Research graph
References from Animal Models of Relevance to the Schizophrenia Prodrome. Local targets link to admitted publications; unresolved targets remain external evidence.
The initial prodrome in psychosis: Descriptive and qualitative aspects
10.3109/00048679609062654 · 1996 · External reference
Mapping the onset of psychosis: The Comprehensive Assessment of At-Risk Mental States
10.1080/j.1440-1614.2005.01714.x · 2005 · External reference
Early detection and intervention in schizophrenia: Research
10.1093/schbul/22.2.327 · 1996 · External reference
Declining transition rates to psychotic disorder in “ultra-high risk” clients: Investigation of a dilution effect
10.1016/j.schres.2015.11.026 · 2016 · External reference
Treatment-resistant schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology
10.1176/appi.ajp.2016.16050503 · 2017 · External reference
Two distinct patterns of treatment resistance: Clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses
10.1017/s0033291716002014 · 2016 · External reference
Treatments of negative symptoms in schizophrenia: Meta-analysis of 168 randomized placebo-controlled trials
10.1093/schbul/sbu170 · 2015 · External reference
“First do no harm.” A systematic review of the prevalence and management of antipsychotic adverse effects
10.1177/0269881114562090 · 2015 · External reference
Schizophrenia, dopamine and the striatum: From biology to symptoms
10.1016/j.tins.2018.12.004 · 2019 · External reference
Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
10.1176/ajp.2006.163.5.790 · 2006 · External reference
Randomized controlled trial of interventions for young people at ultra-high risk of psychosis: Twelve-month outcome
10.4088/jcp.12m07785 · 2013 · External reference
112. Effects of ziprasidone versus placebo in patients at clinical high risk for psychosis
10.1093/schbul/sbx021.150 · 2017 · External reference
108. PREVENT: A randomized controlled trial for the prevention of first-episode psychosis comparing cognitive–behavior therapy (CBT), clinical management, and aripiprazole combined and clinical management and placebo combined
10.1093/schbul/sbx021.146 · 2017 · External reference
A putative animal model of the “prodromal” state of schizophrenia
10.1016/j.biopsych.2004.12.013 · 2005 · External reference
Postpubertal emergence of hyperresponsiveness to stress and to amphetamine after neonatal excitotoxic hippocampal damage: A potential animal model of schizophrenia
10.1038/npp.1993.44 · 1993 · External reference
Brain development during childhood and adolescence: A longitudinal MRI study
10.1038/13158 · 1999 · External reference
The influence of puberty on subcortical brain development
10.1016/j.neuroimage.2013.09.073 · 2014 · External reference
Longitudinal four-dimensional mapping of subcortical anatomy in human development
10.1073/pnas.1316911111 · 2014 · External reference
Typical development of basal ganglia, hippocampus, amygdala and cerebellum from age 7 to 24
10.1016/j.neuroimage.2014.03.072 · 2014 · External reference
Synaptic density in human frontal cortex — Developmental changes and effects of aging
10.1016/0006-8993(79)90349-4 · 1979 · External reference
Extraordinary neoteny of synaptic spines in the human prefrontal cortex
10.1073/pnas.1105108108 · 2011 · External reference
Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood
10.1001/archpsyc.1994.03950060041004 · 1994 · External reference
Functional connectivity of substantia nigra and ventral tegmental area: Maturation during adolescence and effects of ADHD
10.1093/cercor/bhs382 · 2014 · External reference
Age-related reduction in dopamine D1 receptors in the human brain: From late childhood to adulthood, a positron emission tomography study
10.1016/j.neuroscience.2010.01.034 · 2010 · External reference
Postnatal alterations in dopaminergic markers in the human prefrontal cortex
10.1016/j.neuroscience.2006.10.009 · 2007 · External reference
Maturation of the human striatal dopamine system revealed by PET and quantitative MRI
10.1038/s41467-020-14693-3 · 2020 · External reference
Maturational decrease of glutamate in the human cerebral cortex from childhood to young adulthood: A 1H-MR spectroscopy study
10.1038/pr.2017.101 · 2017 · External reference
Expression of interneuron markers in the dorsolateral prefrontal cortex of the developing human and in schizophrenia
10.1176/appi.ajp.2010.09060784 · 2010 · External reference
