Research graph
References from Chronic THC exposure modulates behavioral outcomes and endocannabinoid signaling in HIV-1 Tg26 mice in a sex-dependent manner. Local targets link to admitted publications; unresolved targets remain external evidence.
Degeneration of the cerebellar dentate nucleus and the inferior olivary nuclei in HIV-1-infected brains: a morphometric analysis
10.1007/s004010050502 · 1996 · External reference
Cannabis in painful HIV-associated sensory neuropathy: a randomized placebo-controlled trial
10.1212/01.wnl.0000253187.66183.9c · 2007 · External reference
Differentiating people who use cannabis heavily through latent class analysis
10.1186/s13011-023-00540-3 · 2023 · External reference
Chronic morphine treatment and antiretroviral therapy exacerbate HIV-distal sensory peripheral neuropathy and induce distinct microbial alterations in the HIV Tg26 mouse model
10.3390/ijms25031569 · 2024 · External reference
Beneficial and adverse effects of THC on cognition in the HIV-1 transgenic rat model: importance of exploring task- and sex-dependent outcomes
10.1016/j.bbi.2025.04.030 · 2025 · External reference
A longitudinal characterization of sex-specific somatosensory and spatial memory deficits in HIV Tg26 heterozygous mice
10.1371/journal.pone.0244725 · 2020 · External reference
Cannabinoids and drug metabolizing enzymes: potential for drug-drug interactions and implications for drug safety and efficacy
10.1080/17512433.2022.2148655 · 2022 · External reference
A brainstem-spinal circuit controlling nocifensive behavior
10.1016/j.neuron.2018.10.037 · 2018 · External reference
Polygenic networks in peripheral leukocytes indicate patterns associated with HIV infection and context-dependent effects of cannabis use
2022 · External reference
A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis
10.1523/jneurosci.3923-04.2005 · 2005 · External reference
Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene
10.1111/j.1476-5381.2010.00757.x · 2010 · External reference
The endocannabinoid signalling system: biochemical aspects
10.1016/j.pbb.2005.01.027 · 2005 · External reference
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol
10.1016/j.chembiol.2007.11.006 · 2007 · External reference
Cannabidiol-Delta(9)-tetrahydrocannabinol interactions on acute pain and locomotor activity
10.1016/j.drugalcdep.2017.01.046 · 2017 · External reference
7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder
2021 · External reference
Elevated sCD163 in plasma but not cerebrospinal fluid is a marker of neurocognitive impairment in HIV infection
10.1097/qad.0b013e32836010bd · 2013 · External reference
The cannabinoid acids: nonpsychoactive derivatives with therapeutic potential
10.1016/s0163-7258(98)00069-2 · 1999 · External reference
Cytochrome P450 genes are differentially expressed in female and male hepatocyte retinoid X receptor alpha-deficient mice
10.1210/en.2002-0129 · 2003 · External reference
Cannabis constituent synergy in a mouse neuropathic pain model
10.1097/j.pain.0000000000001051 · 2017 · External reference
The cannabinoid CB1 receptor antagonist, SR141716A, selectively facilitates nociceptive responses of dorsal horn neurones in the rat
10.1038/sj.bjp.0702758 · 1999 · External reference
Mechanisms of action and pharmacokinetics of cannabis
2020 · External reference
Tetrahydrocannabinol and its major metabolites are not (or are poor) substrates or inhibitors of human P-glycoprotein [ATP-binding cassette (ABC) B1] and breast cancer resistance protein (ABCG2)
10.1124/dmd.121.000505 · 2021 · External reference
The endocannabinoid system as a potential therapeutic target for HIV-1-associated neurocognitive disorder
10.1089/can.2022.0267 · 2023 · External reference
Cannabinoid receptor expression in HIV encephalitis and HIV-associated neuropathologic comorbidities
10.1111/j.1365-2990.2011.01177.x · 2011 · External reference
Distinct effects of inflammation on cytochrome P450 regulation and drug metabolism: lessons from experimental models and a potential role for pharmacogenetics
10.3390/genes11121509 · 2020 · External reference
Measuring motor coordination in mice
