Research graph
References from Dose-Dependent Dissociation of Pro-cognitive Effects of Donepezil on Attention and Cognitive Flexibility in Rhesus Monkeys. Local targets link to admitted publications; unresolved targets remain external evidence.
Responses to donepezil in Alzheimer’s disease and Parkinson’s disease
10.1111/j.1749-6632.2002.tb04856.x · 2002 · External reference
Donepezil hydrochloride: A treatment drug for Alzheimer’s disease
10.1002/1528-0691(2001)1:1<63::aid-tcr9>3.0.co;2-j · 2001 · External reference
Cholinesterase as a target for drug development in Alzheimer’s disease
2020 · External reference
Relevance of donepezil in enhancing learning and memory in special populations: A review of the literature
10.1007/s10803-006-0322-8 · 2007 · External reference
Neuromodulation of prefrontal cortex cognitive function in primates: The powerful roles of monoamines and acetylcholine
10.1038/s41386-021-01100-8 · 2022 · External reference
Pharmacological enhancement of memory and executive functioning in laboratory animals
10.1038/npp.2010.158 · 2011 · External reference
Donepezil improves cognition and global function in Alzheimer disease: A 15-week, double-blind, placebo-controlled study. Donepezil Study Group
10.1001/archinte.158.9.1021 · 1998 · External reference
Donepezil-treated patients with probable vascular dementia demonstrate cognitive benefits
10.1111/j.1749-6632.2002.tb04859.x · 2002 · External reference
Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer’s disease
10.1002/gps.1319 · 2005 · External reference
Meta-analysis of randomized controlled trials on the efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer’s disease
10.3389/fnins.2019.00472 · 2019 · External reference
Central cholinergic systems and cognition
10.1146/annurev.psych.48.1.649 · 1997 · External reference
Muscarinic acetylcholine receptors as CNS drug targets
10.1016/j.pharmthera.2007.09.009 · 2008 · External reference
Muscarinic M1 and M4 receptors: Hypothesis driven drug development for schizophrenia
10.1016/j.psychres.2020.112989 · 2020 · External reference
Targeting muscarinic receptors to treat schizophrenia
10.1016/j.bbr.2021.113201 · 2021 · External reference
The M1 muscarinic positive allosteric modulator PQCA improves performance on translatable tests of memory and attention in rhesus monkeys
10.1124/jpet.115.226712 · 2015 · External reference
Gradients of receptor expression in the macaque cortex
2021 · External reference
Striatal, hippocampal, and cortical networks are differentially responsive to the M4- and M1-muscarinic acetylcholine receptor mediated effects of xanomeline [published correction appears in ACS Chem Neurosci 2019; 10:3910]
10.1021/acschemneuro.8b00625 · 2019 · External reference
Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis
10.1002/syn.10310 · 2004 · External reference
Difficulty of visual search modulates neuronal interactions and response variability in the frontal eye field [published correction appears in J Neurophysiol 2008; 99:1050]
10.1152/jn.00522.2007 · 2007 · External reference
Selective enhancement of associative learning by microstimulation of the anterior caudate
10.1038/nn1662 · 2006 · External reference
Indirect pathway from caudate tail mediates rejection of bad objects in periphery
10.1126/sciadv.aaw9297 · 2019 · External reference
Improved cognition without adverse effects: Novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey
10.1007/s00213-014-3813-x · 2015 · External reference
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates
10.1016/j.neuropharm.2012.10.019 · 2013 · External reference
Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
10.1385/jmn:24:1:085 · 2004 · External reference
Sex dimorphisms in the cognitive-enhancing action of the Alzheimer’s drug donepezil in aged Rhesus monkeys
10.1016/s0028-3908(02)00378-7 · 2003 · External reference
The scopolamine-reversal paradigm in rats and monkeys: The importance of computer-assisted operant-conditioning memory tasks for screening drug candidates
10.1007/s00213-007-0887-8 · 2008 · External reference
Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys
10.1007/s002130050310 · 1997 · External reference
Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice
10.1038/sj.npp.1300761 · 2005 · External reference
A computer-automated touchscreen paired-associates learning (PAL) task for mice: Impairments following administration of scopolamine or dicyclomine and improvements following donepezil
10.1007/s00213-010-2050-1 · 2011 · External reference
Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: Acquisition versus consolidation
10.1007/s00213-004-1967-7 · 2005 · External reference
Chromaproline and chromaperidine, nicotine agonists, and donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats
10.1016/s0091-3057(02)00988-7 · 2002 · External reference
Impaired attention in the 3xTgAD mouse model of Alzheimer’s disease: Rescue by donepezil (Aricept)
10.1523/jneurosci.5242-10.2011 · 2011 · External reference
USE: An integrative suite for temporally-precise psychophysical experiments in virtual environments for human, nonhuman, and artificially intelligent agents
10.1016/j.jneumeth.2019.108374 · 2019 · External reference
Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C] methylpiperidin-4-yl acetate ([11C]MP4A) and PET
10.1038/sj.npp.1300759 · 2005 · External reference
Comprehensiv observational assessment: Ia. A systematic, quantitative procedure for assessing the behavioral and physiologic state of the mouse
10.1007/bf00401402 · 1968 · External reference
Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor
10.1016/s0022-3565(24)37092-2 · 1997 · External reference
The muscarinic M1/M4 receptor agonist xanomeline exhibits antipsychotic-like activity in Cebus apella monkeys