Mechanisms contributing to prefrontal cortex maturation during adolescence
10.1016/j.neubiorev.2016.05.013 · 2016 · External reference
The organizing actions of adolescent gonadal steroid hormones on brain and behavioral development
10.1016/j.neubiorev.2016.07.036 · 2016 · External reference
Modeling transformations of neurodevelopmental sequences across mammalian species
10.1523/jneurosci.5746-12.2013 · 2013 · External reference
The adolescent brain and age-related behavioral manifestations
10.1016/s0149-7634(00)00014-2 · 2000 · External reference
Animal models of schizophrenia
10.1111/j.1476-5381.2011.01386.x · 2011 · External reference
Defining the locus of dopaminergic dysfunction in schizophrenia: A meta-analysis and test of the mesolimbic hypothesis
10.1093/schbul/sbx180 · 2018 · External reference
Elevated striatal dopamine function linked to prodromal signs of schizophrenia
10.1001/archgenpsychiatry.2008.514 · 2009 · External reference
Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: Findings in a second cohort
10.1016/j.biopsych.2012.11.017 · 2013 · External reference
Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
10.1093/schbul/sbr194 · 2012 · External reference
Dopamine synthesis capacity before onset of psychosis: A prospective [18F]-DOPA PET imaging study
10.1176/appi.ajp.2011.11010160 · 2011 · External reference
Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: A PET study
10.1038/mp.2011.20 · 2011 · External reference
The amphetamine-induced sensitized state as a model of schizophrenia
10.1016/j.pnpbp.2007.08.025 · 2007 · External reference
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
10.1016/j.neuron.2006.01.023 · 2006 · External reference
The nature of dopamine dysfunction in schizophrenia and what this means for treatment
10.1001/archgenpsychiatry.2012.169 · 2012 · External reference
Insights about striatal circuit function and schizophrenia from a mouse model of dopamine D2 receptor upregulation
10.1016/j.biopsych.2016.07.004 · 2017 · External reference
Social behavior in a genetic model of dopamine dysfunction at different neurodevelopmental time points
10.1111/gbb.12233 · 2015 · External reference
A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia
10.1016/j.neuron.2010.02.014 · 2010 · External reference
Enhanced Dopamine in Prodromal Schizophrenia (EDiPS): A new animal model of relevance to schizophrenia
10.1038/s41537-019-0074-z · 2019 · External reference
Positive symptom phenotypes appear progressively in “EDiPS”, a new animal model of the schizophrenia prodrome
10.1038/s41598-021-83681-4 · 2021 · External reference
A longitudinal examination of the neurodevelopmental impact of prenatal immune activation in mice reveals primary defects in dopaminergic development relevant to schizophrenia
10.1523/jneurosci.5408-09.2010 · 2010 · External reference
Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: A novel neurodevelopmental model of schizophrenia
10.1038/sj.npp.1300248 · 2003 · External reference
Using a maternal immune stimulation model of schizophrenia to study behavioral and neurobiological alterations over the developmental course
10.1016/j.schres.2015.05.010 · 2015 · External reference
Ontogeny of sensorimotor gating and immune impairment induced by prenatal immune challenge in rats: Implications for the etiopathology of schizophrenia
10.1038/mp.2008.44 · 2010 · External reference
Effect of maternal lipopolysaccharide administration on the development of dopaminergic receptors and transporter in the rat offspring
10.1371/journal.pone.0054439 · 2013 · External reference
Neonatal lesions of the left entorhinal cortex affect dopamine metabolism in the rat brain
10.1016/s0006-8993(00)01985-5 · 2000 · External reference
Enhanced amphetamine sensitivity and increased expression of dopamine D2 receptors in postpubertal rats after neonatal excitotoxic lesions of the medial prefrontal cortex
10.1523/jneurosci.16-22-07366.1996 · 1996 · External reference
Neonatal depletion of cortical dopamine: Effects on dopamine turnover and motor behavior in juvenile and adult rats
10.1016/j.devbrainres.2005.02.006 · 2005 · External reference
Extracellular dopamine and norepinephrine in the developing rat prefrontal cortex: Transient effects of early partial loss of dopamine
10.1016/j.brainresbull.2009.01.012 · 2009 · External reference
