Research graph
References from Trehalose, but not other sugars, protects HT22 cells against amyloid-beta toxicity. Local targets link to admitted publications; unresolved targets remain external evidence.
Trehalose reduces the secreted beta-amyloid levels in primary neurons independently of autophagy induction
10.3390/metabo11070421 · 2021 · External reference
Dietary trehalose as a bioactive nutrient
10.3390/nu15061393 · 2023 · External reference
Preservation of frozen yeast cells by trehalose
10.1002/(sici)1097-0290(19991205)65:5<572::aid-bit10>3.0.co;2-7 · 1999 · External reference
Changes in lipid membranes may trigger amyloid toxicity in Alzheimer's disease
10.1371/journal.pone.0182194 · 2017 · External reference
Membrane damage induced by amyloid beta and a potential link with neuroinflammation
10.2174/138161282210160304111702 · 2016 · External reference
Effects of trehalose preconditioning on H9C2 cell viability and autophagy activation in a model of donation after circulatory death for heart transplantation
10.3390/cimb46040210 · 2024 · External reference
Alzheimer's disease: the amyloid cascade hypothesis
10.1126/science.1566067 · 1992 · External reference
Therapeutic potential of trehalose in neurodegenerative diseases: the knowns and unknowns
10.4103/1673-5374.308085 · 2021 · External reference
Trehalose improves the movement ability of Aβarc Drosophila by restoring the damaged mitochondria
10.1515/tnsci-2022-0338 · 2024 · External reference
Trehalose differentially inhibits aggregation and neurotoxicity of beta-amyloid 40 and 42
10.1016/j.nbd.2005.02.003 · 2005 · External reference
Trehalose Inhibits Aβ Generation and Plaque Formation in Alzheimer’s Disease
10.1007/s12035-020-01942-1 · 2020 · External reference
Trehalose inhibits ethanol effects on intact yeast cells and liposomes
10.1016/0005-2736(94)90181-3 · 1994 · External reference
Neurotoxicity of amyloid β-protein: synaptic and network dysfunction
10.1101/cshperspect.a006338 · 2012 · External reference
Trehalose improves survival of electrotransfected mammalian cells
10.1002/1097-0320(20011101)45:3<161::aid-cyto1159>3.0.co;2-7 · 2001 · External reference
Alzheimer’s amyloid β heterogeneous species differentially affect brain endothelial cell viability, blood-brain barrier integrity, and angiogenesis
10.1111/acel.13258 · 2020 · External reference
Trehalose improves cognition in the transgenic Tg2576 mouse model of Alzheimer's disease
10.3233/jad-170322 · 2017 · External reference
Multiple mechanisms of the therapeutic effect of trehalose in inhibition of experimental neurodegeneration
10.1134/s1819712423040190 · 2023 · External reference
Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils
10.1016/j.redox.2016.12.032 · 2017 · External reference
Trehalase and the transport of glucose in the mammalian kidney and intestine
10.1073/pnas.60.3.1007 · 1968 · External reference
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein
10.1074/jbc.m609532200 · 2007 · External reference
Molecular insights for Alzheimer’s disease: an unexplored storyline on the nanoscale impact of nascent Aβ1–42 toward the lipid membrane
10.1021/acsami.2c22196 · 2023 · External reference
Effect of trehalose as an additive to dimethyl sulfoxide solutions on ice formation, cellular viability, and metabolism
10.1016/j.cryobiol.2017.01.001 · 2017 · External reference
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis
10.1074/jbc.m210207200 · 2003 · External reference
Trehalose alters subcellular trafficking and the metabolism of the Alzheimer-associated amyloid precursor protein
10.1074/jbc.m116.719286 · 2016 · External reference
Protective effect of trehalose sugar on amyloid-membrane interactions using BLM electrophysiology
10.1016/j.bpj.2024.05.012 · 2024 · External reference
Quantitative analysis of the influence of trehalose on amyloid-β binding to membranes by localized surface plasmon resonance spectroscopy
2025 · External reference