Research graph
References from Discovery and characterization of potent and efficacious small-molecule parathyroid hormone Receptor-1 (PTH1R) antagonists for the treatment of hypercalcemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Receptors for PTH and PTHrP: their biological importance and functional properties
10.1152/ajprenal.1999.277.5.f665 · 1999 · External reference
Progress, paradox, and potential: parathyroid hormone research over five decades
10.1196/annals.1402.088 · 2007 · External reference
Molecular mechanisms of PTH/PTHrP class B GPCR signaling and pharmacological implications
10.1210/endrev/bnac032 · 2023 · External reference
The roles of parathyroid hormone and calcitonin in bone remodeling: prospects for novel therapeutics
10.2174/187153006776056666 · 2006 · External reference
10.1016/j.tips.2013.11.001
10.1016/j.tips.2013.11.001 · External reference
Structural basis for allosteric modulation of class B G protein-coupled receptors
10.1146/annurev-pharmtox-010919-023301 · 2019 · External reference
Precise Druggability of the PTH type 1 receptor
10.1038/s41589-021-00929-w · 2022 · External reference
Discovery of a small molecule antagonist of the parathyroid hormone receptor by using an N-terminal parathyroid hormone peptide probe
10.1073/pnas.0605125104 · 2007 · External reference
Discovery and characterization of novel, potent, non-peptide parathyroid Hormone-1 receptor antagonists
10.1021/jm0707626 · 2007 · External reference
Discovery of novel PTHR1 antagonists: design, synthesis, and structure activity relationships
10.1016/j.bmcl.2019.07.052 · 2019 · External reference
Discovery of novel, potent, and orally bioavailable Pyrido[2,3-d][1]benzazepin-6-one antagonists for parathyroid hormone receptor 1
10.1016/j.bmc.2020.115524 · 2020 · External reference
Lead optimization of Pyrido[2,3-d][1]benzazepin-6-one derivatives leading to the discovery of a potent, selective, and orally available human parathyroid hormone receptor 1 (hPTHR1) antagonist (DS69910557)
10.1016/j.bmc.2022.116763 · 2022 · External reference
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Physiological and pharmacological roles of PTH and PTHrP in bone using their shared receptor, PTH1R
10.1210/endrev/bnab005 · 2021 · External reference
Functions of RANKL/RANK/OPG in bone modeling and remodeling
10.1016/j.abb.2008.03.018 · 2008 · External reference
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