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References from A target amplification-free CRISPR biosensor with digital microfluidic processing for microRNA profiling in AI-enhanced pediatric sepsis diagnosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Massively multiplexed nucleic acid detection with Cas13
10.1038/s41586-020-2279-8 · 2020 · External reference
MicroRNA as sepsis biomarkers: a comprehensive review
10.3390/ijms25126476 · 2024 · External reference
Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum
10.1038/s41467-021-23497-y · 2021 · External reference
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
10.1126/science.aar6245 · 2018 · External reference
Small and long non-coding RNAs: past, present, and future
10.1016/j.cell.2024.10.024 · 2024 · External reference
MicroRNA-146 represses endothelial activation by inhibiting pro-inflammatory pathways
10.1002/emmm.201202318 · 2013 · External reference
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
10.1007/s00134-021-06506-y · 2021 · External reference
Role of miRNA dysregulation in sepsis
10.1186/s10020-022-00527-z · 2022 · External reference
Study on the diagnostic role of exosome-derived miRNAs in postoperative septic shock and non-septic shock patients
10.1186/s13054-025-05320-y · 2025 · External reference
Nucleic acid detection with CRISPR-Cas13a/C2c2
10.1126/science.aam9321 · 2017 · External reference
Whole blood-derived microRNA signatures in mice exposed to lipopolysaccharides
10.1186/1423-0127-19-69 · 2012 · External reference
CRISPR biosensing architectures for sensitive and multiplexed miRNA detection in disease diagnosis
10.1016/j.snb.2026.140424 · 2026 · External reference
Dual nucleases-assisted cyclic amplification using polydopamine nanospheres-based biosensors for one-pot detection of microRNAs
10.1016/j.bios.2022.114957 · 2023 · External reference
Advances and challenges of signal readout systems in CRISPR-based biosensors for point-of-care testing of nucleic acid
10.1016/j.trac.2024.117856 · 2024 · External reference
Advances in multiplexed techniques for the detection and quantification of microRNAs
10.1039/d0cs00609b · 2021 · External reference
AM-DMF-ddRPA: an all-in-one digital microfluidic platform for rapid and automatic digital nucleic acid analysis
2025 · External reference
Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury
10.1186/s13054-021-03775-3 · 2021 · External reference
The biogenesis and regulation of animal microRNAs
10.1038/s41580-024-00805-0 · 2025 · External reference
Tumor-derived EV miRNA signatures surpass total EV miRNA in supplementing mammography for precision breast cancer diagnosis
10.7150/thno.99245 · 2024 · External reference
Guide-bound structures of an RNA-targeting A-cleaving CRISPR-Cas13a enzyme
10.1038/nsmb.3466 · 2017 · External reference
Single-tube total analysis system for ratiometric detection of exosomal miRNAs in breast cancer diagnosis
10.1016/j.cej.2026.173140 · 2026 · External reference
Hourglass-inspired total analysis system for the sensitive colorimetric detection of exosomal miRNA using the CRISPR-Cas12a system with isothermal amplification
10.1016/j.cej.2025.162729 · 2025 · External reference
CRISPR-Cas12a-assisted nucleic acid detection
10.1038/s41421-018-0028-z · 2018 · External reference
MicroRNAs: circulating biomarkers for the early detection of imperceptible cancers via biosensor and machine-learning advances
10.1038/s41388-024-03076-3 · 2024 · External reference
MicroRNA detection specificity: recent advances and future perspective
10.1021/acs.analchem.8b05909 · 2019 · External reference
Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world
10.1016/s2589-7500(24)00141-9 · 2024 · External reference
Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study
10.1016/s2352-4642(24)00017-8 · 2024 · External reference
International consensus criteria for pediatric sepsis and septic shock
10.1001/jama.2024.0179 · 2024 · External reference
microRNAs in action: biogenesis, function and regulation
10.1038/s41576-023-00611-y · 2023 · External reference
Recent advances in the detection of multiple microRNAs
10.1016/j.trac.2021.116269 · 2021 · External reference
LncRNA SNHG16 reverses the effects of miR-15a/16 on LPS-induced inflammatory pathway
10.1016/j.biopha.2018.07.105 · 2018 · External reference
Pediatric sepsis diagnosis, management, and sub-phenotypes
10.1542/peds.2023-062967 · 2024 · External reference
Immunopathophysiology of human sepsis
10.1016/j.ebiom.2022.104363 · 2022 · External reference
The microRNA network in sepsis: from biomarker discovery to novel targeted therapeutic strategies
10.1080/10408363.2025.2561071 · 2026 · External reference
Digital microfluidics for biological analysis and applications
10.1039/d2lc00756h · 2023 · External reference
Recent progress on biosensors for detection of circulating miRNA biomarkers
10.1016/j.talanta.2025.128219 · 2025 · External reference
CRISPR/RNA aptamer system activated by an AND logic gate for biomarker-driven theranostics
10.1021/jacs.4c08719 · 2025 · External reference
Integrated microfluidic chip for neutrophil extracellular vesicle analysis and gastric cancer diagnosis
10.1021/acsnano.4c16894 · 2025 · External reference
CRISPR/Cas13a-Enhanced porous hydrogel encapsulated photonic barcodes for multiplexed detection of virus
10.1002/smll.202408725 · 2025 · External reference
Machine learning-aided identification of fecal extracellular vesicle microRNA signatures for noninvasive detection of colorectal cancer
10.1021/acsnano.4c16698 · 2025 · External reference
DNA molecular computing with weighted signal amplification for cancer miRNA biomarker diagnostics
10.1002/advs.202416490 · 2025 · External reference
