Research graph
References from Disentangling Independent and Mediated Causal Relationships Between Blood Metabolites, Cognitive Factors, and Alzheimer’s Disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2016 · External reference
Relationship between education and dementia: An updated systematic review
10.1097/wad.0b013e318211c83c · 2011 · External reference
Alzheimer’s disease and intelligence
10.2174/156720511795745276 · 2011 · External reference
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
10.1016/s0140-6736(20)30367-6 · 2020 · External reference
Education, intelligence and Alzheimer’s disease: Evidence from a multivariable two-sample Mendelian randomization study
10.1093/ije/dyz280 · 2020 · External reference
Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
10.1136/bmj.j5375 · 2017 · External reference
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
10.1038/s41588-018-0311-9 · 2019 · External reference
Genomic variation in educational attainment modifies Alzheimer disease risk
10.1212/nxg.0000000000000310 · 2019 · External reference
Metabolomic-guided discovery of Alzheimer’s disease biomarkers from body fluid
10.1002/jnr.24048 · 2017 · External reference
Integrative analysis of metabolomics and transcriptomics data: A unified model framework to identify underlying system pathways
10.1371/journal.pone.0072116 · 2013 · External reference
Application of metabolomics approaches to the study of respiratory diseases
10.4155/bio.12.218 · 2012 · External reference
Evidence of altered phosphatidylcholine metabolism in Alzheimer’s disease
10.1016/j.neurobiolaging.2013.08.001 · 2014 · External reference
Association of blood lipids with Alzheimer’s disease: A comprehensive lipidomics analysis
10.1016/j.jalz.2016.08.003 · 2017 · External reference
Plasma metabolite profiles of Alzheimer’s disease and mild cognitive impairment
10.1021/pr5000895 · 2014 · External reference
Metabolite profiling for the identification of altered metabolic pathways in Alzheimer’s disease
10.1016/j.jpba.2014.10.010 · 2015 · External reference
‘Mendelian randomization’: Can genetic epidemiology contribute to understanding environmental determinants of disease?
10.1093/ije/dyg070 · 2003 · External reference
An examination of multivariable Mendelian randomization in the single-sample and two-sample summary data settings
10.1093/ije/dyy262 · 2019 · External reference
Dissecting causal pathways using mendelian randomization with summarized genetic data: Application to age at menarche and risk of breast cancer
10.1534/genetics.117.300191 · 2017 · External reference
Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer’s disease
10.1073/pnas.2009808118 · 2021 · External reference
Lifetime cognition and late midlife blood metabolites: Findings from a British birth cohort
10.1038/s41398-018-0253-0 · 2018 · External reference
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
10.1038/ncomms11122 · 2016 · External reference
The Alzheimer’s disease neuroimaging initiative: Progress report and future plans
10.1016/j.jalz.2010.03.007 · 2010 · External reference
AddNeuroMed–The European collaboration for the discovery of novel biomarkers for Alzheimer’s disease
10.1111/j.1749-6632.2009.05064.x · 2009 · External reference
Alzheimer’s disease biomarker discovery using SOMAscan multiplexed protein technology
10.1016/j.jalz.2013.09.016 · 2014 · External reference
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
10.1038/s41588-019-0358-2 · 2019 · External reference
Gene discovery and polygenic prediction from a 1.1-million-person GWAS of educational attainment
10.1038/s41588-018-0147-3 · 2018 · External reference
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
10.1038/s41588-018-0152-6 · 2018 · External reference
LD score regression distinguishes confounding from polygenicity in genome-wide association studies
10.1038/ng.3211 · 2015 · External reference
Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions
10.1038/tp.2016.246 · 2016 · External reference
Mendelian randomization analysis with multiple genetic variants using summarized data.
