Research graph
References from Neural Circuitry of Salience and Reward Processing in Psychosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Schizophrenia-An overview
10.1001/jamapsychiatry.2019.3360 · 2020 · External reference
Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: Insights from PET and SPECT imaging
10.2174/138161209788957528 · 2009 · External reference
Elevated striatal dopamine function linked to prodromal signs of schizophrenia
10.1001/archgenpsychiatry.2008.514 · 2009 · External reference
Half a century of antipsychotics and still a central role for dopamine D2 receptors
10.1016/j.pnpbp.2003.09.004 · 2003 · External reference
Treatment resistant schizophrenia: Clinical, biological, and therapeutic perspectives
10.1016/j.nbd.2018.08.016 · 2019 · External reference
Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function
10.1016/j.biopsych.2013.06.011 · 2014 · External reference
Glutamate hypothesis in schizophrenia
10.1111/pcn.12823 · 2019 · External reference
Dopaminergic basis of salience dysregulation in psychosis
10.1016/j.tins.2013.11.003 · 2014 · External reference
Are persistent delusions in schizophrenia associated with aberrant salience?
10.1016/j.scog.2016.04.002 · 2016 · External reference
The neural underpinnings of associative learning in health and psychosis: How can performance be preserved when brain responses are abnormal?
10.1093/schbul/sbq005 · 2010 · External reference
Disrupted prediction-error signal in psychosis: Evidence for an associative account of delusions
10.1093/brain/awm173 · 2007 · External reference
An integrative perspective on the role of dopamine in schizophrenia
10.1016/j.biopsych.2016.05.021 · 2017 · External reference
Dopamine and the aberrant salience hypothesis of schizophrenia
10.1002/wps.20276 · 2016 · External reference
Psychosis as a state of aberrant salience: A framework linking biology, phenomenology, and pharmacology in schizophrenia
10.1176/appi.ajp.160.1.13 · 2003 · External reference
Dopaminergic dysfunction in alcoholism and schizophrenia—Psychopathological and behavioral correlates
10.1016/s0924-9338(02)00628-4 · 2002 · External reference
Striatal presynaptic dopamine in schizophrenia, part II: Meta-analysis of [(18)F/(11)C]-DOPA PET studies
10.1093/schbul/sbr180 · 2013 · External reference
From prediction error to psychosis: Ketamine as a pharmacological model of delusions
10.1177/0269881107077716 · 2007 · External reference
Predictive reward signal of dopamine neurons
10.1152/jn.1998.80.1.1 · 1998 · External reference
Dopamine reward prediction-error signalling: A two-component response
10.1038/nrn.2015.26 · 2016 · External reference
Mesolimbocortical and nigrostriatal dopamine responses to salient non− reward events
10.1016/s0306-4522(00)00019-1 · 2000 · External reference
Contextual interaction between novelty and reward processing within the mesolimbic system
10.1002/hbm.21288 · 2012 · External reference
Precision weighting of cortical unsigned prediction error signals benefits learning, is mediated by dopamine, and is impaired in psychosis [published correction appears in Mol Psychiatry 2021; 26:5334]
10.1038/s41380-020-0803-8 · 2021 · External reference
Dopamine modulates subcortical responses to surprising sounds [published correction appears in PLoS Biol 2020; 18:e3000984]
2020 · External reference
Dopamine in motivational control: Rewarding, aversive, and alerting
10.1016/j.neuron.2010.11.022 · 2010 · External reference
Do patients with schizophrenia exhibit aberrant salience?
