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References from The yin and yang of neuronal mitophagy: Physiological functions and pathological implications in neurodevelopmental disorders. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondrial biogenesis in the axons of vertebrate peripheral neurons
10.1002/dneu.20668 · 2008 · External reference
Brain region-specific altered expression and association of mitochondria-related genes in autism
10.1186/2040-2392-3-12 · 2012 · External reference
Foxp1 in forebrain pyramidal neurons controls gene expression required for spatial learning and synaptic plasticity
10.1523/jneurosci.1005-17.2017 · 2017 · External reference
Mitochondria in developmental and adult neurogenesis
10.1007/s12640-018-9942-y · 2019 · External reference
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
10.1083/jcb.201401070 · 2014 · External reference
Brain-specific Foxp1 deletion impairs neuronal development and causes autistic-like behaviour
10.1038/mp.2014.116 · 2015 · External reference
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
10.1128/mcb.00166-09 · 2009 · External reference
The compartmentalised nature of neuronal mitophagy: molecular insights and implications
2022 · External reference
Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases
10.1038/s44324-025-00049-2 · 2025 · External reference
Role of oxidative stress in epileptogenesis and potential implications for therapy
10.1007/s43440-020-00143-w · 2020 · External reference
Neuronal calcium signaling: function and dysfunction
10.1007/s00018-013-1550-7 · 2014 · External reference
Mitochondria in neurogenesis: Implications for mitochondrial diseases
10.1002/stem.3425 · 2021 · External reference
Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons
10.1016/j.cub.2012.02.005 · 2012 · External reference
Mitochondrial transport and docking in axons
10.1016/j.expneurol.2009.03.024 · 2009 · External reference
Mitochondrial Biogenesis in Neurons: How and Where
10.3390/ijms222313059 · 2021 · External reference
Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
10.1002/cm.21585 · 2020 · External reference
MeCP2, a key contributor to neurological disease, activates and represses transcription
10.1126/science.1153252 · 2008 · External reference
Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons
10.1073/pnas.1106862108 · 2011 · External reference
Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism
10.1111/j.1471-4159.2011.07189.x · 2011 · External reference
2nd, PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria
10.1126/science.1231031 · 2013 · External reference
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells
10.1038/ncb2837 · 2013 · External reference
Proteomic profiling reveals mitochondrial alterations in Rett syndrome
10.1016/j.freeradbiomed.2020.05.014 · 2020 · External reference
Neuropathology of Rett syndrome: case report with neuronal and mitochondrial abnormalities in the brain
10.1177/088307389400900419 · 1994 · External reference
Impaired mitochondrial quality control in Rett Syndrome
10.1016/j.abb.2021.108790 · 2021 · External reference
Ceramide induced mitophagy and tumor suppression
2015 · External reference
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
10.1016/j.cell.2011.06.013 · 2011 · External reference
Transcellular degradation of axonal mitochondria
10.1073/pnas.1404651111 · 2014 · External reference
Heterozygous ambra1 deficiency in mice: a genetic trait with autism-like behavior restricted to the female gender
10.3389/fnbeh.2014.00181 · 2014 · External reference
Epilepsy
10.1038/nrdp.2018.24 · 2018 · External reference
Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1
10.1093/hmg/ddu101 · 2014 · External reference
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα
10.1038/s41467-018-05722-3 · 2018 · External reference
Mitochondrial dysfunction in Rett syndrome
1993 · External reference
Neuronal mitophagy: friend or foe?