10.3791/2609-v · 2013 · External reference
HIV-associated nephropathy in transgenic mice expressing HIV-1 genes
10.1016/0042-6822(91)90759-5 · 1991 · External reference
The endogenous cannabinoid system: a budding source of targets for treating inflammatory and neuropathic pain
10.1038/npp.2017.204 · 2018 · External reference
Recent cannabis use in HIV is associated with reduced inflammatory markers in CSF and blood
10.1212/nxi.0000000000000809 · 2020 · External reference
Cannabis and inflammation in HIV: a review of human and animal studies
10.3390/v13081521 · 2021 · External reference
Evidence for differential modulation of conditioned aversion and fear-conditioned analgesia by CB1 receptors
10.1111/j.1460-9568.2004.03509.x · 2004 · External reference
Cannabinoids, the endocannabinoid system, and pain: a review of preclinical studies
10.1097/j.pain.0000000000002268 · 2021 · External reference
Chronic Delta9-tetrahydrocannabinol treatment has dose-dependent effects on open field exploratory behavior and [(3)H] SR141716A receptor binding in the rat brain
10.1016/j.lfs.2023.121825 · 2023 · External reference
CB(1) receptor signaling: linking neuroplasticity, neuronal types, and mental health outcomes
10.1016/j.neuint.2025.105938 · 2025 · External reference
Isolation, structure, and partial synthesis of an active constituent of hashish
10.1021/ja01062a046 · 1964 · External reference
Pharmacokinetics and pharmacodynamics of cannabinoids
10.2165/00003088-200342040-00003 · 2003 · External reference
The molecular and pharmacological mechanisms of HIV-related neuropathic pain
10.2174/1570159x11311050005 · 2013 · External reference
Cannabinoid receptors: an update on cell signaling, pathophysiological roles and therapeutic opportunities in neurological, cardiovascular, and inflammatory diseases
10.3390/ijms21207693 · 2020 · External reference
Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
10.1038/mp.2011.82 · 2012 · External reference
An endocannabinoid mechanism for stress-induced analgesia
10.1038/nature03658 · 2005 · External reference
Cannabinoid suppression of noxious heat-evoked activity in wide dynamic range neurons in the lumbar dorsal horn of the rat
10.1152/jn.1999.81.2.575 · 1999 · External reference
HIV persistence in tissue macrophages of humanized myeloid-only mice during antiretroviral therapy
10.1038/nm.4319 · 2017 · External reference
CB(1) and CB(2) receptor pharmacology
10.1016/bs.apha.2017.03.007 · 2017 · External reference
The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod
10.1111/j.2042-7158.1968.tb09743.x · 1968 · External reference
Pathogenesis of HIV-associated sensory neuropathy: evidence from in vivo and in vitro experimental models
10.1111/j.1529-8027.2012.00373.x · 2012 · External reference
Correlation of HIV-induced neuroinflammation and synaptopathy with impairment of learning and memory in mice with HAND
10.3390/jcm12165169 · 2023 · External reference
Comparative analysis of sex-based, vendor-based, and species differences in cytochrome P450 metabolism
10.1038/s41598-025-34936-x · 2026 · External reference
Mapping cerebellar degeneration in HIV/AIDS
10.1097/wnr.0b013e328311d374 · 2008 · External reference
Chronic low-dose Δ9-tetrahydrocannabinol (THC) treatment stabilizes dendritic spines in 18-month-old mice
10.1038/s41598-022-27146-2 · 2023 · External reference
Neuronal toxicity in HIV CNS disease
10.2217/fvl.12.57 · 2012 · External reference
CD4(+) T cells expressing viral proteins induce HIV-associated endothelial dysfunction and hypertension through interleukin 1alpha-mediated increases in endothelial NADPH oxidase 1
10.1161/circulationaha.124.070538 · 2025 · External reference
Impairments of motor function while multitasking in HIV
10.3389/fnhum.2017.00212 · 2017 · External reference
Subcutaneous compared with intraperitoneal ketaminexylazine for anesthesia of mice
2016 · External reference
Cannabinol inhibits oxytosis/ferroptosis by directly targeting mitochondria independently of cannabinoid receptors
10.1016/j.freeradbiomed.2022.01.001 · 2022 · External reference
Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction
10.1038/s41467-022-31168-9 · 2022 · External reference
