Research graph
References from GLP-1 Receptor Agonist and GIP/GLP-1 Receptor Dual Agonist Therapeutics at the Intersection of Alcohol Use Disorder, Obesity, and Cardiometabolic Dysfunction. Local targets link to admitted publications; unresolved targets remain external evidence.
Alcohol use and burden for 195 countries and territories, 1990–2016: A systematic analysis for the Global Burden of Disease Study 2016
10.1016/s0140-6736(18)31310-2 · 2018 · External reference
Burden of diseases attributable to excess body weight in 204 countries and territories, 1990–2019
10.1186/s12937-025-01082-z · 2025 · External reference
Prevalence and associations of metabolic syndrome in patients with alcohol use disorder
10.1038/s41598-022-06010-3 · 2022 · External reference
The prevalence of metabolic syndrome in alcohol use disorders: A systematic review and meta-analysis
10.1093/alcalc/agw040 · 2016 · External reference
Burden of high-risk phenotype of heavy alcohol consumption among obese U.S. population: Results from National Health and Nutrition Examination Survey, 1999
2023 · External reference
Crosstalk between alcohol use disorder and obesity: Two sides of the same coin?
10.1038/s41380-025-03259-8 · 2025 · External reference
Drinking and obesity: Alcoholic liver disease/nonalcoholic fatty liver disease interactions
10.1055/s-0040-1701443 · 2020 · External reference
Moderate alcohol consumption is not associated with subclinical cardiovascular damage but with hepatic fibrosis in non-alcoholic fatty liver disease
10.1016/j.alcohol.2020.07.010 · 2020 · External reference
Alcohol-associated liver disease: A review
10.1016/j.gande.2025.01.003 · 2025 · External reference
Non-alcoholic fatty liver disease (NAFLD) and mental illness: Mechanisms linking mood, metabolism and medicines
10.3389/fnins.2022.1042442 · 2022 · External reference
Obesity and its comorbidities: Current treatment options, emerging biological mechanisms, future perspectives and challenges
10.2147/dmso.s540103 · 2025 · External reference
Effects of alcohol consumption and metabolic syndrome on mortality in patients with nonalcoholic and alcohol-related fatty liver disease
10.1016/j.cgh.2018.11.033 · 2019 · External reference
Global burden of liver disease: 2023 update
10.1016/j.jhep.2023.03.017 · 2023 · External reference
Targeting unmet clinical needs in the treatment of alcohol use disorder
10.3389/fpsyt.2022.767506 · 2022 · External reference
Treatment approaches for alcohol use disorder with metabolic dysfunction
10.1016/j.pharmthera.2025.108957 · 2026 · External reference
Diagnosis and pharmacotherapy of alcohol use disorder: A review
10.1001/jama.2018.11406 · 2018 · External reference
The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: The SurPASS clinical trials
10.1007/s13300-020-00981-0 · 2021 · External reference
Efficacy and safety of tirzepatide in type 2 diabetes and obesity management
10.7570/jomes22067 · 2023 · External reference
Tirzepatide for metabolic dysfunction–associated steatohepatitis with liver fibrosis
10.1056/nejmoa2401943 · 2024 · External reference
Recent advances in incretin-based pharmacotherapies for the treatment of obesity and diabetes
10.3389/fendo.2022.838410 · 2022 · External reference
Effects of GLP-1 receptor agonists in alcohol use disorder
10.1111/bcpt.70004 · 2025 · External reference
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
10.1038/s41591-023-02634-8 · 2023 · External reference
A systematic review on the role of glucagon-like peptide-1 receptor agonists on alcohol-related behaviors: Potential therapeutic strategy for alcohol use disorder
10.1017/neu.2025.6 · 2025 · External reference
Biology of incretins: GLP-1 and GIP
10.1053/j.gastro.2007.03.054 · 2007 · External reference
