Research graph
References from Glaucoma as a brain energy disorder: Reevaluating neurodegeneration via modified metabolic pathways. Local targets link to admitted publications; unresolved targets remain external evidence.
The pathophysiology and treatment of glaucoma: a review
10.1001/jama.2014.3192 · 2014 · External reference
Retinal energy metabolism in health and glaucoma
10.1016/j.preteyeres.2020.100881 · 2021 · External reference
Structural and functional brain changes beyond visual system in patients with advanced glaucoma
10.1371/journal.pone.0105931 · 2014 · External reference
Changes of visual pathway and brain connectivity in glaucoma: a systematic review
10.3389/fnins.2018.00363 · 2018 · External reference
Beyond the eye: glaucoma and the brain
10.3390/brainsci15090934 · 2025 · External reference
The connectivity of the resting brain in primary open-angle glaucoma: a systematic review
10.3390/biomedicines13061402 · 2025 · External reference
A metabolomics profiling of glaucoma points to mitochondrial dysfunction, senescence, and polyamines deficiency
10.1167/iovs.18-24938 · 2018 · External reference
Exploring molecular and clinical dimensions of glaucoma as a neurodegenerative disease
10.3390/ijms26189109 · 2025 · External reference
The neurovascular unit in glaucomatous neurodegeneration
10.3389/fcell.2020.00452 · 2020 · External reference
Neurovascular dysfunction in glaucoma
10.1016/j.preteyeres.2023.101217 · 2023 · External reference
Metabolic vulnerability in the neurodegenerative disease glaucoma
10.3389/fnins.2017.00146 · 2017 · External reference
Structural and functional rescue of chronic metabolically stressed optic nerves through respiration
10.1523/jneurosci.3652-17.2018 · 2018 · External reference
Crosstalk between dysfunctional mitochondria and inflammation in glaucomatous neurodegeneration
10.3389/fphar.2021.699623 · 2021 · External reference
Glaucoma: from pathogenic mechanisms to retinal glial cell response to damage
10.3389/fncel.2024.1354569 · 2024 · External reference
Addressing neurodegeneration in glaucoma: mechanisms, challenges, and treatments
10.1016/j.preteyeres.2024.101261 · 2024 · External reference
Mitochondrial function is impaired in the primary visual cortex in an experimental glaucoma model
10.1016/j.abb.2021.108815 · 2021 · External reference
Metabolomics in glaucoma: a systematic review
10.1167/iovs.62.6.9 · 2021 · External reference
Metabolomics in primary open angle glaucoma: a systematic review and meta-analysis
10.3389/fnins.2022.835736 · 2022 · External reference
Identifying potential key metabolic pathways and biomarkers in glaucoma: a systematic review and meta-analysis
2025 · External reference
Glaucoma: now and beyond
10.1016/s0140-6736(23)01289-8 · 2023 · External reference
Disturbed glucose and pyruvate metabolism in glaucoma with neuroprotection by pyruvate or rapamycin
10.1073/pnas.2014213117 · 2020 · External reference
Nicotinamide and pyruvate for neuroenhancement in open-angle glaucoma: a phase 2 randomized clinical trial
10.1001/jamaophthalmol.2021.4576 · 2022 · External reference
Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction
10.1016/j.redox.2021.101988 · 2021 · External reference
Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma
10.1186/s12974-018-1346-7 · 2018 · External reference
Glaucomatous optic neuropathy: mitochondrial dynamics, dysfunction and protection in retinal ganglion cells
10.1016/j.preteyeres.2022.101136 · 2023 · External reference
Association between glaucoma susceptibility with combined defects in mitochondrial oxidative phosphorylation and fatty acid beta oxidation
10.1016/j.mam.2023.101238 · 2024 · External reference
Targeted LC-MS profiling reveals dysregulated glycolytic flux and TCA cycle stalling in POAG plasma
2025 · External reference
Proton magnetic resonance spectroscopy ((1)H-MRS) reveals geniculocalcarine and striate area degeneration in primary glaucoma
2013 · External reference
Magnetic resonance spectroscopy features of the visual pathways in patients with glaucoma
10.1007/s00062-018-0728-7 · 2019 · External reference
Evaluation of corpus geniculatum laterale and vitreous fluid by magnetic resonance spectroscopy in patients with glaucoma; a preliminary study
10.1038/eye.2012.84 · 2012 · External reference
Metabolic alterations within the primary visual cortex in blind patients with end-stage glaucoma: a proton magnetic resonance spectroscopy study
10.3389/fcell.2025.1590460 · 2025 · External reference
Application of advanced magnetic resonance imaging in glaucoma: a narrative review
10.21037/qims-21-790 · 2022 · External reference
Targeting diet and exercise for neuroprotection and neurorecovery in glaucoma
10.3390/cells10020295 · 2021 · External reference
Energy metabolism in the inner retina in health and glaucoma
10.3390/ijms22073689 · 2021 · External reference
Cerebral glucose metabolism in the striate cortex positively correlates with fractional anisotropy values of the optic radiation in patients with glaucoma
10.1111/ceo.12543 · 2015 · External reference
