Research graph
References from Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells. Local targets link to admitted publications; unresolved targets remain external evidence.
The spliceosome: design principles of a dynamic RNP machine
10.1016/j.cell.2009.02.009 · 2009 · External reference
SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS
10.1182/blood.2020004850 · 2020 · External reference
The longitudinal dynamics and natural history of clonal haematopoiesis
10.1038/s41586-022-04785-z · 2022 · External reference
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
10.1038/s41591-022-01883-3 · 2022 · External reference
Life histories of myeloproliferative neoplasms inferred from phylogenies
10.1038/s41586-021-04312-6 · 2022 · External reference
Mutations in the RNA splicing factor SF3B1 promote tumorigenesis through MYC stabilization
10.1158/2159-8290.cd-19-1330 · 2020 · External reference
Single-cell multi-omics defines the cell-type-specific impact of splicing aberrations in human hematopoietic clonal outgrowths
10.1016/j.stem.2023.07.012 · 2023 · External reference
SF3B1-initiating mutations in MDS-RSs target lymphomyeloid hematopoietic stem cells
10.1182/blood-2017-03-776070 · 2017 · External reference
A three-dimensional in vitro model of erythropoiesis recapitulates erythroid failure in myelodysplastic syndromes
10.1038/s41375-019-0532-7 · 2020 · External reference
The K666N mutation in SF3B1 is associated with increased progression of MDS and distinct RNA splicing
10.1182/bloodadvances.2019001127 · 2020 · External reference
TARGET-seq: a protocol for high-sensitivity single-cell mutational analysis and parallel RNA sequencing
2020 · External reference
The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts
10.1038/leu.2012.298 · 2013 · External reference
Iron overload impairs normal hematopoietic stem and progenitor cells through reactive oxygen species and shortens survival in myelodysplastic syndrome mice
10.3324/haematol.2018.193128 · 2018 · External reference
High-throughput transcription profiling identifies putative epigenetic regulators of hematopoiesis
10.1182/blood-2013-02-483537 · 2014 · External reference
Mutations in CHD2 cause defective association with active chromatin in chronic lymphocytic leukemia
10.1182/blood-2014-10-604959 · 2015 · External reference
Impact of spliceosome mutations on RNA splicing in myelodysplasia: dysregulated genes/pathways and clinical associations
10.1182/blood-2018-04-843771 · 2018 · External reference
A nuclear cap binding protein complex involved in pre-mRNA splicing
10.1016/0092-8674(94)90530-4 · 1994 · External reference
SNW1 enables sister chromatid cohesion by mediating the splicing of sororin and APC2 pre-mRNAs
10.15252/embj.201488202 · 2014 · External reference
METTL3-mediated m6A modification controls splicing factor abundance and contributes to aggressive CLL
10.1158/2643-3230.bcd-22-0156 · 2023 · External reference
Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif
10.1093/emboj/18.24.7019 · 1999 · External reference
PHF20L1 as a H3K27me2 reader coordinates with transcriptional repressors to promote breast tumorigenesis
10.1126/sciadv.aaz0356 · 2020 · External reference
Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms
10.1182/blood.2020006868 · 2020 · External reference
SF3B1 mutations induce R-loop accumulation and DNA damage in MDS and leukemia cells with therapeutic implications
10.1038/s41375-020-0753-9 · 2020 · External reference
