Research graph
References from Modeling Intrahippocampal Effects of Anterior Hippocampal Hyperactivity Relevant to Schizophrenia Using Chemogenetic Excitation of Long Axis–Projecting Mossy Cells in the Mouse Dentate Gyrus. Local targets link to admitted publications; unresolved targets remain external evidence.
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
10.1016/j.neuron.2013.02.011 · 2013 · External reference
Anterior hippocampal and orbitofrontal cortical structural brain abnormalities in association with cognitive deficits in schizophrenia
10.1016/j.schres.2009.07.016 · 2009 · External reference
Regionally specific volume deficits along the hippocampal long axis in early and chronic psychosis
10.1016/j.nicl.2018.10.021 · 2018 · External reference
Smaller anterior hippocampal formation volume in antipsychotic-naive patients with first-episode schizophrenia
10.1176/appi.ajp.160.12.2190 · 2003 · External reference
Hippocampal volume in early psychosis: A 2-year longitudinal study
10.1038/s41398-020-00985-1 · 2020 · External reference
Hyperactivity and reduced activation of anterior hippocampus in early psychosis
10.1176/appi.ajp.2019.19020151 · 2019 · External reference
Increased hippocampal CA1 cerebral blood volume in schizophrenia
10.1016/j.nicl.2014.07.004 · 2014 · External reference
Differential targeting of the CA1 subfield of the hippocampal formation by schizophrenia and related psychotic disorders
10.1001/archgenpsychiatry.2009.115 · 2009 · External reference
Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis
10.1038/s41386-017-0004-6 · 2018 · External reference
Intrinsic hippocampal activity as a biomarker for cognition and symptoms in schizophrenia
10.1176/appi.ajp.2013.13070981 · 2014 · External reference
Functional neuroanatomical correlates of episodic memory impairment in early phase psychosis
10.1007/s11682-015-9357-9 · 2016 · External reference
Impact of schizophrenia on anterior and posterior hippocampus during memory for complex scenes
10.1016/j.nicl.2016.11.017 · 2016 · External reference
Disrupted habituation in the early stage of psychosis
2019 · External reference
Sustained activation of the hippocampus in response to fearful faces in schizophrenia
10.1016/j.biopsych.2005.01.033 · 2005 · External reference
Relating basal and phasic hippocampal activity in people with psychosis: A translational bridge to understanding memory deficits?
10.1176/appi.ajp.2019.19090966 · 2019 · External reference
Cognitive deficits caused by prefrontal cortical and hippocampal neural disinhibition
10.1111/bph.13850 · 2017 · External reference
Hippocampal hyperactivity as a druggable circuit-level origin of aberrant salience in schizophrenia
10.3389/fphar.2020.486811 · 2020 · External reference
Dopamine system dysregulation by the hippocampus: Implications for the pathophysiology and treatment of schizophrenia
10.1016/j.neuropharm.2011.05.011 · 2012 · External reference
Hippocampal–prefrontal input supports spatial encoding in working memory
10.1038/nature14445 · 2015 · External reference
Theta rhythms coordinate hippocampal-prefrontal interactions in a spatial memory task
10.1371/journal.pbio.0030402 · 2005 · External reference
Working memory performance correlates with prefrontal-hippocampal theta interactions but not with prefrontal neuron firing rates
2010 · External reference
Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia
10.1038/nature08855 · 2010 · External reference
Theta oscillations in the medial prefrontal cortex are modulated by spatial working memory and synchronize with the hippocampus through its ventral subregion
10.1523/jneurosci.2378-13.2013 · 2013 · External reference
Optogenetic induction of the schizophrenia-related endophenotype of ventral hippocampal hyperactivity causes rodent correlates of positive and cognitive symptoms
10.1038/s41598-018-31163-5 · 2018 · External reference
The enigmatic mossy cell of the dentate gyrus
10.1038/nrn.2016.87 · 2016 · External reference
Hilar mossy cells of the dentate gyrus: A historical perspective
