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References from Exploratory bone–brain transcriptomic associations and an ODE-based digital-twin framework for fracture healing. Local targets link to admitted publications; unresolved targets remain external evidence.
Multimodal biomedical AI
10.1038/s41591-022-01981-2 · 2022 · External reference
Advantages of digital twin technology in orthopedic trauma Surgery – Exploring different clinical use cases
10.1038/s41598-025-04792-w · 2025 · External reference
10.1016/j.injury.2020.11.049
10.1016/j.injury.2020.11.049 · External reference
Reliable and streamlined model setup for digital twin assessment of fracture healing
10.1016/j.jbiomech.2025.112492 · 2025 · External reference
Osteoimmunology: An Overview of the Interplay of the Immune System and the Bone Tissue in Fracture Healing
10.3390/surgeries5020033 · 2024 · External reference
The expression pattern of GDF15 in human brain changes during aging and in Alzheimer’s disease
2023 · External reference
Fracture healing: mechanisms and interventions
10.1038/nrrheum.2014.164 · 2015 · External reference
The local and systemic effects of immune function on fracture healing
10.1097/oi9.0000000000000328 · 2024 · External reference
Myokines and osteokines in aging-related degenerative diseases: Regulatory networks in the muscle-bone-brain axis
10.1016/j.cytogfr.2025.09.001 · 2025 · External reference
Computational Model of Bone Remodeling Integrating Osteocyte Mechanotransduction and Microdamage-Driven Self-Repair
10.1007/s10441-025-09505-4 · 2025 · External reference
Exploring the Potential of Digital Twins in Cancer Treatment: A Narrative Review of Reviews
10.3390/jcm14103574 · 2025 · External reference
Causal effect of blood osteocalcin on the risk of Alzheimer’s disease and the mediating role of energy metabolism. Transl
2024 · External reference
Medical Complications Predict Cognitive Decline in Nondemented Hip Fracture Patients—Results of a Prospective Observational Study
10.1177/0891988718760240 · 2018 · External reference
CDT1 is a Potential Therapeutic Target for the Progression of NAFLD to HCC and the Exacerbation of Cancer
10.2174/0113892029313473240919105819 · 2025 · External reference
Dysregulated Angiopoietin‐Tie signalling contributes to neurovascular dysfunction in Alzheimer’s disease
10.1002/alz.095139 · 2024 · External reference
Digital twins in healthcare: a comprehensive review and future directions
2025 · External reference
Delirium is a risk factor for institutionalization and functional decline in older hip fracture patients
10.1016/j.jpsychores.2013.10.006 · 2014 · External reference
A health digital twin framework for discrete event simulation based optimised critical care workflows
10.1038/s41746-025-01738-4 · 2025 · External reference
Suppression of NFATc1 through NF-kB/PI3K signaling pathway by Oleandrin to inhibit osteoclastogenesis and bone resorption
2024 · External reference
A review of bone fracture healing modelling: from mechanobiological theory to personalized rehabilitation protocols
10.1016/j.bone.2025.117688 · 2026 · External reference
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1
10.1016/j.cancergen.2025.04.007 · 2025 · External reference
Molecular mechanisms and therapeutic implications of the sympathetic nervous system in bone-related disorders: a brain-bone axis perspective
10.1038/s41413-025-00494-1 · 2025 · External reference
Role of Wnt5a in modulation of osteoporotic adipose‐derived stem cells and osteogenesis
10.1111/cpr.13747 · 2025 · External reference
Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair
10.1038/s41598-021-84888-1 · 2021 · External reference
10.1016/j.bone.2016.02.020
10.1016/j.bone.2016.02.020 · External reference
Cognitive decline and reduced bone mineral density under the bone-brain axis: mechanistic insights and imaging evaluation strategies
2026 · External reference
Longitudinal big biological data in the AI era
10.1038/s44320-025-00134-0 · 2025 · External reference
Modulation of the Inflammatory Response and Bone Healing
10.3389/fendo.2020.00386 · 2020 · External reference
Bidirectional association between cognitive impairment and bone mineral density reduction in aging populations: A systematic review and meta-analysis of osteoporosis, osteopenia, and bone mineral content
10.1016/j.bone.2025.117616 · 2025 · External reference
The potential link between the development of Alzheimer’s disease and osteoporosis
2025 · External reference
Single‐Cell Transcriptomic Analysis Reveals Epithelial‐Mesenchymal Transition and Key Gene AGRN as a Universal Programme in Gastrointestinal Tumours by an Artificial Intelligence‐Derived Prognostic Index
2026 · External reference
A review on Mg-based metallic glasses for biomedical scaffolds: experimental and computational modeling
10.20517/microstructures.2024.89 · 2025 · External reference
