Research graph
References from Diagnostic genomic analysis is prognostic in AYA patients with ALL treated on an MRD-stratified pediatric protocol. Local targets link to admitted publications; unresolved targets remain external evidence.
New developments in ALL in AYA
10.1182/hematology.2022000336 · 2022 · External reference
Outcomes and prognostic factors in adolescents and young adults with ALL treated with a modified BFM-90 protocol
10.1182/bloodadvances.2020003526 · 2021 · External reference
Comparison of the results of the treatment of adolescents and young adults with standard-risk acute lymphoblastic leukemia with the Programa Espanol de Tratamiento en Hematologia pediatric-based protocol ALL-96
10.1200/jco.2007.13.7265 · 2008 · External reference
A pediatric regimen for older adolescents and young adults with acute lymphoblastic leukemia: results of CALGB 10403
10.1182/blood-2018-10-881961 · 2019 · External reference
Adolescent and young adult acute lymphoblastic leukemia. Final results of the phase II pediatric-like GIMEMA LAL-1308 trial
10.1002/ajh.26066 · 2021 · External reference
Results of NOPHO ALL2008 treatment for patients aged 1-45 years with acute lymphoblastic leukemia
10.1038/leu.2017.265 · 2018 · External reference
Frequency and prognostic impact of PAX5 p.P80R in pediatric acute lymphoblastic leukemia patients treated on an AIEOP-BFM acute lymphoblastic leukemia protocol
10.1002/gcc.22882 · 2020 · External reference
Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia
10.1182/blood.2022015444 · 2022 · External reference
Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study
10.1182/blood-2009-07-234229 · 2010 · External reference
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia
10.1038/ncomms13331 · 2016 · External reference
PAX5-driven subtypes of B-progenitor acute lymphoblastic leukemia
10.1038/s41588-018-0315-5 · 2019 · External reference
Pre-B acute lymphoblastic leukaemia recurrent fusion, EP300-ZNF384, is associated with a distinct gene expression
10.1038/s41416-018-0022-0 · 2018 · External reference
PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome
10.1182/blood-2018-10-882142 · 2019 · External reference
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
10.1038/ng.3535 · 2016 · External reference
Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia
10.1038/ncomms11790 · 2016 · External reference
Genomic and outcome analyses of Ph-like ALL in NCI standard-risk patients: a report from the Children’s Oncology Group
10.1182/blood-2018-04-841676 · 2018 · External reference
Time to cure for childhood and young adult acute lymphoblastic leukemia is independent of early risk factors: long-term follow-up of the UKALL2003 trial
10.1200/jco.22.00245 · 2022 · External reference
Genetic basis of acute lymphoblastic leukemia
10.1200/jco.2016.70.7836 · 2017 · External reference
An MRD-stratified pediatric protocol is as deliverable in adolescents and young adults as in children with ALL
10.1182/bloodadvances.2021005576 · 2021 · External reference
Persistent MRD before and after allogeneic BMT predicts relapse in children with acute lymphoblastic leukaemia
10.1111/bjh.13142 · 2015 · External reference
High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation
10.1038/leu.2013.44 · 2013 · External reference
Measurable residual disease analysis in paediatric acute lymphoblastic leukaemia patients with ABL-class fusions
10.1038/s41416-022-01806-6 · 2022 · External reference
RaScALL: rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL)
10.1371/journal.pgen.1010300 · 2022 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline
2013 · External reference
ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
10.1093/nar/gkq603 · 2010 · External reference
Integrative genomics viewer
10.1038/nbt.1754 · 2011 · External reference
SOAPfuse: an algorithm for identifying fusion transcripts from paired-end RNA-seq data
10.1186/gb-2013-14-2-r12 · 2013 · External reference
JAFFA: high sensitivity transcriptome-focused fusion gene detection
10.1186/s13073-015-0167-x · 2015 · External reference
FusionCatcher – a tool for finding somatic fusion genes in paired-end RNA-sequencing data
2014 · External reference
Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome
