Research graph
References from Tumor-associated myeloid cells support murine T-ALL in the central nervous system via integrin signaling. Local targets link to admitted publications; unresolved targets remain external evidence.
Pediatric T-cell acute lymphoblastic leukemia
10.1002/gcc.22416 · 2017 · External reference
Management of adults with T-cell lymphoblastic leukemia
10.1182/blood-2016-07-692608 · 2017 · External reference
The genetics and mechanisms of T cell acute lymphoblastic leukaemia
10.1038/nrc.2016.63 · 2016 · External reference
Microenvironmental cues for T-cell acute lymphoblastic leukemia development
10.1111/imr.12402 · 2016 · External reference
The genomic landscape of pediatric and young adult T-lineage acute lymphoblastic leukemia
10.1038/ng.3909 · 2017 · External reference
Advances in the genetics and therapy of acute lymphoblastic leukemia
10.1200/edbk_156628 · 2016 · External reference
The genomic landscape of pediatric acute lymphoblastic leukemia
10.1038/s41588-022-01159-z · 2022 · External reference
T-cell acute lymphoblastic leukemia
10.1182/asheducation-2016.1.580 · 2016 · External reference
Central nervous system status is prognostic in T-cell acute lymphoblastic leukemia: a Children’s Oncology Group report
10.1182/blood.2022018653 · 2023 · External reference
How I prevent and treat central nervous system disease in adults with acute lymphoblastic leukemia
10.1182/blood.2022017035 · 2023 · External reference
Relapsed T cell ALL: current approaches and new directions
10.1007/s11899-019-00501-3 · 2019 · External reference
The physiopathology of T- cell acute lymphoblastic leukemia: focus on molecular aspects
10.3389/fonc.2020.00273 · 2020 · External reference
Pediatric acute lymphoblastic leukemia—conquering the CNS across the choroid plexus
10.1016/j.leukres.2018.07.001 · 2018 · External reference
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia
10.1038/nature08020 · 2009 · External reference
CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS
10.1038/leu.2016.272 · 2017 · External reference
CXCR4 is required for leukemia-initiating cell activity in T cell acute lymphoblastic leukemia
10.1016/j.ccell.2015.05.003 · 2015 · External reference
CXCL12-producing vascular endothelial niches control acute T cell leukemia maintenance
10.1016/j.ccell.2015.05.002 · 2015 · External reference
Role of CXCR4-mediated bone marrow colonization in CNS infiltration by T cell acute lymphoblastic leukemia
10.1189/jlb.5ma0915-394r · 2016 · External reference
Brain borders at the central stage of neuroimmunology
10.1038/s41586-022-05474-7 · 2022 · External reference
Macrophages at CNS interfaces: ontogeny and function in health and disease
10.1038/s41583-019-0201-x · 2019 · External reference
Skull and vertebral bone marrow are myeloid cell reservoirs for the meninges and CNS parenchyma
10.1126/science.abf7844 · 2021 · External reference
Revisiting the mechanisms of CNS immune privilege
10.1016/j.it.2015.08.006 · 2015 · External reference
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature
10.1038/s41593-018-0227-9 · 2018 · External reference
Specification of CNS macrophage subsets occurs postnatally in defined niches
10.1038/s41586-022-04596-2 · 2022 · External reference
Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders
10.1126/science.abf9277 · 2021 · External reference
Endogenous dendritic cells from the tumor microenvironment support T-ALL growth via IGF1R activation
10.1073/pnas.1520245113 · 2016 · External reference
Tumor-associated myeloid cells provide critical support for T-ALL
10.1182/blood.2020007145 · 2020 · External reference
Integrin signaling is critical for myeloid-mediated support of T-cell acute lymphoblastic leukemia
10.1038/s41467-023-41925-z · 2023 · External reference
Organ-specific microenvironment modifies diverse functional and phenotypic characteristics of leukemia-associated macrophages in mouse T cell acute lymphoblastic leukemia
10.4049/jimmunol.1400451 · 2015 · External reference
Hepatic leukemia-associated macrophages exhibit a pro-inflammatory phenotype in Notch1-induced acute T cell leukemia
10.1016/j.imbio.2017.10.009 · 2018 · External reference
Monocyte-derived leukemia-associated macrophages facilitate extramedullary distribution of T-cell acute lymphoblastic leukemia cells
10.1158/0008-5472.can-20-0034 · 2020 · External reference
LIM domain only-2 (LMO2) induces T-cell leukemia by two distinct pathways
10.1371/journal.pone.0085883 · 2014 · External reference
Early TCR expression and aberrant T cell development in mice with endogenous prerearranged T cell receptor genes
10.4049/jimmunol.179.2.928 · 2007 · External reference
Massively parallel digital transcriptional profiling of single cells
10.1038/ncomms14049 · 2017 · External reference
Integrating single-cell transcriptomic data across different conditions, technologies, and species
