Research graph
References from Harnessing Acoustic Energy Against Orthopedic Biofilms: Ultrasound-Based Therapeutic Strategies for Implant-Associated and Bone Infections. Local targets link to admitted publications; unresolved targets remain external evidence.
A Trend for Increased Risk of Revision Surgery due to Deep Infection following Fast-Track Hip Arthroplasty
10.1155/2016/7901953 · 2016 · External reference
Advances and challenges in orthopedic implant-associated infections
10.3390/healthcare12181819 · 2024 · External reference
Early post-operative wound infection in patients undergoing orthopaedic surgery with implant
2017 · External reference
Orthopaedic device-related infection: current and future interventions for improved prevention and treatment
10.1302/2058-5241.1.000037 · 2016 · External reference
Biofilms in clinical infection: pathophysiology, diagnosis, and the evolving therapeutic landscape
10.1128/jcm.01042-25 · 2026 · External reference
Resistance mechanisms of bacterial biofilms on orthopedic implants and research progress on novel anti-biofilm coatings
10.3389/fbioe.2026.1707232 · 2026 · External reference
Host Immune Regulation in Implant-Associated Infection (IAI): What Does the Current Evidence Provide Us to Prevent or Treat IAI?
2023 · External reference
Prosthetic joint infection risk after TKA in the Medicare population
10.1007/s11999-009-1013-5 · 2010 · External reference
Variation in Prosthetic Joint Infection and treatment strategies during 4.5 years of follow-up after primary joint arthroplasty using administrative data of 41397 patients across Australian, European and United States hospitals
10.1186/s12891-017-1569-2 · 2017 · External reference
Recurrent periprosthetic joint infections: diagnosis, management, and outcomes
2024 · External reference
Reinfection rates after one-and two-stage revision surgery for hip and knee arthroplasty: a systematic review and meta-analysis
10.1007/s00402-021-04190-7 · 2023 · External reference
Periprosthetic joint infection: current concepts and outlook
10.1302/2058-5241.4.180092 · 2019 · External reference
Single-stage orthoplastic reconstruction of Gustilo–Anderson Grade III open tibial fractures greatly reduces infection rates
10.1016/j.injury.2015.08.027 · 2015 · External reference
Osteomyelitis in long bones
10.2106/00004623-200410000-00028 · 2004 · External reference
Current concepts of osteomyelitis: from pathologic mechanisms to advanced research methods
10.1016/j.ajpath.2020.02.007 · 2020 · External reference
Biofilm and the Role of Antibiotics in the Treatment of Periprosthetic Hip and Knee Joint Infections
10.2174/1874325001610010636 · 2016 · External reference
The role of microbial biofilms in prosthetic joint infections
10.3109/17453674.2014.966290 · 2015 · External reference
Synovial Fluid-Induced Aggregation Occurs across Staphylococcus aureus Clinical Isolates and is Mechanistically Independent of Attached Biofilm Formation
10.1128/spectrum.00267-21 · 2021 · External reference
Staphylococcus aureus Floating Biofilm Formation and Phenotype in Synovial Fluid Depends on Albumin, Fibrinogen, and Hyaluronic Acid
10.3389/fmicb.2021.655873 · 2021 · External reference
Biofilm Resilience: Molecular Mechanisms Driving Antibiotic Resistance in Clinical Contexts
2025 · External reference
Bacterial persisters: molecular mechanisms and therapeutic development
10.1038/s41392-024-01866-5 · 2024 · External reference
pH variation in medical implant biofilms: Causes, measurements, and its implications for antibiotic resistance
10.3389/fmicb.2022.1028560 · 2022 · External reference
Potentiating hypoxic microenvironment for antibiotic activation by photodynamic therapy to combat bacterial biofilm infections
10.1038/s41467-022-31479-x · 2022 · External reference
Enhancing biofilm disruption and bactericidal efficiency using vancomycin-loaded microbubbles in sonodynamic therapy
10.1093/jacamr/dlaf045 · 2025 · External reference
Sonodynamic antimicrobial chemotherapy: An emerging alternative strategy for microbial inactivation
10.1016/j.ultsonch.2021.105591 · 2021 · External reference
A Review of the Combination Therapy of Low Frequency Ultrasound with Antibiotics
10.1155/2017/2317846 · 2017 · External reference
Ultrasound-mediated therapies for the treatment of biofilms in chronic wounds: a review of present knowledge
10.1111/1751-7915.13471 · 2020 · External reference
Drug Delivery by Ultrasound-Responsive Nanocarriers for Cancer Treatment
10.3390/pharmaceutics13081135 · 2021 · External reference
Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review
10.1002/cbic.202400181 · 2024 · External reference
Ultrasonic strategies for mitigating microbial adhesion and biofilm formation on medical surfaces: a mini review
10.3389/fmicb.2025.1558035 · 2025 · External reference
