Research graph
References from Proof-of-Mechanism Study of the Phosphodiesterase 10 Inhibitor RG7203 in Patients With Schizophrenia and Negative Symptoms. Local targets link to admitted publications; unresolved targets remain external evidence.
Prediction of disability in schizophrenia: Symptoms, cognition, and self-assessment
2019 · External reference
Prevalence of negative symptoms in outpatients with schizophrenia spectrum disorders treated with antipsychotics in routine clinical practice: Findings from the CLAMORS study
10.4088/jcp.08m04250yel · 2010 · External reference
Pharmacological treatment of negative symptoms in schizophrenia: Update and proposal of a clinical algorithm
10.2147/ndt.s201726 · 2019 · External reference
Psychiatric drug development: Diagnosing a crisis
2013 · External reference
Negative symptoms in schizophrenia: Avolition and Occam’s razor
10.1093/schbul/sbn094 · 2010 · External reference
Negative symptoms and the failure to represent the expected reward value of actions: Behavioral and computational modeling evidence
10.1001/archgenpsychiatry.2011.1269 · 2012 · External reference
Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia
10.1016/j.biopsych.2010.10.015 · 2011 · External reference
Probabilistic reversal learning impairments in schizophrenia: Further evidence of orbitofrontal dysfunction
10.1016/j.schres.2007.03.010 · 2007 · External reference
Effort, anhedonia, and function in schizophrenia: Reduced effort allocation predicts amotivation and functional impairment
10.1037/a0036299 · 2014 · External reference
Inefficient effort allocation and negative symptoms in individuals with schizophrenia
10.1016/j.schres.2015.12.017 · 2016 · External reference
Impaired effort allocation in patients with schizophrenia
10.1016/j.schres.2014.11.024 · 2015 · External reference
Ventral striatal hypoactivation is associated with apathy but not diminished expression in patients with schizophrenia
10.1503/jpn.140383 · 2016 · External reference
Dimensional psychiatry: Reward dysfunction and depressive mood across psychiatric disorders
10.1007/s00213-014-3662-7 · 2015 · External reference
Dysfunction of ventral striatal reward prediction in schizophrenia
10.1016/j.neuroimage.2005.07.051 · 2006 · External reference
Neural correlates of reward processing in schizophrenia--Relationship to apathy and depression
10.1016/j.schres.2009.11.007 · 2010 · External reference
An integrative perspective on the role of dopamine in schizophrenia
10.1016/j.biopsych.2016.05.021 · 2017 · External reference
Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum
10.1523/jneurosci.2518-08.2008 · 2008 · External reference
Mechanisms for the modulation of dopamine d(1) receptor signaling in striatal neurons
10.3389/fnana.2011.00043 · 2011 · External reference
Genetic deletion of the striatum-enriched phosphodiesterase PDE10A: Evidence for altered striatal function
10.1016/j.neuropharm.2006.01.012 · 2006 · External reference
Unresolved reference
External reference
The effects of risperidone on the five dimensions of schizophrenia derived by factor analysis: Combined results of the North American trials
10.4088/jcp.v58n1205 · 1997 · External reference
Negative symptoms of schizophrenia are associated with abnormal effort-cost computations
10.1016/j.biopsych.2012.12.022 · 2013 · External reference
Interactions among working memory, reinforcement learning, and effort in value-based choice: A new paradigm and selective deficits in schizophrenia
10.1016/j.biopsych.2017.05.017 · 2017 · External reference
Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia
10.1016/s0893-133x(97)00096-1 · 1998 · External reference
Anticipation of increasing monetary reward selectively recruits nucleus accumbens
10.1523/jneurosci.21-16-j0002.2001 · 2001 · External reference
Physiological characteristics of capacity constraints in working memory as revealed by functional MRI
10.1093/cercor/9.1.20 · 1999 · External reference
Statistical parametric maps in functional imaging: A general linear approach
10.1002/hbm.460020402 · 1994 · External reference
Test-retest reliability of task-based and resting-state blood oxygen level dependence and cerebral blood flow measures
10.1371/journal.pone.0206583 · 2018 · External reference
Visualization of group inference data in functional neuroimaging
10.1007/s12021-008-9042-x · 2009 · External reference
Deficits on conditional associative-learning tasks after frontal- and temporal-lobe lesions in man
10.1016/0028-3932(85)90062-4 · 1985 · External reference
Working memory contributions to reinforcement learning impairments in schizophrenia
10.1523/jneurosci.0989-14.2014 · 2014 · External reference
Mechanisms of working memory impairment in schizophrenia
10.1016/j.biopsych.2016.02.017 · 2016 · External reference
Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia
10.1001/archgenpsychiatry.2009.91 · 2009 · External reference
Prefrontal cortex dysfunction during working memory performance in schizophrenia: Reconciling discrepant findings
10.1016/s0920-9964(02)00294-3 · 2003 · External reference
Reduced prefrontal-parietal effective connectivity and working memory deficits in schizophrenia
10.1523/jneurosci.3405-11.2012 · 2012 · External reference
Abnormal functional activation and connectivity in the working memory network in early-onset schizophrenia
10.1016/j.jaac.2012.06.020 · 2012 · External reference
Dopamine D2 receptors regulate the anatomical and functional balance of basal ganglia circuitry
10.1016/j.neuron.2013.10.041 · 2014 · External reference