10.3389/fncir.2012.00106 · 2013 · External reference
The development, ultrastructure and synaptic connections of the mossy cells of the dentate gyrus
10.1007/bf01170832 · 1985 · External reference
The mossy cells of the fascia dentata: A comparative study of their fine structure and synaptic connections in rodents and primates
10.1002/cne.903120111 · 1991 · External reference
Distribution, ultrastructure, and connectivity of calretinin-immunoreactive mossy cells of the mouse dentate gyrus
10.1002/(sici)1098-1063(1997)7:3<307::aid-hipo6>3.0.co;2-h · 1997 · External reference
Distribution of calretinin immunoreactivity in the mouse dentate gyrus: II. Mossy cells, with special reference to their dorsoventral difference in calretinin immunoreactivity
10.1016/s0306-4522(97)00261-3 · 1998 · External reference
Dentate gyrus mossy cells control spontaneous convulsive seizures and spatial memory
10.1126/science.aan4074 · 2018 · External reference
Excitatory effects of dentate gyrus mossy cells and their ability to influence granule cell firing: An optogenetic study in adult mouse hippocampal slices
2020 · External reference
Ventro-dorsal hippocampal pathway gates novelty-induced contextual memory formation
10.1016/j.cub.2020.09.074 · 2021 · External reference
Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions
10.1523/jneurosci.13-09-03916.1993 · 1993 · External reference
Spatial learning with a minislab in the dorsal hippocampus
10.1073/pnas.92.21.9697 · 1995 · External reference
Electrophysiology of morphologically identified mossy cells of the dentate hilus recorded in guinea pig hippocampal slices
10.1523/jneurosci.08-10-03812.1988 · 1988 · External reference
Comparing phenotypic variation between inbred and outbred mice
10.1038/s41592-018-0224-7 · 2018 · External reference
Ultrasensitive fluorescent proteins for imaging neuronal activity
10.1038/nature12354 · 2013 · External reference
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice
10.1172/jci46229 · 2011 · External reference
Calretinin and calbindin distribution patterns specify subpopulations of type I and type II spiral ganglion neurons in postnatal murine cochlea
10.1002/cne.23535 · 2014 · External reference
Chemogenetic silencing of hippocampal neurons suppresses epileptic neural circuits
10.1172/jci95731 · 2019 · External reference
Altered cortical GABAA receptor composition, physiology, and endocytosis in a mouse model of a human genetic absence epilepsy syndrome
10.1074/jbc.m112.444372 · 2013 · External reference
Hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal CA1 neurons
10.1523/jneurosci.4838-11.2011 · 2011 · External reference
Examining object location and object recognition memory in mice
2014 · External reference
Nucleus accumbens D2R cells signal prior outcomes and control risky decision-making
10.1038/nature17400 · 2016 · External reference
Axon arbors and synaptic connections of hippocampal mossy cells in the rat in vivo
10.1002/(sici)1096-9861(19960304)366:2<270::aid-cne7>3.0.co;2-2 · 1996 · External reference
Commissural projection to the dentate gyrus of the rat: Evidence for feed-forward inhibition
10.1016/0006-8993(81)90413-3 · 1981 · External reference
Associational and commissural collaterals of neurons in the hippocampal formation (hilus fasciae dentatae and subfield CA3)
10.1016/0006-8993(81)90463-7 · 1981 · External reference
Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus
10.1016/j.neuron.2012.12.038 · 2013 · External reference
Mossy cells in the dorsal and ventral dentate gyrus differ in their patterns of axonal projections
10.1523/jneurosci.2455-20.2020 · 2021 · External reference
Distribution of calretinin immunoreactivity in the mouse dentate gyrus. I. General description
10.1007/bf00227262 · 1996 · External reference
Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus
10.1002/hipo.22044 · 2012 · External reference
drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus
10.1002/hipo.22408 · 2015 · External reference