GLP-1 and GIP receptor signaling in beta cells—A review of receptor interactions and co-stimulation
10.1016/j.peptides.2022.170749 · 2022 · External reference
GLP-1 analogues in the neurobiology of addiction: Translational insights and therapeutic perspectives
10.3390/ijms26115338 · 2025 · External reference
Signalling from the periphery to the brain that regulates energy homeostasis
10.1038/nrn.2018.8 · 2018 · External reference
Glucagon-like peptide-1 receptor: Mechanisms and advances in therapy
10.1038/s41392-024-01931-z · 2024 · External reference
The role of nucleus of the solitary tract glucagon-like peptide-1 and prolactin-releasing peptide neurons in stress: Anatomy, physiology and cellular interactions
10.1111/bph.15576 · 2022 · External reference
Glucagon-like Peptide-1 (GLP-1) in the integration of neural and endocrine responses to stress
10.3390/nu12113304 · 2020 · External reference
Bidirectional interactions between the gut microbiota and incretin-based therapies
2025 · External reference
Antiinflammatory actions of glucagon-like peptide-1–based therapies beyond metabolic benefits
10.1172/jci194751 · 2025 · External reference
A brain reward circuit inhibited by next-generation weight-loss drugs in mice
10.1038/s41586-026-10444-4 · 2026 · External reference
Minireview: Finding the sweet spot: Peripheral versus central glucagon-like peptide 1 action in feeding and glucose homeostasis
10.1210/en.2009-0220 · 2009 · External reference
GLP1R and GIPR expression and signaling in pancreatic alpha cells, beta cells and delta cells
10.1016/j.peptides.2024.171179 · 2024 · External reference
Preserved incretin activity of glucagon-like peptide 1 [7–36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
10.1172/jci116186 · 1993 · External reference
The elimination rates of intact GIP as well as its primary metabolite, GIP 3–42, are similar in type 2 diabetic patients and healthy subjects
10.1016/j.regpep.2006.07.007 · 2006 · External reference
Functional GIP receptors are present on adipocytes
10.1210/endo.139.9.6288 · 1998 · External reference
Glucose-dependent insulinotropic polypeptide (GIP)
10.1016/j.molmet.2025.102118 · 2025 · External reference
Glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus regulate food intake
10.1016/j.cmet.2019.07.013 · 2019 · External reference
Hypothalamic and brainstem glucose-dependent insulinotropic polypeptide receptor neurons employ distinct mechanisms to affect feeding
10.1172/jci.insight.164921 · 2023 · External reference
Inhibition of gastric inhibitory polypeptide signaling prevents obesity
10.1038/nm727 · 2002 · External reference
GIPR/GLP-1R dual agonist therapies for diabetes and weight loss-Chemistry, physiology, and clinical applications
10.1016/j.cmet.2023.07.010 · 2023 · External reference
Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor
10.1016/j.cmet.2024.05.010 · 2024 · External reference
The GIP receptor activates futile calcium cycling in white adipose tissue to increase energy expenditure and drive weight loss in mice
10.1016/j.cmet.2024.11.003 · 2025 · External reference
Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
10.1016/j.ejphar.2010.10.059 · 2011 · External reference
Glucose-dependent insulinotropic polypeptide receptor knockout mice are impaired in learning, synaptic plasticity, and neurogenesis
10.1152/jn.00866.2010 · 2011 · External reference
GIP-overexpressing mice demonstrate reduced diet-induced obesity and steatosis, and improved glucose homeostasis
2012 · External reference
The role of glucagon-like peptide 1 (GLP-1) in addictive disorders
10.1111/bph.15677 · 2022 · External reference
The unexpected role of GIP in transforming obesity treatment
10.1016/j.tem.2024.07.022 · 2025 · External reference
What combines best with GLP-1 for obesity treatment: GIP receptor agonists or antagonists?
