Research graph
References from Methotrexate induces alterations in one-carbon metabolism and in plasmalogen and phosphatidylcholine levels in CSF of juvenile rats. Local targets link to admitted publications; unresolved targets remain external evidence.
Stem cell transplantation reverses chemotherapy-induced cognitive dysfunction
10.1158/0008-5472.can-14-2237 · 2015 · External reference
Differential changes in the content of amino acid neurotransmitters in discrete regions of the rat brain prior to the onset and during the course of homocysteine-induced seizures
10.1111/j.1471-4159.1986.tb01780.x · 1986 · External reference
Long-term clinically relevant rodent model of methotrexate-induced cognitive impairment
10.1093/neuonc/noaa086 · 2020 · External reference
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia
10.1200/jco.2013.53.0808 · 2014 · External reference
Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models
10.7150/jca.2.292 · 2011 · External reference
Effects of early chemotherapeutic treatment on learning in adolescent mice: implications for cognitive impairment and remediation in childhood cancer survivors
10.1158/1078-0432.ccr-12-3764 · 2013 · External reference
Lipidomics reveals cerebrospinal-fluid signatures of ALS
10.1038/s41598-017-17389-9 · 2017 · External reference
Cerebral metabolic and circulatory changes in the rat during sustained seizures induced by DL-homocysteine
10.1016/0006-8993(79)90497-9 · 1979 · External reference
“Membrane phospholipids and high-energy metabolites in childhood ataxia with CNS hypomyelination,”
10.1212/wnl.61.5.648 · 2003 · External reference
Pediatric Acute Lymphoblastic Leukemia, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology
10.6004/jnccn.2020.0001 · 2020 · External reference
Oxidative stress and executive function in children receiving chemotherapy for acute lymphoblastic leukemia
10.1002/pbc.22128 · 2009 · External reference
Impaired cognitive function and hippocampal neurogenesis following cancer chemotherapy
10.1158/1078-0432.ccr-11-2000 · 2012 · External reference
Assessing rodent hippocampal involvement in the novel object recognition task. A review
10.1016/j.bbr.2014.08.002 · 2015 · External reference
Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits
10.1158/1078-0432.ccr-13-1179 · 2013 · External reference
Polymorphisms in genes related to oxidative stress are associated with inferior cognitive function after therapy for childhood acute lymphoblastic leukemia
10.1200/jco.2014.59.0273 · 2015 · External reference
Cerebrospinal fluid metabolomic signatures in paediatric MOGAD and POMS
2025 · External reference
Neurocognitive outcome and associated factors in long-term, adult survivors of childhood acute lymphoblastic leukemia, treated without cranial radiation therapy
10.1017/s1355617724000080 · 2024 · External reference
Early methyl donor deficiency alters cAMP signaling pathway and neurosteroidogenesis in the cerebellum of female rat pups
10.1152/ajpendo.00364.2014 · 2014 · External reference
Plasmalogens: targets for oxidants and major lipophilic antioxidants
10.1042/bst0320147 · 2004 · External reference
A new one-trial test for neurobiological studies of memory in rats. III. Spatial vs. non-spatial working memory
10.1016/s0166-4328(05)80315-8 · 1992 · External reference
Alterations in cerebrospinal fluid glycerophospholipids and phospholipase A2 activity in Alzheimer’s disease
10.1194/jlr.m037622 · 2013 · External reference
Precision of a clinical metabolomics profiling platform for use in the identification of inborn errors of metabolism
10.1093/jalm/jfz026 · 2020 · External reference
Clinical metabolomics for inborn errors of metabolism
10.1016/bs.acc.2021.09.001 · 2022 · External reference
Using a murine model to explore the impact of sex and APOE4 on cisplatin-induced cognitive impairment
10.1016/j.bbi.2025.05.010 · 2025 · External reference
Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment
10.1016/j.neuron.2019.04.032 · 2019 · External reference
