Research graph
References from Comprehensive review of in vitro gut-brain axis models in Parkinson’s disease research. Local targets link to admitted publications; unresolved targets remain external evidence.
A Parkinson's disease model composed of 3D bioprinted dopaminergic neurons within a biomimetic peptide scaffold
10.1088/1758-5090/ac7eec · 2022 · External reference
Cortical stimulation relieves parkinsonian pathological activity in vitro
10.1111/ejn.13806 · 2019 · External reference
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
10.1038/nature12726 · 2013 · External reference
The genetic architecture of Parkinson's disease
10.1016/s1474-4422(19)30287-x · 2020 · External reference
3D Cultures of Parkinson's disease-specific dopaminergic neurons for high content phenotyping and drug testing
10.1002/advs.201800927 · 2019 · External reference
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
10.1007/s00702-002-0808-2 · 2003 · External reference
Staging of brain pathology related to sporadic Parkinson's disease
10.1016/s0197-4580(02)00065-9 · 2003 · External reference
Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
10.1016/j.neulet.2005.11.012 · 2006 · External reference
Unraveling brain diseases: the promise of brain-on-a-chip models
10.1016/j.jneumeth.2024.110105 · 2024 · External reference
Electrochemical measurement of serotonin by Au-CNT electrodes fabricated on microporous cell culture membranes
10.1038/s41378-020-00184-4 · 2020 · External reference
Analyzing the bibliometrics of brain-gut axis and Parkinson's disease
2024 · External reference
Oral administration of Proteus mirabilis damages dopaminergic neurons and motor functions in mice
10.1038/s41598-018-19646-x · 2018 · External reference
Structural alterations of the intestinal epithelial barrier in Parkinson's disease
10.1186/s40478-015-0196-0 · 2015 · External reference
Enteric nervous system striped patterning and disease: unexplored pathophysiology
2024 · External reference
The contribution of inflammatory astrocytes to BBB impairments in a brain-chip model of Parkinson's disease
10.1038/s41467-023-39038-8 · 2023 · External reference
Chapter 14 - genetics of Parkinson disease
10.1016/b978-0-444-63233-3.00014-2 · 2018 · External reference
The role of short-chain fatty acids in central nervous system diseases
10.1007/s11010-022-04471-8 · 2022 · External reference
Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
10.1016/s1474-4422(18)30295-3 · 2018 · External reference
The emerging evidence of the Parkinson pandemic
2018 · External reference
Bioengineered models of Parkinson's disease using patient-derived dopaminergic neurons exhibit distinct biological profiles in a 3D microenvironment
10.1007/s00018-021-04047-7 · 2022 · External reference
The microbiota-gut-brain axis in psychiatric disorders
10.3390/ijms231911245 · 2022 · External reference
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
10.1016/s1474-4422(08)70117-0 · 2008 · External reference
Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson's disease
10.1007/s00401-013-1214-6 · 2014 · External reference
Glass-based organ-on-a-chip device for restricting small molecular absorption
10.1016/j.jbiosc.2018.10.019 · 2019 · External reference
An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins
10.1063/5.0200459 · 2024 · External reference
Colonic bacterial composition in Parkinson's disease
10.1002/mds.26307 · 2015 · External reference
A gut-brain axis-on-a-chip for studying transport across epithelial and endothelial barriers
10.1016/j.jiec.2021.06.021 · 2021 · External reference
Effect of gut microbiota-derived metabolites and extracellular vesicles on neurodegenerative disease in a gut-brain axis chip
10.1186/s40580-024-00413-w · 2024 · External reference
Gut bacterial profiles in Parkinson's disease: a systematic review
10.1111/cns.13990 · 2023 · External reference
Sodium butyrate exerts protective effect against Parkinson's disease in mice via stimulation of glucagon like peptide-1
10.1016/j.jns.2017.08.3235 · 2017 · External reference
An integrated microfluidic chip for studying the effects of neurotransmitters on neurospheroids
10.1039/d2lc00755j · 2023 · External reference
Derivation of human midbrain-specific organoids from neuroepithelial stem cells