10.3389/fcell.2020.611938 · 2021 · External reference
Impaired mitochondrial dynamics and mitophagy in neuronal models of tuberous sclerosis complex
10.1016/j.celrep.2016.09.054 · 2016 · External reference
Using tuberous sclerosis complex to understand the impact of MTORC1 signaling on mitochondrial dynamics and mitophagy in neurons
10.1080/15548627.2016.1277310 · 2017 · External reference
Abnormal mitochondria in the Rett syndrome
10.1016/s0387-7604(88)80010-x · 1988 · External reference
Programmed mitophagy is essential for the glycolytic switch during cell differentiation
10.15252/embj.201695916 · 2017 · External reference
BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
10.1080/15548627.2017.1332567 · 2018 · External reference
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
10.7554/elife.50260 · 2020 · External reference
Neuronal lysosomes
10.1016/j.neulet.2018.04.005 · 2019 · External reference
Mitochondrial dysfunction in autism spectrum disorder: unique abnormalities and targeted treatments
2020 · External reference
Regulation of mitophagy by the Gp78 E3 ubiquitin ligase
10.1091/mbc.e12-08-0607 · 2013 · External reference
Structural and biochemical advances on the recruitment of the autophagy-initiating ULK and TBK1 complexes by autophagy receptor NDP52
10.1126/sciadv.abi6582 · 2021 · External reference
NDP52 interacts with mitochondrial RNA poly(A) polymerase to promote mitophagy
10.15252/embr.201846363 · 2018 · External reference
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
2019 · External reference
GLS2 reduces the occurrence of epilepsy by affecting mitophagy function in mouse hippocampal neurons
10.1111/cns.70036 · 2024 · External reference
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
10.1038/ncb2012 · 2010 · External reference
Deregulation of ER-mitochondria contact formation and mitochondrial calcium homeostasis mediated by VDAC in fragile X syndrome
10.1016/j.devcel.2023.03.002 · 2023 · External reference
Mitochondrial dysfunction in autism
10.1001/jama.2010.1706 · 2010 · External reference
Autism genome-wide copy number variation reveals ubiquitin and neuronal genes
10.1038/nature07953 · 2009 · External reference
Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): implications for the disease phenotype
10.1016/j.mito.2014.02.012 · 2014 · External reference
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex
10.1073/pnas.1106454108 · 2011 · External reference
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
10.1038/embor.2012.14 · 2012 · External reference
Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome
10.1096/fj.202000283rr · 2020 · External reference
Fragile X syndrome
10.1038/nrdp.2017.65 · 2017 · External reference
Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy
10.1016/j.neuron.2022.01.035 · 2022 · External reference
Building and decoding ubiquitin chains for mitophagy
10.1038/nrm.2017.129 · 2018 · External reference
Transfer of mitochondria from astrocytes to neurons after stroke
10.1038/nature18928 · 2016 · External reference
BNIP3 phosphorylation by JNK1/2 promotes mitophagy via enhancing its stability under hypoxia
10.1038/s41419-022-05418-z · 2022 · External reference
A crosstalk between phosphorylation and ubiquitination of BNIP3 regulates mitophagy under hypoxia
10.1080/27694127.2023.2197637 · 2023 · External reference
The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy
10.1016/j.molcel.2015.08.016 · 2015 · External reference
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
2008 · External reference
Prkn knockout mice show autistic-like behaviors and aberrant synapse formation
10.1016/j.isci.2022.104573 · 2022 · External reference
De novo gene disruptions in children on the autistic spectrum
10.1016/j.neuron.2012.04.009 · 2012 · External reference
Regulatory roles of mitochondria and metabolism in neurogenesis
10.1016/j.conb.2021.05.003 · 2021 · External reference
Selective autophagy: ATG8 family proteins, LIR motifs and cargo receptors
10.1016/j.jmb.2019.07.016 · 2020 · External reference
ALFY-controlled DVL3 autophagy regulates wnt signaling, determining human brain size
10.1371/journal.pgen.1005919 · 2016 · External reference
NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy
