Research graph
References from lncRNA H19 downregulation mediates oxidative stress-induced osteogenic dysfunction. Local targets link to admitted publications; unresolved targets remain external evidence.
Age- and sex-related changes in iliac cortical bone mass and remodeling
10.1016/8756-3282(93)90092-o · 1993 · External reference
A comprehensive overview on osteoporosis and its risk factors
10.2147/tcrm.s138000 · 2018 · External reference
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
10.1038/s41580-020-00314-w · 2021 · External reference
Senescence-associated intrinsic mechanisms of osteoblast dysfunctions
10.1111/j.1474-9726.2011.00669.x · 2011 · External reference
Oxidative stress, caloric restriction, and aging
10.1126/science.273.5271.59 · 1996 · External reference
Oxidative stress modulates osteoblastic differentiation of vascular and bone cells
10.1016/s0891-5849(01)00610-4 · 2001 · External reference
Oxidative stress in bone remodeling: role of antioxidants
10.11138/ccmbm/2017.14.1.209 · 2017 · External reference
Resveratrol protects osteocytes against oxidative stress in ovariectomized rats through AMPK/JNK1-dependent pathway leading to promotion of autophagy and inhibition of apoptosis
10.1038/s41420-023-01331-2 · 2023 · External reference
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
10.1074/jbc.m702810200 · 2007 · External reference
ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFkappaB activation
10.1007/s00018-022-04186-5 · 2022 · External reference
PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease
10.1002/bies.10357 · 2003 · External reference
Histone deimination antagonizes arginine methylation
10.1016/j.cell.2004.08.020 · 2004 · External reference
Citrullination/methylation crosstalk on histone H3 regulates ER-target gene transcription
10.1021/acschembio.7b00241 · 2017 · External reference
Histones, DNA, and citrullination promote neutrophil extracellular trap inflammation by regulating the localization and activation of TLR4
10.1016/j.celrep.2020.107602 · 2020 · External reference
Regulation of protein Citrullination through p53/PADI4 network in DNA damage response
10.1158/0008-5472.can-09-2280 · 2009 · External reference
Regulation of histone modification and chromatin structure by the p53-PADI4 pathway
10.1038/ncomms1676 · 2012 · External reference
Peptidylarginine deiminase 2 plays a key role in osteogenesis by enhancing RUNX2 stability through citrullination
10.1038/s41419-023-06101-7 · 2023 · External reference
Arginine citrullination at the C-terminal domain controls RNA polymerase II transcription
10.1016/j.molcel.2018.10.016 · 2019 · External reference
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis
10.1038/ng1206 · 2003 · External reference
PADI2 is significantly associated with rheumatoid arthritis
10.1371/journal.pone.0081259 · 2013 · External reference
Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus
10.1172/jci67390 · 2013 · External reference
PAD2-mediated citrullination contributes to efficient oligodendrocyte differentiation and myelination
10.1016/j.celrep.2019.03.108 · 2019 · External reference
Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models
10.1186/s40478-022-01433-5 · 2022 · External reference
Citrullination and the protein code: crosstalk between post-translational modifications in cancer
2023 · External reference
PADI2-mediated citrullination promotes prostate cancer progression
10.1158/0008-5472.can-17-0150 · 2017 · External reference
PADI2 gene confers susceptibility to breast cancer and plays tumorigenic role via ACSL4, BINC3 and CA9 signaling
10.1186/s12935-016-0335-0 · 2016 · External reference
Long non-coding RNAs: definitions, functions, challenges and recommendations
10.1038/s41580-022-00566-8 · 2023 · External reference
The role and mechanism of long non-coding RNA H19 in stem cell osteogenic differentiation
10.1186/s10020-021-00350-y · 2021 · External reference
H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA
2016 · External reference
Epigenetic mechanisms underlying the imprinting of the mouse H19 gene
10.1101/gad.7.9.1663 · 1993 · External reference
Parental-origin-specific epigenetic modification of the mouse H19 gene
10.1038/362751a0 · 1993 · External reference
A paternal-specific methylation imprint marks the alleles of the mouse H19 gene
10.1038/ng0495-407 · 1995 · External reference
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
10.1038/35013100 · 2000 · External reference
