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References from PIWI-interacting RNAs in neurological and neuropsychiatric disorders and potential for clinical development. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1002/alz.13809
10.1002/alz.13809 · 2024 · External reference
piRNA/PIWI Protein Complex as a Potential Biomarker in Sporadic Amyotrophic Lateral Sclerosis
10.1007/s12035-021-02686-2 · 2022 · External reference
A novel class of small RNAs bind to MILI protein in mouse testes
10.1038/nature04916 · 2006 · External reference
Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D. melanogaster germline
10.1016/s0960-9822(01)00299-8 · 2001 · External reference
STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein
10.1007/s00418-011-0897-9 · 2012 · External reference
LINE-1 elements in structural variation and disease
10.1146/annurev-genom-082509-141802 · 2011 · External reference
Saliva RNA Biomarkers of Gastrointestinal Dysfunction in Children With Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine
10.3389/fpsyt.2021.824933 · 2022 · External reference
Engrailed homeoprotein blocks degeneration in adult dopaminergic neurons through LINE-1 repression
10.15252/embj.201797374 · 2018 · External reference
DNA methylation in repetitive elements and Alzheimer disease
10.1016/j.bbi.2011.01.017 · 2011 · External reference
Adult neurogenesis and “immature” neurons in mammals: an evolutionary trade-off in plasticity?
10.1007/s00429-023-02717-9 · 2023 · External reference
Rett syndrome: a review of clinical manifestations and therapeutic approaches
10.3389/frsle.2024.1373489 · 2024 · External reference
Opportunities and challenges in studying the extracellular vesicle corona
10.1038/s41556-022-00983-z · 2022 · External reference
Current Understanding of piRNA in Cardiovascular Diseases
10.3389/fmmed.2021.791931 · 2022 · External reference
Hypoxic Postconditioning Offers Neuroprotection Against Transient Cerebral Ischemia via Down-Regulation of rno_piR_011022
2025 · External reference
Mouse Piwi interactome identifies binding mechanism of Tdrkh Tudor domain to arginine methylated Miwi
10.1073/pnas.0911640106 · 2009 · External reference
Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology
2020 · External reference
Analysis of Faecal Microbiota and Small ncRNAs in Autism: Detection of miRNAs and piRNAs with Possible Implications in Host-Gut Microbiota Cross-Talk
10.3390/nu14071340 · 2022 · External reference
Major depressive disorder: hypothesis, mechanism, prevention and treatment
2024 · External reference
piRNA-Guided Genome Defense: From Biogenesis to Silencing
10.1146/annurev-genet-120417-031441 · 2018 · External reference
L1 drives IFN in senescent cells and promotes age-associated inflammation
10.1038/s41586-018-0784-9 · 2019 · External reference
The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements
10.1038/nature10547 · 2011 · External reference
Human endogenous retrovirus HERVK(HML-2) RNA causes neurodegeneration through Toll-like receptors
10.1172/jci.insight.131093 · 2020 · External reference
Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke
10.18632/aging.102278 · 2019 · External reference
Pathogenic Huntingtin Repeat Expansions in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis
10.1016/j.neuron.2020.11.005 · 2021 · External reference
Altered expression of PIWI RNA in the rat brain after transient focal ischemia
10.1161/strokeaha.110.598391 · 2011 · External reference
Two-factor authentication underpins the precision of the piRNA pathway
10.1038/s41586-024-07963-3 · 2024 · External reference
TDRD5 binds piRNA precursors and selectively enhances pachytene piRNA processing in mice
2018 · External reference
HIV-1 Tat and cocaine coexposure impacts piRNAs to affect astrocyte energy metabolism
10.2217/epi-2021-0252 · 2022 · External reference
Overview of Extracellular Vesicles, Their Origin, Composition, Purpose, and Methods for Exosome Isolation and Analysis
10.3390/cells8070727 · 2019 · External reference
Small Non-coding RNAs Are Dysregulated in Huntington’s Disease Transgenic Mice Independently of the Therapeutic Effects of an Environmental Intervention
10.1007/s12035-021-02342-9 · 2021 · External reference
Molecular profiling of neurons based on connectivity
10.1016/j.cell.2014.03.059 · 2014 · External reference
Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus
10.1016/j.stem.2011.03.010 · 2011 · External reference
