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References from Instructive interaction between myelodysplastic hematopoiesis and the bone marrow microenvironment at the single-cell level. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection
10.1084/jem.20201541 · 2021 · External reference
Mapping distinct bone marrow niche populations and their differentiation paths
10.1016/j.celrep.2019.06.031 · 2019 · External reference
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
10.1038/nature08851 · 2010 · External reference
Mesenchymal inflammation drives genotoxic stress in hematopoietic stem cells and predicts disease evolution in human pre-leukemia
10.1016/j.stem.2016.08.021 · 2016 · External reference
Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts
10.1038/nature12883 · 2014 · External reference
Oncogenic kras(G12D) activation in the nonhematopoietic bone marrow microenvironment causes myelodysplastic syndrome in mice
10.1158/1541-7786.mcr-20-0275 · 2021 · External reference
Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche
10.1016/j.stem.2014.06.020 · 2014 · External reference
Neuropathy of haematopoietic stem cell niche is essential for myeloproliferative neoplasms
10.1038/nature13383 · 2014 · External reference
Arteriolar niches maintain haematopoietic stem cell quiescence
10.1038/nature12612 · 2013 · External reference
Stress-induced changes in bone marrow stromal cell populations revealed through single-cell protein expression mapping
10.1016/j.stem.2019.06.003 · 2019 · External reference
A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
10.1016/j.cell.2019.04.040 · 2019 · External reference
The bone marrow microenvironment at single-cell resolution
10.1038/s41586-019-1104-8 · 2019 · External reference
Human cell engraftment after busulfan or irradiation conditioning of NOD/SCID mice
2006 · External reference
Myelodysplastic cells in patients reprogram mesenchymal stromal cells to establish a transplantable stem cell niche disease unit
10.1016/j.stem.2014.02.014 · 2014 · External reference
Preclinical evaluation of eltrombopag in a PDX model of myelodysplastic syndromes
10.1038/s41375-021-01327-w · 2022 · External reference
Preclinical modeling of myelodysplastic syndromes
10.1038/leu.2017.172 · 2017 · External reference
Heterogeneous bone-marrow stromal progenitors drive myelofibrosis via a druggable alarmin axis
10.1016/j.stem.2020.11.004 · 2021 · External reference
Perturbation-response genes reveal signaling footprints in cancer gene expression
10.1038/s41467-017-02391-6 · 2018 · External reference
Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
10.7554/elife.43803 · 2019 · External reference
CellPhoneDB: inferring cell-cell communication from combined expression of multi-subunit ligand-receptor complexes
10.1038/s41596-020-0292-x · 2020 · External reference
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization
10.1038/s41556-019-0439-6 · 2020 · External reference
OmniPath: guidelines and gateway for literature-curated signaling pathway resources
10.1038/nmeth.4077 · 2016 · External reference
CrossTalkeR: analysis and visualisation of ligand receptor networks
10.1093/bioinformatics/btab370 · 2021 · External reference
Cytokines increase engraftment of human acute myeloid leukemia cells in immunocompromised mice but not engraftment of human myelodysplastic syndrome cells
10.3324/haematol.2017.183202 · 2018 · External reference
MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis
10.1016/j.celrep.2022.110805 · 2022 · External reference
Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity
10.1016/j.cell.2019.01.031 · 2019 · External reference
Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
10.1038/s41590-021-01059-0 · 2021 · External reference
Bone marrow stromal cells from MDS and AML patients show increased adipogenic potential with reduced delta-like-1 expression
10.1038/s41598-021-85122-8 · 2021 · External reference
Bone marrow mesenchymal stromal cell-derived extracellular matrix displays altered glycosaminoglycan structure and impaired functionality in myelodysplastic syndromes
10.3389/fonc.2022.961473 · 2022 · External reference
Insufficient stromal support in MDS results from molecular and functional deficits of mesenchymal stromal cells
10.1038/leu.2013.193 · 2013 · External reference
Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs
10.1038/leu.2016.91 · 2016 · External reference
Bone marrow stroma cells promote induction of a chemoresistant and prognostic unfavorable S100A8/A9high AML cell subset
10.1182/bloodadvances.2021005938 · 2022 · External reference
CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance
10.1016/j.ccell.2015.05.002 · 2015 · External reference
Human gene-engineered calreticulin mutant stem cells recapitulate MPN hallmarks and identify targetable vulnerabilities
10.1038/s41375-023-01848-6 · 2023 · External reference
Engineering human mini-bones for the standardized modeling of healthy hematopoiesis, leukemia, and solid tumor metastasis
10.1126/scitranslmed.abm6391 · 2022 · External reference
Species heterogeneity in macrophage expression of the CD4 antigen
10.1084/jem.166.2.613 · 1987 · External reference
CD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection
10.1128/jvi.00616-14 · 2014 · External reference