Methotrexate chemotherapy induces persistent tri-glial dysregulation that underlies chemotherapy-related cognitive impairment
10.1016/j.cell.2018.10.049 · 2019 · External reference
Changes in cognition and astrocytic reactivity in a female rodent model of chemotherapy-induced cognitive impairment are variable both acutely and chronically
2024 · External reference
Metabolite levels measured using magnetic resonance spectroscopy in pediatric methotrexate-induced leukoencephalopathy
10.1002/pbc.31957 · 2025 · External reference
Asymmetric distribution of plasmalogens and their roles-a mini review
10.3390/membranes13090764 · 2023 · External reference
Acute lymphoblastic leukemia in children
10.1056/nejmra1400972 · 2015 · External reference
Matplotlib: a 2D graphics environment
10.1109/mcse.2007.55 · 2007 · External reference
Acute lymphoblastic leukaemia
10.1016/s0140-6736(12)62187-4 · 2013 · External reference
Chemotherapy-only treatment effects on long-term neurocognitive functioning in childhood ALL survivors: a review and meta-analysis
10.1182/blood-2015-02-627414 · 2015 · External reference
The national cancer institute clinical trials planning meeting to address gaps in observational and intervention trials for cancer-related cognitive impairment
10.1093/jnci/djae209 · 2025 · External reference
Choroid plexus-CSF-targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy
10.1016/j.neuron.2022.08.009 · 2022 · External reference
Are cognitive and educational development affected by age at which prophylactic therapy is given in acute lymphoblastic leukaemia?
10.1136/adc.58.12.953 · 1983 · External reference
Animal models of chemotherapy-induced cognitive decline in preclinical drug development
10.1007/s00213-021-05977-7 · 2021 · External reference
Evidence of brain methyltransferase inhibition and early brain involvement in HIV-positive patients
10.1016/0140-6736(91)91570-k · 1991 · External reference
Increase in oxidative stress as measured by cerebrospinal fluid lipid peroxidation during treatment for childhood acute lymphoblastic leukemia
10.1097/mph.0000000000000258 · 2015 · External reference
Circulating ethanolamine plasmalogen indices in Alzheimer’s disease: Relation to diagnosis, cognition, and CSF tau
10.1002/alz.12110 · 2020 · External reference
Intrathecal methotrexate induces focal cognitive deficits and increases cerebrospinal fluid homocysteine
10.1016/j.pbb.2010.03.003 · 2010 · External reference
Systemic methotrexate induces spatial memory deficits and depletes cerebrospinal fluid folate in rats
10.1016/j.pbb.2009.10.008 · 2010 · External reference
The importance of working memory for school achievement in primary school children with intellectual or learning disabilities
10.1016/j.ridd.2016.08.007 · 2016 · External reference
Gut dysbiosis and homocysteine: a couple for boosting neurotoxicity in Huntington disease
10.1515/revneuro-2021-0164 · 2022 · External reference
Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders
10.1016/s0166-2236(03)00032-8 · 2003 · External reference
Cognitive function of children and adolescent survivors of acute lymphoblastic leukemia: a meta-analysis
10.3892/ol.2021.12523 · 2021 · External reference
Neurotoxicity in leukemic children receiving prophylactic cranial irradiation and maintenance high dose methotrexate
10.1203/00006450-197404000-00389 · 1974 · External reference
Interactions of steroid, methotrexate, and radiation determine neurotoxicity in an animal model to study therapy for childhood leukemia
10.1203/00006450-199402000-00009 · 1994 · External reference
Cellular mechanisms and treatments for chemobrain: insight from aging and neurodegenerative diseases
10.15252/emmm.202012075 · 2020 · External reference
MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation
10.1093/nar/gkae253 · 2024 · External reference
Gender difference in motor impairments induced by chronic administration of vinblastine
2014 · External reference
Differences in CSF phospholipid concentration by traumatic brain injury outcome