10.1038/cdd.2015.160 · 2016 · External reference
Docking of Axonal Mitochondria by Syntaphilin Controls Their Mobility and Affects Short-Term Facilitation
10.1016/j.cell.2007.11.024 · 2008 · External reference
Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model
10.1111/j.1471-4159.2012.07936.x · 2012 · External reference
The multifaceted role of mitochondria in autism spectrum disorder
2024 · External reference
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
10.1016/j.molcel.2009.01.020 · 2009 · External reference
Metabolic and homeostatic changes in seizures and acquired epilepsy-mitochondria, calcium dynamics and reactive oxygen species
10.3390/ijms18091935 · 2017 · External reference
Ubiquitin is phosphorylated by PINK1 to activate parkin
10.1038/nature13392 · 2014 · External reference
Interplay of mitochondria-associated membrane proteins and autophagy: Implications in neurodegeneration
10.1016/j.mito.2024.101874 · 2024 · External reference
Mitochondrial protein biogenesis in the synapse is supported by local translation
10.15252/embr.201948882 · 2020 · External reference
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
10.1038/nature14893 · 2015 · External reference
Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size
10.1093/brain/awz198 · 2019 · External reference
The myriad roles of Miro in the nervous system: axonal transport of mitochondria and beyond
2014 · External reference
BNIP3 mediates pre-myelinating oligodendrocyte cell death in hypoxia and ischemia
10.1111/jnc.12314 · 2013 · External reference
FUNDC1: A Promising Mitophagy Regulator at the Mitochondria-Associated Membrane for Cardiovascular Diseases
10.3389/fcell.2021.788634 · 2021 · External reference
Foxp1 Regulates Cortical Radial Migration and Neuronal Morphogenesis in Developing Cerebral Cortex
10.1371/journal.pone.0127671 · 2015 · External reference
BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
10.1038/s41419-021-04469-y · 2021 · External reference
Transcription Factor Forkhead Box P (Foxp) 1 reduces brain damage during cerebral ischemia–reperfusion injury in mice through FUN14 domain-containing protein 1
10.1016/j.neuroscience.2023.07.029 · 2023 · External reference
ATP Synthase c-subunit leak causes aberrant cellular metabolism in fragile X Syndrome
10.1016/j.cell.2020.07.008 · 2020 · External reference
Fndc-1 contributes to paternal mitochondria elimination in C. elegans
10.1016/j.ydbio.2019.06.016 · 2019 · External reference
FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation
10.1080/15548627.2021.1872885 · 2021 · External reference
Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions
10.1016/j.neuron.2017.04.004 · 2017 · External reference
The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases
10.1016/j.bcp.2021.114891 · 2022 · External reference
GPR50 regulates neuronal development as a mitophagy receptor
10.1038/s41419-024-06978-y · 2024 · External reference
Mitochondrial epilepsy, a challenge for neurologists
10.3390/ijms232113216 · 2022 · External reference
Autism spectrum disorder
10.1038/s41572-019-0138-4 · 2020 · External reference
A cellular perspective on brain energy metabolism and functional imaging
10.1016/j.neuron.2015.03.035 · 2015 · External reference
Axonal transport and mitochondrial function in neurons
10.3389/fncel.2019.00373 · 2019 · External reference
Dimerization of mitophagy receptor BNIP3L/NIX is essential for recruitment of autophagic machinery
10.1080/15548627.2020.1755120 · 2021 · External reference
Neuronal mitophagy in neurodegenerative diseases
10.3389/fnmol.2017.00064 · 2017 · External reference
Differentiation by nerve growth factor (NGF) involves mechanisms of crosstalk between energy homeostasis and mitochondrial remodeling
10.1038/s41419-018-0429-9 · 2018 · External reference
Intramembrane protease PARL defines a negative regulator of PINK1- and PARK2/Parkin-dependent mitophagy
10.1080/15548627.2015.1063763 · 2015 · External reference
Impact of LITAF on mitophagy and neuronal damage in epilepsy via MCL-1 ubiquitination
10.1111/cns.70191 · 2025 · External reference
Mitostasis in neurons: maintaining mitochondria in an extended cellular architecture
10.1016/j.neuron.2017.09.055 · 2017 · External reference
Sexual dimorphism of AMBRA1-related autistic features in human and mouse
