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References from BIRC5 upregulation enhances DNMT3A-mutant T-ALL cell survival and pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
T-cell acute lymphoblastic leukemia
10.3324/haematol.2008.004150 · 2009 · External reference
Clinical features and treatment outcome of childhood T-lineage acute lymphoblastic leukemia according to the apparent maturational stage of T-lineage leukemic blasts: a Children's Cancer Group study
10.1200/jco.1997.15.6.2214 · 1997 · External reference
Nelarabine induces complete remissions in adults with relapsed or refractory T-lineage acute lymphoblastic leukemia or lymphoblastic lymphoma: Cancer and Leukemia Group B study 19801
10.1182/blood-2006-11-056754 · 2007 · External reference
Primary refractory and relapsed adult acute lymphoblastic leukemia: characteristics, treatment results, and prognosis with salvage therapy
10.1002/(sici)1097-0142(19991001)86:7<1216::aid-cncr17>3.0.co;2-o · 1999 · External reference
The genetics and molecular biology of T-ALL
10.1182/blood-2016-10-706465 · 2017 · External reference
Aberrant signaling pathways in T-cell acute lymphoblastic leukemia
10.3390/ijms18091904 · 2017 · External reference
Deficient T cell fate specification in mice with an induced inactivation of Notch1
10.1016/s1074-7613(00)80054-0 · 1999 · External reference
Notch1 expression in early lymphopoiesis influences B versus T lineage determination
10.1016/s1074-7613(00)80105-3 · 1999 · External reference
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
10.1126/science.1102160 · 2004 · External reference
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
10.1084/jem.183.5.2283 · 1996 · External reference
Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia
10.1172/jci35090 · 2008 · External reference
The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes
10.1038/ncomms4630 · 2014 · External reference
Mutational spectrum of adult T-ALL
10.18632/oncotarget.2218 · 2015 · External reference
DNMT3A mutation is associated with increased age and adverse outcome in adult T-cell acute lymphoblastic leukemia
10.3324/haematol.2018.197848 · 2019 · External reference
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
10.1101/gad.186411.111 · 2012 · External reference
Clinicopathologic effect of DNMT3A mutation in adult T-cell acute lymphoblastic leukemia
10.1016/j.clml.2015.11.003 · 2016 · External reference
The molecular profile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 and DNMT3A are associated with poor prognosis in T-ALL
10.1002/gcc.22039 · 2013 · External reference
Prognostic relevance of integrated genetic profiling in adult T-cell acute lymphoblastic leukemia
10.1182/blood-2013-03-491092 · 2013 · External reference
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
10.1038/leu.2011.44 · 2011 · External reference
DNMT3A mutations in acute myeloid leukemia
10.1056/nejmoa1005143 · 2010 · External reference
ETV6 mutations in early immature human T cell leukemias
10.1084/jem.20112239 · 2011 · External reference
Dnmt3a regulates T-cell development and suppresses T-ALL transformation
10.1038/leu.2017.89 · 2017 · External reference
The origin and evolution of mutations in acute myeloid leukemia
10.1016/j.cell.2012.06.023 · 2012 · External reference
Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia
10.1158/1078-0432.ccr-07-1474 · 2007 · External reference
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
10.1038/ng.3909 · 2017 · External reference
CpG Island hypermethylation mediated by DNMT3A is a consequence of AML progression
10.1016/j.cell.2017.01.021 · 2017 · External reference
KDM6B protects T-ALL cells from NOTCH1-induced oncogenic stress
10.1038/s41375-023-01853-9 · 2023 · External reference
Direct regulation of intestinal fate by Notch
10.1073/pnas.0505690102 · 2005 · External reference
Txnip enhances fitness of Dnmt3a-mutant hematopoietic stem cells via p21
10.1158/2643-3230.bcd-21-0132 · 2022 · External reference
Efficacy of JAK/STAT pathway inhibition in murine xenograft models of early T-cell precursor (ETP) acute lymphoblastic leukemia
10.1182/blood-2014-06-580480 · 2015 · External reference
HOXA9 cooperates with activated JAK/STAT signaling to drive leukemia development
10.1158/2159-8290.cd-17-0583 · 2018 · External reference
JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias
10.1038/leu.2017.136 · 2017 · External reference
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor
10.4049/jimmunol.0901929 · 2010 · External reference
Role of STAT3 in liver regeneration: survival, DNA synthesis, inflammatory reaction and liver mass recovery
10.1038/labinvest.3700630 · 2007 · External reference
Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
10.1128/mcb.24.18.8037-8047.2004 · 2004 · External reference
PRC2 loss induces chemoresistance by repressing apoptosis in T cell acute lymphoblastic leukemia
10.1084/jem.20180570 · 2018 · External reference
Treatment of acute lymphoblastic leukemia
10.1056/nejmra052603 · 2006 · External reference
IAP family proteins--suppressors of apoptosis
10.1101/gad.13.3.239 · 1999 · External reference
Suppression of survivin promoter activity by YM155 involves disruption of Sp1-DNA interaction in the survivin core promoter
2012 · External reference
Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib
10.1182/blood-2015-03-633404 · 2015 · External reference
Impact of genomic alterations on outcomes in myelofibrosis patients undergoing JAK1/2 inhibitor therapy
10.1182/bloodadvances.2017009530 · 2017 · External reference
MIPSS70+ version 2.0: mutation and karyotype-enhanced International Prognostic Scoring System for primary myelofibrosis
10.1200/jco.2018.78.9867 · 2018 · External reference
Loss of function mutations in PTPN6 promote STAT3 deregulation via JAK3 kinase in diffuse large B-cell lymphoma
10.18632/oncotarget.6300 · 2015 · External reference
Overexpression of survivin initiates hematologic malignancies in vivo
10.1038/leu.2010.198 · 2010 · External reference
A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
10.1038/nm0897-917 · 1997 · External reference
Validating survivin as a cancer therapeutic target
10.1038/nrc968 · 2003 · External reference