Reactive astrocyte nomenclature, definitions, and future directions
2021 · External reference
Transposable elements and Alzheimer’s disease pathogenesis
10.1016/j.tins.2022.12.003 · 2023 · External reference
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics
10.1074/mcp.m113.035600 · 2014 · External reference
Inflamm-aging: An Evolutionary Perspective on Immunosenescence
10.1111/j.1749-6632.2000.tb06651.x · 2000 · External reference
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
10.1038/s41574-018-0059-4 · 2018 · External reference
Tau promotes neurodegeneration through global chromatin relaxation
10.1038/nn.3639 · 2014 · External reference
Adult Neurogenesis in the Human Dentate Gyrus
10.1002/hipo.23655 · 2025 · External reference
A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals
10.1016/j.molcel.2018.08.007 · 2018 · External reference
Relaxed targeting rules help PIWI proteins silence transposons
10.1038/s41586-023-06257-4 · 2023 · External reference
Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets
2023 · External reference
Rheumatoid arthritis: pathogenesis and therapeutic advances
2024 · External reference
The Screening of Piwi-Interacting RNA Biomarkers in Sporadic Parkinson’s Disease
2024 · External reference
LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification
10.1126/sciadv.adh9543 · 2023 · External reference
Piwil2 (Mili) sustains neurogenesis and prevents cellular senescence in the postnatal hippocampus
10.15252/embr.202153801 · 2023 · External reference
Huntington disease: Advances in the understanding of its mechanisms
2020 · External reference
The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria
10.1016/j.molcel.2019.04.006 · 2019 · External reference
PIWI proteins contribute to apoptosis during the UPR in human airway epithelial cells
10.1038/s41598-018-34861-2 · 2018 · External reference
Unresolved reference
External reference
Characterization of piRNAs across postnatal development in mouse brain
10.1038/srep25039 · 2016 · External reference
The evolution, distribution and diversity of endogenous retroviruses
10.1023/a:1024455415443 · 2003 · External reference
A germline-specific class of small RNAs binds mammalian Piwi proteins
2006 · External reference
CTRL + INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome
10.15252/embr.201642743 · 2016 · External reference
A novel class of small RNAs in mouse spermatogenic cells
10.1101/gad.1434406 · 2006 · External reference
Tau Activates Transposable Elements in Alzheimer’s Disease
10.1016/j.celrep.2018.05.004 · 2018 · External reference
Databases and computational methods for the identification of piRNA-related molecules: A survey
10.1016/j.csbj.2024.01.011 · 2024 · External reference
Evolutionary history of the vertebrate Piwi gene family
10.7717/peerj.12451 · 2021 · External reference
Maternal immune activation as an epidemiological risk factor for neurodevelopmental disorders: Considerations of timing, severity, individual differences, and sex in human and rodent studies
10.3389/fnins.2023.1135559 · 2023 · External reference
Expression of PRMT5 correlates with malignant grade in gliomas and plays a pivotal role in tumor growth in vitro
10.1007/s11060-014-1419-0 · 2014 · External reference
Maternal immune activation and neuroinflammation in human neurodevelopmental disorders
2021 · External reference
Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
10.1155/2021/8884642 · 2021 · External reference
Global long interspersed nuclear element 1 DNA methylation in a Colombian sample of patients with late-onset Alzheimer’s disease
10.1177/1533317513505132 · 2014 · External reference
DNA methylation age of human tissues and cell types
10.1186/gb-2013-14-10-r115 · 2013 · External reference
Active transposition in genomes
10.1146/annurev-genet-110711-155616 · 2012 · External reference
Gene expression profile of the hippocampus of rats subjected to traumatic brain injury
10.1002/jcb.28848 · 2019 · External reference
PIWI-interacting RNA expression regulates pathogenesis in a Caenorhabditis elegans model of Lewy body disease
2023 · External reference
Argonaute proteins: key players in RNA silencing
10.1038/nrm2321 · 2008 · External reference
Exosomes/microvesicles target SARS-CoV-2 via innate and RNA-induced immunity with PIWI-piRNA system
2021 · External reference
The contribution of de novo coding mutations to autism spectrum disorder