10.1016/j.stemcr.2017.03.010 · 2017 · External reference
Alpha-synuclein pathology is associated with astrocyte senescence in a midbrain organoid model of familial Parkinson's disease
10.1016/j.mcn.2024.103919 · 2024 · External reference
Gut microbiota dysfunction as reliable non-invasive early diagnostic biomarkers in the pathophysiology of Parkinson's disease: a critical review
10.5056/jnm17105 · 2018 · External reference
The PRISMA 2020 statement: an updated guideline for reporting systematic reviews
10.1016/j.ijsu.2021.105906 · 2021 · External reference
Sodium butyrate rescues dopaminergic cells from alpha-synuclein-induced transcriptional deregulation and DNA damage
10.1093/hmg/ddx114 · 2017 · External reference
Progression of Parkinson's disease pathology is reproduced by intragastric administration of rotenone in mice
10.1371/journal.pone.0008762 · 2010 · External reference
Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
10.1038/srep00898 · 2012 · External reference
Modeling alpha-synuclein pathology in a human brain-chip to assess blood-brain barrier disruption
10.1038/s41467-021-26066-5 · 2021 · External reference
Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
10.1126/science.276.5321.2045 · 1997 · External reference
In vitro ameliorative effects of sinapic acid on Parkinson related neurotoxicity in SHSY5Y cell lines
10.4103/ijnpnd.ijnpnd_67_22 · 2023 · External reference
Challenges and future perspectives in modeling neurodegenerative diseases using organ-on-a-chip technology
10.1002/advs.202403892 · 2024 · External reference
An organ-on-a-chip engineered platform to study the microbiota–gut–brain axis in neurodegeneration
10.1016/j.molmed.2019.07.006 · 2019 · External reference
Global Parkinson's Genetics Program Identification of genetic risk loci and causal insights associated with Parkinson's disease in African and African admixed populations: a genome-wide association study
10.1016/s1474-4422(23)00283-1 · 2023 · External reference
Fecal markers of intestinal inflammation and intestinal permeability are elevated in Parkinson's disease
10.1016/j.parkreldis.2018.02.022 · 2018 · External reference
Development of in vitro model of exosome transport in microfluidic gut-brain axis-on-a-chip
10.1039/d4lc00490f · 2024 · External reference
Beneficial effects of sodium butyrate in 6-OHDA induced neurotoxicity and behavioral abnormalities: modulation of histone deacetylase activity
10.1016/j.bbr.2015.05.052 · 2015 · External reference
10.1101/2022.08.19.504522
10.1101/2022.08.19.504522 · External reference
Sodium butyrate improves locomotor impairment and early mortality in a rotenone-induced Drosophila model of Parkinson’s disease
10.1016/j.neuroscience.2013.04.037 · 2013 · External reference
Pathological α-synuclein in gastrointestinal tissues from prodromal Parkinson disease patients
10.1002/ana.24648 · 2016 · External reference
The role of gut bacterial metabolites in brain development, aging and disease
10.3390/nu13030732 · 2021 · External reference
Human physiomimetic model integrating microphysiological systems of the gut, liver, and brain for studies of neurodegenerative diseases
10.1126/sciadv.abd1707 · 2021 · External reference
The intestinal barrier in parkinson's disease: current state of knowledge
2019 · External reference
Development of Trp-AuNPs-rGO based electrochemical active biosensing interface for dopamine detection
10.1016/j.chphi.2024.100726 · 2024 · External reference
The microbiota-gut-brain axis and neurodevelopmental disorders
10.1093/procel/pwad026 · 2023 · External reference
P4 Group Incidence of Parkinson disease in North America
10.1038/s41531-022-00410-y · 2022 · External reference
Serum short-chain fatty acids and its correlation with motor and non-motor symptoms in Parkinson's disease patients
10.1186/s12883-021-02544-7 · 2022 · External reference
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation
10.1016/j.nbd.2020.104814 · 2020 · External reference
Current and projected future economic burden of Parkinson's disease in the U.S
2020 · External reference
Advances in gut–brain organ chips
10.1111/cpr.13724 · 2024 · External reference
Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-gut-brain axis
10.1186/s40168-021-01107-9 · 2021 · External reference