Prenatal restraint stress differentially modifies basal and stimulated dopamine and noradrenaline release in the nucleus accumbens shell: An ‘in vivo’ microdialysis study in adolescent and young adult rats
10.1111/j.1460-9568.2008.06364.x · 2008 · External reference
The pathophysiological impact of stress on the dopamine system is dependent on the state of the critical period of vulnerability [published correction appears in Mol Psychiatry 2020; 25:3449]
10.1038/s41380-019-0514-1 · 2020 · External reference
Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits
10.1016/j.neuron.2010.01.019 · 2010 · External reference
Peripubertal mGluR2/3 agonist treatment prevents hippocampal dysfunction and dopamine system hyperactivity in adulthood in MAM model of schizophrenia
10.1093/schbul/sbab047 · 2021 · External reference
Nature of glutamate alterations in schizophrenia: A meta-analysis of proton magnetic resonance spectroscopy studies
10.1001/jamapsychiatry.2016.0442 · 2016 · External reference
Association of age, antipsychotic medication, and symptom severity in schizophrenia with proton magnetic resonance spectroscopy brain glutamate level: A mega-analysis of individual participant-level data
10.1001/jamapsychiatry.2021.0380 · 2021 · External reference
Higher levels of glutamate in the associative-striatum of subjects with prodromal symptoms of schizophrenia and patients with first-episode psychosis
10.1038/npp.2011.65 · 2011 · External reference
Striatal glutamate and the conversion to psychosis: A prospective 1H-MRS imaging study
10.1017/s1461145712000314 · 2013 · External reference
Association of hippocampal glutamate levels with adverse outcomes in individuals at clinical high risk for psychosis
10.1001/jamapsychiatry.2018.3252 · 2019 · External reference
Hippocampal pathology in individuals at ultra-high risk for psychosis: A multi-modal magnetic resonance study
10.1016/j.neuroimage.2010.04.012 · 2010 · External reference
Metabolic maturation of the human brain from birth through adolescence: Insights from in vivo magnetic resonance spectroscopy
10.1093/cercor/bhs283 · 2013 · External reference
Longitudinal in vivo maturational changes of metabolites in the prefrontal cortex of rats exposed to polyinosinic-polycytidylic acid in utero
10.1016/j.euroneuro.2015.09.022 · 2015 · External reference
Prenatal immune activation induces age-related alterations in rat offspring: Effects upon NMDA receptors and behaviors
10.1016/j.bbr.2019.111946 · 2019 · External reference
Post-pubertal disruption of medial prefrontal cortical dopamine-glutamate interactions in a developmental animal model of schizophrenia
10.1016/j.biopsych.2006.10.012 · 2007 · External reference
The NMDA receptor and schizophrenia: From pathophysiology to treatment
10.1016/bs.apha.2016.01.006 · 2016 · External reference
Progressive reduction in cortical thickness as psychosis develops: A multisite longitudinal neuroimaging study of youth at elevated clinical risk
10.1016/j.biopsych.2014.05.023 · 2015 · External reference
Progressive structural brain changes during development of psychosis
10.1093/schbul/sbq113 · 2012 · External reference
Longitudinal structural MRI findings in individuals at genetic and clinical high risk for psychosis: A systematic review
10.3389/fpsyt.2021.620401 · 2021 · External reference
Imaging patients with psychosis and a mouse model establishes a spreading pattern of hippocampal dysfunction and implicates glutamate as a driver
10.1016/j.neuron.2013.02.011 · 2013 · External reference
Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat
10.1016/j.biopsych.2011.06.007 · 2011 · External reference
Early or late gestational exposure to maternal immune activation alters neurodevelopmental trajectories in mice: An integrated neuroimaging, behavioral, and transcriptional study
10.1016/j.biopsych.2021.03.017 · 2021 · External reference
Progressive neuroanatomical changes caused by Grin1 loss-of-function mutation
10.1016/j.nbd.2019.104527 · 2019 · External reference
Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: A longitudinal in vivo MRI study
10.1016/j.bbi.2016.12.008 · 2017 · External reference
Pre-frontal parvalbumin interneurons in schizophrenia: A meta-analysis of post-mortem studies
10.1007/s00702-019-02080-2 · 2019 · External reference
Differential regulation of parvalbumin and calretinin interneurons in the prefrontal cortex during adolescence
10.1007/s00429-013-0508-8 · 2014 · External reference
