Research graph
References from Ambroxol induces myeloma cell death by inhibiting autophagy. Local targets link to admitted publications; unresolved targets remain external evidence.
International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma
10.1016/s1470-2045(14)70442-5 · 2014 · External reference
Recent trends in multiple myeloma incidence and survival by age, race, and ethnicity in the United States
10.1182/bloodadvances.2016002493 · 2017 · External reference
Methods in mammalian autophagy research
10.1016/j.cell.2010.01.028 · 2010 · External reference
A plastic SQSTM1/p62-dependent autophagyic reserve maintains proteostasis and determines proteasome inhibitor susceptibility in multiple myeloma cells
10.1080/15548627.2015.1052928 · 2015 · External reference
Plasma cells require autophagy for sustainable immunoglobulin production
10.1038/ni.2524 · 2013 · External reference
Proteasome inhibitors for multiple myeloma
10.1093/jjco/hyy108 · 2018 · External reference
Combined autophagy and proteasome inhibition. A phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma
10.4161/auto.29264 · 2014 · External reference
Establishment of five human myeloma cell lines
10.1007/bf02623725 · 1989 · External reference
A myeloma cell line established from a patient refractory to thalidomide therapy revealed high-risk cytogenetic abnormalities and produced vascular endothelial growth factor
10.1038/bcj.2013.13 · 2013 · External reference
GTN057, a komaroviquinone derivative, induced myeloma cells' death in vivo and inhibited c-MET tyrosine kinase
10.1002/cam4.5691 · 2023 · External reference
Large-area fluorescence and electron microscopic correlative imaging with multibeam scanning electron microscopy
10.3389/fncir.2019.00029 · 2019 · External reference
Maturation of autophagic vacuoles in mammalian cells
10.4161/auto.1.1.1270 · 2005 · External reference
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
10.1016/0065-2571(84)90007-4 · 1984 · External reference
Drug combination studies and their synergy quantification using the Chou-Talalay method
10.1158/0008-5472.can-09-1947 · 2010 · External reference
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
10.1182/blood-2006-02-003103 · 2007 · External reference
Simvastatin-induced apoptosis in osteosarcoma cells: a key role of RhoA-AMPK/p38 MAPK signaling in antitumor activity
10.1158/1535-7163.mct-16-0499 · 2017 · External reference
Ambroxol enhances anti-cancer effect of microtubule-stabilization drug to lung carcinoma through blocking autophagy flux in lysosome-dependent way
2017 · External reference
Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells
10.1158/1535-7163.mct-11-0979 · 2012 · External reference
Panobinostat mediated cell death: a novel therapeutic approach for osteosarcoma
10.18632/oncotarget.26038 · 2018 · External reference
Targeting autophagy in cancer
10.1038/nrc.2017.53 · 2017 · External reference
Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation
10.1038/cddis.2013.440 · 2013 · External reference
A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells
10.1016/j.bbrc.2019.10.119 · 2020 · External reference
Histone deacetylase inhibitors VPA and TSA induce apoptosis and autophagy in pancreatic cancer cells
10.1007/s13402-017-0314-z · 2017 · External reference
Downregulation of Mcl-1 by panobinostat potentiates proton beam therapy in hepatocellular carcinoma cells
10.3390/cells10030554 · 2021 · External reference
Bortezomib antagonizes microtubule-interfering drug-induced apoptosis by inhibiting G2/M transition and MCL-1 degradation
10.1038/cddis.2013.440 · 2013 · External reference
Histone deacetylase inhibitor enhances the efficacy of MEK inhibitor through NOXA-mediated MCL1 degradation in triple-negative and inflammatory breast cancer
10.1158/1078-0432.ccr-16-2622 · 2017 · External reference
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implications
10.1073/pnas.2536759100 · 2004 · External reference
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulation Bcl2 and perturbing the cellular redox state
10.1128/mcb.21.4.1249-1259.2001 · 2001 · External reference
Blockade of XBP1 splicing by inhibition of IRE1⍺ is a promising therapeutic option in multiple myeloma
10.1182/blood-2011-07-366633 · 2012 · External reference
Sirtuin 2 dysregulates autophagy in high-fat-exposed immune-tolerant macrophages
10.3390/cells10040731 · 2021 · External reference
ATF3-activated accelerating effect of LINC00941/lncIAPF on fibroblast-to-myofibroblast differentiation by blocking autophagy depending on ELAVL1/HuR in pulmonary fibrosis
10.1080/15548627.2022.2046448 · 2022 · External reference
Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1
10.1016/j.leukres.2006.06.021 · 2007 · External reference
Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancy
10.4161/auto.5.8.10122 · 2009 · External reference
Idarubicin induces mTOR-dependent cytotoxic autophagy in leukemic cells
10.1016/j.yexcr.2014.05.021 · 2014 · External reference
Targeting autophagy to treat cancer: challenges and opportunities
10.3389/fphar.2020.590344 · 2020 · External reference
Perioperative lung protection provided by high-dose ambroxol in patients with lung cancer
10.1007/s12013-015-0590-z · 2015 · External reference
Upgrading the evidence for the use of ambroxol in Gaucher disease and GBA related Parkinson: investigator initiated registry based on real life data
10.1002/ajh.26131 · 2021 · External reference
Exploring the efficacy and safety of ambroxol in Gaucher disease, an overview of clinical studies
10.3389/fphar.2024.1335058 · 2024 · External reference
Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer
10.1074/jbc.m510023200 · 2006 · External reference
Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties
2002 · External reference
Anti-inflammatory properties of ambroxol
2008 · External reference
Attenuation of sialylation augments antitumor immunity and improves response to immunotherapy in ovarian cancer
10.1158/0008-5472.can-22-3260 · 2023 · External reference
Identification of compound CA-5f as a novel late-stage autophagy inhibitor with potent anti-tumor effect against non-small cell lung cancer
10.1080/15548627.2018.1511503 · 2019 · External reference
Foxk proteins repress the initiation of starvation-induced atrophy and autophagy programs
10.1038/ncb3062 · 2014 · External reference
