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References from Olfactory receptors as tumor suppressors in cutaneous T-cell lymphoma via p38γ pathway modulation. Local targets link to admitted publications; unresolved targets remain external evidence.
p38γ MAPK is required for inflammation-associated colon tumorigenesis
10.1038/onc.2015.158 · 2016 · External reference
The p38 MAPK stress pathway as a tumor suppressor or more?
10.2741/2951 · 2008 · External reference
Multi-kinase inhibitor with anti-p38γ activity in cutaneous T-cell lymphoma
10.1016/j.jid.2018.04.030 · 2018 · External reference
Targeting the non-ATP-binding pocket of the MAP kinase p38γ mediates a novel mechanism of cytotoxicity in cutaneous T-cell lymphoma (CTCL)
10.1002/1873-3468.14186 · 2021 · External reference
Activating p38 MAPK: new tricks for an old kinase
10.4161/cc.4.9.2043 · 2005 · External reference
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
10.1038/ni1177 · 2005 · External reference
Alternative ZAP70-p38 signals prime a classical p38 pathway through LAT and SOS to support regulatory T cell differentiation
10.1126/scisignal.aao0736 · 2019 · External reference
Counter-regulation of T cell effector function by differentially activated p38
10.1084/jem.20131917 · 2014 · External reference
Expression profile of ectopic olfactory receptors determined by deep sequencing
10.1371/journal.pone.0055368 · 2013 · External reference
Promotion of cancer cell invasiveness and metastasis emergence caused by olfactory receptor stimulation
10.1371/journal.pone.0085110 · 2014 · External reference
Functional expression of olfactory receptors in human primary melanoma and melanoma metastasis
10.1111/exd.13316 · 2017 · External reference
Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid
10.1073/pnas.1719746115 · 2018 · External reference
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
10.1021/jm0306430 · 2004 · External reference
Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ
10.1038/srep29881 · 2016 · External reference
Relationship between homo-oligomerization of a mammalian olfactory receptor and its activation state demonstrated by bioluminescence resonance energy transfer
10.1074/jbc.m110.184580 · 2011 · External reference
The BioGRID database: a comprehensive biomedical resource of curated protein, genetic, and chemical interactions
10.1002/pro.3978 · 2021 · External reference
shinyDepMap, a tool to identify targetable cancer genes and their functional connections from Cancer Dependency Map data
10.7554/elife.57116 · 2021 · External reference
Prediction of synergism from chemical-genetic interactions by machine learning
10.1016/j.cels.2015.12.003 · 2015 · External reference
Genome-wide CRISPR-Cas9 screens expose genetic vulnerabilities and mechanisms of temozolomide sensitivity in glioblastoma stem cells
10.1016/j.celrep.2019.03.047 · 2019 · External reference
Survival-based CRISPR genetic screens across a panel of permissive cell lines identify common and cell-specific SARS-CoV-2 host factors
10.1016/j.heliyon.2022.e12744 · 2023 · External reference
RASA2 ablation in T cells boosts antigen sensitivity and long-term function
10.1038/s41586-022-05126-w · 2022 · External reference
Immunological study on CD3 defective cutaneous T cell lymphoma cells from a patient with Sezary syndrome
10.1046/j.1365-2249.1998.00649.x · 1998 · External reference
Cutaneous T-cell lymphoma
10.1016/j.cll.2017.06.006 · 2017 · External reference
Leukaemic cutaneous T-cell lymphoma-manifesting papuloerythroderma with CD3(-) CD4(+) phenotype
10.2340/00015555-0786 · 2010 · External reference
The Bgee suite: integrated curated expression atlas and comparative transcriptomics in animals
10.1093/nar/gkaa793 · 2021 · External reference
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
10.1016/j.ccell.2015.09.018 · 2015 · External reference
Olfactory receptor gene abundance in invasive breast carcinoma
10.1038/s41598-019-50085-4 · 2019 · External reference
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition
10.1016/0092-8674(91)90418-x · 1991 · External reference
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
10.1126/science.7509083 · 1994 · External reference
Humans can discriminate more than 1 trillion olfactory stimuli [published correction appears in Science. 2024;383(6685):eado6457]
10.1126/science.1249168 · 2014 · External reference
Olfactory receptors in non-chemosensory tissues
10.5483/bmbrep.2012.45.11.232 · 2012 · External reference
Olfactory receptors expressed in various non-olfactory tissues [in Japanese]
2018 · External reference
Odorant receptors containing conserved amino acid sequences in transmembrane domain 7 display distinct expression patterns in mammalian tissues
2017 · External reference
Characterizing the expression of the human olfactory receptor gene family using a novel DNA microarray
10.1186/gb-2007-8-5-r86 · 2007 · External reference
Olfactory receptors as biomarkers in human breast carcinoma tissues
10.3389/fonc.2018.00033 · 2018 · External reference
Activation of an olfactory receptor inhibits proliferation of prostate cancer cells
10.1074/jbc.m109.012096 · 2009 · External reference
Understanding the molecular mechanisms of odorant binding and activation of the human OR52 family
10.1038/s41467-023-43983-9 · 2023 · External reference
Activation of odorant receptor in colorectal cancer cells leads to inhibition of cell proliferation and apoptosis
10.1371/journal.pone.0172491 · 2017 · External reference
In silico peptide repertoire of human olfactory receptor proteomes on high-stringency mass spectrometry
10.1021/acs.jproteome.8b00494 · 2019 · External reference
Helional-induced activation of human olfactory receptor 2J3 promotes apoptosis and inhibits proliferation in a non-small-cell lung cancer cell line
10.1016/j.ejcb.2016.11.004 · 2017 · External reference
Olfactory receptor OR2AT4 regulates human hair growth
10.1038/s41467-018-05973-0 · 2018 · External reference
Discovery of (-)-epigallocatechin gallate, a novel olfactory receptor 2AT4 agonist that regulates proliferation and apoptosis in leukemia cells
10.1016/j.heliyon.2024.e30298 · 2024 · External reference
The role of epigenetic modifications in neurodevelopmental disorders: a systematic review
10.1016/j.neubiorev.2018.07.011 · 2018 · External reference
Integrated characterisation of cancer genes identifies key molecular biomarkers in stomach adenocarcinoma
10.1136/jclinpath-2019-206400 · 2020 · External reference
Pan-cancer analysis identifies olfactory receptor family 7 subfamily A member 5 as a potential biomarker for glioma
10.7717/peerj.17631 · 2024 · External reference
Olfactory receptor family 7 subfamily C member 1 is a novel marker of colon cancer-initiating cells and is a potent target of immunotherapy
10.1158/1078-0432.ccr-15-1709 · 2016 · External reference
Exploring olfactory receptor family 7 subfamily C member 1 as a novel oral cancer stem cell target for immunotherapy
10.1111/cas.15873 · 2023 · External reference
Characterization of the olfactory receptor OR10H1 in human urinary bladder cancer
10.3389/fphys.2018.00456 · 2018 · External reference
Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation
10.1111/exd.13132 · 2017 · External reference
Candidate oncogenes, ARHGAP4, NOS3, and OR51B5, for the development of scirrhous-type gastric cancer
10.21873/anticanres.16026 · 2022 · External reference
Orphan receptors in prostate cancer
10.1002/pros.24370 · 2022 · External reference
The activation of OR51E1 causes growth suppression of human prostate cancer cells
10.18632/oncotarget.10197 · 2016 · External reference
The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex
10.1073/pnas.86.9.3277 · 1989 · External reference
Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity
10.1371/journal.pcbi.1003004 · 2013 · External reference
The structural basis of odorant recognition in insect olfactory receptors
10.1038/s41586-021-03794-8 · 2021 · External reference
Functional properties of insect olfactory receptors: ionotropic receptors and odorant receptors
10.1007/s00441-020-03363-x · 2021 · External reference