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References from Multiplex gene editing models of del(7q) reveal combined CUX1 and EZH2 loss drives clonal expansion and drug resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Does aneuploidy cause cancer?
10.1016/j.ceb.2006.10.002 · 2006 · External reference
The diverse consequences of aneuploidy
10.1038/s41556-018-0243-8 · 2019 · External reference
HSF1 deficiency and impaired HSP90-dependent protein folding are hallmarks of aneuploid human cells
10.15252/embj.201488648 · 2014 · External reference
Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells
10.1126/science.1160058 · 2008 · External reference
Aneuploidy as a promoter and suppressor of malignant growth
10.1038/s41568-020-00321-1 · 2021 · External reference
Functional analysis of a chromosomal deletion associated with myelodysplastic syndromes using isogenic human induced pluripotent stem cells
10.1038/nbt.3178 · 2015 · External reference
Therapy-related myeloid neoplasms: when genetics and environment collide
10.1038/nrc.2017.60 · 2017 · External reference
Functional evidence implicating chromosome 7q22 haploinsufficiency in myelodysplastic syndrome pathogenesis
10.7554/elife.07839 · 2015 · External reference
The genomic landscape of pediatric myelodysplastic syndromes
10.1038/s41467-017-01590-5 · 2017 · External reference
Genomic classification in acute myeloid leukemia
10.1056/nejmc1608739 · 2016 · External reference
Cytogenetic features in myelodysplastic syndromes
10.1007/s00277-008-0483-y · 2008 · External reference
Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series
10.1182/blood-2002-11-3343 · 2003 · External reference
International Consensus Classification of myeloid neoplasms and acute leukemias: integrating morphologic, clinical, and genomic data
10.1182/blood.2022015850 · 2022 · External reference
The 5th edition of the World Health Organization classification of haematolymphoid tumours: myeloid and histiocytic/dendritic neoplasms
10.1038/s41375-022-01613-1 · 2022 · External reference
Characterization of large structural genetic mosaicism in human autosomes
10.1016/j.ajhg.2015.01.011 · 2015 · External reference
Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations
10.1038/s41586-018-0321-x · 2018 · External reference
Interplay between chromosomal alterations and gene mutations shapes the evolutionary trajectory of clonal hematopoiesis
10.1038/s41467-020-20565-7 · 2021 · External reference
Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
10.1038/s41591-021-01411-9 · 2021 · External reference
Copy number alterations detected as clonal hematopoiesis of indeterminate potential
10.1182/bloodadvances.2017007922 · 2017 · External reference
Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: a case-control study
10.1016/s1470-2045(16)30626-x · 2017 · External reference
The enigma of monosomy 7
10.1182/blood-2017-12-822262 · 2018 · External reference
The significance of CUX1 and chromosome 7 in myeloid malignancies
10.1097/moh.0000000000000699 · 2022 · External reference
Genomics of deletion 7 and 7q in myeloid neoplasm: from pathogenic culprits to potential synthetic lethal therapeutic targets
10.1038/s41375-023-02003-x · 2023 · External reference
CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
10.1182/blood-2012-04-426965 · 2013 · External reference
Gene dosage effect of CUX1 in a murine model disrupts HSC homeostasis and controls the severity and mortality of MDS
10.1182/blood-2017-10-810028 · 2018 · External reference
Loss of a 7q gene, CUX1, disrupts epigenetically driven DNA repair and drives therapy-related myeloid neoplasms
10.1182/blood.2020009195 · 2021 · External reference
Cut-like homeobox 1 (CUX1) tumor suppressor gene haploinsufficiency induces apoptosis evasion to sustain myeloid leukemia
10.1038/s41467-021-22750-8 · 2021 · External reference
A genetic map of the response to DNA damage in human cells
10.1016/j.cell.2020.05.040 · 2020 · External reference
SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice
10.15252/embj.2018100158 · 2018 · External reference
Genome-wide identification and characterization of novel factors conferring resistance to topoisomerase II poisons in cancer