10.1017/s0033291708003863 · 2009 · External reference
Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis [published correction appears in Schizphr Bull 2016; 42:1303]
10.1093/schbul/sbs147 · 2013 · External reference
Modeling subjective relevance in schizophrenia and its relation to aberrant salience
10.1371/journal.pcbi.1006319 · 2018 · External reference
Dopamine synthesis capacity in patients with treatment-resistant schizophrenia
10.1176/appi.ajp.2012.12010144 · 2012 · External reference
The nature of dopamine dysfunction in schizophrenia and what this means for treatment
10.1001/archgenpsychiatry.2012.169 · 2012 · External reference
Striatal activity is associated with deficits of cognitive control and aberrant salience for patients with schizophrenia
10.3389/fnhum.2015.00687 · 2016 · External reference
Emotionally neutral stimuli are not neutral in schizophrenia: A mini review of functional neuroimaging studies
10.3389/fpsyt.2016.00115 · 2016 · External reference
Changes in EEG spectral power on perception of neutral and emotional words in patients with schizophrenia, their relatives, and healthy subjects from the general population
10.1007/s11055-008-9013-6 · 2008 · External reference
Attention to irrelevant cues is related to positive symptoms in schizophrenia
10.1093/schbul/sbr192 · 2013 · External reference
What you want may not be what you like: A test of the aberrant salience hypothesis in schizophrenia risk
10.3758/s13415-020-00807-3 · 2020 · External reference
Brain responses to different types of salience in antipsychotic naïve first episode psychosis: An fMRI study
10.1038/s41398-018-0250-3 · 2018 · External reference
Absolute coding of stimulus novelty in the human substantia nigra/VTA
10.1016/j.neuron.2006.06.021 · 2006 · External reference
Neural circuitry of novelty salience processing in psychosis risk: Association with clinical outcome
10.1093/schbul/sbz089 · 2020 · External reference
Altered subcortical emotional salience processing differentiates Parkinson’s patients with and without psychotic symptoms
10.1016/j.nicl.2020.102277 · 2020 · External reference
Deficits in domains of social cognition in schizophrenia: A meta-analysis of the empirical evidence
10.1093/schbul/sbs080 · 2013 · External reference
Neural response to emotional salience in schizophrenia
10.1038/sj.npp.1300679 · 2005 · External reference
Subjective emotional over-arousal to neutral social scenes in paranoid schizophrenia
10.1007/s00406-011-0227-1 · 2012 · External reference
Looking at the other side of the coin: A meta-analysis of self-reported emotional arousal in people with schizophrenia
10.1016/j.schres.2012.09.005 · 2012 · External reference
P300 as an index of transition to psychosis and of remission: Data from a clinical high risk for psychosis study and review of literature
10.1016/j.schres.2019.02.014 · 2020 · External reference
Aberrant salience is related to reduced reinforcement learning signals and elevated dopamine synthesis capacity in healthy adults
10.1523/jneurosci.0805-15.2015 · 2015 · External reference
Substantia nigra/ventral tegmental reward prediction error disruption in psychosis
10.1038/sj.mp.4002157 · 2008 · External reference
Abnormal reward prediction-error signalling in antipsychotic naive individuals with first-episode psychosis or clinical risk for psychosis
10.1038/s41386-018-0056-2 · 2018 · External reference
Pavlovian reward prediction and receipt in schizophrenia: Relationship to anhedonia
10.1371/journal.pone.0035622 · 2012 · External reference
A review of reward processing and motivational impairment in schizophrenia
10.1093/schbul/sbt197 · 2014 · External reference
Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
10.1038/npp.2008.214 · 2009 · External reference
Striatal dopamine and reward prediction error signaling in unmedicated schizophrenia patients
10.1093/schbul/sbaa055 · 2020 · External reference
Modulation of motivational salience processing during the early stages of psychosis
10.1016/j.schres.2015.04.036 · 2015 · External reference
Dopamine, prediction error and beyond
10.1177/1073858420907591 · 2021 · External reference
Expected value and prediction error abnormalities in depression and schizophrenia
10.1093/brain/awr059 · 2011 · External reference
Disambiguating ventral striatum fMRI-related BOLD signal during reward prediction in schizophrenia
10.1038/mp.2012.1 · 2012 · External reference
Striatal dysfunction during reversal learning in unmedicated schizophrenia patients
10.1016/j.neuroimage.2013.11.034 · 2014 · External reference
Integrating schizophrenia
10.1093/oxfordjournals.schbul.a033324 · 1998 · External reference
Frontal responses during learning predict vulnerability to the psychotogenic effects of ketamine: Linking cognition, brain activity, and psychosis
