Research graph
References from Transcriptomic profiling of peripheral blood cells during mandibular fracture healing: the iBeam study. Local targets link to admitted publications; unresolved targets remain external evidence.
Nonunion of the mandible: an analysis of contributing factors
10.1053/joms.2000.7258 · 2000 · External reference
The impact of treatment delay on malunion and nonunion after open reduction of mandible fractures
10.1089/fpsam.2020.0607 · 2021 · External reference
Fracture healing research: recent insights
2023 · External reference
Interleukin-22 drives the proliferation, migration and osteogenic differentiation of mesenchymal stem cells: a novel cytokine that could contribute to new bone formation in spondyloarthropathies
2017 · External reference
T cell immunomodulation by clinically used allogeneic human cancellous bone fragments: a potential novel immunotherapy tool
10.1038/s41598-018-31979-1 · 2018 · External reference
Defective proliferation and osteogenic potential with altered immunoregulatory phenotype of native bone marrow-multipotential stromal cells in atrophic fracture non-union
10.1038/s41598-019-53927-3 · 2019 · External reference
Mesenchymal stem cells, autoimmunity and rheumatoid arthritis
10.1093/qjmed/hcu033 · 2014 · External reference
Multipotent mesenchymal stromal cells in rheumatoid arthritis and systemic lupus erythematosus; from a leading role in pathogenesis to potential therapeutic saviors?
10.3389/fimmu.2021.643170 · 2021 · External reference
Mandibular fractures: diagnosis and management
10.1055/s-0041-1735818 · 2021 · External reference
Infection rates of an intraoral versus extraoral approach to mandibular fracture repairs are equal: a systematic review and meta-analysis
10.1016/j.joms.2024.01.011 · 2024 · External reference
Distinct intrinsic and extrinsic factors differentially regulate skeletal stem cells in calvaria versus long bones during bone regeneration
10.3390/ijms26199413 · 2025 · External reference
Dual-targeted nanoplatform regulating the bone immune microenvironment enhances fracture healing
10.1021/acsami.1c17420 · 2021 · External reference
Modulation of the inflammatory response and bone healing
10.3389/fendo.2020.00386 · 2020 · External reference
Fracture hematoma is a potent proinflammatory mediator of neutrophil function
10.1097/01.ta.0000169866.88781.f1 · 2005 · External reference
S100A8/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation
10.3390/cells11020236 · 2022 · External reference
The roles of immune cells in bone healing; what we know, do not know and future perspectives
10.1016/j.injury.2016.10.008 · 2016 · External reference
Bone marrow-derived IGF-1 orchestrates maintenance and regeneration of the adult skeleton
10.1073/pnas.2203779120 · 2023 · External reference
IGF signaling pathway in bone and cartilage development, homeostasis, and disease
10.1096/fj.202401298r · 2024 · External reference
Bone injury and fracture healing biology
2015 · External reference
Macrophage subtype and cytokine expression characterization during the acute inflammatory phase of mouse bone fracture repair
10.1002/jor.24603 · 2020 · External reference
Transplantation of IL-10-overexpressing bone marrow-derived mesenchymal stem cells ameliorates diabetic-induced impaired fracture healing in mice
10.1007/s12195-019-00608-w · 2020 · External reference
The biology of fracture healing
10.1016/j.injury.2011.03.031 · 2011 · External reference
Chondrocyte-to-osteoblast transformation in mandibular fracture repair
10.1002/jor.24904 · 2021 · External reference
Osteoimmunology of fracture healing
10.1007/s11914-024-00869-z · 2024 · External reference
gammadelta17T cells hinder mandibular bone defect healing
10.1177/00220345251391194 · 2026 · External reference
T cell related osteoimmunology in fracture healing: potential targets for augmenting bone regeneration
10.1016/j.jot.2024.12.004 · 2025 · External reference
Prognostic implications of a CD8(+) T(EMRA) to CD4(+)T(reg) imbalance in mandibular fracture healing: a prospective analysis of immune profiles