10.1158/0008-5472.can-15-0380 · 2015 · External reference
A whole-genome CRISPR screen identifies a role of MSH2 in cisplatin-mediated cell death in muscle-invasive bladder cancer
10.1016/j.eururo.2018.10.040 · 2019 · External reference
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells
10.1038/s41586-018-0670-5 · 2018 · External reference
Spindle assembly checkpoint inhibition can resensitize p53-null stem cells to cancer chemotherapy
10.1158/0008-5472.can-18-3024 · 2019 · External reference
A highly annotated database of genes associated with platinum resistance in cancer
10.1038/s41388-021-02055-2 · 2021 · External reference
Ribosomal protein S11 influences glioma response to TOP2 poisons
10.1038/s41388-020-1342-0 · 2020 · External reference
Genetic screens in human cells using the CRISPR-Cas9 system
10.1126/science.1246981 · 2014 · External reference
The BioGRID database: a comprehensive biomedical resource of curated protein, genetic, and chemical interactions
10.1002/pro.3978 · 2021 · External reference
Molecular signatures database (MSigDB) 3.0
10.1093/bioinformatics/btr260 · 2011 · External reference
Highly efficient genome editing of murine and human hematopoietic progenitor cells by CRISPR/Cas9
10.1016/j.celrep.2016.09.092 · 2016 · External reference
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity
10.1038/sj.emboj.7600402 · 2004 · External reference
The roles of Polycomb repressive complexes in mammalian development and cancer
10.1038/s41580-021-00341-1 · 2021 · External reference
Loss of the histone methyltransferase EZH2 induces resistance to multiple drugs in acute myeloid leukemia
10.1038/nm.4247 · 2017 · External reference
The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers
10.1128/mcb.01181-13 · 2013 · External reference
Multiple roles for the MLL/COMPASS family in the epigenetic regulation of gene expression and in cancer
10.1146/annurev-cancerbio-050216-034333 · 2017 · External reference
Kmt2c mutations enhance HSC self-renewal capacity and convey a selective advantage after chemotherapy
10.1016/j.celrep.2021.108751 · 2021 · External reference
Genetic mechanisms of primary chemotherapy resistance in pediatric acute myeloid leukemia
10.1038/s41375-019-0402-3 · 2019 · External reference
Loss of MLL5 results in pleiotropic hematopoietic defects, reduced neutrophil immune function, and extreme sensitivity to DNA demethylation
10.1182/blood-2008-06-162263 · 2009 · External reference
Impaired function of primitive hematopoietic cells in mice lacking the mixed-lineage-leukemia homolog MLL5
10.1182/blood-2008-02-142638 · 2009 · External reference
MLL5 contributes to hematopoietic stem cell fitness and homeostasis
10.1182/blood-2008-05-159905 · 2009 · External reference
Prognostic importance of histone methyltransferase MLL5 expression in acute myeloid leukemia
10.1200/jco.2010.31.1118 · 2011 · External reference
Recruitment of KMT2C/MLL3 to DNA damage sites mediates DNA damage responses and regulates PARP inhibitor sensitivity in cancer
10.1158/0008-5472.can-21-0688 · 2021 · External reference
The lysine-specific methyltransferase KMT2C/MLL3 regulates DNA repair components in cancer
10.15252/embr.201846821 · 2019 · External reference
DNA damage-induced HSPC malfunction depends on ROS accumulation downstream of IFN-1 signaling and bid mobilization
10.1016/j.stem.2016.08.007 · 2016 · External reference
Polycomb repressive complex 2 contributes to DNA double-strand break repair
10.4161/cc.25795 · 2013 · External reference
Global epigenetic analysis reveals H3K27 methylation as a mediator of double strand break repair
2021 · External reference
Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
10.1016/j.cell.2018.03.022 · 2018 · External reference
AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
10.1073/pnas.171321298 · 2001 · External reference
Murine models of acute myeloid leukemia
10.3389/fonc.2022.854973 · 2022 · External reference
Mouse hematopoietic stem cell identification and analysis
10.1002/cyto.a.20674 · 2009 · External reference
PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells
10.1182/blood-2018-05-850339 · 2018 · External reference
Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis
10.1182/blood-2011-12-397620 · 2012 · External reference
Genomic characterization of acute myeloid leukemia with aberrations of chromosome 7: a multinational cohort of 523 patients
10.1182/blood-2023-185627 · 2023 · External reference
Frequent retention of heterozygosity for point mutations in p53 and Ikaros in N-ethyl-N-nitrosourea-induced mouse thymic lymphomas
10.1016/j.mrfmmm.2005.01.010 · 2005 · External reference
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN
10.1182/blood.2022016867 · 2022 · External reference
PPM1D mutations drive clonal hematopoiesis in response to cytotoxic chemotherapy
10.1016/j.stem.2018.10.004 · 2018 · External reference
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
10.1038/nm.4210 · 2016 · External reference
Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignancies in an Ezh1-dependent manner
10.1182/blood-2015-03-634428 · 2015 · External reference
LIN28B overexpression defines a novel fetal-like subgroup of juvenile myelomonocytic leukemia
10.1182/blood-2015-09-667808 · 2016 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
The histone H3 lysine 9 methyltransferases G9a and GLP regulate polycomb repressive complex 2-mediated gene silencing
10.1016/j.molcel.2013.12.005 · 2014 · External reference
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island
2008 · External reference
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands
10.1016/j.ccr.2011.09.012 · 2011 · External reference
Doxorubicin-induced DNA damage causes extensive ubiquitination of ribosomal proteins associated with a decrease in protein translation
10.1074/mcp.ra118.000652 · 2018 · External reference
Transcriptional responses to DNA damage
10.1016/j.dnarep.2019.05.002 · 2019 · External reference
Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia
10.1016/j.ccell.2022.10.002 · 2023 · External reference
A stem cell molecular signature
10.1126/science.1073823 · 2002 · External reference
WikiPathways 2024: next generation pathway database
10.1093/nar/gkad960 · 2024 · External reference
Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
10.1093/nar/gkn550 · 2008 · External reference
Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability
10.1242/jcs.215525 · 2018 · External reference
Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage
10.1038/s41598-017-16480-5 · 2017 · External reference
Identification of RPS14 as a 5q- syndrome gene by RNA interference screen
10.1038/nature06494 · 2008 · External reference
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
10.1038/nm.2054 · 2010 · External reference
Cell intrinsic and extrinsic factors synergize in mice with haploinsufficiency for Tp53, and two human del(5q) genes, Egr1 and Apc
10.1182/blood-2013-05-506568 · 2014 · External reference
A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions
10.1073/pnas.1206062109 · 2012 · External reference
Single-cell RNA-seq reveals a distinct transcriptome signature of aneuploid hematopoietic cells
10.1182/blood-2017-08-803353 · 2017 · External reference
Inhibition of EZH2 transactivation function sensitizes solid tumors to genotoxic stress
10.1073/pnas.2105898119 · 2022 · External reference
Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential
10.1038/s41467-018-02858-0 · 2018 · External reference
Clonal hematopoiesis: mechanisms driving dominance of stem cell clones
2020 · External reference
Age-related clonal hematopoiesis associated with adverse outcomes
10.1056/nejmoa1408617 · 2014 · External reference
Somatic mutations and clonal hematopoiesis in aplastic anemia
10.1056/nejmoa1414799 · 2015 · External reference
Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly
10.1182/blood-2017-02-769869 · 2017 · External reference
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
10.1038/s41591-022-01883-3 · 2022 · External reference
Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms
10.1016/j.celrep.2021.108989 · 2021 · External reference
Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS
10.1016/j.molcel.2021.02.033 · 2021 · External reference
Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7
10.1016/j.ccr.2013.08.011 · 2013 · External reference