10.1001/archpsyc.63.6.611 · 2006 · External reference
Evidence of reward system dysfunction in youth at clinical high-risk for psychosis from two event-related fMRI paradigms
10.1016/j.schres.2019.03.017 · 2020 · External reference
Dopamine synthesis capacity before onset of psychosis: A prospective [18F]-DOPA PET imaging study
10.1176/appi.ajp.2011.11010160 · 2011 · External reference
Methamphetamine-induced disruption of frontostriatal reward learning signals: Relation to psychotic symptoms
10.1176/appi.ajp.2013.12070978 · 2013 · External reference
Improvement of brain reward abnormalities by antipsychotic monotherapy in schizophrenia
10.1001/archgenpsychiatry.2012.847 · 2012 · External reference
Adaptive prediction error coding in the human midbrain and striatum facilitates behavioral adaptation and learning efficiency
10.1016/j.neuron.2016.04.019 · 2016 · External reference
Substrates of human prediction error for incentives, perception, cognition, and action
2021 · External reference
Abnormal prediction error processing in schizophrenia and depression
10.1002/hbm.25453 · 2021 · External reference
Ventral striatal activation during reward processing in psychosis: A neurofunctional meta-analysis
10.1001/jamapsychiatry.2015.2196 · 2015 · External reference
The roles of reward, default, and executive control networks in set-shifting impairments in schizophrenia
10.1371/journal.pone.0057257 · 2013 · External reference
Motivational deficits in schizophrenia relate to abnormalities in cortical learning rate signals
10.3758/s13415-018-0643-z · 2018 · External reference
Impaired associative learning in chronic schizophrenics and their first-degree relatives: A study of latent inhibition and the Kamin blocking effect
10.1016/s0920-9964(00)00141-9 · 2001 · External reference
Translational assessment of reward and motivational deficits in psychiatric disorders
2016 · External reference
Dopamine, learning and motivation
10.1038/nrn1406 · 2004 · External reference
Modeling human methamphetamine use patterns in mice: Chronic and binge methamphetamine exposure, reward function and neurochemistry
10.1111/adb.12502 · 2018 · External reference
Effort, avolition and motivational experience in schizophrenia: Analysis of behavioral and neuroimaging data with relationships to daily motivational experience
10.1177/2167702620901558 · 2020 · External reference
Volumetric analysis of frontal lobe regions in schizophrenia: Relation to cognitive function and symptomatology
10.1016/s0006-3223(98)00266-2 · 1999 · External reference
Morphology of the orbitofrontal cortex in first-episode schizophrenia: Relationship with negative symptomatology
10.1016/j.pnpbp.2006.11.022 · 2007 · External reference
Anterior cingulate glutamate levels related to clinical status following treatment in first-episode schizophrenia
10.1038/npp.2012.113 · 2012 · External reference
Unresolved reference
1919 · External reference
Unresolved reference
1950 · External reference
Anhedonia
2000 · External reference
Unresolved reference
2013 · External reference
Anhedonia in schizophrenia: Distinctions between anticipatory and consummatory pleasure
10.1016/j.schres.2007.03.008 · 2007 · External reference
Reward anticipation and trait anhedonia: An electrophysiological investigation in subjects with schizophrenia
10.1016/j.clinph.2016.01.006 · 2016 · External reference
Incentive motivation in first-episode psychosis: A behavioural study
10.1186/1471-244x-8-34 · 2008 · External reference
Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release
10.1523/jneurosci.2058-08.2008 · 2008 · External reference
Reward anticipation in schizophrenia: A coordinate-based meta-analysis
10.1016/j.schres.2019.12.041 · 2020 · External reference
The relation between dopamine D2 receptor blockade and the brain reward system: A longitudinal study of first-episode schizophrenia patients
10.1017/s0033291718004099 · 2020 · External reference
Dysfunction of ventral striatal reward prediction in schizophrenic patients treated with typical, not atypical, neuroleptics
10.1007/s00213-006-0405-4 · 2006 · External reference
Negative symptoms and reward disturbances in schizophrenia before and after antipsychotic monotherapy
10.1177/1550059417744120 · 2018 · External reference
Diminishing striatal activation across adolescent development during reward anticipation in offspring of schizophrenia patients
10.1016/j.schres.2015.11.018 · 2016 · External reference
Reward processing in schizophrenia: A deficit in the representation of value
10.1093/schbul/sbn068 · 2008 · External reference
Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia
10.1002/hbm.24049 · 2018 · External reference