10.3389/fimmu.2024.1476009 · 2024 · External reference
Natural and induced immune responses in oral cavity and saliva
10.1186/s12865-025-00713-8 · 2025 · External reference
The mucosal immune system in the oral cavity-an orchestra of T cell diversity
10.1038/ijos.2014.48 · 2014 · External reference
T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair
10.1371/journal.pone.0040044 · 2012 · External reference
Trends in mandibular fractures in the USA: a 20-year retrospective analysis
10.1111/edt.12857 · 2023 · External reference
Causal analysis approaches in Ingenuity Pathway Analysis
10.1093/bioinformatics/btt703 · 2014 · External reference
Temporal molecular signatures of early human clavicle fracture healing: characterization of hematological, cytokine, and miRNA profiles
10.3390/ijms26188825 · 2025 · External reference
Novel proteomic insights into hip fractures in the elderly: unraveling immunologic biomarkers, temporal expression patterns, and clinical correlations
10.2147/jir.s513035 · 2025 · External reference
Decoding the immune landscape following hip fracture in elderly patients: unveiling temporal dynamics through single-cell RNA sequencing
10.1186/s12979-023-00380-6 · 2023 · External reference
Dynamics of early signalling events during fracture healing and potential serum biomarkers of fracture non-union in humans
10.3390/jcm9020492 · 2020 · External reference
Integrating spatial and single-cell transcriptomics to characterize mouse long bone fracture healing process
10.1038/s42003-025-08316-0 · 2025 · External reference
The association between the levels of CRP, IL-10, PLA2, Fbg and prognosis in traumatic fracture of lower limb
10.3892/etm.2016.3746 · 2016 · External reference
Insulinlike growth factor gene expression in human fracture callus
10.1007/bf01321886 · 1993 · External reference
Changes of serum levels of osteocalcin, alkaline phosphatase, IGF-I and IGF-binding protein-3 during fracture healing
10.1016/s0020-1383(02)00380-7 · 2003 · External reference
Long bone fracture healing: IGF-I concentrations and specific binding to erythrocytes
10.1515/jpem.1996.9.4.491 · 1996 · External reference
Quantification of TGF-ss1, PDGF and IGF-1 cytokine expression after fracture treatment vs. non-union therapy via masquelet
10.1016/j.injury.2015.11.007 · 2016 · External reference
Single-cell transcriptomic analysis identifies systemic immunosuppressive myeloid cells and local monocytes/macrophages as key regulators in polytrauma-induced immune dysregulation
10.1038/s41413-025-00444-x · 2025 · External reference
Neutrophils in tissue trauma of the skin, bone, and lung: two sides of the same coin
10.1155/2018/8173983 · 2018 · External reference
The crucial role of neutrophil granulocytes in bone fracture healing
10.22203/ecm.v032a10 · 2016 · External reference
Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model
10.1002/jbmr.354 · 2011 · External reference
Changes in macrophage and inflammatory cytokine expressions during fracture healing in an ovariectomized mice model
10.1186/s12891-021-04360-z · 2021 · External reference
The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives
10.21037/sci-2022-038 · 2023 · External reference
Single-cell RNAseq provides insight into altered immune cell populations in human fracture nonunions
10.1002/jor.25452 · 2023 · External reference
Biomarkers of inflammation and innate immunity in atrophic nonunion fracture
10.1186/s12967-016-1019-1 · 2016 · External reference
Monocytes: super cells for bone regeneration
10.1097/id.0b013e31823fcf85 · 2012 · External reference
Monocyte/macrophage lineage cells from fetal erythromyeloid progenitors orchestrate bone remodeling and repair
10.3389/fcell.2021.622035 · 2021 · External reference
Multimodal analyses of immune cells during bone repair identify macrophages as a therapeutic target in musculoskeletal trauma
10.1038/s41413-024-00347-3 · 2024 · External reference
Macrophage-osteoclast associations: origin, polarization, and subgroups
10.3389/fimmu.2021.778078 · 2021 · External reference