Role of the Neurologic System in Fracture Healing: An Extensive Review
10.1007/s11914-023-00844-0 · 2024 · External reference
A hybrid bioregulatory model of angiogenesis during bone fracture healing
10.1007/s10237-010-0241-7 · 2011 · External reference
Beyond Structure: The Interplay of Bone and Brain During Alzheimer’s Disease
10.1002/cph4.70075 · 2025 · External reference
Artificial-intelligence-driven Innovations in Mechanistic Computational Modeling and Digital Twins for Biomedical Applications
10.1016/j.jmb.2025.169181 · 2025 · External reference
Mechanobiology-guided machine learning models for predicting long bone fracture healing across diverse scenarios
10.1016/j.compbiomed.2025.110683 · 2025 · External reference
Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers
10.1177/0271678x16655551 · 2016 · External reference
The therapeutic potential of descending regulatory pathways from brain to bone in osteoporosis: focusing on the brain-bone axis
2026 · External reference
Cardiometabolic Risk Reduction with Digital Twinning: A Narrative Review
10.1016/j.ahj.2025.07.033 · 2025 · External reference
The role of exercise in enhancing brain and cerebrovascular health via the bone–brain axis: implications for surgical and clinical interventions
10.1097/js9.0000000000003030 · 2025 · External reference
Integrated lipidomics and computational analyses reveal cardiolipin dysregulation as a therapeutic target in bortezomib-induced peripheral neuropathy
10.1016/j.cpan.2025.02.002 · 2025 · External reference
The GTEx Consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
An improved mathematical modeling of bone remodeling: the role of stability in predicting bone health
10.1186/s13662-025-03934-8 · 2025 · External reference
Menopause triggers microglia-associated neuroinflammation in Parkinson’s disease
10.1016/j.brainres.2025.149649 · 2025 · External reference
Individual hearts: computational models for improved management of cardiovascular disease
10.1136/heartjnl-2024-324177 · 2026 · External reference
Mind Gaps and Bone Snaps: Exploring the Connection Between Alzheimer’s Disease and Osteoporosis
10.1007/s11914-023-00851-1 · 2024 · External reference
Dissecting the Implications of Calumenin in Malignancy and Heterogeneity of the Microenvironment of Clear Cell Renal Cell Carcinoma Using Multi-Omics Data
10.1007/s43657-024-00169-7 · 2024 · External reference
PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis
10.24976/discov.med.202436187.152 · 2024 · External reference
10.1002/imm3.70008
10.1002/imm3.70008 · External reference
Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways
10.1186/s13287-021-02263-3 · 2021 · External reference
Advancements in Imaging Technologies and AI Integration for Neurodegenerative Disease Management: A Narrative Review
10.1177/15353508251393056 · 2025 · External reference
Early Biological Orchestration in Fracture Healing: Decoding the Crosstalk between Inflammation, Coagulation, and Metabolism
10.1007/s12015-026-11076-x · 2026 · External reference
Diagnostic utility of GDF15 in neurodegenerative diseases: A systematic review and meta‐analysis
10.1002/brb3.2502 · 2022 · External reference
Exploring the Immune-Related Molecular Mechanisms Underlying the Comorbidity of Temporal Lobe Epilepsy and Major Depressive Disorder through Integrated Data Set Analysis
2025 · External reference
Novel injectable composite incorporating denosumab promotes bone regeneration via bone homeostasis regulation
2024 · External reference
Multilayer Gelatin-Supported BMP-9 Coating Promotes Osteointegration and Neo-Bone Formation at the n-CDHA/PAA Composite Biomaterial-Bone Interface
10.31083/j.fbl2909326 · 2024 · External reference
Single‐cell RNA sequencing reveals distinct immune cell subsets in phalangeal and soft‐tissue recurrence of giant cell tumor of bone
10.1002/med4.10 · 2023 · External reference
From Coffee Alkaloid to Ovarian Targets: An Integrated Computational Framework for Trigonelline in Ovarian Aging
10.1002/fsn3.71421 · 2026 · External reference
Bone-brain interaction: mechanisms and potential intervention strategies of biomaterials
10.1038/s41413-025-00404-5 · 2025 · External reference
The Potential Influence of Bone-Derived Modulators on the Progression of Alzheimer’s Disease
10.3233/jad-181249 · 2019 · External reference
Sirt5 desuccinylates Cdc42 to mediate osteoclastogenesis and bone remodeling in mice
2024 · External reference
Research progress in Alzheimer’s disease and bone-brain axis
10.1016/j.arr.2024.102341 · 2024 · External reference
Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans
2026 · External reference
Regulating Osteogenic Fate: How Dexamethasone Targets the CAST-CAPN1-ATP5A1 Axis in BMSCs
10.24976/discov.med.202537194.48 · 2025 · External reference
Growth and differentiation factor 15: An emerging therapeutic target for brain diseases
10.5582/bst.2024.01305 · 2025 · External reference