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References from Early-life maternal separation induces anxiety-like behavior in male mice associated with reduced dentate gyrus neurogenesis and hippocampal inflammatory remodeling. Local targets link to admitted publications; unresolved targets remain external evidence.
Early adversity alters brain architecture and increases susceptibility to mental health disorders
10.1038/s41583-025-00948-9 · 2025 · External reference
Effects of early life adverse experiences on the brain: implications from maternal separation models in rodents
10.3389/fnins.2014.00166 · 2014 · External reference
Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms
10.3389/fnbeh.2022.1013865 · 2022 · External reference
Maternal separation as early-life stress: Mechanisms of neuropsychiatric disorders and inspiration for neonatal care
10.1016/j.brainresbull.2024.111058 · 2024 · External reference
One-week maternal separation caused sex-specific changes in behavior and hippocampal metabolomics of offspring rats
10.3390/brainsci14121275 · 2024 · External reference
A single 24h maternal separation at PND 9 promotes behavioral resilience of female C57BL/6J mice and the possible role of hippocampal Homer1a
10.1016/j.heliyon.2024.e27037 · 2024 · External reference
Sex differential effects of early maternal separation on PTSD susceptibility in adult rats accompanied by telomere shortening in the hippocampus
10.1016/j.neuroscience.2024.11.058 · 2025 · External reference
Maternal separation after postnatal day 10 induces increase in depression-like behavior with decrease in hippocampal dendritic spines, but no change in anxiety-like behavior in male rats
10.1016/j.bbr.2025.115617 · 2025 · External reference
Developmental functions of microglia: Impact of psychosocial and physiological early life stress
10.1016/j.neuropharm.2024.110084 · 2024 · External reference
Early-life stress induces depression-like behavior and synaptic-plasticity changes in a maternal separation rat model: gender difference and metabolomics study
10.3389/fphar.2020.00102 · 2020 · External reference
Are the dorsal and ventral hippocampus functionally distinct structures?
10.1016/j.neuron.2009.11.031 · 2010 · External reference
Pattern separation in the dentate gyrus and CA3 of the hippocampus
10.1126/science.1135801 · 2007 · External reference
The role of adult hippocampal neurogenesis in brain health and disease
10.1038/s41380-018-0036-2 · 2019 · External reference
Functions and dysfunctions of adult hippocampal neurogenesis
10.1146/annurev-neuro-071013-014134 · 2014 · External reference
The impact of adult neurogenesis on affective functions: of mice and men
10.1038/s41380-024-02504-w · 2024 · External reference
Adult hippocampal neurogenesis and affective disorders: new neurons for psychic well-being
10.3389/fnins.2021.594448 · 2021 · External reference
Maternal separation during lactation affects recognition memory, emotional behaviors, hippocampus and gut microbiota composition in C57BL6J adolescent female mice
10.1016/j.bbr.2024.115249 · 2025 · External reference
Maternal separation-induced histone acetylation correlates with BDNF-programmed synaptic changes in an animal model of PTSD with sex differences
10.1007/s12035-020-02224-6 · 2021 · External reference
Stressed microglia: neuroendocrine-neuroimmune interactions in the stress response
10.1210/endocr/bqad088 · 2023 · External reference
Priming of microglia with dysfunctional gut microbiota impairs hippocampal neurogenesis and fosters stress vulnerability of mice
10.1016/j.bbi.2023.10.031 · 2024 · External reference
Subcutaneous Mycobacterium vaccae ameliorates the effects of early life adversity alone or in combination with chronic stress during adulthood in male and female mice
10.1016/j.ynstr.2023.100568 · 2023 · External reference
Understanding role of maternal separation in depression, anxiety, and pain behaviour: a mini review of preclinical research with focus on neuroinflammatory pathways
10.1002/jdn.70002 · 2025 · External reference
Effects of maternal separation on punishment-driven risky decision making in adolescence and adulthood
10.1016/j.nlm.2024.108016 · 2025 · External reference
The medial prefrontal cortex differentially regulates stress-induced c-fos expression in the forebrain depending on type of stressor
10.1046/j.1460-9568.2003.02932.x · 2003 · External reference
Targeting immune cell migration as therapy for inflammatory disease: a review
10.3389/fimmu.2025.1650760 · 2025 · External reference
Blocking P2Y2 purinergic receptor prevents the development of lipopolysaccharide-induced acute respiratory distress syndrome