10.1038/nature13908 · 2014 · External reference
Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy
10.1002/jcp.27214 · 2019 · External reference
PIWI-Interacting RNA: Its Biogenesis and Functions
10.1146/annurev-biochem-060614-034258 · 2015 · External reference
A combined miRNA–piRNA signature to detect Alzheimer’s disease
10.1038/s41398-019-0579-2 · 2019 · External reference
Multiple sclerosis
10.1016/s0140-6736(23)01473-3 · 2024 · External reference
Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus
10.1007/s11064-006-9184-x · 2006 · External reference
piRNA associates with immune diseases
10.1186/s12964-024-01724-5 · 2024 · External reference
Identification of a potential non-coding RNA biomarker signature for amyotrophic lateral sclerosis
10.1093/braincomms/fcaa053 · 2020 · External reference
Transposable Elements: A Common Feature of Neurodevelopmental and Neurodegenerative Disorders
10.1016/j.tig.2020.05.004 · 2020 · External reference
piRNA and miRNA Can Suppress the Expression of Multiple Sclerosis Candidate Genes
2023 · External reference
piRNAs in the human retina and retinal pigment epithelium reveal a potential role in intracellular trafficking and oxidative stress
10.1039/d3mo00122a · 2024 · External reference
Advances in different adult stem cell-derived exosomal non-coding RNAs for the treatment of neurological disorders: a narrative review
10.3389/fcell.2024.1459246 · 2024 · External reference
Tudor Domain Containing Protein TDRD12 Expresses at the Acrosome of Spermatids in Mouse Testis
2015 · External reference
Epigenome-wide study uncovers large-scale changes in histone acetylation driven by tau pathology in aging and Alzheimer’s human brains
10.1038/s41593-018-0291-1 · 2019 · External reference
Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS
2017 · External reference
Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes
2020 · External reference
Detection of PIWI and piRNAs in the mitochondria of mammalian cancer cells
10.1016/j.bbrc.2014.02.112 · 2014 · External reference
Initial sequencing and analysis of the human genome
10.1038/35057062 · 2001 · External reference
Characterization of the piRNA complex from rat testes
2006 · External reference
Identification of piRNAs in the central nervous system
10.1261/rna.2565011 · 2011 · External reference
Disrupting the hippocampal Piwi pathway enhances contextual fear memory in mice
10.1016/j.nlm.2019.04.002 · 2019 · External reference
A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons
10.1016/j.neuroscience.2017.11.018 · 2018 · External reference
PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage
10.1016/j.mad.2018.03.009 · 2018 · External reference
Microglia and macrophages in brain homeostasis and disease
2017 · External reference
PIWI-interacting RNA MIABEPIR regulates cerebral endothelial cell function via DAPK2 pathway in offspring following maternal immune activation
10.1002/ctm2.70260 · 2025 · External reference
Human endogenous retrovirus-K contributes to motor neuron disease
10.1126/scitranslmed.aac8201 · 2015 · External reference
Mammalian PIWI-piRNA-target complexes reveal features for broad and efficient target silencing
10.1038/s41594-024-01287-6 · 2024 · External reference
FBXO24 modulates mRNA alternative splicing and MIWI degradation and is required for normal sperm formation and piRNA production
10.7554/elife.91666.3 · 2024 · External reference
TDP-43 safeguards the embryo genome from L1 retrotransposition
10.1126/sciadv.abq3806 · 2022 · External reference
High expression of PIWIL2 promotes tumor cell proliferation, migration and predicts a poor prognosis in glioma
10.3892/or.2017.5647 · 2017 · External reference
Knockout Gene-Based Evidence for PIWI-Interacting RNA Pathway in Mammals
2021 · External reference
Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons
10.1016/j.celrep.2019.04.003 · 2019 · External reference
SPOCD1 promotes the proliferation and metastasis of glioma cells by up-regulating PTX3
2018 · External reference
Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
2022 · External reference
PIWIL3/OIP5-AS1/miR-367-3p/CEBPA feedback loop regulates the biological behavior of glioma cells
10.7150/thno.21740 · 2018 · External reference
Neurobiology of Schizophrenia: A Comprehensive Review
2022 · External reference
Changes in the Small Noncoding RNAome During M1 and M2 Macrophage Polarization
2022 · External reference