2021 · External reference
A brainstem circuit for nausea suppression
10.1016/j.celrep.2022.110953 · 2022 · External reference
The importance of glucose-dependent insulinotropic polypeptide receptor activation for the effects of tirzepatide
10.1111/dom.15216 · 2023 · External reference
GIPR agonism mediates weight-independent insulin sensitization by tirzepatide in obese mice
10.1172/jci146353 · 2021 · External reference
Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist
10.1172/jci.insight.140532 · 2020 · External reference
Chronic diseases and conditions related to alcohol use
10.35946/arcr.v35.2.06 · 2013 · External reference
Metabolic profiling of alcohol consumption in 9778 young adults
10.1093/ije/dyw175 · 2016 · External reference
The effects of wine consumption and lipid profile: A systematic review and meta-analysis of clinical trials
10.1016/j.jnha.2025.100539 · 2025 · External reference
Association of high-intensity binge drinking with lipid and liver function enzyme levels
10.1001/jamanetworkopen.2019.5844 · 2019 · External reference
Sex-specific associations between alcohol consumption and incidence of hypertension: A systematic review and meta-analysis of cohort studies
10.1161/jaha.117.008202 · 2018 · External reference
Alcohol use and cardiovascular disease: A scientific statement from the American Heart Association
10.1161/cir.0000000000001341 · 2025 · External reference
Alcohol use disorder with metabolic dysfunction is associated with adverse health impacts in a United States clinical setting
10.1111/adb.70128 · 2026 · External reference
Gut Microbiome-Liver-Brain axis in Alcohol Use Disorder. The role of gut dysbiosis and stress in alcohol-related cognitive impairment progression: Possible therapeutic approaches
2025 · External reference
Evaluating the relationship between alcohol consumption, tobacco use, and cardiovascular disease: A multivariable Mendelian randomization study
10.1371/journal.pmed.1003410 · 2020 · External reference
Alcohol consumption and obesity: An update
10.1007/s13679-014-0129-4 · 2015 · External reference
Progression of alcoholic and non-alcoholic steatohepatitis: Common metabolic aspects of innate immune system and oxidative stress
10.2133/dmpk.dmpk-10-rv-087 · 2011 · External reference
Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease
10.1186/s12967-023-04166-8 · 2023 · External reference
Alcohol-associated liver disease
10.1172/jci176345 · 2024 · External reference
Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): Functional analysis of lipid metabolism pathways
10.1042/cs20220572 · 2022 · External reference
Alcohol consumption and risk of liver cirrhosis: A systematic review and meta-analysis
10.14309/ajg.0000000000000340 · 2019 · External reference
The impact of obesity and metabolic syndrome on alcoholic liver disease
10.1016/j.cld.2013.09.006 · 2014 · External reference
The role of alcohol use in the aetiology and progression of liver disease: A narrative review and a quantification
10.1111/dar.13286 · 2021 · External reference
Alcohol consumption and metabolic syndrome: Clinical and epidemiological impact on liver disease
10.1016/j.jhep.2022.08.030 · 2023 · External reference
The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission
10.1172/jci.insight.170671 · 2023 · External reference
Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
10.1016/j.ebiom.2023.104642 · 2023 · External reference
Gut peptide GLP-1 and its analogue, exendin-4, decrease alcohol intake and reward
10.1371/journal.pone.0061965 · 2013 · External reference
IUPHAR review—Glucagon-like peptide-1 (GLP-1) and substance use disorders: An emerging pharmacotherapeutic target
10.1016/j.phrs.2024.107312 · 2024 · External reference
Exenatide once weekly for alcohol use disorder investigated in a randomized, placebo-controlled clinical trial
10.1172/jci.insight.159863 · 2022 · External reference
Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats
10.1097/fbp.0000000000000609 · 2021 · External reference
The glucagon-like peptide-1 receptor as a potential treatment target in alcohol use disorder: Evidence from human genetic association studies and a mouse model of alcohol dependence
10.1038/tp.2015.68 · 2015 · External reference
Differential association between the GLP1R gene variants and brain functional connectivity according to the severity of alcohol use