Corresponding decrease in neuronal markers signals progressive parvalbumin neuron loss in MAM schizophrenia model
10.1017/s146114571400056x · 2014 · External reference
An augmented dopamine system function is present prior to puberty in the methylazoxymethanol acetate rodent model of schizophrenia
10.1002/dneu.22172 · 2014 · External reference
10.1007/s00213-007-0729-8
10.1007/s00213-007-0729-8 · 2007 · External reference
Developmental GABAergic deficit enhances methamphetamine-induced apoptosis
10.1007/s00213-011-2269-5 · 2011 · External reference
Long-term effects of neonatal exposure to MK-801 on recognition memory and excitatory-inhibitory balance in rat hippocampus
10.1016/j.neuroscience.2015.09.003 · 2015 · External reference
Age-dependent specific changes in area CA2 of the hippocampus and social memory deficit in a mouse model of the 22q11.2 deletion syndrome
10.1016/j.neuron.2015.11.036 · 2016 · External reference
Dendritic spine pathology in schizophrenia
10.1016/j.neuroscience.2012.04.044 · 2013 · External reference
Synaptic loss in schizophrenia: A meta-analysis and systematic review of synaptic protein and mRNA measures
10.1038/s41380-018-0041-5 · 2019 · External reference
Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats
10.1038/s41467-019-14122-0 · 2020 · External reference
Prenatal immune challenge induces developmental changes in the morphology of pyramidal neurons of the prefrontal cortex and hippocampus in rats
10.1016/j.schres.2008.10.003 · 2009 · External reference
Periadolescent maturation of the prefrontal cortex is sex-specific and is disrupted by prenatal stress
10.1002/cne.23262 · 2013 · External reference
Prenatal stress alters spine density and dendritic length of nucleus accumbens and hippocampus neurons in rat offspring
10.1002/syn.20664 · 2009 · External reference
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice
10.1038/s41593-020-00763-8 · 2021 · External reference
Immune involvement in the pathogenesis of schizophrenia: A meta-analysis on postmortem brain studies
10.1038/tp.2017.4 · 2017 · External reference
Neuroinflammation in schizophrenia: Meta-analysis of in vivo microglial imaging studies
10.1017/s0033291718003057 · 2019 · External reference
Microglial activity in people at ultra high risk of psychosis and in schizophrenia: An [(11)C]PBR28 PET brain imaging study [published correction appears in Am J Psychiatry 2017; 174:402]
10.1176/appi.ajp.2015.14101358 · 2016 · External reference
PET imaging of putative microglial activation in individuals at ultra-high risk for psychosis, recently diagnosed and chronically ill with schizophrenia
10.1038/tp.2017.193 · 2017 · External reference
Schizophrenia associated sensory gating deficits develop after adolescent microglia activation
10.1016/j.bbi.2016.05.018 · 2016 · External reference
Age-related changes in neuroinflammation and prepulse inhibition in offspring of rats treated with Poly I:C in early gestation
10.1186/s12993-019-0154-2 · 2019 · External reference
Evidences for a progressive microglial activation and increase in iNOS expression in rats submitted to a neurodevelopmental model of schizophrenia: Reversal by clozapine
10.1016/j.schres.2013.10.040 · 2013 · External reference
Flow cytometric characterization of microglia in the offspring of polyI:C treated mice
10.1016/j.brainres.2016.02.004 · 2016 · External reference
Maternal immune activation causes age- and region-specific changes in brain cytokines in offspring throughout development
10.1016/j.bbi.2012.07.008 · 2013 · External reference
Maternal immune activation in rats blunts brain cytokine and kynurenine pathway responses to a second immune challenge in early adulthood
10.1016/j.pnpbp.2018.09.011 · 2019 · External reference
Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia
10.1038/mp.2017.47 · 2017 · External reference
Static and dynamic cognitive deficits in childhood preceding adult schizophrenia: A 30-year study
10.1176/appi.ajp.2009.09040574 · 2010 · External reference
Predicting schizophrenia: Findings from the Edinburgh High-Risk Study
10.1192/bjp.186.1.18 · 2005 · External reference
Negative symptoms in youths with psychosis spectrum features: Complementary scales in relation to neurocognitive performance and function
10.1016/j.schres.2015.05.037 · 2015 · External reference
How do established developmental risk-factors for schizophrenia change the way the brain develops?