From the genome’s perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs
10.1002/bies.202400125 · 2025 · External reference
LINE-1 regulates cortical development by acting as long non-coding RNAs
2023 · External reference
Transcriptome-wide piRNA profiling in human brains for aging genetic factors
2019 · External reference
Differential L1 regulation in pluripotent stem cells of humans and apes
2013 · External reference
Intranasal wnt3a attenuates neuronal apoptosis through Frz1/PIWIL1a/FOXM1 pathway in MCAO rats
10.1523/jneurosci.2352-17.2018 · 2018 · External reference
LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease
10.1139/bcb-2023-0134 · 2024 · External reference
The promise of exosome applications in treating central nervous system diseases
10.1111/cns.13743 · 2021 · External reference
LINE-1 protein localization and functional dynamics during the cell cycle
2018 · External reference
Pinpointing Novel Plasma and Brain Proteins for Common Ocular Diseases: A Comprehensive Cross-Omics Integration Analysis
10.3390/ijms251910236 · 2024 · External reference
Piwi/PRG-1 Argonaute and TGF-β Mediate Transgenerational Learned Pathogenic Avoidance
10.1016/j.cell.2019.05.024 · 2019 · External reference
Opposite regulation of piRNAs, rRNAs and miRNAs in the blood after subarachnoid hemorrhage
10.1007/s00109-020-01922-x · 2020 · External reference
L1 retrotransposition in neurons is modulated by MeCP2
10.1038/nature09544 · 2010 · External reference
Roles for small noncoding RNAs in silencing of retrotransposons in the mammalian brain
10.1073/pnas.1609287113 · 2016 · External reference
PIWI-interacting RNAs: small RNAs with big functions
10.1038/s41576-018-0073-3 · 2019 · External reference
Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates
10.1016/j.biopsych.2020.10.016 · 2021 · External reference
Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice
10.1073/pnas.1316316110 · 2013 · External reference
iSmaRT: a toolkit for a comprehensive analysis of small RNA-Seq data
10.1093/bioinformatics/btx647 · 2017 · External reference
Function and dysfunction of microglia during brain development: Consequences for synapses and neural circuits
10.3389/fnsyn.2017.00009 · 2017 · External reference
Microglia states and nomenclature: A field at its crossroads
10.1016/j.neuron.2022.10.020 · 2022 · External reference
The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in the piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster
2014 · External reference
Adult Neural Stem Cell Regulation by Small Non-coding RNAs: Physiological Significance and Pathological Implications
10.3389/fncel.2021.781434 · 2022 · External reference
Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA
10.1080/15592294.2019.1600389 · 2019 · External reference
piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells
10.1101/gad.240895.114 · 2014 · External reference
Pathological manifestation of human endogenous retrovirus K in frontotemporal dementia
10.1038/s43856-021-00060-w · 2021 · External reference
Unresolved reference
External reference
Expression and regulation of PIWIL-proteins and PIWI-interacting RNAs in rheumatoid arthritis
10.1371/journal.pone.0166920 · 2016 · External reference
Quantitative Analysis of L1-Retrotransposons in Alzheimer’s Disease and Aging
10.1134/s0006297917080120 · 2017 · External reference
Transcriptome-wide piRNA profiling in human brains of Alzheimer’s disease
10.1016/j.neurobiolaging.2017.05.020 · 2017 · External reference
Small non-coding RNA expression from anterior cingulate cortex in schizophrenia shows sex specific regulation
10.1016/j.schres.2016.11.024 · 2017 · External reference
A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity
10.1016/j.cell.2012.02.057 · 2012 · External reference
Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system
10.1016/j.pneurobio.2021.102181 · 2022 · External reference
Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
10.1016/j.celrep.2024.114061 · 2024 · External reference
Stability and flexibility of epigenetic gene regulation in mammalian development
10.1038/nature05918 · 2007 · External reference
Differential expression and correlation of immunoregulation related piRNA in rheumatoid arthritis
10.3389/fimmu.2023.1175924 · 2023 · External reference
Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing
10.1038/nature10672 · 2011 · External reference