10.1038/s41598-022-17190-3 · 2022 · External reference
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
10.1038/mp.2017.153 · 2017 · External reference
Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
10.1038/s41591-023-02653-5 · 2023 · External reference
Semaglutide: A Promising Treatment for Alcohol Use Disorder
2023 · External reference
Repurposing semaglutide and liraglutide for alcohol use disorder
10.1001/jamapsychiatry.2024.3599 · 2025 · External reference
Associations of semaglutide with incidence and recurrence of alcohol use disorder in real-world population
10.1038/s41467-024-48780-6 · 2024 · External reference
Impact of GLP-1 receptor agonists on alcohol-related liver disease development and progression in alcohol use disorder
10.1111/apt.70007 · 2025 · External reference
Transforming steatotic liver disease management: The emerging role of GLP-1 receptor agonists
10.1097/hc9.0000000000000561 · 2024 · External reference
Effects of dulaglutide on alcohol consumption during smoking cessation
10.1172/jci.insight.170419 · 2023 · External reference
Once-weekly semaglutide in adults with alcohol use disorder: A randomized clinical trial
10.1001/jamapsychiatry.2024.4789 · 2025 · External reference
Once-weekly semaglutide versus placebo in patients with alcohol use disorder and comorbid obesity: A randomised, double-blind, placebo-controlled trial
10.1016/s0140-6736(26)00305-3 · 2026 · External reference
Semaglutide, tirzepatide, and Retatrutide attenuate the interoceptive effects of alcohol in male and female rats
10.1007/s00213-025-06854-3 · 2025 · External reference
Genetic variability of incretin receptors and alcohol dependence: A pilot study
10.3389/fnmol.2022.908948 · 2022 · External reference
Whole exome sequencing analysis identifies genes for alcohol consumption
10.1038/s41467-024-50132-3 · 2024 · External reference
Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging
10.1038/s43587-023-00455-5 · 2023 · External reference
Genetically modeled GLP1R and GIPR agonism reduce binge drinking and alcohol-associated phenotypes: A multi-ancestry drug-target Mendelian randomization study
10.1038/s41380-025-03199-3 · 2025 · External reference
Genetic drug target validation using Mendelian randomisation
10.1038/s41467-020-16969-0 · 2020 · External reference
Mendelian randomization
10.1038/s43586-021-00092-5 · 2022 · External reference
Semaglutide and Tirzepatide reduce alcohol consumption in individuals with obesity
10.1038/s41598-023-48267-2 · 2023 · External reference
The association between glucose-dependent insulinotropic polypeptide and/or glucagon-like peptide-1 receptor agonist prescriptions and substance-related outcomes in patients with opioid and alcohol use disorders: A real-world data analysis
10.1111/add.16679 · 2025 · External reference
Effect of tirzepatide versus insulin degludec on liver fat content and abdominal adipose tissue in people with type 2 diabetes (SURPASS-3 MRI): A substudy of the randomised, open-label, parallel-group, phase 3 SURPASS-3 trial
10.1016/s2213-8587(22)00070-5 · 2022 · External reference
Neurobiology of addiction: A neurocircuitry analysis
10.1016/s2215-0366(16)00104-8 · 2016 · External reference
Food addiction: A common neurobiological mechanism with drug abuse
10.2741/4618 · 2018 · External reference
Largely overlapping neuronal substrates of reactivity to drug, gambling, food and sexual cues: A comprehensive meta-analysis
10.1016/j.euroneuro.2016.06.013 · 2016 · External reference
BMI modulates calorie-dependent dopamine changes in accumbens from glucose intake
2014 · External reference
Increased admission for alcohol dependence after gastric bypass surgery compared with restrictive bariatric surgery
10.1001/jamasurg.2013.700 · 2013 · External reference
Bariatric surgery and risk of alcohol use disorder: A register-based cohort study
10.1093/ije/dyaa147 · 2021 · External reference
An analysis on the role of glucagon-like peptide 1 receptor agonists in cognitive and mental health disorders
10.1038/s44220-025-00390-x · 2025 · External reference
Accumbal ghrelin and glucagon-like peptide 1 signaling in alcohol reward in female rats
10.1097/wnr.0000000000001071 · 2018 · External reference