Patterns of age-related shrinkage in cerebellum and brainstem observed in vivo using three-dimensional MRI volumetry
10.1093/cercor/9.7.712 · 1999 · External reference
Distribution of cannabinoid receptors in the central and peripheral nervous system
10.1007/3-540-26573-2_10 · 2005 · External reference
Metabolomic profiling of cannabis use and cannabis intoxication in humans
10.1038/s41386-025-02082-7 · 2025 · External reference
Suppression of noxious stimulus-evoked activity in the ventral posterolateral nucleus of the thalamus by a cannabinoid agonist: correlation between electrophysiological and antinociceptive effects
10.1523/jneurosci.16-20-06601.1996 · 1996 · External reference
Delta(9)-tetrahydrocannabinol discrimination: Effects of route of administration in mice
2023 · External reference
An analgesia circuit activated by cannabinoids
10.1038/26481 · 1998 · External reference
The impact of cannabinoids on inflammasome signaling in HIV-1 infection
2023 · External reference
Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy
10.1016/j.neuropharm.2014.11.024 · 2015 · External reference
Elevated brain cannabinoid CB1 receptor availability in post-traumatic stress disorder: a positron emission tomography study
10.1038/mp.2013.61 · 2013 · External reference
Efficacy of Delta(9) -tetrahydrocannabinol (THC) alone or in combination with a 1:1 ratio of cannabidiol (CBD) in reversing the spatial learning deficits in old mice
10.3389/fnagi.2021.718850 · 2021 · External reference
Molecular architecture of endocannabinoid signaling at nociceptive synapses mediating analgesia
10.1111/j.1460-9568.2009.06751.x · 2009 · External reference
Frequency of cannabis use and medical cannabis use among persons living with HIV in the United States: findings from a nationally representative sample
10.1521/aeap.2018.30.2.169 · 2018 · External reference
The parabrachial nucleus: CGRP neurons function as a general alarm
10.1016/j.tins.2018.03.007 · 2018 · External reference
Intravenous injection in man of 9 -tetrahydrocannabinol and 11-OH- 9 -tetrahydrocannabinol
10.1126/science.177.4049.633 · 1972 · External reference
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
10.1038/sj.bjp.0707442 · 2008 · External reference
A lipid gate for the peripheral control of pain
10.1523/jneurosci.3475-14.2014 · 2014 · External reference
Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice
10.1016/j.bbi.2019.04.029 · 2019 · External reference
Adult neurogenic deficits in HIV-1 Tg26 transgenic mice
10.1186/s12974-018-1322-2 · 2018 · External reference
Advances in developing CAR T-cell therapy for HIV cure
10.3389/fimmu.2020.00361 · 2020 · External reference
The worldwide prevalence of anxiety in acquired immune deficiency syndrome patients: a systematic review and meta-analysis
2021 · External reference
Effects of acute THC challenge on behavior and neuroinflammation in HIV-1 Tg26 mice vary based on HIV status, chronic THC history, and sex
10.1016/j.bbi.2026.106476 · 2026 · External reference
Tissue distribution and gender-divergent expression of 78 cytochrome P450 mRNAs in mice
10.1093/toxsci/kfr240 · 2011 · External reference
Expression of UDP-glucuronosyltransferase isoform mRNAs during inflammation and infection in mouse liver and kidney
10.1124/dmd.105.007435 · 2006 · External reference
HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-gamma-inducible protein 10 levels compared with nonusing HIV patients
10.1097/qad.0000000000001704 · 2018 · External reference
Characteristics of motor dysfunction in longstanding human immunodeficiency virus
10.1093/cid/ciz986 · 2020 · External reference
HIV-associated synaptic degeneration
10.1186/s13041-017-0321-z · 2017 · External reference
Reversal of age-related cognitive impairments in mice by an extremely low dose of tetrahydrocannabinol
10.1016/j.neurobiolaging.2017.09.025 · 2018 · External reference
Motor control and aging: links to age-related brain structural, functional, and biochemical effects
10.1016/j.neubiorev.2009.10.005 · 2010 · External reference
Targeting the latent reservoir for HIV-1
10.1016/j.immuni.2018.04.030 · 2018 · External reference
