Research graph
References from Pharmacological targeting of CBX7 alters the epigenetic landscape and induces differentiation of leukemic cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Balancing dormant and self-renewing hematopoietic stem cells
10.1016/j.gde.2009.08.005 · 2009 · External reference
Epigenetic regulators as the gatekeepers of hematopoiesis
2020 · External reference
Comparison and validation of the 2022 European LeukemiaNet guidelines in acute myeloid leukemia
2022 · External reference
Cancer statistics, 2023
2023 · External reference
Escape from treatment; the different faces of leukemic stem cells and therapy resistance in acute myeloid leukemia
10.3389/fonc.2021.659253 · 2021 · External reference
Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies
10.1038/s41392-023-01342-6 · 2023 · External reference
New drugs before, during, and after hematopoietic stem cell transplantation for patients with acute myeloid leukemia
10.3324/haematol.2022.280798 · 2023 · External reference
Epigenetic changes as a target in aging haematopoietic stem cells and age-related malignancies
10.3390/cells8080868 · 2019 · External reference
Polycomb group proteins in cancer: multifaceted functions and strategies for modulation
10.1093/narcan/zcab039 · 2021 · External reference
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1
10.1016/j.immuni.2004.11.004 · 2004 · External reference
The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
10.1182/blood-2005-09-3585 · 2006 · External reference
Role of the polycomb group proteins in hematopoietic stem cells
10.1111/j.1440-169x.2010.01191.x · 2010 · External reference
Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells
10.1182/blood-2012-08-451666 · 2013 · External reference
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
10.1038/ncb2701 · 2013 · External reference
CBX7 induces self-renewal of human normal and malignant hematopoietic stem and progenitor cells by canonical and non-canonical interactions
10.1016/j.celrep.2019.01.050 · 2019 · External reference
The Polycomb-associated factor PHF19 controls hematopoietic stem cell state and differentiation
10.1126/sciadv.abb2745 · 2020 · External reference
Polycomb-group proteins in hematopoietic stem cell regulation and hematopoietic neoplasms
10.1038/leu.2012.368 · 2013 · External reference
Occupying chromatin: Polycomb mechanisms for getting to genomic targets, stopping transcriptional traffic, and staying put
10.1016/j.molcel.2013.02.013 · 2013 · External reference
The CBX family of proteins in transcriptional repression and memory
2020 · External reference
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells
10.1016/j.molcel.2021.09.018 · 2021 · External reference
Tracing dynamics and clonal heterogeneity of Cbx7-induced leukemic stem cells by cellular barcoding
10.1016/j.stemcr.2014.10.012 · 2015 · External reference
Role of the chromobox protein CBX7 in lymphomagenesis
10.1073/pnas.0608721104 · 2007 · External reference
DNMT3A R882 mutants interact with Polycomb proteins to block haematopoietic stem and leukaemic cell differentiation
10.1038/ncomms10924 · 2016 · External reference
Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain
10.1016/j.chembiol.2014.11.021 · 2015 · External reference
Discovery of small-molecule allosteric inhibitors of PfATC as antimalarials
10.1021/jacs.2c08128 · 2022 · External reference
Polycomb paralog chromodomain inhibitors active against both CBX6 and CBX8∗
10.1002/cmdc.202100262 · 2021 · External reference
Structure-guided discovery of selective antagonists for the chromodomain of Polycomb repressive protein CBX7
10.1021/acsmedchemlett.6b00042 · 2016 · External reference
Discovery of an in vivo chemical probe of the lysine methyltransferases G9a and GLP
10.1021/jm401480r · 2013 · External reference
Clinical impact of gene mutations and lesions detected by SNP-array karyotyping in acute myeloid leukemia patients in the context of gemtuzumab ozogamicin treatment: results of the ALFA-0701 trial
10.18632/oncotarget.1536 · 2014 · External reference
Enasidenib in mutant IDH2 relapsed or refractory acute myeloid leukemia
10.1182/blood-2017-04-779405 · 2017 · External reference
Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML
10.1056/nejmoa1716984 · 2018 · External reference
CPX-351 (cytarabine and daunorubicin) liposome for injection versus conventional cytarabine plus daunorubicin in older patients with newly diagnosed secondary acute myeloid leukemia
10.1200/jco.2017.77.6112 · 2018 · External reference
Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia
10.1182/blood-2018-08-868752 · 2019 · External reference
FDA approval summary: glasdegib for newly diagnosed acute myeloid leukemia
10.1158/1078-0432.ccr-19-0365 · 2019 · External reference
Gilteritinib or chemotherapy for relapsed or refractory FLT3-mutated AML
10.1056/nejmoa1902688 · 2019 · External reference
Oral cedazuridine/decitabine for MDS and CMML: a phase 2 pharmacokinetic/pharmacodynamic randomized crossover study
10.1182/blood.2019004143 · 2020 · External reference
Oral azacitidine maintenance therapy for acute myeloid leukemia in first remission
10.1056/nejmoa2004444 · 2020 · External reference
CBX7 is dualistic in cancer progression based on its function and molecular interactions
2021 · External reference
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
10.1056/nejmoa1301689 · 2013 · External reference
Integrative analysis of drug response and clinical outcome in acute myeloid leukemia
10.1016/j.ccell.2022.07.002 · 2022 · External reference
A potent, selective CBX2 chromodomain ligand and its cellular activity during prostate cancer neuroendocrine differentiation
10.1002/cbic.202100118 · 2021 · External reference
Selective inhibition of CBX6: a methyllysine reader protein in the Polycomb family