Orientation of mouse H19 ICR affects imprinted H19 gene expression through promoter methylation-dependent and -independent mechanisms
10.1038/s42003-021-02939-9 · 2021 · External reference
Long non-coding RNAs: new players in cell differentiation and development
10.1038/nrg3606 · 2014 · External reference
Long non-coding RNA H19 promotes the osteogenic differentiation of rat ectomesenchymal stem cells via Wnt/beta-catenin signaling pathway
2018 · External reference
Long noncoding RNA H19 promotes osteoblast differentiation via TGF-beta1/Smad3/HDAC signaling pathway by deriving miR-675
10.1002/stem.2225 · 2015 · External reference
lncRNA H19 mediates BMP9-induced osteogenic differentiation of mesenchymal stem cells (MSCs) through Notch signaling
10.18632/oncotarget.18655 · 2017 · External reference
Unraveling the dynamics of osteoblast differentiation in MC3T3-E1 cells: transcriptomic insights into matrix mineralization and cell proliferation
10.1016/j.bone.2025.117442 · 2025 · External reference
Nicotinamide enhances osteoblast differentiation through activation of the mitochondrial antioxidant defense system
10.1038/s12276-023-01041-w · 2023 · External reference
Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration
10.1093/rb/rbae055 · 2024 · External reference
Uncovering direct targets of MiR-19a involved in lung cancer progression
10.1371/journal.pone.0137887 · 2015 · External reference
The senescence-associated secretory phenotype: the dark side of tumor suppression
10.1146/annurev-pathol-121808-102144 · 2010 · External reference
Cellular senescence: when bad things happen to good cells
10.1038/nrm2233 · 2007 · External reference
The LncRNA H19/miR-193a-3p axis modifies the radio-resistance and chemotherapeutic tolerance of hepatocellular carcinoma cells by targeting PSEN1
10.1002/jcb.26883 · 2018 · External reference
MiR-193a-3p interaction with HMGB1 downregulates human endothelial cell proliferation and migration
10.1038/srep44137 · 2017 · External reference
Increased PRL-1 in BM-derived MSCs triggers anaerobic metabolism via mitochondria in a cholestatic rat model
10.1016/j.omtn.2023.01.017 · 2023 · External reference
PTP4A1 promotes TGFbeta signaling and fibrosis in systemic sclerosis
10.1038/s41467-017-01168-1 · 2017 · External reference
PTH regulates osteogenesis and suppresses adipogenesis through Zfp467 in a feed-forward, PTH1R-cyclic AMP-dependent manner
10.7554/elife.83345 · 2023 · External reference
Cyclic AMP signaling in bone marrow stromal cells has reciprocal effects on the ability of mesenchymal stem cells to differentiate into mature osteoblasts versus mature adipocytes
10.1007/s12020-012-9717-9 · 2012 · External reference
PTH1R actions on bone using the cAMP/protein kinase A pathway
2021 · External reference
Stickler syndrome caused by COL2A1 mutations: genotype-phenotype correlation in a series of 100 patients
10.1038/ejhg.2010.23 · 2010 · External reference
Dominant and recessive forms of fibrochondrogenesis resulting from mutations at a second locus, COL11A2
10.1002/ajmg.a.34406 · 2012 · External reference
PLCgamma2 regulates osteoclastogenesis via its interaction with ITAM proteins and GAB2
10.1172/jci28775 · 2006 · External reference
Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7
10.1016/j.cell.2007.06.053 · 2007 · External reference
Possible physiological role of H19 RNA
10.1002/mc.10075 · 2002 · External reference
Long noncoding RNA H19 regulates the therapeutic efficacy of mesenchymal stem cells in rats with severe acute pancreatitis by sponging miR-138-5p and miR-141-3p
10.1186/s13287-020-01940-z · 2020 · External reference
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
10.1073/pnas.1016758108 · 2011 · External reference
The imprinted H19 noncoding RNA is a primary microRNA precursor
10.1261/rna.351707 · 2007 · External reference
The double-edged sword of H19 lncRNA: insights into cancer therapy
10.1016/j.canlet.2020.11.006 · 2021 · External reference
Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor alpha target gene activation
10.1073/pnas.1203280109 · 2012 · External reference
Evolutionary analysis reveals the role of a non-catalytic domain of peptidyl arginine deiminase 2 in transcriptional regulation
10.1016/j.isci.2024.109584 · 2024 · External reference
Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions
10.1016/j.molcel.2011.08.027 · 2011 · External reference
The genomic binding sites of a noncoding RNA
10.1073/pnas.1113536108 · 2011 · External reference