Loss of the Mili-interacting Tudor domain–containing protein-1 activates transposons and alters the Mili-associated small RNA profile
2009 · External reference
Integrative DNA methylation and gene expression analysis of cognitive behavioral therapy response in children and adolescents with obsessive-compulsive disorder; a pilot study
2021 · External reference
piRNAs are regulators of metabolic reprogramming in stem cells
2024 · External reference
Piwi proteins and piRNAs in mammalian oocytes and early embryos
10.1016/j.celrep.2015.02.062 · 2015 · External reference
piRNAclusterDB 2.0: update and expansion of the piRNA cluster database
10.1093/nar/gkab622 · 2021 · External reference
Small RNA sequencing revealed dysregulated piRNAs in Alzheimer’s disease and their probable role in pathogenesis
10.1039/c6mb00699j · 2017 · External reference
Unresolved reference
External reference
Fragile X syndrome: clinical presentation, pathology and treatment
2020 · External reference
Transposable Elements, Inflammation, and Neurological Disease
10.3389/fneur.2019.00894 · 2019 · External reference
Circulating non-coding rnas as a signature of autism spectrum disorder symptomatology
10.3390/ijms22126549 · 2021 · External reference
Noncoding RNAs in neurodegeneration
10.1038/nrn.2017.90 · 2017 · External reference
Identification of eight members of the Argonaute family in the human genome
10.1016/s0888-7543(03)00129-0 · 2003 · External reference
Tdrkh is essential for spermatogenesis and participates in primary piRNA biogenesis in the germline
10.1038/emboj.2013.121 · 2013 · External reference
piRNAs warrant investigation in Rett Syndrome: an omics perspective
10.1155/2012/396737 · 2012 · External reference
Alzheimer’s disease
10.1016/s0140-6736(20)32205-4 · 2021 · External reference
Sporadic Parkinson’s disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs
10.1186/s40478-018-0561-x · 2018 · External reference
Emerging diagnostics and therapeutics for Alzheimer disease
10.1038/s41591-023-02505-2 · 2023 · External reference
Stroke: Molecular mechanisms and therapies: Update on recent developments
10.1016/j.neuint.2022.105458 · 2023 · External reference
Dysregulation of MicroRNAs and PIWI-Interacting RNAs in a Caenorhabditis elegans Parkinson’s Disease Model Overexpressing Human α-Synuclein and Influence of tdp-1
10.3389/fnins.2021.600462 · 2021 · External reference
The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline
10.1016/j.devcel.2009.10.012 · 2009 · External reference
Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression
10.1016/j.cell.2012.10.040 · 2012 · External reference
Potential of Non-Coding RNA as Biomarkers for Progressive Supranuclear Palsy
10.3390/ijms232314554 · 2022 · External reference
Phased piRNAs tackle transposons
2015 · External reference
An atlas of the protein-coding genes in the human, pig, and mouse brain
10.1126/science.aay5947 · 2020 · External reference
Small non-coding RNA transcriptomic profiling in adult and fetal human brain
2024 · External reference
Alzheimer’s Patient Microglia Exhibit Enhanced Aging and Unique Transcriptional Activation
10.1016/j.celrep.2020.107843 · 2020 · External reference
Obsessive–compulsive disorder
2019 · External reference
Parkinson disease therapy: current strategies and future research priorities
2024 · External reference
The interferon-inducible protein TDRD7 inhibits AMP-activated protein kinase and thereby restricts autophagy-independent virus replication
10.1074/jbc.ra120.013533 · 2020 · External reference
The birth of piRNAs: how mammalian piRNAs are produced, originated, and evolved
10.1007/s00335-021-09927-8 · 2021 · External reference
Pathogenic tau-induced piRNA depletion promotes neuronal death through transposable element dysregulation in neurodegenerative tauopathies
10.1038/s41593-018-0194-1 · 2018 · External reference
piRNA Rules of Engagement
10.1016/j.devcel.2018.03.006 · 2018 · External reference
Diseases of the nERVous system: Retrotransposon activity in neurodegenerative disease
10.1186/s13100-019-0176-1 · 2019 · External reference
Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration
10.1093/hmg/ddr437 · 2012 · External reference
Decoding ALS: From genes to mechanism
10.1038/nature20413 · 2016 · External reference
F33. EXPLORING DIFFERENTIAL EXPRESSION OF NEURONAL PIRNAS IN MAJOR DEPRESSION SUBJECTS IN A LARGE POST MORTEM BRAIN SAMPLE
10.1016/j.euroneuro.2024.08.444 · 2024 · External reference
