Research graph
References from Cerebrospinal fluid attenuates the efficacy of methotrexate against acute lymphoblastic leukemia cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Central nervous system disease in hematologic malignancies: historical perspective and practical applications
10.1053/j.seminoncol.2009.05.002 · 2009 · External reference
Central nervous system involvement in childhood acute lymphoblastic leukemia: challenges and solutions
10.1038/s41375-022-01714-x · 2022 · External reference
Flow cytometric detection of malignant blasts in cerebrospinal fluid: a biomarker of central nervous system involvement in childhood acute lymphoblastic leukemia
10.3390/biom12060813 · 2022 · External reference
Intrathecal amethopterin in neurological manifestations of leukemia
10.1001/archinte.1958.00260140111016 · 1958 · External reference
Central nervous system pharmacology of antileukemic drugs
10.1097/00043426-198921000-00017 · 1989 · External reference
The blood-brain barrier and cancer: transporters, treatment, and Trojan horses
10.1158/1078-0432.ccr-06-2854 · 2007 · External reference
Management of CNS disease in pediatric acute lymphoblastic leukemia
10.1007/s11899-021-00640-6 · 2022 · External reference
Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA
10.1182/blood-2016-06-721712 · 2017 · External reference
Multiomic profiling of central nervous system leukemia identifies mRNA translation as a therapeutic target
10.1158/2643-3230.bcd-20-0216 · 2022 · External reference
The central nervous system microenvironment influences the leukemia transcriptome and enhances leukemia chemo-resistance
10.3324/haematol.2016.152926 · 2017 · External reference
Metabolic adaptation of acute lymphoblastic leukemia to the central nervous system microenvironment is dependent on Stearoyl CoA desaturase
10.1038/s43018-020-00115-2 · 2020 · External reference
Central nervous system involvement in childhood acute lymphoblastic leukemia is linked to upregulation of cholesterol biosynthetic pathways
10.1038/s41375-022-01722-x · 2022 · External reference
Central nervous system involvement in acute lymphoblastic leukemia is mediated by vascular endothelial growth factor
10.1182/blood-2017-03-769315 · 2017 · External reference
New cellular markers at diagnosis are associated with isolated central nervous system relapse in paediatric B-cell precursor acute lymphoblastic leukaemia
10.1111/bjh.13887 · 2016 · External reference
A balanced view of the cerebrospinal fluid composition and functions: focus on adult humans
10.1016/j.expneurol.2015.07.027 · 2015 · External reference
The meninges enhance leukaemia survival in cerebral spinal fluid
10.1111/bjh.16270 · 2020 · External reference
Measuring methotrexate polyglutamates in red blood cells: a new LC-MS/MS-based method
10.1007/s00216-012-6581-7 · 2013 · External reference
The antifolates
10.1016/j.hoc.2012.02.002 · 2012 · External reference
Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance
10.1016/j.drup.2012.07.002 · 2012 · External reference
Proliferative kinetics of central nervous system (CNS) leukemia
10.1002/1097-0142(197507)36:1<232::aid-cncr2820360126>3.0.co;2-f · 1975 · External reference
Proliferative kinetics of the leukemic cells in meningeal leukemia
10.1002/1097-0142(197809)42:3<1255::aid-cncr2820420334>3.0.co;2-m · 1978 · External reference
Intrinsic and acquired resistance to methotrexate in acute leukemia
10.1056/nejm199610033351408 · 1996 · External reference
Molecular mechanisms of resistance to antifolates, a review
10.18388/abp.1995_4899 · 1995 · External reference
Toward a better understanding of folate metabolism in health and disease
10.1084/jem.20181965 · 2019 · External reference
Identification of methotrexate transport deficiency in mammalian cells using fluoresceinated methotrexate and flow cytometry
10.1073/pnas.84.20.7154 · 1987 · External reference
Folate, folic acid and 5-methyltetrahydrofolate are not the same thing
10.3109/00498254.2013.845705 · 2014 · External reference
Determination of 5-methyltetrahydrofolate in cerebrospinal fluid of paediatric patients: reference values for a paediatric population
10.1016/j.cca.2006.03.004 · 2006 · External reference
Quantitation of 5-methyltetrahydrofolate in cerebrospinal fluid using liquid chromatography-electrospray-tandem mass spectrometry
10.1007/978-1-0716-2565-1_28 · 2022 · External reference
A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
10.1038/s41467-020-16747-y · 2020 · External reference
The integrated stress response
10.15252/embr.201642195 · 2016 · External reference
The integrated stress response in cancer progression: a force for plasticity and resistance
10.3389/fonc.2023.1206561 · 2023 · External reference
Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals
10.1083/jcb.201702058 · 2017 · External reference
The integrated stress response as a key pathway downstream of mitochondrial dysfunction
2022 · External reference
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response
10.1126/scitranslmed.aax2863 · 2019 · External reference
Clinical pharmacology of intrathecal methotrexate. I. Pharmacokinetics in nontoxic patients after lumbar injection
1977 · External reference
Role of drug concentration, duration of exposure, and endogenous metabolites in determining methotrexate cytotoxicity
1977 · External reference
Very high-dose methotrexate (33.6 g/m(2)) as central nervous system preventive therapy for childhood acute lymphoblastic leukemia: results of National Cancer Institute/Children’s Cancer Group trials CCG-191P, CCG-134P and CCG-144P
10.1080/10428190600942769 · 2006 · External reference
A slow-release methotrexate formulation for intrathecal chemotherapy
10.1007/bf00685832 · 1993 · External reference
Efficacy and toxicity of intrathecal liposomal cytarabine in first-line therapy of childhood acute lymphoblastic leukemia
10.1097/mph.0000000000000642 · 2016 · External reference
The two faces of the integrated stress response in cancer progression and therapeutic strategies
10.1016/j.biocel.2021.106059 · 2021 · External reference
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation
10.1073/pnas.1815767116 · 2019 · External reference
Systematic review and meta-analysis of randomized trials of central nervous system directed therapy for childhood acute lymphoblastic leukemia
10.1002/pbc.24228 · 2013 · External reference
Intrathecal liposomal cytarabine in relapsed or refractory infant and pediatric leukemias: the Children’s Hospital of Philadelphia experience and review of the literature
10.1097/mph.0b013e3181ec0c25 · 2010 · External reference
Impact of intrathecal triple therapy versus intrathecal methotrexate on disease-free survival for high-risk B-lymphoblastic leukemia: Children’s Oncology Group study AALL1131
10.1200/jco.19.02892 · 2020 · External reference
10.1182/blood-2005-12-011809
10.1182/blood-2005-12-011809 · 2006 · External reference
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy
10.1016/j.neuron.2022.08.009 · 2022 · External reference
Ornithine decarboxylase prevents methotrexate-induced apoptosis by reducing intracellular reactive oxygen species production
10.1007/s10495-005-2947-z · 2005 · External reference