Reduced oxidative phosphorylation and increased glycolysis in human glaucoma lamina cribrosa cells
10.1167/iovs.61.13.4 · 2020 · External reference
Transneuronal degeneration in the brain during glaucoma
10.3389/fnagi.2021.643685 · 2021 · External reference
The physiological optics of the lens
10.1016/j.preteyeres.2016.09.002 · 2017 · External reference
A cellular perspective on brain energy metabolism and functional imaging
10.1016/j.neuron.2015.03.035 · 2015 · External reference
Sweet sixteen for ANLS
10.1038/jcbfm.2011.149 · 2012 · External reference
Metabolic alterations within the primary visual cortex in early open-angle glaucoma patients: a proton magnetic resonance spectroscopy study
10.1097/ijg.0000000000001098 · 2018 · External reference
The primary vascular dysregulation syndrome: implications for eye diseases
10.1186/1878-5085-4-14 · 2013 · External reference
Altered neurovascular coupling in subcortical ischemic vascular disease
2021 · External reference
Glaucoma in adults-screening, diagnosis, and management: a review
10.1001/jama.2020.21899 · 2021 · External reference
Diffuse brain damage in normal tension glaucoma
10.1002/hbm.23862 · 2018 · External reference
Investigations into hypoxia and oxidative stress at the optic nerve head in a rat model of glaucoma
10.3389/fnins.2017.00478 · 2017 · External reference
Endothelin-1 levels and biomarkers of oxidative stress in glaucoma patients
10.1007/s10792-014-9979-8 · 2015 · External reference
Diet, exercise, and lifestyle in glaucoma: current evidence and future perspectives
10.3390/nu17213369 · 2025 · External reference
The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma
10.1007/s00401-011-0807-1 · 2011 · External reference
Mitochondrial and microtubule defects in exfoliation glaucoma
10.1016/j.freeradbiomed.2025.03.046 · 2025 · External reference
Taxol facilitates axon regeneration in the mature CNS
10.1523/jneurosci.4885-10.2011 · 2011 · External reference
Neuronal and astrocytic interactions modulate brain endothelial properties during metabolic stresses of in vitro cerebral ischemia
10.1186/1478-811x-12-7 · 2014 · External reference
Tract specificity of age effects on diffusion tensor imaging measures of white matter health
10.3389/fnagi.2021.628865 · 2021 · External reference
Early microglia activation in a mouse model of chronic glaucoma
10.1002/cne.22516 · 2011 · External reference
When is a control not a control? Reactive microglia occur throughout the control contralateral pathway of retinal ganglion cell projections in experimental glaucoma
10.1167/tvst.10.1.22 · 2021 · External reference
Astrocyte and microglial activation in the lateral geniculate nucleus and visual cortex of glaucomatous and optic nerve transected primates
2009 · External reference
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma
10.1172/jci44646 · 2011 · External reference
Glaucoma as a metabolic optic neuropathy: making the case for nicotinamide treatment in glaucoma
10.1097/ijg.0000000000000767 · 2017 · External reference
Metabolic syndrome is associated with ocular hypertension and glaucoma
10.1097/ijg.0000000000001593 · 2020 · External reference
Fixel-based analysis of visual pathway white matter in primary open-angle glaucoma
10.1167/iovs.19-27447 · 2019 · External reference
Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma
10.1016/j.visres.2012.03.012 · 2012 · External reference
Functional MRI signal changes in primary visual cortex corresponding to the central normal visual field of patients with primary open-angle glaucoma
10.1167/iovs.09-4834 · 2010 · External reference
Adenosine triphosphate (ATP) and protein aggregation in age-related vision-threatening ocular diseases
10.3390/metabo13101100 · 2023 · External reference
Associations between metabolomics findings and brain hypometabolism in mild cognitive impairment and Alzheimer's disease
10.2174/0115672050350196250110092338 · 2024 · External reference
Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics
10.1371/journal.pone.0063644 · 2013 · External reference
Integrative analysis of blood metabolomics and PET brain neuroimaging data for Parkinson's disease
10.1016/j.nbd.2019.01.003 · 2019 · External reference
The impact of ocular blood flow in glaucoma
10.1016/s1350-9462(02)00008-3 · 2002 · External reference
Molecular regulation of neuroinflammation in glaucoma: current knowledge and the ongoing search for new treatment targets
10.1016/j.preteyeres.2021.100998 · 2022 · External reference
Targeting the NLRP3 inflammasome in glaucoma
10.3390/biom11081239 · 2021 · External reference
Advances and prospects in deuterium metabolic imaging (DMI): a systematic review of in vivo studies
10.1186/s41747-024-00464-y · 2024 · External reference
Systematic review of 31P-magnetic resonance spectroscopy studies of brain high energy phosphates and membrane phospholipids in aging and Alzheimer's disease
10.3389/fnagi.2023.1183228 · 2023 · External reference
Deuterium metabolic imaging for 3D mapping of glucose metabolism in humans with central nervous system lesions at 3T
10.1002/mrm.29830 · 2024 · External reference