A53t mutant alpha-synuclein induces tau-dependent postsynaptic impairment independently of neurodegenerative changes
10.1523/jneurosci.0344-18.2018 · 2018 · External reference
Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation
10.1016/j.celrep.2024.113774 · 2024 · External reference
A distinct small RNA pathway silences selfish genetic elements in the germline
10.1126/science.1129333 · 2006 · External reference
Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
10.1101/gad.1814809 · 2009 · External reference
Astrocytes and microglia: in sickness and in health
10.1016/j.tins.2020.01.003 · 2020 · External reference
Modelling amyotrophic lateral sclerosis: Progress and possibilities
10.1242/dmm.029058 · 2017 · External reference
SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
2014 · External reference
Loss of the Androgen Receptor Cofactor p44/WDR77 Induces Astrogliosis
10.1128/mcb.00298-12 · 2012 · External reference
Cloning and functional characterization of a novel mitochondrial N-ethylmaleimide-sensitive glycerol-3-phosphate acyltransferase (GPAT2)
10.1016/j.abb.2007.06.033 · 2007 · External reference
Emerging roles and functional mechanisms of PIWI-interacting RNAs
10.1038/s41580-022-00528-0 · 2022 · External reference
piRBase: integrating piRNA annotation in all aspects
10.1093/nar/gkab1012 · 2022 · External reference
Exosomal noncoding RNAs in central nervous system diseases: biological functions and potential clinical applications
10.3389/fnmol.2022.1004221 · 2022 · External reference
RNF17 blocks promiscuous activity of PIWI proteins in mouse testes
10.1101/gad.265215.115 · 2015 · External reference
Small non-coding RNAs: New class of biomarkers and potential therapeutic targets in neurodegenerative disease
10.3389/fgene.2019.00364 · 2019 · External reference
piRNA loading triggers MIWI translocation from the intermitochondrial cement to chromatoid body during mouse spermatogenesis
2024 · External reference
piRNAs: From biogenesis to function
10.1242/dev.094037 · 2014 · External reference
Hallmarks of neurodegenerative diseases
10.1016/j.cell.2022.12.032 · 2023 · External reference
Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia
2024 · External reference
Novel roles of PIWI proteins and PIWI-interacting RNAs in human health and diseases
2023 · External reference
Defining the functions of PIWI-interacting RNAs
10.1038/s41580-021-00336-y · 2021 · External reference
Exosomal miRNAs in central nervous system diseases: biomarkers, pathological mediators, protective factors and therapeutic agents
10.1016/j.pneurobio.2019.101694 · 2019 · External reference
Epigenetic insights into Fragile X Syndrome
10.3389/fcell.2024.1432444 · 2024 · External reference
Widespread expression of piRNA-like molecules in somatic tissues
10.1093/nar/gkr298 · 2011 · External reference
PIWI Slicing and EXD1 Drive Biogenesis of Nuclear piRNAs from Cytosolic Targets of the Mouse piRNA Pathway
10.1016/j.molcel.2015.11.009 · 2016 · External reference
Innate and Adaptive Immunity of Murine Neural Stem Cell-Derived piRNA Exosomes/Microvesicles against Pseudotyped SARS-CoV-2 and HIV-Based Lentivirus
10.1016/j.isci.2020.101806 · 2020 · External reference
The Role of DNA Methylation in Ischemic Stroke: A Systematic Review
10.3389/fneur.2020.566124 · 2020 · External reference
Attenuation of Piwil2 induced by hypoxic postconditioning prevents cerebral ischemic injury by inhibiting CREB2 promoter methylation
10.1111/bpa.13109 · 2023 · External reference
Dysregulation of Human Somatic piRNA Expression in Parkinson’s Disease Subtypes and Stages
2022 · External reference
A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome
10.7554/elife.98081.2 · 2024 · External reference
Novel function of PIWIL1 in neuronal polarization and migration via regulation of microtubule-associated proteins
10.1186/s13041-015-0131-0 · 2015 · External reference
Extracellular vesicles piwi-interacting RNAs from skin mucus for identification of infected Cynoglossus semilaevis with Vibrio harveyi
10.1016/j.fsi.2021.02.001 · 2021 · External reference
A SnoRNA-derived piRNA interacts with human interleukin-4 pre-mRNA and induces its decay in nuclear exosomes
2015 · External reference
PIWI-interacting RNAs: Critical roles and therapeutic targets in cancer
10.1016/j.canlet.2023.216189 · 2023 · External reference
Autism spectrum disorder: pathogenesis, biomarker, and intervention therapy
2024 · External reference