Achievement motivation in early schizophrenia: Relationship with symptoms, cognition and functional outcome
10.1111/eip.12405 · 2018 · External reference
Effort-based decision making: A novel approach for assessing motivation in schizophrenia
10.1093/schbul/sbv071 · 2015 · External reference
Amotivation in schizophrenia: Integrated assessment with behavioral, clinical, and imaging measures
10.1093/schbul/sbu026 · 2014 · External reference
Effort-based decision-making impairment in patients with clinically stabilized first-episode psychosis and its relationship with amotivation and psychosocial functioning
10.1016/j.euroneuro.2019.03.006 · 2019 · External reference
Brain activity and connectivity differences in reward value discrimination during effort computation in schizophrenia
10.1007/s00406-020-01145-8 · 2021 · External reference
Subcortical dopamine and cognition in schizophrenia: Looking beyond psychosis in preclinical models
10.3389/fnins.2020.00542 · 2020 · External reference
Impairments in goal-directed action and reversal learning in a proportion of individuals with psychosis
10.3758/s13415-022-01026-8 · 2022 · External reference
Corticostriatal control of goal-directed action is impaired in schizophrenia
10.1016/j.biopsych.2014.06.005 · 2015 · External reference
Impairments in action–outcome learning in schizophrenia
10.1038/s41398-018-0103-0 · 2018 · External reference
Dopamine, psychosis and schizophrenia: The widening gap between basic and clinical neuroscience
10.1038/s41398-017-0071-9 · 2018 · External reference
The role of dopamine in the prelimbic cortex and the dorsomedial striatum in instrumental conditioning
10.1093/cercor/bhp151 · 2010 · External reference
Dynamic nigrostriatal dopamine biases action selection
10.1016/j.neuron.2017.02.029 · 2017 · External reference
Effort-cost decision-making in psychosis and depression: Could a similar behavioral deficit arise from disparate psychological and neural mechanisms?
10.1017/s0033291717002525 · 2018 · External reference
Development of corticostriatal connectivity constrains goal-directed behavior during adolescence
10.1038/s41467-017-01369-8 · 2017 · External reference
Ventral striatal dopamine reflects behavioral and neural signatures of model-based control during sequential decision making
10.1073/pnas.1417219112 · 2015 · External reference
Neurodevelopmental shifts in learned value transfer on cognitive control during adolescence
10.1016/j.dcn.2019.100730 · 2019 · External reference
Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia
2017 · External reference
Functional connectivity in antipsychotic-treated and antipsychotic-naive patients with first-episode psychosis and low risk of self-harm or aggression: A secondary analysis of a randomized clinical trial
10.1001/jamapsychiatry.2021.1422 · 2021 · External reference
Deciphering reward-based decision-making in schizophrenia: A meta-analysis and behavioral modeling of the Iowa Gambling Task
10.1016/j.schres.2018.09.009 · 2019 · External reference
Probabilistic reversal learning in schizophrenia: Stability of deficits and potential causal mechanisms
10.1093/schbul/sbv226 · 2016 · External reference
A replication study of JTC bias, genetic liability for psychosis and delusional ideation
10.1017/s0033291720003578 · 2022 · External reference
Cost evaluation during decision-making in patients at early stages of psychosis
10.1162/cpsy_a_00020 · 2019 · External reference
Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis
2020 · External reference
Altered activation in association with reward-related trial-and-error learning in patients with schizophrenia
10.1016/j.neuroimage.2009.12.031 · 2010 · External reference
Volatility estimates increase choice switching and relate to prefrontal activity in schizophrenia
2020 · External reference
Reward-driven decision-making impairments in schizophrenia
10.1016/j.schres.2018.11.004 · 2019 · External reference
Neural, behavioural and real-life correlates of social context sensitivity and social reward learning during interpersonal interactions in the schizophrenia spectrum
10.1177/00048674211010327 · 2022 · External reference
Attentional set-shifting ability in first-episode and established schizophrenia: Relationship to working memory
10.1016/j.schres.2009.03.039 · 2009 · External reference
Translational studies of goal-directed action as a framework for classifying deficits across psychiatric disorders
10.3389/fnsys.2014.00101 · 2014 · External reference
Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
10.1038/nn804 · 2002 · External reference
Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning
10.1016/j.neuron.2006.01.023 · 2006 · External reference
