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References from Aberrant heterochromatin silences immune response genes in chronic lymphocytic leukemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Linking cell signaling and the epigenetic machinery
10.1038/nbt1010-1033 · 2010 · External reference
Signaling epigenetics: novel insights on cell signaling and epigenetic regulation
10.1002/iub.557 · 2011 · External reference
Epigenetic plasticity and the hallmarks of cancer
10.1126/science.aal2380 · 2017 · External reference
The chromatin accessibility landscape of primary human cancers
10.1126/science.aav1898 · 2018 · External reference
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
10.1126/science.aad5944 · 2016 · External reference
PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D
10.1126/science.aah6893 · 2017 · External reference
Developmental chromatin programs determine oncogenic competence in melanoma
10.1126/science.abc1048 · 2021 · External reference
Chromatin assembly factor 1 suppresses epigenetic reprogramming toward adaptive drug resistance
10.1016/j.jncc.2020.12.003 · 2021 · External reference
The language of chromatin modification in human cancers
10.1038/s41568-021-00357-x · 2021 · External reference
Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia
10.1182/blood-2015-02-585042 · 2015 · External reference
Chronic lymphocytic leukaemia: from genetics to treatment
10.1038/s41571-019-0239-8 · 2019 · External reference
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
10.1038/ng.2443 · 2012 · External reference
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia
10.1016/j.ccell.2014.10.012 · 2014 · External reference
The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia
10.1038/s41591-018-0028-4 · 2018 · External reference
Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks
10.15252/msb.20188339 · 2019 · External reference
B cell receptor signaling drives APOBEC3 expression via direct enhancer regulation in chronic lymphocytic leukemia B cells
10.1038/s41408-022-00690-w · 2022 · External reference
CUT&Tag for efficient epigenomic profiling of small samples and single cells
10.1038/s41467-019-09982-5 · 2019 · External reference
Unresolved reference
2020 · External reference
Unresolved reference
2020 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Peak calling by sparse enrichment analysis for CUT&RUN chromatin profiling
10.1186/s13072-019-0287-4 · 2019 · External reference
deepTools2: a next generation web server for deep-sequencing data analysis
10.1093/nar/gkw257 · 2016 · External reference
GREAT improves functional interpretation of cis-regulatory regions
10.1038/nbt.1630 · 2010 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Immune response dysfunction in chronic lymphocytic leukemia: dissecting molecular mechanisms and microenvironmental conditions
10.3390/ijms21051825 · 2020 · External reference
Regulation of chromatin by histone modifications
10.1038/cr.2011.22 · 2011 · External reference
Modification of enhancer chromatin: what, how, and why?
10.1016/j.molcel.2013.01.038 · 2013 · External reference
Novel neurotrophin-1/B cell-stimulating factor-3: a cytokine of the IL-6 family
10.1073/pnas.96.20.11458 · 1999 · External reference
Interleukin-1 as innate mediator of T cell immunity
10.3389/fimmu.2020.621931 · 2021 · External reference
IL-1 acts directly on CD4 T cells to enhance their antigen-driven expansion and differentiation
10.1073/pnas.0902745106 · 2009 · External reference
IL-1 enhances expansion, effector function, tissue localization, and memory response of antigen-specific CD8 T cells
10.1084/jem.20122006 · 2013 · External reference
Facultative heterochromatin: is there a distinctive molecular signature?
10.1016/j.molcel.2007.09.011 · 2007 · External reference
Corrupted coordination of epigenetic modifications leads to diverging chromatin states and transcriptional heterogeneity in CLL
10.1038/s41467-019-09645-5 · 2019 · External reference
Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities
10.1182/blood-2010-07-155663 · 2011 · External reference
H3K9me3-heterochromatin loss at protein-coding genes enables developmental lineage specification
10.1126/science.aau0583 · 2019 · External reference
Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis
10.1038/ng.3753 · 2017 · External reference
Cell-type-specific control of enhancer activity by H3K9 trimethylation
10.1016/j.molcel.2012.05.011 · 2012 · External reference
SETDB1/NSD-dependent H3K9me3/H3K36me3 dual heterochromatin maintains gene expression profiles by bookmarking poised enhancers
10.1016/j.molcel.2021.12.037 · 2022 · External reference
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
10.1038/nature10113 · 2011 · External reference
Preneoplastic alterations define CLL DNA methylome and persist through disease progression and therapy
10.1158/2643-3230.bcd-19-0058 · 2021 · External reference
Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells
10.1038/ni.2641 · 2013 · External reference
DNA methylation dynamics during B cell maturation underlie a continuum of disease phenotypes in chronic lymphocytic leukemia
10.1038/ng.3488 · 2016 · External reference
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation
10.1038/s41467-020-20849-y · 2021 · External reference
MEC1 and MEC2: two new cell lines derived from B-chronic lymphocytic leukaemia in prolymphocytoid transformation
