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References from A feedforward loop between ACLY and MYC supports T-ALL progression in vivo. Local targets link to admitted publications; unresolved targets remain external evidence.
Acute lymphoblastic leukaemia
10.1038/s41572-024-00525-x · 2024 · External reference
Metabolic dependencies and vulnerabilities in leukemia
10.1101/gad.326470.119 · 2019 · External reference
SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
10.1038/s41375-020-0845-6 · 2021 · External reference
A novel and highly effective mitochondrial uncoupling drug in T-cell leukemia
10.1182/blood.2020008955 · 2021 · External reference
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia
10.1038/nm.3955 · 2015 · External reference
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
10.1126/science.1102160 · 2004 · External reference
Acetyl-CoA metabolism in cancer
10.1038/s41568-022-00543-5 · 2023 · External reference
A therapeutically targetable NOTCH1-SIRT1-KAT7 axis in T-cell leukemia
10.1158/2643-3230.bcd-22-0098 · 2023 · External reference
Chromatin kinases act on transcription factors and histone tails in regulation of inducible transcription
10.1016/j.molcel.2016.09.026 · 2016 · External reference
Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis
10.1158/2159-8290.cd-18-0567 · 2019 · External reference
Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8+ T Cells
10.1158/0008-5472.can-21-4052 · 2022 · External reference
Nuclear Phosphoproteomic Screen Uncovers ACLY as Mediator of IL-2-induced Proliferation of CD4+ T lymphocytes
10.1074/mcp.m115.057158 · 2016 · External reference
An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia
10.1038/ng.2913 · 2014 · External reference
ETV6 mutations in early immature human T cell leukemias
10.1084/jem.20112239 · 2011 · External reference
The genomic basis of childhood T-lineage acute lymphoblastic leukaemia
10.1038/s41586-024-07807-0 · 2024 · External reference
A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation
10.1016/j.cell.2014.04.046 · 2014 · External reference
ATP-citrate lyase controls a glucose-to-acetate metabolic switch
10.1016/j.celrep.2016.09.069 · 2016 · External reference
Transgenic mice with hematopoietic and lymphoid specific expression of Cre
10.1002/immu.200310005 · 2003 · External reference
Antileukemic effects of AMPK activators on BCR-ABL-expressing cells
10.1182/blood-2011-01-332783 · 2011 · External reference
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update.
10.1093/nar/gkw377 · 2016 · External reference
Benchmark and integration of resources for the estimation of human transcription factor activities
10.1101/gr.240663.118 · 2019 · External reference
ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury
10.1038/s41419-023-05932-8 · 2023 · External reference
A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer
10.1038/s41388-020-01553-z · 2021 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia
10.1038/nm.3665 · 2014 · External reference
The NOTCH1-MYC highway toward T-cell acute lymphoblastic leukemia
10.1182/blood-2016-09-692582 · 2017 · External reference
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
10.1038/nature10334 · 2011 · External reference
Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation
10.1016/j.cmet.2014.06.004 · 2014 · External reference
Targeting Myc interacting proteins as a winding path in cancer therapy
2021 · External reference
A c-Myc-SIRT1 feedback loop regulates cell growth and transformation
10.1083/jcb.200809167 · 2009 · External reference
ATP-citrate lyase (ACLY) inhibitors as therapeutic agents: a patenting perspective
10.1080/13543776.2022.2067478 · 2022 · External reference
Targeting ACLY sensitizes castration-resistant prostate cancer cells to AR antagonism by impinging on an ACLY-AMPK-AR feedback mechanism
10.18632/oncotarget.9666 · 2016 · External reference
Bempedoic acid: first approval
10.1007/s40265-020-01308-w · 2020 · External reference
Recent advance of ATP citrate lyase inhibitors for the treatment of cancer and related diseases
10.1016/j.bioorg.2023.106933 · 2024 · External reference
An allosteric mechanism for potent inhibition of human ATP-citrate lyase
10.1038/s41586-019-1094-6 · 2019 · External reference