Glucagon-like peptide-1 receptors in nucleus accumbens, ventral hippocampus, and lateral septum reduce alcohol reinforcement in mice
10.1037/pha0000620 · 2023 · External reference
Differential effects of intra-ventral tegmental area ghrelin and glucagon-like peptide-1 on the stimulatory action of D-amphetamine and cocaine-induced ethanol intake in male Sprague Dawley rats
10.1016/j.bbr.2021.113726 · 2022 · External reference
Glucagon-like peptide-1 (GLP-1) receptor agonist prevents development of tolerance to anti-anxiety effect of ethanol and withdrawal-induced anxiety in rats
10.1007/s11011-014-9627-z · 2015 · External reference
Use of GLP-1 receptor agonists and subsequent risk of alcohol-related events. A nationwide register-based cohort and self-controlled case series study
10.1111/bcpt.13776 · 2022 · External reference
Glucagon-like peptide-1 receptor agonists for antipsychotic-associated cardio-metabolic risk factors: A systematic review and individual participant data meta-analysis
10.1111/dom.13522 · 2019 · External reference
Effect of glucagon-like Peptide-1 receptor agonists on cardio-metabolic risk factors among obese/overweight individuals treated with antipsychotic drug classes: An updated systematic review and meta-analysis of randomized controlled trials
10.3390/biomedicines11030669 · 2023 · External reference
The use of liraglutide 3.0 mg daily in the management of overweight and obesity in people with schizophrenia, schizoaffective disorder and first episode psychosis: Results of a pilot randomized, double-blind, placebo-controlled trial
10.1111/dom.14334 · 2021 · External reference
Liraglutide promotes improvements in objective measures of cognitive dysfunction in individuals with mood disorders: A pilot, open-label study
10.1016/j.jad.2016.09.056 · 2017 · External reference
Adjunctive liraglutide treatment in patients with persistent or recurrent type 2 diabetes after metabolic surgery (GRAVITAS): A randomised, double-blind, placebo-controlled trial
10.1016/s2213-8587(19)30157-3 · 2019 · External reference
Patient-reported outcomes among patients using exenatide twice daily or insulin in clinical practice in six European countries: The CHOICE prospective observational study
10.1186/1477-7525-11-217 · 2013 · External reference
Metabolic dysfunction and alcohol-related liver disease (MetALD): Position statement by an expert panel on alcohol-related liver disease
10.1016/j.jhep.2024.11.028 · 2025 · External reference
Sex differences in response to treatment with glucagon-like peptide 1 receptor agonists: Opportunities for a tailored approach to diabetes and obesity care
10.3390/jpm12030454 · 2022 · External reference
Efficacy and safety of GLP-1 receptor agonists, dual agonists, and Retatrutide for weight loss in adults with overweight or obesity: A bayesian NMA
10.1002/oby.24360 · 2025 · External reference
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: A systematic review and meta-analysis
10.1007/s00125-022-05715-4 · 2022 · External reference
Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers
10.1007/s12020-020-02394-2 · 2020 · External reference
GLP1 receptor agonists reduce fluid intake in primary polydipsia
10.1210/jendso/bvab048.1052 · 2021 · External reference
Alcohol’s impact on the gut and liver
10.3390/nu13093170 · 2021 · External reference
Alcohol use disorder and the gut
10.1111/add.15147 · 2021 · External reference
Pancreatitis risk associated with GLP-1 receptor agonists, considered as a single class, in a comorbidity-free subgroup of type 2 diabetes patients in the United States: A propensity score-matched analysis
10.3390/jcm14030944 · 2025 · External reference
Quantifying alcohol consumption: Self-report, transdermal assessment, and prediction of dependence symptoms
10.1016/j.addbeh.2015.06.042 · 2015 · External reference
Scoping review of assessment tools for, magnitudes of and factors associated with problem drinking in population-based studies
10.1136/bmjopen-2023-080657 · 2024 · External reference
Old and new biomarkers of alcohol abuse: Narrative review
10.3390/jcm12062124 · 2023 · External reference
Global consensus recommendations for metabolic dysfunction-associated steatotic liver disease and steatohepatitis
10.1053/j.gastro.2025.02.044 · 2025 · External reference
Psychiatric comorbidities in alcohol use disorder
