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References from Human brain assembloids as a model of anaesthetic-induced neural dynamics in vitro. Local targets link to admitted publications; unresolved targets remain external evidence.
The neural circuits underlying general anesthesia and sleep
10.1213/ane.0000000000005361 · 2021 · External reference
Anesthesia and the neurobiology of consciousness
10.1016/j.neuron.2024.03.002 · 2024 · External reference
Consciousness and anesthesia
10.1126/science.1149213 · 2008 · External reference
Towards a better understanding of anesthesia emergence mechanisms: research and clinical implications
10.5662/wjm.v8.i2.9 · 2018 · External reference
The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones
10.1111/j.1476-5381.1991.tb12479.x · 1991 · External reference
Potentiation, activation and blockade of GABAA receptors of clonal murine hypothalamic GT1-7 neurones by propofol
10.1111/j.1476-5381.1995.tb15903.x · 1995 · External reference
Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons
10.1523/jneurosci.14-12-07747.1994 · 1994 · External reference
Methionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anesthetics
10.1016/s0028-3908(01)00141-1 · 2001 · External reference
A propofol binding site on mammalian GABAA receptors identified by photolabeling
10.1038/nchembio.1340 · 2013 · External reference
Three classes of propofol binding sites on GABAA receptors
10.1016/j.jbc.2024.107778 · 2024 · External reference
The effects of propofol on local field potential spectra, action potential firing rate, and their temporal relationship in humans and felines
10.3389/fnhum.2013.00136 · 2013 · External reference
Propofol and etomidate depress cortical, thalamic, and reticular formation neurons during anesthetic-induced unconsciousness
10.1213/ane.0b013e3182405228 · 2012 · External reference
Propofol decreases spike firing frequency with an increase in spike synchronization in the cerebral cortex
10.1016/j.jphs.2019.11.005 · 2020 · External reference
Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness
10.1073/pnas.1210907109 · 2012 · External reference
Slow-wave activity saturation and thalamocortical isolation during propofol anesthesia in humans
10.1126/scitranslmed.3006007 · 2013 · External reference
Electroencephalographic variation during end maintenance and emergence from surgical anesthesia
10.1371/journal.pone.0106291 · 2014 · External reference
A comparison of EEG determinants of near-awakening from isoflurane and fentanyl anesthesia. Spectral edge, median power frequency, and delta ratio
10.1213/00000539-198908000-00005 · 1989 · External reference
Electroencephalogram signatures of loss and recovery of consciousness from propofol
10.1073/pnas.1221180110 · 2013 · External reference
The origin of extracellular fields and currents—EEG, ECoG, LFP and spikes
10.1038/nrn3241 · 2012 · External reference
General anesthesia, sleep, and coma
10.1056/nejmra0808281 · 2010 · External reference
Brain function in coma, vegetative state, and related disorders
10.1016/s1474-4422(04)00852-x · 2004 · External reference
EEG complexity as a measure of depth of anesthesia for patients
10.1109/10.966601 · 2001 · External reference
Complexity of multi-dimensional spontaneous EEG decreases during propofol induced general anaesthesia
10.1371/journal.pone.0133532 · 2015 · External reference
Consciousness is supported by near-critical slow cortical electrodynamics
10.1073/pnas.2024455119 · 2022 · External reference
On the complexity of finite sequences
10.1109/tit.1976.1055501 · 1976 · External reference
Consciousness among delta waves: a paradox?
10.1093/brain/awab095 · 2021 · External reference
Consciousness, anesthesia, and the thalamocortical system
10.1097/aln.0b013e318277a9c6 · 2013 · External reference
Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness
10.1073/pnas.1017069108 · 2010 · External reference
Anesthetic action on extra-synaptic receptors: effects in neural population models of EEG activity
10.3389/fnsys.2014.00232 · 2014 · External reference
General anesthesia and the neural correlates of consciousness
10.1016/s0079-6123(05)50017-7 · 2005 · External reference
Characterization of GABAergic seizure regulation in the midline thalamus
10.1016/0028-3908(90)90026-n · 1990 · External reference
Metabolic activation of intercortical and corticothalamic pathways during enflurane anesthesia in rats
10.1097/00000542-198805000-00017 · 1988 · External reference
Anesthetic action on the transmission delay between cortex and thalamus explains the beta-buzz observed under propofol anesthesia
10.1371/journal.pone.0179286 · 2017 · External reference
Interacting Turing-Hopf instabilities drive symmetry-breaking transitions in a mean-field model of the cortex: a mechanism for the slow oscillation
2013 · External reference
Meanfield modeling of propofol-induced changes in spontaneous EEG rhythms
10.1016/j.neuroimage.2012.02.042 · 2012 · External reference
Criticality supports cross-frequency cortical-thalamic information transfer during conscious states
10.7554/elife.86547 · 2024 · External reference
Brain organoids: advances, applications and challenges
10.1242/dev.166074 · 2019 · External reference
Identification of neural oscillations and epileptiform changes in human brain organoids
10.1038/s41593-021-00906-5 · 2021 · External reference
New frontiers in modeling tuberous sclerosis with human stem cell-derived neurons and brain organoids
10.1002/dvdy.60 · 2020 · External reference
Modeling genetic epileptic encephalopathies using brain organoids
10.15252/emmm.202013610 · 2021 · External reference
Human 3D cellular model of hypoxic brain injury of prematurity
10.1038/s41591-019-0436-0 · 2019 · External reference
KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
10.1016/j.stem.2024.03.004 · 2024 · External reference