The promise of low-intensity ultrasound: A review on sonosensitizers and sonocatalysts by ultrasonic activation for bacterial killing
10.1016/j.ultsonch.2021.105781 · 2021 · External reference
Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives
10.1021/acsbiomaterials.1c00587 · 2021 · External reference
Antibacterial sonodynamic nanomedicine: mechanism, category, and applications
2025 · External reference
Microbubble cavitation restores Staphylococcus aureus antibiotic susceptibility in vitro and in a septic arthritis model
10.1038/s42003-023-04752-y · 2023 · External reference
Equine or porcine synovial fluid as a novel ex vivo model for the study of bacterial free-floating biofilms that form in human joint infections
10.1371/journal.pone.0221012 · 2019 · External reference
Synergistic Low-Intensity Pulsed Ultrasound-Activated Vancomycin-Loaded Microbubbles for MRSA Biofilm Eradication and Bone Regeneration in Periprosthetic Joint Infection
10.1021/acsbiomaterials.5c02018 · 2026 · External reference
LIPUS-responsive meropenem-loaded nanobubbles enable biofilm disruption and bone repair in orthopedic implant-associated infections
10.1016/j.jconrel.2025.114119 · 2025 · External reference
Application of antimicrobial sonodynamic therapy as a potential treatment modality in dentistry: A literature review
10.1016/j.jds.2023.11.006 · 2024 · External reference
Ultrasound-responsive gallium protoporphyrin and oxygen loaded perfluoropentane nanodroplets for effective sonodynamic therapy of implant infections
10.1039/d4nr01244e · 2024 · External reference
Antibacterial coatings: challenges, perspectives, and opportunities
10.1016/j.tibtech.2015.09.002 · 2015 · External reference
Synergistic sonodynamic and ion-interference therapy effectively treats osteomyelitis and promotes neural and osteogenic regeneration
2026 · External reference
NIR-induced improvement of catalytic activity and antibacterial performance over AuAg nanorods in Rambutan-like Fe3O4@ AgAu@ PDA magnetic nanospheres
10.1016/j.jhazmat.2022.130616 · 2023 · External reference
Bioactive Glasses‐Based Nanozymes Composite Macroporous Cryogel with Antioxidative, Antibacterial, and Pro‐Healing Properties for Diabetic Infected Wound Repair
10.1002/adhm.202302073 · 2023 · External reference
Cu-MOFs based photocatalyst triggered antibacterial platform for wound healing: 2D/2D Schottky junction and DFT calculation
10.1016/j.jhazmat.2023.131531 · 2023 · External reference
Disrupting biofilm tolerance by ionic microbubble-mediated copper ion surge for infection clearance
10.1021/acsnano.5c08035 · 2025 · External reference
Pathogen‐targeting bimetallic nanozymes as ultrasonic‐augmented ROS generator against multidrug resistant bacterial infection
10.1002/adhm.202300449 · 2023 · External reference
Hybrid Ultrasound‐Enhanced and Self‐Cascade‐Catalysis‐Mediated System with Lewis Acid Active Centers for Treating MRSA‐Infected Osteomyelitis
10.1002/adhm.202502586 · 2026 · External reference
Microwave‐responsive nanoplatform with robust ROS generation and inhibiting effects of two‐component system and quorum sensing for the treatment of MRSA‐induced osteomyelitis
10.1002/adfm.202405421 · 2024 · External reference
Remodeling microenvironment for implant‐associated osteomyelitis by dual metal peroxide
10.1002/adhm.202303529 · 2024 · External reference
Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection
10.1073/pnas.1922211117 · 2020 · External reference
Sonocatalytic multifunctional hydrogel in-situ remodels the infectious microenvironment for eradicating refractory osteomyelitis
10.1016/j.jconrel.2026.114686 · 2026 · External reference
Rapid photo-sonotherapy for clinical treatment of bacterial infected bone implants by creating oxygen deficiency using sulfur doping
10.1021/acsnano.9b08686 · 2020 · External reference
Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis
10.1007/s11914-019-00548-4 · 2019 · External reference
Immune dysfunction during S. aureus biofilm-associated implant infections: opportunities for novel therapeutic strategies
10.1038/s41522-025-00782-y · 2025 · External reference
Managing Bone Infections Beyond Systemic Antibiotics: A Scoping Review
10.3390/pathogens15020201 · 2026 · External reference
Enhancing hip arthroplasty outcomes: the multifaceted advantages, limitations, and future directions of 3D printing technology
2024 · External reference
From bone to blood flow: tissue engineering in orthopedics–a narrative review
10.52965/001c.132223 · 2025 · External reference
Ultrasound microbubbles enhance human β-defensin 3 against biofilms
10.1016/j.jss.2015.05.030 · 2015 · External reference
Ultrasound-targeted microbubble destruction enhances human β-defensin 3 activity against antibiotic-resistant Staphylococcus biofilms
10.1007/s10753-013-9630-2 · 2013 · External reference