10.1002/gepi.21758 · 2013 · External reference
Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease
10.1161/circresaha.117.312086 · 2018 · External reference
Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator
10.1002/gepi.21965 · 2016 · External reference
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · 2018 · External reference
PRSice-2: Polygenic Risk Score software for biobank-scale data
10.1093/gigascience/giz082 · 2019 · External reference
Conducting meta-analyses in R with the metafor package
2010 · External reference
A comparison of methods to test mediation and other intervening variable effects
10.1037/1082-989x.7.1.83 · 2002 · External reference
Mendelian randomization with invalid instruments: Effect estimation and bias detection through Egger regression
10.1093/ije/dyv080 · 2015 · External reference
Guidelines for performing Mendelian randomization investigations
10.12688/wellcomeopenres.15555.1 · 2019 · External reference
Selecting likely causal risk factors from high-throughput experiments using multivariable Mendelian randomization
10.1038/s41467-019-13870-3 · 2020 · External reference
Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
10.3389/fncel.2013.00038 · 2013 · External reference
Nonadditive effects of genes in human metabolomics
10.1534/genetics.115.175760 · 2015 · External reference
Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia
10.1371/journal.pgen.1007667 · 2018 · External reference
An atlas of genetic influences on human blood metabolites
10.1038/ng.2982 · 2014 · External reference
Common methods for performing Mendelian randomization
10.3389/fcvm.2018.00051 · 2018 · External reference
Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies
10.1016/j.jalz.2017.11.012 · 2018 · External reference
Chapter 70 - Glutamine as a potential neuroprotectant in Alzheimer’s disease
2015 · External reference
Elevated glutamate and glutamine levels in the cerebrospinal fluid of patients with probable Alzheimer’s disease and depression
10.3389/fpsyt.2018.00561 · 2018 · External reference
Prevalence of coronary heart disease in the Framingham Offspring Study: Role of lipoprotein cholesterols
10.1016/0002-9149(80)90516-0 · 1980 · External reference
HDL and reverse cholesterol transport
10.1161/circresaha.119.312617 · 2019 · External reference
Relationship between HDL functional characteristics and cardiovascular health and potential impact of dietary patterns: A narrative review
10.3390/nu11061231 · 2019 · External reference
HDL from an Alzheimer’s disease perspective
10.1097/mol.0000000000000604 · 2019 · External reference
Risk prediction of late-onset Alzheimer’s disease implies an oligogenic architecture
10.1038/s41467-020-18534-1 · 2020 · External reference
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease
10.1038/ng.2802 · 2013 · External reference
Genome-wide association study identifies 74 loci associated with educational attainment
10.1038/nature17671 · 2016 · External reference
A combined analysis of genetically correlated traits identifies 187 loci and a role for neurogenesis and myelination in intelligence
10.1038/s41380-017-0001-5 · 2019 · External reference
LDL and HDL subclasses in acute ischemic stroke: Prediction of risk and short-term mortality
10.1016/j.atherosclerosis.2009.11.040 · 2010 · External reference
Positive correlation between elevated plasma cholesterol levels and cognitive impairments in LDL receptor knockout mice: Relevance of cortico-cerebral mitochondrial dysfunction and oxidative stress
10.1016/j.neuroscience.2011.09.009 · 2011 · External reference
Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function
10.1016/j.jash.2014.04.007 · 2014 · External reference
LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: The Hisayama study
10.1161/strokeaha.108.529537 · 2009 · External reference
Triglycerides are negatively correlated with cognitive function in nondemented aging adults
10.1037/neu0000335 · 2017 · External reference
Obesity and hypertriglyceridemia produce cognitive impairment
10.1210/en.2007-1722 · 2008 · External reference
Lipids and cognition
10.3233/jad-2010-091576 · 2010 · External reference
Serum triglycerides in Alzheimer disease: Relation to neuroimaging and CSF biomarkers
10.1212/wnl.0000000000009436 · 2020 · External reference
HMDB 4.0: The human metabolome database for 2018
10.1093/nar/gkx1089 · 2018 · External reference
Signs and symptoms preceding the diagnosis of Alzheimer’s disease: A systematic scoping review of literature from 1937 to 2016
10.1136/bmjopen-2016-015746 · 2017 · External reference
Cerebrospinal fluid biomarkers for understanding multiple aspects of Alzheimer’s disease pathogenesis
10.1007/s00018-019-03040-5 · 2019 · External reference
Association of cerebrospinal fluid neurofilament light concentration with Alzheimer disease progression
10.1001/jamaneurol.2015.3037 · 2016 · External reference
Review and meta-analysis of biomarkers and diagnostic imaging in Alzheimer’s disease
10.3233/jad-2011-110458 · 2011 · External reference
