Research graph
References from Targeting transcription-replication conflicts using G-quadruplexes stabilizers in multiple myeloma. Local targets link to admitted publications; unresolved targets remain external evidence.
Multiple myeloma
10.1038/nrdp.2017.46 · 2017 · External reference
del(17p) without TP53 mutation confers a poor prognosis in intensively treated newly diagnosed patients with multiple myeloma
10.1182/blood.2020008346 · 2021 · External reference
Multiple myeloma
10.1016/s0140-6736(21)00135-5 · 2021 · External reference
Targeted immunotherapy: harnessing the immune system to battle multiple myeloma
10.1038/s41420-024-01818-6 · 2024 · External reference
Mechanisms of oncogene-induced replication stress: jigsaw falling into place
10.1158/2159-8290.cd-17-1461 · 2018 · External reference
Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX
10.1038/leu.2011.94 · 2011 · External reference
Hypertranscription and replication stress in cancer
10.1016/j.trecan.2021.04.006 · 2021 · External reference
Increased global transcription activity as a mechanism of replication stress in cancer
10.1038/ncomms13087 · 2016 · External reference
Mutational processes contributing to the development of multiple myeloma
10.1038/s41408-019-0221-9 · 2019 · External reference
G-quadruplex–R-loop interactions and the mechanism of anticancer G-quadruplex binders
10.1093/nar/gkaa944 · 2020 · External reference
DNA secondary structures: stability and function of G-quadruplex structures
10.1038/nrg3296 · 2012 · External reference
G-quadruplexes: a promising target for cancer therapy
10.1186/s12943-021-01328-4 · 2021 · External reference
G-quadruplex, friend or foe: the role of the G-quartet in anticancer strategies
10.1016/j.molmed.2020.05.002 · 2020 · External reference
A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres
10.1021/ja805615w · 2008 · External reference
Small molecule-induced DNA damage identifies alternative DNA structures in human genes
10.1038/nchembio.780 · 2012 · External reference
DNA damage and genome instability by G-quadruplex ligands are mediated by R loops in human cancer cells
10.1073/pnas.1810409116 · 2019 · External reference
Unresolved reference
2011 · External reference
Development of gene expression-based score to predict sensitivity of multiple myeloma cells to DNA methylation inhibitors
10.1158/1535-7163.mct-12-0721 · 2012 · External reference
Transcription/replication conflicts in tumorigenesis and their potential role as novel therapeutic targets in multiple myeloma
10.3390/cancers13153755 · 2021 · External reference
Genes with a spike expression are clustered in chromosome (sub)bands and spike (sub)bands have a powerful prognostic value in patients with multiple myeloma
10.3324/haematol.2011.046821 · 2012 · External reference
PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs
10.1186/s13148-018-0554-4 · 2018 · External reference
Targeting cellular iron homeostasis with ironomycin in diffuse large B-cell lymphoma
10.1158/0008-5472.can-21-0218 · 2022 · External reference
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)
10.1016/j.jbc.2024.105646 · 2024 · External reference
Transcription dynamics prevent RNA-mediated genomic instability through SRPK2-dependent DDX23 phosphorylation
10.1016/j.celrep.2016.12.050 · 2017 · External reference
Combined inhibition of Wee1 and Chk1 as a therapeutic strategy in multiple myeloma
10.3389/fonc.2023.1271847 · 2023 · External reference
Profiling cell type abundance and expression in bulk tissues with CIBERSORTx
10.1007/978-1-0716-0301-7_7 · 2020 · External reference
Orchestration of chromatin-based processes: mind the TRRAP
10.1038/sj.onc.1210605 · 2007 · External reference
Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks
10.1038/ncb1343 · 2006 · External reference
RNA-sequencing-based transcriptomic score with prognostic and theranostic values in multiple myeloma
10.3390/jpm11100988 · 2021 · External reference
Gene abnormalities in multiple myeloma; the relevance of TP53, MDM2, and CDKN2A
2003 · External reference
IRF4 addiction in multiple myeloma
10.1038/nature07064 · 2008 · External reference
Roles for TNF-receptor associated factor 3 (TRAF3) in lymphocyte functions
10.1016/j.cytogfr.2013.12.002 · 2014 · External reference
Targeting TRAF3 downstream signaling pathways in B cell neoplasms
2015 · External reference
The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development
10.1126/scisignal.aaa5157 · 2015 · External reference
ASXL1/2 mutations and myeloid malignancies
10.1186/s13045-022-01336-x · 2022 · External reference
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
10.1016/j.ccr.2012.06.032 · 2012 · External reference
Clonal and subclonal TP53 molecular impairment is associated with prognosis and progression in multiple myeloma
10.1038/s41408-022-00610-y · 2022 · External reference
Development and validation of a cytogenetic prognostic index predicting survival in multiple myeloma
10.1200/jco.18.00776 · 2019 · External reference
Mutational spectrum, copy number changes, and outcome: results of a sequencing study of patients with newly diagnosed myeloma
10.1200/jco.2014.59.1503 · 2015 · External reference
Concepts of double hit and triple hit disease in multiple myeloma, entity and prognostic significance
10.1038/s41598-020-62885-0 · 2020 · External reference