Single-cell RNA sequencing reveals B cells are important regulators in fracture healing
10.3389/fendo.2021.666140 · 2021 · External reference
The local and systemic effects of immune function on fracture healing
2024 · External reference
Pronounced impairment of B cell differentiation during bone regeneration in adult immune experienced mice
10.3389/fimmu.2025.1511902 · 2025 · External reference
Interleukin 10-deficient mice develop osteopenia, decreased bone formation, and mechanical fragility of long bones
10.1053/j.gastro.2004.06.013 · 2004 · External reference
Down-regulation of expression of osteoblast and osteocyte markers in periodontal tissues associated with the spontaneous alveolar bone loss of interleukin-10 knockout mice
10.1111/j.1600-0722.2009.00706.x · 2010 · External reference
Accelerated alveolar bone loss in mice lacking interleukin-10: late onset
10.1111/j.1600-0765.2004.00724.x · 2004 · External reference
Accelerated alveolar bone loss in mice lacking interleukin-10
10.1177/154405910308200812 · 2003 · External reference
Regulatory B cell is critical in bone union process through suppressing proinflammatory cytokines and stimulating Foxp3 in Treg cells
10.1111/1440-1681.12719 · 2017 · External reference
STAT3 promotes bone fracture healing by enhancing the FOXP3 expression and the suppressive function of regulatory T cells
10.1111/apm.12706 · 2017 · External reference
IL-10 induces MC3T3-E1 cells differentiation towards osteoblastic fate in murine model
10.1111/jcmm.14832 · 2020 · External reference
Effect of interleukin-10 on gene expression of osteoclastogenic regulatory molecules in the rat dental follicle
10.1111/j.1600-0722.2006.00283.x · 2006 · External reference
Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells
10.1016/j.bone.2007.05.016 · 2007 · External reference
Interleukin-10 inhibits osteoclastogenesis by reducing NFATc1 expression and preventing its translocation to the nucleus
10.1186/1471-2121-8-4 · 2007 · External reference
Insulin-like growth factor 2-enhanced osteogenic differentiation of stem cell spheroids by regulation of Runx2 and Col1 expression
10.3892/etm.2021.9814 · 2021 · External reference
Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis
10.1016/s1096-6374(02)00044-8 · 2002 · External reference
Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation
10.1002/jbmr.133 · 2010 · External reference
Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia
10.1016/j.jphs.2022.03.007 · 2022 · External reference
High serum IGFBP-2 is predictive of increased bone turnover in aging men and women
10.1359/jbmr.070306 · 2007 · External reference
Serum levels of insulin-like growth factor (IGF); IGF-binding proteins-3, -4, and -5; and their relationships to bone mineral density and the risk of vertebral fractures in postmenopausal women
10.1007/s00223-005-0163-z · 2006 · External reference
Insulin-like growth factors I and II: aging and bone density in women
10.1210/jcem-59-4-701 · 1984 · External reference
Serum concentrations of insulin-like growth factor II are not changed by short-term fasting and refeeding
10.1210/jcem-67-6-1231 · 1988 · External reference
Transcriptome profiling and network analysis provide insights into the pathogenesis of vulvar lichen sclerosus
2022 · External reference
The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
2023 · External reference
Haematological setpoints are a stable and patient-specific deep phenotype
10.1038/s41586-024-08264-5 · 2025 · External reference
A longitudinal study of gene expression in healthy individuals
2009 · External reference
Evaluating the stability of RNA-Seq transcriptome profiles and drug-induced immune-related expression changes in whole blood
10.1371/journal.pone.0133315 · 2015 · External reference
Bone development by Hedgehog and Wnt signaling, Runx2, and Sp7
10.1007/s00774-024-01551-1 · 2025 · External reference
Serum levels of IL-6 and IL-10 on admission correlate with complications in elderly patients with hip fracture
2024 · External reference
The effect of inflammation on bone
2020 · External reference
