Research graph
References from Opposing Control of Dopamine Neuron Excitability by Orexin (Hypocretin) Receptors 1 and 2. Local targets link to admitted publications; unresolved targets remain external evidence.
Motivational activation: a unifying hypothesis of orexin/hypocretin function
10.1038/nn.3810 · 2014 · External reference
Orexin axons in the rat ventral tegmental area synapse infrequently onto dopamine and gamma-aminobutyric acid neurons
10.1002/cne.21420 · 2007 · External reference
Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control
10.1038/s41380-023-02329-z · 2024 · External reference
Divergent modulation of dopaminergic neurons by hypocretin/orexin receptors 1 and 2 shapes dopaminergic cell activity and socioemotional behavior
10.1016/j.biopsych.2026.05.022 · 2026 · External reference
Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine
10.1016/j.neuron.2006.01.016 · 2006 · External reference
Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons
10.1111/j.1460-9568.2008.06397.x · 2008 · External reference
Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins
10.1523/jneurosci.23-01-00007.2003 · 2003 · External reference
Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
10.1254/jphs.92.259 · 2003 · External reference
Orexin (hypocretin) and addiction
10.1016/j.tins.2021.09.002 · 2021 · External reference
Orexin reserve: A mechanistic framework for the role of orexins (hypocretins) in addiction
10.1016/j.biopsych.2022.06.027 · 2022 · External reference