Chromosome 1q21 abnormalities refine outcome prediction in patients with multiple myeloma - a meta-analysis of 2,596 trial patients
10.3324/haematol.2021.278888 · 2021 · External reference
BrdU incorporation in multiparameter flow cytometry: a new cell cycle assessment approach in multiple myeloma
10.1002/cyto.b.21730 · 2019 · External reference
Structural basis of pyridostatin and its derivatives specifically binding to G-quadruplexes
10.1021/jacs.2c04775 · 2022 · External reference
Comprehensive characterization of the mutational landscape in multiple myeloma cell lines reveals potential drivers and pathways associated with tumor progression and drug resistance
10.7150/thno.28374 · 2019 · External reference
Comprehensive characterization of the epigenetic landscape in multiple myeloma
10.7150/thno.54453 · 2022 · External reference
Higher-order G-quadruplexes in promoters are untapped drug targets
10.3389/fchem.2023.1211512 · 2023 · External reference
RNA G-quadruplex structures control ribosomal protein production
10.1038/s41598-021-01847-6 · 2021 · External reference
Analysis of translation using polysome profiling
2017 · External reference
Cell cycle control in cancer
10.1038/s41580-021-00404-3 · 2022 · External reference
BRD4 prevents R-loop formation and transcription-replication conflicts by ensuring efficient transcription elongation
10.1016/j.celrep.2020.108166 · 2020 · External reference
RNase H2 degrades toxic RNA:DNA hybrids behind stalled forks to promote replication restart
10.15252/embj.2022113104 · 2023 · External reference
The BLM helicase is a new therapeutic target in multiple myeloma involved in replication stress survival and drug resistance
10.3389/fimmu.2022.983181 · 2022 · External reference
IMiD resistance in multiple myeloma: current understanding of the underpinning biology and clinical impact
2023 · External reference
Utilizing BMP-2 muteins for treatment of multiple myeloma
10.1371/journal.pone.0174884 · 2017 · External reference
Bone morphogenetic protein (BMP)-2 induces apoptosis in human myeloma cells
10.1080/10428190290012182 · 2002 · External reference
Germline lysine-specific demethylase 1 (LSD1/KDM1A) mutations confer susceptibility to multiple myeloma
10.1158/0008-5472.can-17-1900 · 2018 · External reference
Proteasome function is required for DNA damage response and Fanconi anemia pathway activation
10.1158/0008-5472.can-07-1015 · 2007 · External reference
Bortezomib-induced “BRCAness” sensitizes multiple myeloma cells to PARP inhibitors
10.1182/blood-2011-06-363911 · 2011 · External reference
Human THO–Sin3A interaction reveals new mechanisms to prevent R-loops that cause genome instability
10.15252/embj.201797208 · 2017 · External reference
RNA polymerase I inhibition with CX-5461 as a novel therapeutic strategy to target MYC in multiple myeloma
10.1111/bjh.14525 · 2017 · External reference
BRD4 prevents the accumulation of R-loops and protects against transcription–replication collision events and DNA damage
10.1038/s41467-020-17503-y · 2020 · External reference
Dissecting the impact of bromodomain inhibitors on the interferon regulatory factor 4-MYC oncogenic axis in multiple myeloma
10.1002/hon.3016 · 2022 · External reference
Decoding regulatory associations of G-quadruplex with epigenetic and transcriptomic functional components
10.3389/fgene.2022.957023 · 2022 · External reference
Widespread genetic heterogeneity in multiple myeloma: implications for targeted therapy
10.1016/j.ccr.2013.12.015 · 2014 · External reference
Molecular mechanisms and cellular functions of cGAS–STING signalling
10.1038/s41580-020-0244-x · 2020 · External reference
The replication stress response on a narrow path between genomic instability and inflammation
10.3389/fcell.2021.702584 · 2021 · External reference
p53 engages the cGAS/STING cytosolic DNA sensing pathway for tumor suppression
10.1016/j.molcel.2022.12.023 · 2023 · External reference
A new G-quadruplex-specific photosensitizer inducing genome instability in cancer cells by triggering oxidative DNA damage and impeding replication fork progression
10.1093/nar/gkad365 · 2023 · External reference
A synthetic lethal approach to drug targeting of G-quadruplexes based on CX-5461
10.1016/j.bmcl.2023.129384 · 2023 · External reference
First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study
10.1158/2159-8290.cd-18-1455 · 2019 · External reference
Results of the phase I CCTG IND.231 trial of CX-5461 in patients with advanced solid tumors enriched for DNA-repair deficiencies
10.1038/s41467-022-31199-2 · 2022 · External reference
The G-quadruplex DNA stabilizing drug pyridostatin promotes DNA damage and downregulates transcription of Brca1 in neurons
10.18632/aging.101282 · 2017 · External reference
Small-molecule G-quadruplex stabilizers reveal a novel pathway of autophagy regulation in neurons
10.7554/elife.52283 · 2020 · External reference
G-quadruplex binders as cytostatic modulators of innate immune genes in cancer cells
10.1093/nar/gkab500 · 2021 · External reference
Discovery of a novel G-quadruplex and histone deacetylase (HDAC) dual-targeting agent for the treatment of triple-negative breast cancer
10.1021/acs.jmedchem.2c01058 · 2022 · External reference
Lenalidomide induces degradation of IKZF1 and IKZF3
10.4161/21624011.2014.941742 · 2014 · External reference
Achieving clinical success with BET inhibitors as anti-cancer agents
10.1038/s41416-021-01321-0 · 2021 · External reference