Hippocampal differential expression underlying the neuroprotective effect of delta-9-tetrahydrocannabinol microdose on old mice
10.3389/fnins.2023.1182932 · 2023 · External reference
Cannabinoids' role in modulating central and peripheral immunity in neurodegenerative diseases
10.3390/ijms25126402 · 2024 · External reference
Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids
10.1615/critrevneurobiol.v15.i2.10 · 2003 · External reference
The role of endocannabinoids in physiological processes and disease pathology: a comprehensive review
10.3390/jcm14082851 · 2025 · External reference
Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin
10.1186/s12883-018-1047-y · 2018 · External reference
Enhanced brain disposition and effects of Delta9-tetrahydrocannabinol in P-glycoprotein and breast cancer resistance protein knockout mice
10.1371/journal.pone.0035937 · 2012 · External reference
Cannabinoid agonist administration within the cerebellar cortex impairs motor learning
10.1016/j.nlm.2018.06.015 · 2020 · External reference
Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
10.1002/glia.20983 · 2010 · External reference
Role of myeloid cells in HIV-1-host interplay
10.1007/s13365-014-0281-3 · 2015 · External reference
Breaking down the barrier: the effects of HIV-1 on the blood-brain barrier
10.1016/j.brainres.2011.05.015 · 2011 · External reference
Changes in neuron number in the cerebellar cortex of the ageing mouse
1989 · External reference
Endocannabinoid signaling from 2-arachidonoylglycerol to CB(1) cannabinoid receptor facilitates reward-based learning of motor sequence
10.1016/j.neuroscience.2019.09.040 · 2019 · External reference
The CB2 receptor and its role as a regulator of inflammation
10.1007/s00018-016-2300-4 · 2016 · External reference
The endocannabinoid system as a potential therapeutic target for pain modulation
10.5152/balkanmedj.2014.13103 · 2014 · External reference
Inflammatory signaling on cytochrome P450-mediated drug metabolism in hepatocytes
2022 · External reference
Low-dose delta-9-tetrahydrocannabinol as beneficial treatment for aged APP/PS1 mice
2022 · External reference
Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis
10.1212/wnl.0000000000010752 · 2020 · External reference
Cannabis exposure is associated with a lower likelihood of neurocognitive impairment in people living with HIV
10.1097/qai.0000000000002211 · 2020 · External reference
Unresolved reference
2025 · External reference
Antagonism of the discriminative stimulus effects of delta 9-tetrahydrocannabinol in rats and rhesus monkeys
10.1016/s0022-3565(25)12022-3 · 1995 · External reference
HIV tat protein selectively impairs CB1 receptor-mediated presynaptic inhibition at excitatory but not inhibitory synapses
10.1523/eneuro.0119-20.2020 · 2020 · External reference
Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
10.1371/journal.pone.0305868 · 2024 · External reference
Mini-review: the therapeutic role of cannabinoids in neuroHIV
10.1016/j.neulet.2021.135717 · 2021 · External reference
Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
10.3389/fnins.2024.1358555 · 2024 · External reference
Effects of acute Delta(9)-tetrahydrocannabinol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
10.1016/j.brainres.2023.148638 · 2024 · External reference
Acute effects of monoacylglycerol lipase inhibitor ABX1431 on neuronal hyperexcitability, nociception, locomotion, and the endocannabinoid system in HIV-1 tat male mice
10.1089/can.2023.0247 · 2024 · External reference
Anti-inflammatory effects of recreational marijuana in virally suppressed youth with HIV-1 are reversed by use of tobacco products in combination with marijuana
10.1186/s12977-022-00594-4 · 2022 · External reference
Cortical neuroinflammation contributes to long-term cognitive dysfunctions following adolescent delta-9-tetrahydrocannabinol treatment in female rats
10.1016/j.euroneuro.2015.09.021 · 2015 · External reference
Long-term HIV-1 tat expression in the brain led to neurobehavioral, pathological, and epigenetic changes reminiscent of accelerated aging
10.14336/ad.2019.0323 · 2020 · External reference