10.1038/nbt.4096 · 2018 · External reference
Immunological genome project and systems immunology
10.1016/j.it.2013.03.004 · 2013 · External reference
Gene expression commons: an open platform for absolute gene expression profiling
10.1371/journal.pone.0040321 · 2012 · External reference
High-dimensional single-cell mapping of central nervous system immune cells reveals distinct myeloid subsets in health, aging, and disease
10.1016/j.immuni.2018.01.011 · 2018 · External reference
Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation
10.1126/science.aat7554 · 2019 · External reference
Prognostic significance of ETP phenotype and minimal residual disease in T-ALL: a Children’s Oncology Group study
10.1182/blood.2023020678 · 2023 · External reference
Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia
10.1016/s1470-2045(08)70314-0 · 2009 · External reference
Early T-cell precursor acute lymphoblastic leukemia: diagnosis, updates in molecular pathogenesis, management, and novel therapies
10.3389/fonc.2021.750789 · 2021 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
10.1038/ng1180 · 2003 · External reference
CCL3-CCR5 axis promotes cell migration and invasion of colon adenocarcinoma via Akt signaling pathway
10.1002/tox.23675 · 2023 · External reference
Relevance of CCL3/CCR5 axis in oral carcinogenesis
10.18632/oncotarget.16882 · 2017 · External reference
Role of the CCL2-CCR2 signalling axis in cancer: mechanisms and therapeutic targeting
10.1111/cpr.13115 · 2021 · External reference
Targeting the CCL2/CCR2 axis in cancer immunotherapy: one stone, three birds?
10.3389/fimmu.2021.771210 · 2021 · External reference
The CCL5/CCR5 axis in cancer progression
10.3390/cancers12071765 · 2020 · External reference
A novel role of hematopoietic CCL5 in promoting triple-negative mammary tumor progression by regulating generation of myeloid-derived suppressor cells
10.1038/cr.2012.178 · 2013 · External reference
ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival
10.1038/ncomms12702 · 2016 · External reference
Overcoming NOTCH1-driven chemoresistance in T-cell acute lymphoblastic leukemia via metabolic intervention with oxphos inhibitor
10.1182/blood-2020-136801 · 2020 · External reference
PID: the pathway interaction database
10.1093/nar/gkn653 · 2009 · External reference
Tumor-Associated Macrophages in Tumor Immunity
10.3389/fimmu.2020.583084 · 2020 · External reference
Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation
10.1042/bst20150107 · 2015 · External reference
Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal
10.1002/eji.201445427 · 2016 · External reference
Macrophages and metabolism in the tumor microenvironment
10.1016/j.cmet.2019.06.001 · 2019 · External reference
The complex role of tumor-infiltrating macrophages
10.1038/s41590-022-01267-2 · 2022 · External reference
Novel markers to delineate murine M1 and M2 macrophages
10.1371/journal.pone.0145342 · 2015 · External reference
Macrophage polarization: different gene signatures in M1(LPS+) vs. classically and M2(LPS–) vs. alternatively activated macrophages
10.3389/fimmu.2019.01084 · 2019 · External reference
Clinical utility and pharmacology of high-dose methotrexate in the treatment of primary CNS lymphoma
10.1586/14737175.6.5.635 · 2006 · External reference
Intravenous methotrexate as central nervous system (CNS) prophylaxis is associated with a low risk of CNS recurrence in high-risk patients with diffuse large B-cell lymphoma
10.1002/cncr.25278 · 2010 · External reference
The CNS immune-privilege goes down the drain(age)
10.1016/j.tips.2018.11.006 · 2019 · External reference
Metabolic reprogramming in macrophage responses
10.1186/s40364-020-00251-y · 2021 · External reference
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis
10.1016/j.immuni.2023.01.011 · 2023 · External reference
The impact of interferon-regulatory factors to macrophage differentiation and polarization into M1 and M2
10.1016/j.imbio.2017.10.005 · 2018 · External reference
Interferon gamma induces reversible metabolic reprogramming of M1 macrophages to sustain cell viability and pro-inflammatory activity
10.1016/j.ebiom.2018.02.009 · 2018 · External reference
The metabolic signature of macrophage responses
10.3389/fimmu.2019.01462 · 2019 · External reference
T-ALL in CNS-3 status needs improvement
10.1182/blood.2022019532 · 2023 · External reference
Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: reconciling biological concepts and clinical issues
10.1016/j.blre.2019.04.003 · 2019 · External reference
A rare subgroup of leukemia stem cells harbors relapse-inducing potential in acute lymphoblastic leukemia
10.1016/j.exphem.2018.09.006 · 2019 · External reference
Characterization of rare, dormant, and therapy-resistant cells in acute lymphoblastic leukemia
10.1016/j.ccell.2016.11.002 · 2016 · External reference
