role of the aging microenvironment on the fate of PDGFRbeta lineage cells in skeletal muscle repair
10.1186/s13287-022-03072-y · 2022 · External reference
Deciphering the age-dependent changes of pulmonary fibroblasts in mice by single-cell transcriptomics
10.3389/fcell.2023.1287133 · 2023 · External reference
Age-dependent Pdgfrbeta signaling drives adipocyte progenitor dysfunction to alter the beige adipogenic niche in male mice
10.1038/s41467-023-37386-z · 2023 · External reference
Endothelial PDGF-BB/PDGFR-beta signaling promotes osteoarthritis by enhancing angiogenesis-dependent abnormal subchondral bone formation
10.1038/s41413-022-00229-6 · 2022 · External reference
Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis
10.1074/jbc.m114.563064 · 2014 · External reference
Silencing platelet-derived growth factor receptor-beta enhances the radiosensitivity of C6 glioma cells in vitro and in vivo
10.3892/ol.2017.6143 · 2017 · External reference
Inhibition of PDGFR by CP-673451 induces apoptosis and increases cisplatin cytotoxicity in NSCLC cells via inhibiting the Nrf2-mediated defense mechanism
10.1016/j.toxlet.2018.05.033 · 2018 · External reference
Nintedanib induces senolytic effect via STAT3 inhibition
10.1038/s41419-022-05207-8 · 2022 · External reference
JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age
10.1073/pnas.1515386112 · 2015 · External reference
PDGFRbeta promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma
10.1186/s12943-022-01640-7 · 2022 · External reference
Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma
10.1158/1541-7786.mcr-21-0832 · 2023 · External reference
Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma
10.1073/pnas.1610970113 · 2016 · External reference
HER2-Targeted Tyrosine Kinase Inhibitors Cause Therapy-Induced-Senescence in Breast Cancer Cells
10.3390/cancers11020197 · 2019 · External reference
Sunitinib induces cellular senescence via p53/Dec1 activation in renal cell carcinoma cells
10.1111/cas.12176 · 2013 · External reference
Sunitinib stimulates cellular senescence of gastrointestinal stromal tumor cells through inhibition of SIRT1
10.1134/s1068162024605329 · 2025 · External reference
Geroconversion: irreversible step to cellular senescence
10.4161/15384101.2014.985507 · 2014 · External reference
Bleomycin induces cellular senescence in alveolar epithelial cells
10.1183/09031936.03.00011903 · 2003 · External reference
F. d′Adda di Fagagna, Cellular senescence: when bad things happen to good cells
10.1038/nrm2233 · 2007 · External reference