10.1016/s2215-0366(19)30222-6 · 2019 · External reference
Chronic glucose-dependent insulinotropic polypeptide receptor (GIPR) agonism desensitizes adipocyte GIPR activity mimicking functional GIPR antagonism
10.1038/s41467-020-18751-8 · 2020 · External reference
GIP-derived GIP receptor antagonists—A review of their role in GIP receptor pharmacology
10.1016/j.peptides.2024.171212 · 2024 · External reference
Recent advances in alcohol metabolism: From the gut to the brain
10.1152/physrev.00053.2024 · 2025 · External reference
A complex interplay between nutrition and alcohol use disorder: Implications for breaking the vicious cycle
10.2174/0113816128292367240510111746 · 2024 · External reference
Metabolism disrupting chemicals and metabolic disorders
10.1016/j.reprotox.2016.10.001 · 2017 · External reference
Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: A randomized controlled trial
10.1001/jama.287.19.2559 · 2002 · External reference
Chronic alcohol consumption potentiates the development of diabetes through pancreatic β-cell dysfunction
10.4331/wjbc.v6.i1.1 · 2015 · External reference
Prevalence patterns of overweight and obesity in the world: An age-period-cohort analysis
10.1371/journal.pone.0324733 · 2025 · External reference
An age-period-cohort approach to studying long-term trends in obesity and overweight in England (1992–2019)
10.1002/oby.23657 · 2023 · External reference
Projected prevalence and mortality associated with alcohol-related liver disease in the USA, 2019–40: A modelling study
10.1016/s2468-2667(20)30062-1 · 2020 · External reference
Changing landscape of alcohol-associated liver disease in younger individuals, women, and ethnic minorities
10.1111/liv.15933 · 2024 · External reference
Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National epidemiologic survey on alcohol and related conditions
10.1001/archpsyc.61.8.807 · 2004 · External reference
Pharmacotherapy for co-occurring alcohol use disorder and post-traumatic stress disorder: Targeting the opioidergic, noradrenergic, serotonergic, and GABAergic/glutamatergic systems
10.35946/arcr.v39.2.09 · 2018 · External reference
Metabolomic alteration induced by psychotropic drugs: Short-term metabolite profile as a predictor of weight gain evolution
10.1111/cts.13122 · 2021 · External reference
Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: A systematic review and network meta-analysis
10.1016/s2215-0366(19)30416-x · 2020 · External reference
Antipsychotics and glucose metabolism: How brain and body collide
10.1152/ajpendo.00164.2018 · 2019 · External reference
Association of antihypertensive drug target genes with psychiatric disorders: A Mendelian randomization study
10.1001/jamapsychiatry.2021.0005 · 2021 · External reference
Tirzepatide as compared with semaglutide for the treatment of obesity
10.1056/nejmoa2416394 · 2025 · External reference
Once-monthly Maridebart cafraglutide for the treatment of obesity — A Phase 2 trial
10.1056/nejmoa2504214 · 2025 · External reference
1861-LB: Efficacy and safety of HRS9531, a novel dual GLP-1/GIP receptor agonist, in obese adults—A Phase 2 trial
10.2337/db24-1861-lb · 2024 · External reference
Efficacy and safety of CT-868, a novel, fully biased, dual glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide receptor agonist, in type 2 diabetes: A double-blind, randomized placebo controlled phase 2 trial
10.1111/dom.70006 · 2025 · External reference
CT-388, a novel once-weekly dual GLP-1 and GIP receptor modulator, is safe, well-tolerated, and produces more than 8% weight loss in four weeks in overweight and obese adults
10.2337/db23-75-lb · 2023 · External reference
142-OR: Safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of a dual GLP-1/GIP receptor agonist (HDM1005)—A Phase I, randomized, double-blind, placebo-controlled, single and multiple dose-escalation study
10.2337/db25-142-or · 2025 · External reference
Disruption of GIP/GIPR axis in human adipose tissue is linked to obesity and insulin resistance
10.1210/jc.2013-3350 · 2014 · External reference
GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells
10.1093/ejendo/lvac004 · 2023 · External reference
Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus
10.1016/j.peptides.2010.12.010 · 2011 · External reference