Hilar mossy cell degeneration causes transient dentate granule cell hyperexcitability and impaired pattern separation
10.1016/j.neuron.2012.10.036 · 2012 · External reference
In vivo imaging of dentate gyrus mossy cells in behaving mice
10.1016/j.neuron.2016.12.019 · 2017 · External reference
Spatial representations of granule cells and mossy cells of the dentate gyrus
10.1016/j.neuron.2016.12.026 · 2017 · External reference
Physiological properties and behavioral correlates of hippocampal granule cells and mossy cells
10.1016/j.neuron.2016.12.011 · 2017 · External reference
Framing spatial cognition: Neural representations of proximal and distal frames of reference and their roles in navigation
10.1152/physrev.00021.2010 · 2011 · External reference
Rearing on hind legs, environmental novelty, and the hippocampal formation
10.1515/revneuro.2006.17.1-2.111 · 2006 · External reference
Hippocampal network dynamics during rearing episodes
10.1016/j.celrep.2018.04.021 · 2018 · External reference
Ultrastructural localization of neurotransmitter immunoreactivity in mossy cell axons and their synaptic targets in the rat dentate gyrus
10.1002/(sici)1098-1063(1997)7:5<559::aid-hipo11>3.0.co;2-# · 1997 · External reference
AAV-mediated anterograde transsynaptic tagging: Mapping corticocollicular input-defined neural pathways for defense behaviors
10.1016/j.neuron.2016.11.045 · 2017 · External reference
Synaptic specificity and application of anterograde transsynaptic AAV for probing neural circuitry
10.1523/jneurosci.2158-19.2020 · 2020 · External reference
The hippocampal CA3 network: An in vivo intracellular labeling study
10.1002/cne.903390204 · 1994 · External reference
HDAC inhibition modulates hippocampus-dependent long-term memory for object location in a CBP-dependent manner
10.1101/lm.1986911 · 2011 · External reference
An excitatory and epileptogenic effect of dentate gyrus mossy cells in a mouse model of epilepsy
10.1016/j.celrep.2019.10.100 · 2019 · External reference
Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons
10.1152/jn.1995.74.1.179 · 1995 · External reference
Differential recruitment of dentate gyrus interneuron types by commissural versus perforant pathways
10.1093/cercor/bhv127 · 2016 · External reference
Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice
10.1523/jneurosci.1724-20.2021 · 2021 · External reference
Ionic currents underlying rhythmic bursting of ventral mossy cells in the developing mouse dentate gyrus
10.1046/j.1460-9568.2003.02569.x · 2003 · External reference
Acute restraint stress decreases c-fos immunoreactivity in hilar mossy cells of the adult dentate gyrus
10.1007/s00429-016-1349-z · 2017 · External reference
Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo
10.1002/hipo.22138 · 2013 · External reference
Dorsal and ventral mossy cells differ in their axonal projections throughout the dentate gyrus of the mouse hippocampus
10.1002/hipo.23314 · 2021 · External reference
The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory
10.1038/nn.3359 · 2013 · External reference
Mossy cells control adult neural stem cell quiescence and maintenance through a dynamic balance between direct and indirect pathways
10.1016/j.neuron.2018.07.010 · 2018 · External reference
Parallel emergence of stable and dynamic memory engrams in the hippocampus
10.1038/s41586-018-0191-2 · 2018 · External reference
Dentate gyrus volume deficit in schizophrenia
10.1017/s0033291719001144 · 2020 · External reference
Hippocampal volume and hippocampal neuron density, number and size in schizophrenia: A systematic review and meta-analysis of postmortem studies [published online ahead of print Jul 28]
2020 · External reference
Glutamate receptors and transporters in the hippocampus in schizophrenia
10.1196/annals.1300.006 · 2003 · External reference
The hippocampus in schizophrenia: A review of the neuropathological evidence and its pathophysiological implications
10.1007/s00213-003-1761-y · 2004 · External reference
A mesoscale connectome of the mouse brain
10.1038/nature13186 · 2014 · External reference