10.1038/s41398-021-01273-2 · 2021 · External reference
Electrophysiological endophenotypes for schizophrenia
10.1097/hrp.0000000000000110 · 2016 · External reference
Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
10.1016/j.biopsych.2008.04.019 · 2008 · External reference
A meta-analysis of mismatch negativity in schizophrenia: From clinical risk to disease specificity and progression
10.1016/j.biopsych.2015.08.025 · 2016 · External reference
Reduced prepulse inhibition in adolescents at risk for psychosis: A 2-year follow-up study
10.1503/jpn.100063 · 2011 · External reference
Mismatch responses and deviance detection in N-methyl-D-aspartate (NMDA) receptor hypofunction and developmental models of schizophrenia
10.1016/j.biopsycho.2015.06.015 · 2016 · External reference
Clozapine administration in adolescence prevents postpubertal emergence of brain structural pathology in an animal model of schizophrenia
10.1016/j.biopsych.2009.07.005 · 2009 · External reference
Evaluating early preventive antipsychotic and antidepressant drug treatment in an infection-based neurodevelopmental mouse model of schizophrenia
10.1093/schbul/sbn131 · 2010 · External reference
Neonatal excitotoxic ventral hippocampal damage alters dopamine response to mild repeated stress and to chronic haloperidol
10.1002/syn.890200205 · 1995 · External reference
Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions
10.1038/sj.npp.1300791 · 2006 · External reference
Risperidone administered during asymptomatic period of adolescence prevents the emergence of brain structural pathology and behavioral abnormalities in an animal model of schizophrenia
10.1093/schbul/sbq040 · 2011 · External reference
Effects of risperidone treatment in adolescence on hippocampal neurogenesis, parvalbumin expression, and vascularization following prenatal immune activation in rats
10.1016/j.bbi.2011.11.004 · 2012 · External reference
Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation
10.1016/j.jpsychires.2011.02.007 · 2011 · External reference
Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response
10.1016/j.physbeh.2012.02.004 · 2012 · External reference
Peripubertal diazepam administration prevents the emergence of dopamine system hyperresponsivity in the MAM developmental disruption model of schizophrenia
10.1038/npp.2013.101 · 2013 · External reference
Amygdala hyperactivity in MAM model of schizophrenia is normalized by peripubertal diazepam administration
10.1038/npp.2016.42 · 2016 · External reference
Valproic acid (VPA) reduces sensorimotor gating deficits and HDAC2 overexpression in the MAM animal model of schizophrenia
10.1016/j.pharep.2015.04.004 · 2015 · External reference
Juvenile antioxidant treatment prevents adult deficits in a developmental model of schizophrenia
10.1016/j.neuron.2014.07.028 · 2014 · External reference
N-acetyl cysteine reverses bio-behavioural changes induced by prenatal inflammation, adolescent methamphetamine exposure and combined challenges
10.1007/s00213-017-4776-5 · 2018 · External reference
Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of schizophrenia
10.1016/j.nlm.2017.02.004 · 2017 · External reference
Effects of pubertal cannabinoid administration on attentional set-shifting and dopaminergic hyper-responsivity in a developmental disruption model of schizophrenia
2014 · External reference
Improved social interaction, recognition and working memory with cannabidiol treatment in a prenatal infection (poly I:C) rat model
10.1038/npp.2017.40 · 2017 · External reference
Effect of maternal immune activation on the kynurenine pathway in preadolescent rat offspring and on MK801-induced hyperlocomotion in adulthood: Amelioration by COX-2 inhibition
10.1016/j.bbi.2014.05.011 · 2014 · External reference
Effects of omega-3 dietary supplement in prevention of positive, negative and cognitive symptoms: A study in adolescent rats with ketamine-induced model of schizophrenia
10.1016/j.schres.2012.08.002 · 2012 · External reference
Preventive treatments for psychosis: Umbrella review (just the evidence)
10.3389/fpsyt.2019.00764 · 2019 · External reference
Dopamine, psychosis and schizophrenia: The widening gap between basic and clinical neuroscience
10.1038/s41398-017-0071-9 · 2018 · External reference
Striatal dopamine mediates hallucination-like perception in mice
10.1126/science.abf4740 · 2021 · External reference
Schizophrenia: A concise overview of incidence, prevalence, and mortality
10.1093/epirev/mxn001 · 2008 · External reference
From onset and prodromal stage to a life-long course of schizophrenia and its symptom dimensions: How sex, age, and other risk factors influence incidence and course of illness
10.1155/2019/9804836 · 2019 · External reference
Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males
10.1016/j.neulet.2014.02.023 · 2014 · External reference
Multifaceted origins of sex differences in the brain
10.1098/rstb.2015.0106 · 2016 · External reference
Longitudinal analyses of blood transcriptome during conversion to psychosis
10.1093/schbul/sby009 · 2019 · External reference
Development of proteomic prediction models for transition to psychotic disorder in the clinical high-risk state and psychotic experiences in adolescence
10.1001/jamapsychiatry.2020.2459 · 2021 · External reference
Biomarkers in schizophrenia: A brief conceptual consideration
10.1155/2013/510402 · 2013 · External reference
Behavioral, neuroanatomical, and molecular correlates of resilience and susceptibility to maternal immune activation
10.1038/s41380-020-00952-8 · 2021 · External reference
Cellular-scale probes enable stable chronic subsecond monitoring of dopamine neurochemicals in a rodent model
10.1038/s42003-018-0147-y · 2018 · External reference
Ultrafast neuronal imaging of dopamine dynamics with designed genetically encoded sensors
10.1126/science.aat4422 · 2018 · External reference
PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence
10.1073/pnas.1321109111 · 2014 · External reference
Unresolved reference
1987 · External reference