A comparative transcriptomic analysis of glucagon-like peptide-1 receptor- and glucose-dependent insulinotropic polypeptide receptor-expressing cells in the hypothalamus
10.1016/j.appet.2022.106022 · 2022 · External reference
Distinct identity of GLP-1R, GLP-2R, and GIPR expressing cells and signaling circuits within the gastrointestinal tract
10.3389/fcell.2021.703966 · 2021 · External reference
Glucose-dependent insulinotropic polypeptide regulates dipeptide absorption in mouse jejunum
10.1152/ajpgi.00098.2013 · 2013 · External reference
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics
10.1038/s41467-020-14309-w · 2020 · External reference
Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies
10.1093/eurjpc/zwad050 · 2023 · External reference
Role of adipose tissue GLP-1R expression in metabolic improvement after bariatric surgery in patients with type 2 diabetes
10.1038/s41598-019-42770-1 · 2019 · External reference
Activation of GLP-1 receptors enhances the osteogenic differentiation process of STRO-1-positive BMSCs
10.1007/s11033-025-10648-3 · 2025 · External reference
Anatomical and functional characterization of central amygdala glucagon-like peptide 1 receptor expressing neurons
10.3389/fnbeh.2021.724030 · 2021 · External reference
Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: Results from the National epidemiologic survey on alcohol and related conditions
10.1001/archpsyc.61.8.807 · ExternalCitation · doi-reference
Diagnosis and pharmacotherapy of alcohol use disorder: A review
10.1001/jama.2018.11406 · ExternalCitation · doi-reference
Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: A randomized controlled trial
10.1001/jama.287.19.2559 · ExternalCitation · doi-reference
Association of high-intensity binge drinking with lipid and liver function enzyme levels
10.1001/jamanetworkopen.2019.5844 · ExternalCitation · doi-reference
Association of antihypertensive drug target genes with psychiatric disorders: A Mendelian randomization study
10.1001/jamapsychiatry.2021.0005 · ExternalCitation · doi-reference
Repurposing semaglutide and liraglutide for alcohol use disorder
10.1001/jamapsychiatry.2024.3599 · ExternalCitation · doi-reference
Once-weekly semaglutide in adults with alcohol use disorder: A randomized clinical trial
10.1001/jamapsychiatry.2024.4789 · ExternalCitation · doi-reference
Increased admission for alcohol dependence after gastric bypass surgery compared with restrictive bariatric surgery
10.1001/jamasurg.2013.700 · ExternalCitation · doi-reference
An age-period-cohort approach to studying long-term trends in obesity and overweight in England (1992–2019)
10.1002/oby.23657 · ExternalCitation · doi-reference
Efficacy and safety of GLP-1 receptor agonists, dual agonists, and Retatrutide for weight loss in adults with overweight or obesity: A bayesian NMA
10.1002/oby.24360 · ExternalCitation · doi-reference
Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: A systematic review and meta-analysis
10.1007/s00125-022-05715-4 · ExternalCitation · doi-reference
Semaglutide, tirzepatide, and Retatrutide attenuate the interoceptive effects of alcohol in male and female rats
10.1007/s00213-025-06854-3 · ExternalCitation · doi-reference
Glucagon-like peptide-1 (GLP-1) receptor agonist prevents development of tolerance to anti-anxiety effect of ethanol and withdrawal-induced anxiety in rats
10.1007/s11011-014-9627-z · ExternalCitation · doi-reference
Activation of GLP-1 receptors enhances the osteogenic differentiation process of STRO-1-positive BMSCs
10.1007/s11033-025-10648-3 · ExternalCitation · doi-reference
Effects of glucagon-like peptide-1 receptor agonists on fluid intake in healthy volunteers
10.1007/s12020-020-02394-2 · ExternalCitation · doi-reference
The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: The SurPASS clinical trials
10.1007/s13300-020-00981-0 · ExternalCitation · doi-reference
Alcohol consumption and obesity: An update
10.1007/s13679-014-0129-4 · ExternalCitation · doi-reference
Quantifying alcohol consumption: Self-report, transdermal assessment, and prediction of dependence symptoms
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Moderate alcohol consumption is not associated with subclinical cardiovascular damage but with hepatic fibrosis in non-alcoholic fatty liver disease
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