Research graph
References from Nanopore sensing with machine learning-assisted analysis for real-time single-molecule detection of MDM2-p53TAD interactions. Local targets link to admitted publications; unresolved targets remain external evidence.
A generalizable nanopore sensor for highly specific protein detection at single-molecule precision
10.1038/s41467-023-36944-9 · 2023 · External reference
Facing and overcoming sensitivity challenges in biomolecular NMR spectroscopy
10.1002/anie.201410653 · 2015 · External reference
Study of strong to ultratight protein interactions using differential scanning calorimetry
10.1021/bi00481a024 · 1990 · External reference
Deep learning-assisted single-molecule detection of protein post-translational modifications with a biological nanopore
10.1021/acsnano.3c08623 · 2024 · External reference
XGBoost: a scalable tree boosting system
2016 · External reference
Inhibiting the p53-MDM2 interaction: an important target for cancer therapy
10.1038/nrc991 · 2003 · External reference
Structural details on mdm2-p53 interaction
10.1074/jbc.m508578200 · 2005 · External reference
Profiling protein-protein interactions to predict the efficacy of B-cell-lymphoma-2-homology-3 mimetics for acute myeloid leukaemia
10.1038/s41551-024-01241-3 · 2024 · External reference
Deep learning of Nanopore sensing signals using a Bi-Path network
10.1021/acsnano.1c03842 · 2021 · External reference
SAR by (Protein-Observed) (19)F NMR
10.1021/acs.accounts.9b00377 · 2019 · External reference
Protein interaction analysis by surface plasmon resonance
10.1007/978-1-0716-3147-8_19 · 2023 · External reference
Protein reconstitution into freestanding planar lipid membranes for electrophysiological characterization
10.1038/nprot.2015.003 · 2015 · External reference
Molecular mimicry-based repositioning of nutlin-3 to anti-apoptotic Bcl-2 family proteins
10.1021/ja109521f · 2011 · External reference
Random Decision Forests
10.1109/icdar.1995.598994 · 1995 · External reference
Single-molecule fingerprinting of protein-drug interaction using a funneled biological nanopore
10.1038/s41467-023-37098-4 · 2023 · External reference
Improving single-molecule antibody detection selectivity through optimization of peptide epitope presentation in OmpG nanopore
10.1021/acssensors.3c00528 · 2023 · External reference
Overcoming limitations of FRET measurements
10.1002/cyto.a.22851 · 2016 · External reference
Mapping the conformational energy landscape of Abl kinase using ClyA nanopore tweezers
10.1038/s41467-022-31215-5 · 2022 · External reference
The OncoPPi network of cancer-focused protein-protein interactions to inform biological insights and therapeutic strategies
10.1038/ncomms14356 · 2017 · External reference
Recent advances in the development of protein-protein interactions modulators: mechanisms and clinical trials
10.1038/s41392-020-00315-3 · 2020 · External reference
Automated electrical quantification of vitamin B1 in a bodily fluid using an engineered Nanopore sensor
10.1002/anie.202107807 · 2021 · External reference
Label-Free mapping of multivalent binding pathways with ligand-receptor-anchored nanopores
10.1021/jacs.4c04934 · 2024 · External reference
Screening for protein-protein interactions using Forster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM)
10.1038/srep28186 · 2016 · External reference
Ordering of the N-terminus of human MDM2 by small molecule inhibitors
10.1021/ja305839b · 2012 · External reference
Single-molecule analysis of interaction between p53TAD and MDM2 using aerolysin nanopores
10.1039/d1sc00386k · 2021 · External reference
Isothermal titration calorimetry of protein-protein interactions
10.1006/meth.1999.0852 · 1999 · External reference
Isothermal titration calorimetry of membrane proteins - progress and challenges
10.1016/j.bbamem.2013.05.023 · 2014 · External reference
Discovery of a small molecule MDM2 inhibitor (AMG 232) for treating cancer
10.1021/jm500627s · 2014 · External reference
Single-Molecule-Based, label-free monitoring of molecular glue efficacies for promoting protein-protein interactions using YaxAB nanopores
10.1021/acsnano.4c11436 · 2024 · External reference
Small molecules, big targets: drug discovery faces the protein-protein interaction challenge
10.1038/nrd.2016.29 · 2016 · External reference
Single-Molecule analyte recognition with ClyA nanopores equipped with internal protein adaptors
10.1021/jacs.5b01520 · 2015 · External reference
Discovery of AMG 232, a potent, selective, and orally bioavailable MDM2-p53 inhibitor in clinical development
10.1021/jm401753e · 2014 · External reference
Real-time measurement of protein–protein interactions at single-molecule resolution using a biological nanopore
10.1038/nbt.4316 · 2019 · External reference
Real-Time conformational changes and controlled orientation of native proteins inside a protein nanoreactor
10.1021/jacs.7b10106 · 2017 · External reference
Characterization of protein-protein interactions by isothermal titration calorimetry
2004 · External reference
Interactome networks and human disease
10.1016/j.cell.2011.02.016 · 2011 · External reference
Live or let die: the cell's response to p53
10.1038/nrc864 · 2002 · External reference
Nanopore-Based measurements of protein size, fluctuations, and conformational changes
10.1021/acsnano.7b01212 · 2017 · External reference
Phoneme recognition using time-delay neural networks
10.1109/29.21701 · 1989 · External reference
Engineering of protein nanopores for sequencing, chemical or protein sensing and disease diagnosis
10.1016/j.copbio.2017.11.006 · 2018 · External reference
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces
10.1038/nature06526 · 2007 · External reference
A guide to signal processing algorithms for nanopore sensors
10.1021/acssensors.1c01618 · 2021 · External reference
Beta-barrel nanopores as diagnostic sensors: an engineering perspective
2024 · External reference
Single antibody-antigen interactions monitored via transient ionic current recording using nanopore sensors
10.1039/c7cc03927a · 2017 · External reference
Real-time shape approximation and fingerprinting of single proteins using a nanopore
10.1038/nnano.2016.267 · 2017 · External reference
Specific detection of proteins by a nanobody-functionalized Nanopore sensor
10.1021/acsnano.2c12733 · 2023 · External reference