Reinforcement and reversal learning in first-episode psychosis
10.1093/schbul/sbn078 · 2008 · External reference
Reinforcement learning as an intermediate phenotype in psychosis? Deficits sensitive to illness stage but not associated with polygenic risk of schizophrenia in the general population
10.1016/j.schres.2020.04.022 · 2020 · External reference
Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia
10.3389/fncel.2013.00111 · 2013 · External reference
Identifying cognitive remediation change through computational modelling—Effects on reinforcement learning in schizophrenia
10.1093/schbul/sbt152 · 2014 · External reference
Attention shaping: A reward-based learning method to enhance skills training outcomes in schizophrenia
10.1093/schbul/sbm150 · 2009 · External reference
Reward learning as a potential target for pharmacological augmentation of cognitive remediation for schizophrenia: A roadmap for preclinical development
10.3389/fnins.2013.00103 · 2013 · External reference
The circuitry of dopamine system regulation and its disruption in schizophrenia: Insights into treatment and prevention
10.1093/schbul/sbx199 · 2019 · External reference
Real time and delayed effects of subcortical low intensity focused ultrasound
10.1038/s41598-021-85504-y · 2021 · External reference
Real-time functional magnetic resonance imaging neurofeedback for the relief of distressing auditory-verbal hallucinations: Methodological and empirical advances
10.1093/schbul/sbaa103 · 2020 · External reference
At-risk mental state for psychosis: Identification and current treatment approaches
10.1192/apt.bp.115.015487 · 2016 · External reference
Beyond the “at risk mental state” concept: Transitioning to transdiagnostic psychiatry
10.1002/wps.20514 · 2018 · External reference
Altered activation and connectivity in a hippocampal-basal ganglia-midbrain circuit during salience processing in subjects at ultra high risk for psychosis
10.1038/tp.2017.174 · 2017 · External reference
Novelty or surprise?
10.3389/fpsyg.2013.00907 · 2013 · External reference
Separate neural representations of prediction error valence and surprise: Evidence from an fMRI meta-analysis
10.1002/hbm.24047 · 2018 · External reference
A salience theory of learning and behavior: With perspectives on neurobiology and cognition
10.1007/s10764-007-9179-8 · 2007 · External reference
The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task
10.1002/hbm.24184 · 2018 · External reference
Opioids for hedonic experience and dopamine to get ready for it
10.1007/s00213-006-0521-1 · 2007 · External reference
Ventral striatal activation during reward processing in subjects with ultra-high risk for schizophrenia
10.1159/000337130 · 2012 · External reference
Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults
10.1016/j.neubiorev.2020.11.004 · 2021 · External reference
Choosing to make an effort: The role of striatum in signaling physical effort of a chosen action
10.1152/jn.00027.2010 · 2010 · External reference
Effort-based cost-benefit valuation and the human brain
10.1523/jneurosci.4515-08.2009 · 2009 · External reference
Anterior cingulate neurons in the rat map anticipated effort and reward to their associated action sequences
10.1152/jn.01012.2011 · 2012 · External reference
Activational and effort-related aspects of motivation: Neural mechanisms and implications for psychopathology
10.1093/brain/aww050 · 2016 · External reference
The role of dopamine in dynamic effort-reward integration
10.1038/s41386-020-0669-0 · 2020 · External reference
Dopamine promotes cognitive effort by biasing the benefits versus costs of cognitive work
10.1126/science.aaz5891 · 2020 · External reference
Mesolimbic dopamine signals the value of work
10.1038/nn.4173 · 2016 · External reference
Dissociable cost and benefit encoding of future rewards by mesolimbic dopamine
10.1038/nn.2460 · 2010 · External reference
What is the relationship between dopamine and effort?
10.1016/j.tins.2018.10.001 · 2019 · External reference
Opposing effects of acute and chronic d-amphetamine on decision-making in rats
10.1016/j.neuroscience.2016.04.021 · 2017 · External reference
Preferential involvement by nucleus accumbens shell in mediating probabilistic learning and reversal shifts
10.1523/jneurosci.5058-13.2014 · 2014 · External reference
Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex
10.1523/jneurosci.1521-08.2008 · 2008 · External reference
Multifaceted contributions by different regions of the orbitofrontal and medial prefrontal cortex to probabilistic reversal learning
10.1523/jneurosci.3366-15.2016 · 2016 · External reference
Modulation of value-based decision making behavior by subregions of the rat prefrontal cortex
10.1007/s00213-020-05454-7 · 2020 · External reference