10.1016/s0145-2126(98)00154-4 · 1999 · External reference
Prolonged lymphocytosis during ibrutinib therapy is associated with distinct molecular characteristics and does not indicate a suboptimal response to therapy
10.1182/blood-2013-09-527853 · 2014 · External reference
Chromatin mapping and single-cell immune profiling define the temporal dynamics of ibrutinib response in CLL
10.1038/s41467-019-14081-6 · 2020 · External reference
Adaptation of chronic lymphocytic leukemia to ibrutinib is mediated by epigenetic plasticity of residual disease and by-pass signaling via MAPK pathway
10.1002/hon.29_2879 · 2021 · External reference
Hallmarks of cancer: new dimensions
10.1158/2159-8290.cd-21-1059 · 2022 · External reference
The role of enhancers in cancer
10.1038/nrc.2016.62 · 2016 · External reference
Enhancer architecture and essential core regulatory circuitry of chronic lymphocytic leukemia
10.1016/j.ccell.2018.11.001 · 2018 · External reference
Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia
10.1038/ncomms14175 · 2017 · External reference
Outcomes of COVID-19 in patients with CLL: a multicenter international experience
10.1182/blood.2020006965 · 2020 · External reference
Expression of regeneration and tolerance factor on B cell chronic lymphocytic leukemias: a possible mechanism for escaping immune surveillance
10.1002/(sici)1096-8652(199905)61:1<46::aid-ajh9>3.0.co;2-g · 1999 · External reference
Acquired CD40-ligand deficiency in chronic lymphocytic leukemia
10.1038/nm0997-984 · 1997 · External reference
The effect of immunoglobulin VH gene mutation status and other prognostic factors on the incidence of major infections in patients with chronic lymphocytic leukemia
10.1002/cncr.22094 · 2006 · External reference
Heterogeneity of serum IgG subclass deficiencies in B chronic lymphocytic leukemia
10.1006/clim.1998.4617 · 1999 · External reference
Management of infectious complications in patients with chronic lymphocytic leukemia
10.1182/asheducation-2007.1.332 · 2007 · External reference
Infectious complications of chronic lymphocytic leukemia
10.1053/j.seminoncol.2005.12.013 · 2006 · External reference
EBF1 is essential for B-lineage priming and establishment of a transcription factor network in common lymphoid progenitors
10.4049/jimmunol.181.5.3364 · 2008 · External reference
Ebf1 or Pax5 haploinsufficiency synergizes with STAT5 activation to initiate acute lymphoblastic leukemia
10.1084/jem.20101947 · 2011 · External reference
Ebf1 in DNA repair and leukemogenesis
10.1182/blood-2015-05-639427 · 2015 · External reference
The B29 (immunoglobulin beta-chain) gene is a genetic target for early B-cell factor
10.1128/mcb.19.1.392 · 1999 · External reference
EBF and E47 collaborate to induce expression of the endogenous immunoglobulin surrogate light chain genes
10.1016/s1074-7613(00)80507-5 · 1997 · External reference
Hypogammaglobulinemia in newly diagnosed chronic lymphocytic leukemia: natural history, clinical correlates, and outcomes
10.1002/cncr.29438 · 2015 · External reference
The induction of antibody production by IL-6 is indirectly mediated by IL-21 produced by CD4+ T cells
10.1084/jem.20081571 · 2009 · External reference
T cells from CLL patients exhibit features of T-cell exhaustion but retain capacity for cytokine production
10.1182/blood-2012-09-457531 · 2013 · External reference
T-cells in chronic lymphocytic leukemia: guardians or drivers of disease?
10.1038/s41375-020-0873-2 · 2020 · External reference
The humoral immune response to high-dose influenza vaccine in persons with monoclonal B-cell lymphocytosis (MBL) and chronic lymphocytic leukemia (CLL)
10.1016/j.vaccine.2021.01.001 · 2021 · External reference
Humoral responses against SARS-CoV-2 and variants of concern after mRNA vaccines in patients with non-Hodgkin lymphoma and chronic lymphocytic leukemia
10.1200/jco.22.00088 · 2022 · External reference
Enhancer activity requires CBP/P300 bromodomain-dependent histone H3K27 acetylation
10.1016/j.celrep.2018.07.041 · 2018 · External reference
Histone H3K27ac separates active from poised enhancers and predicts developmental state
10.1073/pnas.1016071107 · 2010 · External reference
Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition
10.1016/j.molcel.2021.04.015 · 2021 · External reference
Achieving clinical success with BET inhibitors as anti-cancer agents
10.1038/s41416-021-01321-0 · 2021 · External reference
Histone editing elucidates the functional roles of H3K27 methylation and acetylation in mammals
10.1038/s41588-022-01091-2 · 2022 · External reference
Histone H3K27 acetylation is dispensable for enhancer activity in mouse embryonic stem cells
10.1186/s13059-020-01957-w · 2020 · External reference
In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells
10.1172/jci23409 · 2005 · External reference
Reduction of B cell turnover in chronic lymphocytic leukaemia
10.1111/j.1365-2141.2008.07348.x · 2008 · External reference
Parental nucleosome segregation and the inheritance of cellular identity
10.1038/s41576-020-00312-w · 2021 · External reference
Active and repressed chromatin domains exhibit distinct nucleosome segregation during DNA replication
10.1016/j.cell.2019.10.009 · 2019 · External reference
Diverse heterochromatin states restricting cell identity and reprogramming
10.1016/j.tibs.2023.02.007 · 2023 · External reference