Characterization of neural mechanotransduction response in human traumatic brain injury organoid model
10.1038/s41598-023-40431-y · 2023 · External reference
Understanding primary blast injury: high frequency pressure acutely disrupts neuronal network dynamics in cerebral organoids
10.1089/neu.2022.0044 · 2022 · External reference
Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex
10.1038/s41467-022-35536-3 · 2022 · External reference
Assembling human brain organoids
10.1126/science.aau5729 · 2019 · External reference
The origin and specification of cortical interneurons
10.1038/nrn1954 · 2006 · External reference
Development and functional diversification of cortical interneurons
10.1016/j.neuron.2018.10.009 · 2018 · External reference
Modeling cortical versus hippocampal network dysfunction in a human brain assembloid model of epilepsy and intellectual disability
2024 · External reference
Increased risk of intraoperative awareness in patients with a history of awareness
10.1097/aln.0000000000000023 · 2013 · External reference
Genetic analysis of patients who experienced awareness with recall while under general anesthesia
10.1097/aln.0000000000002877 · 2019 · External reference
Effects of general anesthetics on synaptic transmission and plasticity
10.2174/1570159x19666210803105232 · 2022 · External reference
Variant-specific changes in persistent or resurgent sodium current in SCN8A-related epilepsy patient-derived neurons
10.1093/brain/awaa247 · 2020 · External reference
A comprehensive resource for induced pluripotent stem cells from patients with primary tauopathies
10.1016/j.stemcr.2019.09.006 · 2019 · External reference
Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP
10.1038/s41398-018-0319-z · 2018 · External reference
Self-organized cerebral organoids with human-specific features predict effective drugs to combat Zika virus infection
10.1016/j.celrep.2017.09.047 · 2017 · External reference
Assembly of functionally integrated human forebrain spheroids
10.1038/nature22330 · 2017 · External reference
FieldTrip: open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data
10.1155/2011/156869 · 2011 · External reference
SpikeInterface, a unified framework for spike sorting
10.7554/elife.61834 · 2020 · External reference
A fully automated approach to spike sorting
10.1016/j.neuron.2017.08.030 · 2017 · External reference
Single-cell analysis of prenatal and postnatal human cortical development
10.1126/science.adf0834 · 2023 · External reference
General anesthesia globally synchronizes activity selectively in layer 5 cortical pyramidal neurons
10.1016/j.neuron.2022.03.032 · 2022 · External reference
Structural basis of GABARAP-mediated GABAA receptor trafficking and functions on GABAergic synaptic transmission
10.1038/s41467-020-20624-z · 2021 · External reference
The gamma-aminobutyric acid type A (GABAA) receptor-associated protein (GABARAP) promotes GABAA receptor clustering and modulates the channel kinetics
10.1073/pnas.190133497 · 2000 · External reference
The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
10.1038/16697 · 1999 · External reference
Cation-chloride cotransporters in neuronal development, plasticity and disease
10.1038/nrn3819 · 2014 · External reference
Two developmental switches in GABAergic signalling: the K+-Cl- cotransporter KCC2 and carbonic anhydrase CAVII
10.1113/jphysiol.2004.077495 · 2005 · External reference
GABA and glutamate in the preterm neonatal brain: in-vivo measurement by magnetic resonance spectroscopy
10.1016/j.neuroimage.2021.118215 · 2021 · External reference
Impaired oligodendrocyte development following preterm birth: promoting GABAergic action to improve outcomes
10.3389/fped.2021.618052 · 2021 · External reference
Effectiveness and safety of propofol in newborn infants
10.1542/peds.2007-3132 · 2008 · External reference
Cerebral and systemic hemodynamic effects of intravenous bolus administration of propofol in neonates
10.1159/000271224 · 2010 · External reference
Intravenous propofol allows fast intubation in neonates and young infants undergoing major surgery
10.3389/fped.2019.00321 · 2019 · External reference
Propofol use in newborns and children: is it safe? A systematic review
10.1016/j.jped.2019.08.011 · 2020 · External reference
Determination of diffusion and partition coefficients of propofol in rat brain tissue: implications for studies of drug action in vitro
10.1093/bja/aeh272 · 2004 · External reference
Effects of propofol treatment in neural progenitors derived from human-induced pluripotent stem cells
10.1155/2017/9182748 · 2017 · External reference
Propofol-induced anesthesia in mice is mediated by gamma-aminobutyric acid-A and excitatory amino acid receptors
10.1213/01.ane.0000059742.62646.40 · 2003 · External reference
Propofol anaesthesia in mice is potentiated by muscimol and reversed by bicuculline
10.1093/bja/83.4.665 · 1999 · External reference
Motor and electrocorticographic epileptic activity induced by bicuculline in developing rats
10.1111/j.1528-1157.1989.tb05332.x · 1989 · External reference
Complex oscillatory waves emerging from cortical organoids model early human brain network development
10.1016/j.stem.2019.08.002 · 2019 · External reference
Neural control of brain state
10.1016/j.conb.2014.09.010 · 2014 · External reference
hESC-derived thalamic organoids form reciprocal projections when fused with cortical organoids
10.1016/j.stem.2018.12.015 · 2019 · External reference
A theoretically based index of consciousness independent of sensory processing and behavior
10.1126/scitranslmed.3006294 · 2013 · External reference
The ethics of cerebral organoid research: being conscious of consciousness
10.1016/j.stemcr.2019.08.003 · 2019 · External reference
Brain organoids, consciousness, ethics and moral status
10.1016/j.semcdb.2022.03.020 · 2023 · External reference
The case against organoid consciousness
10.1007/s12152-024-09548-3 · 2024 · External reference