10.1038/sj.npp.1300151 · 2003 · External reference
Modulation of arousal and sleep/wake architecture by M1 PAM VU0453595 across young and aged rodents and nonhuman primates
10.1038/s41386-020-00812-7 · 2020 · External reference
A kiosk station for the assessment of multiple cognitive domains and enrichment of monkeys
10.3389/fnbeh.2021.721069 · 2021 · External reference
Executive system dysfunction occurs as early as middle-age in the rhesus monkey
10.1016/j.neurobiolaging.2005.08.004 · 2006 · External reference
Dissociable components of rule-guided behavior depend on distinct medial and prefrontal regions
10.1126/science.1172377 · 2009 · External reference
Solid phase microextraction-based miniaturized probe and protocol for extraction of neurotransmitters from brains in vivo
10.1021/acs.analchem.9b00995 · 2019 · External reference
Multineuromodulator measurements across fronto-striatal network areas of the behaving macaque using solid-phase microextraction
10.1152/jn.00321.2019 · 2019 · External reference
Chemistry of the adaptive mind: Lessons from dopamine
10.1016/j.neuron.2019.09.035 · 2019 · External reference
Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels
10.1111/j.1460-9568.2004.03614.x · 2004 · External reference
Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
10.1523/jneurosci.1521-08.2008 · 2008 · External reference
The role of primate prefrontal cortex in bias and shift between visual dimensions
10.1093/cercor/bhz072 · 2020 · External reference
Unresolved reference
2012 · External reference
Selective inhibition of distracting input
10.1016/j.bbr.2017.10.010 · 2018 · External reference
Long-range attention networks: Circuit motifs underlying endogenously controlled stimulus selection
10.1016/j.tins.2015.08.009 · 2015 · External reference
Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility
10.1016/j.jphysparis.2016.07.001 · 2016 · External reference
Double dissociation of nicotinic α7 and α4/β2 sub-receptor agonists for enhancing learning and attentional filtering of distraction
2018 · External reference
A computational psychiatry approach identifies how alpha-2A noradrenergic agonist guanfacine affects feature-based reinforcement learning in the macaque
10.1038/srep40606 · 2017 · External reference
Nicotinic receptors and attention
10.1007/978-3-319-13665-3_5 · 2015 · External reference
Cholinergic, but not dopaminergic or noradrenergic, enhancement sharpens visual spatial perception in humans
10.1523/jneurosci.2405-16.2017 · 2017 · External reference
Effects of ventral striatum lesions on stimulus-based versus action-based reinforcement learning
10.1523/jneurosci.0631-17.2017 · 2017 · External reference
Top-down attentional deficits in macaques with lesions of lateral prefrontal cortex
10.1523/jneurosci.2939-07.2007 · 2007 · External reference
Dynamic network connectivity: A new form of neuroplasticity
10.1016/j.tics.2010.05.003 · 2010 · External reference
Basal forebrain lesions in monkeys disrupt attention but not learning and memory [published correction appears in J Neurosci 1995; 15]
10.1523/jneurosci.14-01-00167.1994 · 1994 · External reference
Nicotinic α7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex
10.1073/pnas.1307849110 · 2013 · External reference
Muscarinic M1 receptors modulate working memory performance and activity via KCNQ potassium channels in the primate prefrontal cortex
10.1016/j.neuron.2020.02.030 · 2020 · External reference
Prefrontal dopamine and behavioral flexibility: Shifting from an “inverted-U” toward a family of functions
10.3389/fnins.2013.00062 · 2013 · External reference
Muscarinic M1 receptor overstimulation disrupts working memory activity for rules in primate prefrontal cortex
10.1016/j.neuron.2018.05.027 · 2018 · External reference
Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits
10.1016/j.brainres.2004.11.042 · 2005 · External reference
Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer’s disease
10.1097/00004714-200212000-00012 · 2002 · External reference
Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer’s disease
10.2165/00023210-200115050-00004 · 2001 · External reference
Donepezil and rivastigmine: Pharmacokinetic profile and brain-targeting after intramuscular administration in rats
2020 · External reference
Direct and indirect pathways for choosing objects and actions
10.1111/ejn.13876 · 2019 · External reference
Theory of solid-phase microextraction
10.1093/chromsci/38.7.270 · 2000 · External reference
Solid-phase microextraction: A complementary invivosampling method to microdialysis
10.1002/anie.201304538 · 2013 · External reference
In vivo brain sampling using a microextraction probe reveals metabolic changes in rodents after deep brain stimulation
10.1021/acs.analchem.9b01540 · 2019 · External reference
Optimization of solid phase microextraction coatings for liquid chromatography mass spectrometry determination of neurotransmitters
10.1016/j.chroma.2014.03.035 · 2014 · External reference
Toward the future of psychiatric diagnosis: The seven pillars of RDoC
10.1186/1741-7015-11-126 · 2013 · External reference
Modulatory compartments in cortex and local regulation of cholinergic tone
10.1016/j.jphysparis.2016.08.001 · 2016 · External reference
Endogenous acetylcholine and its modulation of cortical microcircuits to enhance cognition
10.1007/7854_2020_138 · 2020 · External reference
The effect of acetylcholinesterase inhibition on the release of acetylcholine from the striatum in vivo: Interaction with autoreceptor responses
10.1016/0304-3940(90)90101-e · 1990 · External reference
Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons
10.1016/j.ejphar.2005.10.028 · 2005 · External reference