10.1021/acsmedchemlett.5b00378 · 2016 · External reference
Optimization of ligands using focused DNA-encoded libraries to develop a selective, cell-permeable CBX8 chromodomain inhibitor
10.1021/acschembio.9b00654 · 2020 · External reference
Reprogramming CBX8-PRC1 function with a positive allosteric modulator
10.1016/j.chembiol.2021.10.003 · 2022 · External reference
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1
10.1038/nchembio.2007 · 2016 · External reference
Discovery and characterization of a cellular potent positive allosteric modulator of the Polycomb repressive complex 1 chromodomain, CBX7
10.1016/j.chembiol.2019.07.013 · 2019 · External reference
CBX chromodomain inhibition enhances chemotherapy response in glioblastoma multiforme
2016 · External reference
Comparative measurement of spontaneous apoptosis in pediatric acute leukemia by different techniques
10.1002/cyto.b.10056 · 2003 · External reference
Low spontaneous apoptosis index at diagnosis predicts a high-risk phenotype in paediatric acute lymphoblastic leukaemia
10.4103/ijmr.ijmr_303_16 · 2018 · External reference
Differentiation therapy of myeloid leukemia: four decades of development
2021 · External reference
Id2 expression increases with differentiation of human myeloid cells
10.1182/blood.v87.12.5225.bloodjournal87125225 · 1996 · External reference
Differential regulation of granulopoiesis by the basic helix-loop-helix transcriptional inhibitors Id1 and Id2
10.1182/blood-2004-12-4883 · 2005 · External reference
Id2 and E proteins orchestrate the initiation and maintenance of MLL-rearranged acute myeloid leukemia
10.1016/j.ccell.2016.05.019 · 2016 · External reference
Shared and distinct functions of the transcription factors IRF4 and IRF8 in myeloid cell development
10.1371/journal.pone.0025812 · 2011 · External reference
IRF-4 expression in the human myeloid lineage: up-regulation during dendritic cell differentiation and inhibition by 1alpha,25-dihydroxyvitamin D3
10.1189/jlb.0205090 · 2005 · External reference
MafB is an inducer of monocytic differentiation
10.1093/emboj/19.9.1987 · 2000 · External reference
Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells
10.1038/sj.cdd.4401860 · 2006 · External reference
The vitamin D3/Hox-A10 pathway supports MafB function during the monocyte differentiation of human CD34+ hemopoietic progenitors
10.4049/jimmunol.181.8.5660 · 2008 · External reference
A novel glycogen synthase kinase-3 inhibitor optimized for acute myeloid leukemia differentiation activity
10.1158/1535-7163.mct-15-0566 · 2016 · External reference
Reactive oxygen species activate differentiation gene transcription of acute myeloid leukemia cells via the JNK/c-JUN signaling pathway
10.1016/j.leukres.2018.03.012 · 2018 · External reference
The AAA+ATPase RUVBL2 is essential for the oncogenic function of c-MYB in acute myeloid leukemia
10.1038/s41375-019-0495-8 · 2019 · External reference
Ubiquitin-dependent degradation of CDK2 drives the therapeutic differentiation of AML by targeting PRDX2
10.1182/blood-2017-10-813139 · 2018 · External reference
The palmitoyltransferase ZDHHC21 regulates oxidative phosphorylation to induce differentiation block and stemness in AML
2023 · External reference
Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia
10.1186/s13148-021-01011-x · 2021 · External reference
BMI1 gene expression in myeloid leukemias and its impact on prognosis
10.1016/j.bcmd.2014.07.002 · 2014 · External reference
Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring
10.1007/s00277-010-1128-5 · 2011 · External reference
Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice
10.1126/sciadv.1600972 · 2016 · External reference
Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo
10.1038/s41375-018-0126-9 · 2018 · External reference
Ubiquitin-specific peptidase 3 induces TPA-mediated leukemia cell differentiation via regulating H2AK119ub
10.1080/19768354.2019.1661283 · 2019 · External reference
The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells
10.1038/bcj.2017.8 · 2017 · External reference
Epigenetic regulation of Bmi1 by ubiquitination and proteasomal degradation inhibit Bcl-2 in acute myeloid leukemia
10.1021/acsami.0c06186 · 2020 · External reference
Polycomb complexes PRC1 and their function in hematopoiesis
10.1016/j.exphem.2016.12.006 · 2017 · External reference
CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis
10.1016/j.ccr.2011.09.008 · 2011 · External reference
EZH2 and BCL6 cooperate to assemble CBX8-BCOR complex to repress bivalent promoters, mediate germinal center formation and lymphomagenesis
10.1016/j.ccell.2016.07.006 · 2016 · External reference
BCOR binding to MLL-AF9 is essential for leukemia via altered EYA1, SIX, and MYC activity
10.1158/2643-3230.bcd-20-0036 · 2020 · External reference
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
10.1016/j.celrep.2016.09.079 · 2016 · External reference
Silencing of retrotransposons by SETDB1 inhibits the interferon response in acute myeloid leukemia
10.1083/jcb.201612160 · 2017 · External reference
The methyltransferase G9a regulates HoxA9-dependent transcription in AML
10.1101/gad.236794.113 · 2014 · External reference
The histone methyltransferase inhibitor A-366 uncovers a role for G9a/GLP in the epigenetics of leukemia
10.1371/journal.pone.0131716 · 2015 · External reference
Effect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells
10.1016/j.leukres.2017.09.015 · 2017 · External reference
H3K9 dimethylation safeguards cancer cells against activation of the interferon pathway
10.1126/sciadv.abf8627 · 2022 · External reference
Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
10.3389/fcell.2023.1076458 · 2023 · External reference
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia
10.1182/blood-2009-09-240978 · 2010 · External reference