10.1038/tp.2017.213 · 2017 · External reference
Aberrant redox homoeostasis and mitochondrial dysfunction in Rett syndrome
10.1042/bst20140071 · 2014 · External reference
AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection
10.1016/j.celrep.2024.115001 · 2024 · External reference
Altered zinc transport disrupts mitochondrial protein processing/import in fragile X-associated tremor/ataxia syndrome
10.1093/hmg/ddr211 · 2011 · External reference
Altered bioenergetics in primary dermal fibroblasts from adult carriers of the FMR1 premutation before the onset of the neurodegenerative disease fragile X-associated tremor/ataxia syndrome
10.1007/s12311-016-0779-8 · 2016 · External reference
Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy
10.1038/s41598-018-29421-7 · 2018 · External reference
Wdfy3 regulates glycophagy, mitophagy, and synaptic plasticity
10.1177/0271678x211027384 · 2021 · External reference
Unconventional initiation of PINK1/Parkin mitophagy by Optineurin
10.1016/j.molcel.2023.04.021 · 2023 · External reference
Mitochondria and neuronal survival
10.1152/physrev.2000.80.1.315 · 2000 · External reference
Ambra1 shapes hippocampal inhibition/excitation balance: role in neurodevelopmental disorders
10.1007/s12035-018-0911-5 · 2018 · External reference
Nix is a selective autophagy receptor for mitochondrial clearance
10.1038/embor.2009.256 · 2010 · External reference
Molecular mechanisms and physiological functions of mitophagy
10.15252/embj.2020104705 · 2021 · External reference
Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans
10.1038/nature14300 · 2015 · External reference
Foxp1 regulates neural stem cell self-renewal and bias toward deep layer cortical fates
10.1016/j.celrep.2020.01.034 · 2020 · External reference
Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder
10.1096/fj.201902677r · 2020 · External reference
Calcium-dependent mitochondrial function and dysfunction in neurons
10.1111/j.1742-4658.2010.07754.x · 2010 · External reference
Mitochondrial biogenesis and clearance: a balancing act
10.1111/febs.13820 · 2017 · External reference
ULK1 promotes mitophagy via phosphorylation and stabilization of BNIP3
10.1038/s41598-021-00170-4 · 2021 · External reference
Mitochondrial contributions to neuronal development and function
10.1515/hsz-2017-0333 · 2018 · External reference
Mul1 restrains Parkin-mediated mitophagy in mature neurons by maintaining ER-mitochondrial contacts
10.1038/s41467-019-11636-5 · 2019 · External reference
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons
10.1074/jbc.m112.391680 · 2013 · External reference
Tuberous sclerosis complex: a review
2017 · External reference
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
10.1073/pnas.1523926113 · 2016 · External reference
Phosphorylation of the mitochondrial autophagy receptor Nix enhances its interaction with LC3 proteins
10.1038/s41598-017-01258-6 · 2017 · External reference
Evidence of mitochondrial dysfunction in fragile X-associated tremor/ataxia syndrome
10.1042/bj20091960 · 2010 · External reference
Role of Mitochondria-ER Contact Sites in Mitophagy
10.3390/biom13081198 · 2023 · External reference
Retention of mitochondria in mature human red blood cells as the result of autophagy impairment in rett syndrome
10.1038/s41598-017-12069-0 · 2017 · External reference
PARK2 copy number aberrations in two children presenting with autism spectrum disorder: further support of an association and possible evidence for a new microdeletion/microduplication syndrome
10.1002/ajmg.b.31176 · 2011 · External reference
Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex
10.1186/s11689-018-9237-x · 2018 · External reference
NIX is required for programmed mitochondrial clearance during reticulocyte maturation
10.1073/pnas.0708818104 · 2007 · External reference
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells
10.1523/jneurosci.4441-10.2011 · 2011 · External reference
PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol
10.1186/s12915-017-0470-7 · 2018 · External reference
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice
10.1038/s41593-019-0338-y · 2019 · External reference
Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration
10.1038/nrn3156 · 2012 · External reference
Mitochondrial dysfunction in the pathogenesis of rett syndrome: implications for mitochondria-targeted therapies
10.3389/fncel.2017.00058 · 2017 · External reference
Roles of mitochondria in neuronal development
10.5483/bmbrep.2018.51.11.226 · 2018 · External reference
Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine
10.2119/molmed.2016.00122 · 2016 · External reference
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
10.1073/pnas.1103295108 · 2011 · External reference
Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases
10.1038/ng.3792 · 2017 · External reference
AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1
10.1038/cdd.2014.190 · 2015 · External reference
The PINK1, synphilin-1 and SIAH-1 complex constitutes a novel mitophagy pathway
10.1093/hmg/ddw189 · 2016 · External reference
Mitochondria, energy, and metabolism in neuronal health and disease
10.1002/1873-3468.14298 · 2022 · External reference
Parkin interacts with Ambra1 to induce mitophagy
10.1523/jneurosci.1917-11.2011 · 2011 · External reference
Spatiotemporal control of ULK1 Activation by NDP52 and TBK1 during selective autophagy
10.1016/j.molcel.2019.02.010 · 2019 · External reference
Mitochondrial dysfunction and oxidative stress contribute to cognitive and motor impairment in FOXP1 syndrome
10.1073/pnas.2112852119 · 2022 · External reference
Disrupted mitochondrial network drives deficits of learning and memory in a mouse model of FOXP1 haploinsufficiency
10.3390/genes13010127 · 2022 · External reference
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility
10.1016/j.cell.2011.10.018 · 2011 · External reference
Association of mitochondrial DNA content, heteroplasmies and inter-generational transmission with autism
10.1038/s41467-022-30805-7 · 2022 · External reference
Critical role of dysfunctional mitochondria and defective mitophagy in autism spectrum disorders
10.1016/j.brainresbull.2020.12.022 · 2021 · External reference
Epilepsy in mitochondrial diseases-current state of knowledge on aetiology and treatment
10.3390/children8070532 · 2021 · External reference
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
10.1073/pnas.1405752111 · 2014 · External reference
Mitophagy in refractory temporal lobe epilepsy patients with hippocampal sclerosis
10.1007/s10571-017-0492-2 · 2018 · External reference
Unraveling the nexus of age, epilepsy, and mitochondria: exploring the dynamics of cellular energy and excitability
10.3389/fphar.2024.1469053 · 2024 · External reference
SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy
10.1080/15548627.2019.1643185 · 2019 · External reference
Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice
10.1073/pnas.1808247115 · 2018 · External reference
BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes
10.1080/15548627.2020.1871204 · 2021 · External reference
10.1083/jcb.200406038
10.1083/jcb.200406038 · External reference
Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder
10.1186/s13229-016-0087-7 · 2016 · External reference
FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions
10.1096/fj.201901735r · 2020 · External reference
MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin
10.7554/elife.01958 · 2014 · External reference
Mitochondria and Other Organelles in Neural Development and Their Potential as Therapeutic Targets in Neurodegenerative Diseases
2022 · External reference
Succinate accumulation induces mitochondrial reactive oxygen species generation and promotes status epilepticus in the kainic acid rat model
2020 · External reference
FUNDC1 mediated mitophagy in epileptic hippocampal neuronal injury induced by magnesium-free fluid
10.1007/s11064-022-03749-z · 2023 · External reference
Somatic autophagy of axonal mitochondria in ischemic neurons
10.1083/jcb.201804101 · 2019 · External reference
The inhibition of PGAM5 suppresses seizures in a kainate-induced epilepsy model via mitophagy reduction
10.3389/fnmol.2022.1047801 · 2022 · External reference
Intracellular calcium homeostasis and its dysregulation underlying epileptic seizures
10.1016/j.seizure.2022.11.007 · 2022 · External reference
Modulation of Serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis
10.1074/jbc.m112.399345 · 2013 · External reference