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References from A cAMP-Related Gene Network in Microglia Is Inversely Regulated by Morphine Tolerance and Withdrawal. Local targets link to admitted publications; unresolved targets remain external evidence.
Deaths involving fentanyl, fentanyl analogs, and U-47700—10 states, July-December 2016
10.15585/mmwr.mm6643e1 · 2017 · External reference
Increases in drug and opioid-involved overdose deaths—United States, 2010-2015
10.15585/mmwr.mm655051e1 · 2016 · External reference
Differential behavioral and molecular alterations upon protracted abstinence from cocaine versus morphine, nicotine, THC and alcohol
10.1111/adb.12405 · 2017 · External reference
Mu-opioid receptor activation induces transcriptional plasticity in the central extended amygdala
10.1111/j.1460-9568.2008.06273.x · 2008 · External reference
Protracted abstinence from distinct drugs of abuse shows regulation of a common gene network
10.1111/j.1369-1600.2011.00365.x · 2012 · External reference
Targeting morphine-responsive neurons: Generation of a knock-in mouse line expressing Cre recombinase from the Mu-opioid receptor gene locus
10.1523/eneuro.0433-19.2020 · 2020 · External reference
Glial and neuroinflammatory targets for treating substance use disorders
10.1016/j.drugalcdep.2017.08.003 · 2017 · External reference
Glial and neuroimmune mechanisms as critical modulators of drug use and abuse
10.1038/npp.2016.121 · 2017 · External reference
Glial mechanisms underlying substance use disorders
10.1111/ejn.14163 · 2019 · External reference
Microglia emerge as central players in brain disease
10.1038/nm.4397 · 2017 · External reference
Detection and function of opioid receptors on cells from the immune system
10.1128/cdli.7.5.719-723.2000 · 2000 · External reference
Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at mu-opioid receptor-expressing glia
10.1093/brain/awr281 · 2011 · External reference
Microglia express Mu opioid receptor: Insights from transcriptomics and fluorescent reporter mice
10.3389/fpsyt.2018.00726 · 2018 · External reference
Site-specific regulation of P2X7 receptor function in microglia gates morphine analgesic tolerance
10.1523/jneurosci.0852-17.2017 · 2017 · External reference
Negative feedback control of neuronal activity by microglia
10.1038/s41586-020-2777-8 · 2020 · External reference
Microglial Gi-dependent dynamics regulate brain network hyperexcitability
10.1038/s41593-020-00756-7 · 2021 · External reference
CCL5 and cytokine expression in the rat brain: Differential modulation by chronic morphine and morphine withdrawal
10.1016/j.bbi.2013.08.006 · 2013 · External reference
Reduction of opioid withdrawal and potentiation of acute opioid analgesia by systemic AV411 (ibudilast)
10.1016/j.bbi.2008.09.012 · 2009 · External reference
Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents
10.1038/nm.4281 · 2017 · External reference
Procyanidins alleviates morphine tolerance by inhibiting activation of NLRP3 inflammasome in microglia
10.1186/s12974-016-0520-z · 2016 · External reference
The activation of mu-opioid receptor potentiates LPS-induced NF-kB promoting an inflammatory phenotype in microglia
10.1002/1873-3468.12313 · 2016 · External reference
Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation
10.1073/pnas.1602070113 · 2016 · External reference
Discovery of a novel site of opioid action at the innate immune pattern-recognition receptor TLR4 and its role in addiction
10.1016/b978-0-12-801284-0.00006-3 · 2014 · External reference
Essential role of toll-like receptor 2 in morphine-induced microglia activation in mice
10.1016/j.neulet.2010.11.063 · 2011 · External reference
Astrocytes locally translate transcripts in their peripheral processes
10.1073/pnas.1617782114 · 2017 · External reference
Re-evaluating microglia expression profiles using RiboTag and cell isolation strategies
10.1038/s41590-018-0110-6 · 2018 · External reference
Morphine-induced analgesic tolerance, locomotor sensitization and physical dependence do not require modification of mu opioid receptor, cdk5 and adenylate cyclase activity
10.1016/j.neuropharm.2007.10.015 · 2008 · External reference
Loss of mu opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia
10.1038/nm.4262 · 2017 · External reference
Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress
10.1038/s41380-020-0750-4 · 2021 · External reference
The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update
10.1093/nar/gkw343 · 2016 · External reference
Salmon provides fast and bias-aware quantification of transcript expression
10.1038/nmeth.4197 · 2017 · External reference
Stress induces divergent gene expression among lateral habenula efferent pathways
10.1016/j.ynstr.2020.100268 · 2020 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs
10.1093/nar/gkz401 · 2019 · External reference
WGCNA: An R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Unresolved reference
2010 · External reference
Unresolved reference
2021 · External reference
3DMorph automatic analysis of microglial morphology in three dimensions from ex vivo and in vivo imaging
10.1523/eneuro.0266-18.2018 · 2018 · External reference
Brain cell type specific gene expression and co-expression network architectures
10.1038/s41598-018-27293-5 · 2018 · External reference
Defining clusters from a hierarchical cluster tree: the Dynamic Tree Cut package for R
10.1093/bioinformatics/btm563 · 2008 · External reference
Nanoscale surveillance of the brain by microglia via cAMP-regulated filopodia
10.1016/j.celrep.2019.05.010 · 2019 · External reference
Transcriptional profiling of microglia; current state of the art and future perspectives
10.1002/glia.23767 · 2020 · External reference
Phactrs 1-4: A family of protein phosphatase 1 and actin regulatory proteins
10.1073/pnas.0401673101 · 2004 · External reference
Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus
10.1038/srep09666 · 2015 · External reference
Efferent pathways of the mouse lateral habenula
10.1002/cne.23662 · 2015 · External reference
P2Y12 receptor mediates microglial activation via RhoA/ROCK pathway in the trigeminal nucleus caudalis in a mouse model of chronic migraine
10.1186/s12974-019-1603-4 · 2019 · External reference
Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain
10.1016/j.bbi.2015.11.007 · 2016 · External reference
Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents
10.1016/j.nbd.2014.06.011 · 2014 · External reference