10.1182/blood-2009-08-239681 · 2010 · External reference
Deregulation of DUX4 and ERG in acute lymphoblastic leukemia
10.1038/ng.3691 · 2016 · External reference
DUX hunting-clinical features and diagnostic challenges associated with DUX4-rearranged leukaemia
10.3390/cancers12102815 · 2020 · External reference
Multi-cohort transcriptomic subtyping of B-cell acute lymphoblastic leukemia
10.3390/ijms23094574 · 2022 · External reference
Visualizing data using t-SNE
2008 · External reference
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
10.1182/blood-2016-03-643544 · 2016 · External reference
International Consensus classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data
10.1182/blood.2022015850 · 2022 · External reference
The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms
10.1038/s41375-022-01620-2 · 2022 · External reference
Molecular classification improves risk assessment in adult BCR-ABL1-negative B-ALL
10.1182/blood.2020010144 · 2021 · External reference
Whole genome sequencing provides comprehensive genetic testing in childhood B-cell acute lymphoblastic leukaemia
10.1038/s41375-022-01806-8 · 2023 · External reference
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial
10.1038/s41375-022-01799-4 · 2023 · External reference
NGS better discriminates true MRD positivity for the risk stratification of childhood ALL treated on an MRD-based protocol
10.1182/blood.2022017003 · 2023 · External reference
Genetic alterations in childhood acute lymphoblastic leukemia: interactions with clinical features and treatment response
10.3390/cancers13164068 · 2021 · External reference
Distinct clinical characteristics of DUX4- and PAX5-altered childhood B-lymphoblastic leukemia
10.1182/bloodadvances.2021004895 · 2021 · External reference
ERG deletions in childhood acute lymphoblastic leukemia with DUX4 rearrangements are mostly polyclonal, prognostically relevant and their detection rate strongly depends on screening method sensitivity
10.3324/haematol.2018.204487 · 2019 · External reference
Characterization of novel, recurrent genomic rearrangements as sensitive MRD targets in childhood B-cell precursor ALL
10.1038/s41408-019-0257-x · 2019 · External reference
Genomics improves risk stratification of adults with T-cell acute lymphoblastic leukemia enrolled in measurable residual disease-oriented trials
10.3324/haematol.2022.281196 · 2023 · External reference
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia
10.1002/cam4.4024 · 2021 · External reference
The clinicogenomic landscape of induction failure in childhood and young adult T-cell acute lymphoblastic leukemia
10.1200/jco.22.02734 · 2023 · External reference
MRD-based therapeutic decisions in genetically defined subsets of adolescents and young adult Philadelphia-negative ALL
10.3390/cancers13092108 · 2021 · External reference
Genotype-specific minimal residual disease interpretation improves stratification in pediatric acute lymphoblastic leukemia
10.1200/jco.2017.74.0449 · 2018 · External reference
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia
10.1056/nejmoa1403088 · 2014 · External reference
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
10.1016/s1470-2045(08)70314-0 · 2009 · External reference
Clinical significance of early T-cell precursor acute lymphoblastic leukaemia: results of the Tokyo Children’s Cancer Study Group Study L99-15
10.1111/j.1365-2141.2011.08955.x · 2012 · External reference
Outcome for children and young people with early T-cell precursor acute lymphoblastic leukaemia treated on a contemporary protocol, UKALL 2003
10.1111/bjh.12882 · 2014 · External reference
Prognostic impact of chromosomal abnormalities and copy number alterations in adult B-cell precursor acute lymphoblastic leukaemia: a UKALL14 study
10.1038/s41375-021-01448-2 · 2022 · External reference
A validated novel continuous prognostic index to deliver stratified medicine in pediatric acute lymphoblastic leukemia
10.1182/blood.2019003191 · 2020 · External reference
Effect of BMI on toxicities and survival among adolescents and young adults treated on DFCI Consortium ALL trials
10.1182/bloodadvances.2023009976 · 2023 · External reference
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia
10.1038/s41586-024-07807-0 · 2024 · External reference