Synergistic photothermal-sonodynamic therapy for antibacterial and immune reprogramming in chronic osteomyelitis
10.1016/j.jconrel.2025.113612 · 2025 · External reference
Ultrasound-activated MoS2@Fe3O4 nanoplatform orchestrates biofilm disruption and immune reprogramming in implant-associated infections
10.1186/s12951-025-03995-7 · 2026 · External reference
Biodegradable oxygen-evolving metalloantibiotics for spatiotemporal sono-metalloimmunotherapy against orthopaedic biofilm infections
10.1038/s41467-024-52489-x · 2024 · External reference
Specific Activation of the STING Pathway by Engineering Piezoelectric Hydrogel Microspheres for Boosting Implant Infection Immunotherapy
10.1021/acsnano.4c16606 · 2025 · External reference
Ultrasound‐stimulated “exocytosis” by cell‐like microbubbles enhances antibacterial species penetration and immune activation against implant infection
2024 · External reference
Engineered Nanovesicles for the Precise and Noninvasive Treatment of Deep Osteomyelitis Caused by MRSA Infection with Enhanced Immune Response
10.1021/acsami.4c20893 · 2025 · External reference
Ultrasound-Activated Selenium Nanocarrier: Bactericidal Enhancement and Osseointegration Promotion for Implant-Associated Infections
10.1002/adhm.202500523 · 2025 · External reference
Single-atom Zr doped heterojunction enhanced piezocatalysis for implant infection therapy through synergistic metal immunotherapy with sonodynamic and physical puncture
10.1186/s12951-025-03309-x · 2025 · External reference
Biofilms in periprosthetic orthopedic infections
10.2217/fmb.14.64 · 2014 · External reference
Orthopaedic biofilm infections
10.1111/apm.12687 · 2017 · External reference
Biofilms-What Should the Orthopedic Surgeon know?
10.1007/s43465-022-00782-6 · 2023 · External reference
Treatment of Prosthetic Joint Infection with Debridement, Antibiotics and Irrigation with Implant Retention - a Narrative Review
10.7150/jbji.24285 · 2018 · External reference
Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guidelines by the Infectious Diseases Society of America
10.1093/cid/cis803 · 2013 · External reference
Chronic osteomyelitis: what the surgeon needs to know
10.1302/2058-5241.1.000017 · 2016 · External reference
Osteomyelitis: recent advances in pathophysiology and therapeutic strategies
10.1016/j.jor.2016.10.004 · 2017 · External reference
Mechanisms of Antibiotic Failure During Staphylococcus aureus Osteomyelitis
10.3389/fimmu.2021.638085 · 2021 · External reference
Optimal management of chronic osteomyelitis: current perspectives
10.2147/orr.s50753 · 2015 · External reference
Panoramic description of ROS-based nanotechnology for osteomyelitis therapy: Challenges, opportunities, and prospects
10.7150/thno.124716 · 2026 · External reference
Investigation of synovial fluid induced Staphylococcus aureus aggregate development and its impact on surface attachment and biofilm formation
10.1371/journal.pone.0231791 · 2020 · External reference
Guideline for management of septic arthritis in native joints (SANJO)
10.5194/jbji-8-29-2023 · 2023 · External reference
Septic Arthritis of Native Joints
10.1016/j.idc.2017.01.001 · 2017 · External reference
Antibiotic Tolerance of Staphylococcus aureus Biofilm in Periprosthetic Joint Infections and Antibiofilm Strategies
2020 · External reference
Rational molecular design and emerging applications of small-molecule sonosensitizers for sonodynamic therapy
10.1016/j.ccr.2026.217693 · 2026 · External reference
Emerging synergistic strategies for enhanced antibacterial sonodynamic therapy: Advances and prospects
10.1016/j.ultsonch.2025.107288 · 2025 · External reference
Orthopedic Implant Infection Management: Prevention, Barrier Breakthrough, and Immunomodulation
10.1021/acsnano.4c17509 · 2025 · External reference
Stage-specific therapeutic strategies for combating bacterial biofilm infections: Recent advances and future perspectives
10.1016/j.jconrel.2026.114815 · 2026 · External reference
Metabolic modulation-mediated antibiotic and immune activation for treatment of chronic lung infections
10.1021/acsnano.4c03527 · 2024 · External reference
Nanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
10.1186/s40824-023-00405-7 · 2023 · External reference
Ultrasound-responsive catalytic microbubbles enhance biofilm elimination and immune activation to treat chronic lung infections
10.1126/sciadv.ade5446 · 2023 · External reference
Low-Intensity Pulsed Ultrasound Stimulation for Bone Fractures Healing: A Review
10.1002/jum.15738 · 2022 · External reference
Low intensity pulsed ultrasound for bone healing: systematic review of randomized controlled trials
2017 · External reference
Piezoelectric-Enhanced Nanocatalysts Trigger Neutrophil N1 Polarization against Bacterial Biofilm by Disrupting Redox Homeostasis
2025 · External reference