10.3389/fimmu.2023.1310098 · 2023 · External reference
Tight junction proteins at the blood-brain barrier: far more than claudin-5
10.1007/s00018-019-03030-7 · 2019 · External reference
Transcriptional regulation of the human alpha2(I) collagen gene (COL1A2), an informative model system to study fibrotic diseases
10.1016/j.matbio.2006.05.002 · 2006 · External reference
Adult hippocampal neurogenesis and cognitive flexibility - linking memory and mood
10.1038/nrn.2017.45 · 2017 · External reference
Deletion of TrkB in adult progenitors alters newborn neuron integration into hippocampal circuits and increases anxiety-like behavior
10.1073/pnas.0803702105 · 2008 · External reference
Controversies and insights into cytokine regulation of neurogenesis and behavior in adult rodents
10.3389/fimmu.2025.1550660 · 2025 · External reference
Tumor necrosis factor-alpha modulates survival, proliferation, and neuronal differentiation in neonatal subventricular zone cell cultures
10.1634/stemcells.2007-0914 · 2008 · External reference
The role of inflammation in perinatal brain injury
10.1038/nrneurol.2015.13 · 2015 · External reference
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway
10.1073/pnas.0408258102 · 2004 · External reference
Neural stem cells fate under neuroinflammatory conditions and oxidative stress response
10.3389/fncel.2025.1736865 · 2025 · External reference
Harnessing the Stem Cell Niche in Regenerative Medicine: innovative Avenue to Combat Neurodegenerative Diseases
10.3390/ijms25020993 · 2024 · External reference
Female rodents are not more variable than male rodents: a meta-analysis of preclinical studies of fear and anxiety
10.1016/j.neubiorev.2022.104962 · 2022 · External reference
Effect of estrous cycle on behavior of females in rodent tests of anxiety
2021 · External reference
Age and an obesogenic diet affect mouse behaviour in a sex-dependent manner
10.1111/ejn.16070 · 2023 · External reference
Sex-specific spatial memory deficits associated with region-specific neuroinflammatory changes in the dorsal hippocampus of rats exposed to neonatal repeated maternal separation
10.1016/j.bbi.2025.06.031 · 2025 · External reference
Neurobiology of resilience in depression: immune and vascular insights from human and animal studies
10.1111/ejn.14547 · 2021 · External reference
Programming of the adult HPA axis after neonatal separation and environmental stress in male and female rats
10.1210/en.2018-00370 · 2018 · External reference
Long-term maternal separation potentiates depressive-like behaviours and neuroinflammation in adult male C57/BL6J mice
10.1016/j.pbb.2020.172953 · 2020 · External reference
Current opinion on the use of c-Fos in neuroscience
10.3390/neurosci3040050 · 2022 · External reference
Rethinking c-Fos for understanding drug action in the brain
10.1093/jb/mvad110 · 2024 · External reference
Effects of early life adversity on immediate early gene expression: systematic review and 3-level meta-analysis of rodent studies
10.1371/journal.pone.0253406 · 2022 · External reference
Developmental changes in desensitisation of c-Fos expression induced by repeated maternal separation in pre-weaned mice
10.1111/j.1365-2826.2012.02377.x · 2013 · External reference
Immediate early gene c-fos in the brain: focus on glial cells
10.3390/brainsci12060687 · 2022 · External reference
Stress-induced c-fos expression in the medial prefrontal cortex differentially affects the main residing cell phenotypes
10.1016/j.heliyon.2024.e39325 · 2024 · External reference
Dorsal dentate gyrus, a key regulator for mood and psychiatric disorders
10.1016/j.biopsych.2023.01.005 · 2023 · External reference
Quiescent adult neural stem cells: developmental origin and regulatory mechanisms
10.1007/s12264-024-01206-1 · 2024 · External reference
Adult hippocampal neurogenesis shapes adaptation and improves stress response: a mechanistic and integrative perspective
10.1038/s41380-021-01136-8 · 2022 · External reference
Early life events and maturation of the dentate gyrus: implications for neurons and glial cells
10.3390/ijms23084261 · 2022 · External reference
Roles of microglia in adult hippocampal neurogenesis in depression and their therapeutics
10.3389/fimmu.2023.1193053 · 2023 · External reference
The intricate interplay between microglia and adult neurogenesis in Alzheimer's disease
10.3389/fncel.2024.1456253 · 2024 · External reference
Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus
10.1038/s41593-024-01848-4 · 2025 · External reference
Characterization of the neurogenic niche in the aging dentate gyrus using iterative immunofluorescence imaging
10.7554/elife.68000 · 2022 · External reference