10.1177/1099800409346056 · 2010 · External reference
Influence of ApoE genotype on doxorubicin-induced cognitive impairment in juvenile rats
10.1038/s41598-025-33104-5 · 2025 · External reference
Doxorubicin causes cognitive impairment and alters gut microbiota in both male and female juvenile rats
10.1038/s41598-025-12352-5 · 2025 · External reference
“Scikit-learn: machine learning in python
2011 · External reference
A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia
10.1002/pbc.21544 · 2008 · External reference
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Lipid metabolism disorder in cerebrospinal fluid related to Parkinson’s disease
10.3390/brainsci13081166 · 2023 · External reference
Interaction of dihydrofolate reductase with methotrexate: ensemble and single-molecule kinetics
10.1073/pnas.172501499 · 2002 · External reference
Neurobiological basis of chemotherapy-induced cognitive impairment: a review of rodent research
10.1016/j.neubiorev.2010.09.006 · 2011 · External reference
Assay of S-methylmethionine and S-adenosylmethionine homocysteine transmethylases
10.1016/0006-3002(59)90089-7 · 1959 · External reference
Methotrexate: distribution in cerebrospinal fluid after intravenous, ventricular and lumbar injections
10.1056/nejm197507242930402 · 1975 · External reference
Protein N-homocysteinylation: from cellular toxicity to neurodegeneration
10.1016/j.bbagen.2015.08.013 · 2015 · External reference
Long-term results of Dana-Farber cancer institute ALL consortium protocols for children with newly diagnosed acute lymphoblastic leukemia (1985-2000)
10.1038/leu.2009.253 · 2010 · External reference
Observations of unprecedented remissions following novel treatment for acute leukemia in children in 1948
10.1258/jrsm.2012.12k013 · 2012 · External reference
Oxidative stress and neurobehavioral problems in pediatric acute lymphoblastic leukemia patients undergoing chemotherapy
10.1097/mph.0b013e3181c9af84 · 2010 · External reference
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Complementary roles of broad cerebrospinal fluid proteomics and precision studies in pediatric acute lymphoblastic leukemia
2026 · External reference
Liposomal cytarabine induces less neurocognitive dysfunction than intrathecal methotrexate in an animal model
10.1097/mph.0000000000000888 · 2018 · External reference
Thigmotaxis as a test for anxiolytic activity in rats
10.1016/0091-3057(88)90413-3 · 1988 · External reference
Sex-specific associations between chemotherapy, chronic conditions, and neurocognitive impairment in acute lymphoblastic leukemia survivors: a report from the childhood cancer survivor study
10.1093/jnci/djaa136 · 2021 · External reference
Cognitive and behavioral risk factors for low quality of life in survivors of childhood acute lymphoblastic leukemia
10.1038/s41390-020-01230-7 · 2021 · External reference
Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist
10.1016/j.bbr.2011.08.006 · 2011 · External reference
10.1200/jco.2012.43.2070
10.1200/jco.2012.43.2070 · 2013 · External reference
Correlation of the ratio of S-adenosyl-L-methionine to S-adenosyl-L-homocysteine in the brain and cerebrospinal fluid of the pig: implications for the determination of this methylation ratio in human brain
10.1042/cs0820093 · 1992 · External reference
Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model
10.1016/j.neuropharm.2018.07.007 · 2018 · External reference
Cognitive impairment persists at least 1 year after juvenile rats are treated with methotrexate
10.1016/j.neuropharm.2021.108939 · 2022 · External reference
Wnt signaling pathways are dysregulated in rat female cerebellum following early methyl donor deficiency
10.1007/s12035-018-1128-3 · 2019 · External reference
Cross-talk between miRNAs from the Dlk1-Dio3 locus and histone methylation to protect male cerebellum from methyl donor deficiency
10.1002/mnfr.202300040 · 2023 · External reference
CSF metabolomic signature during therapy for childhood acute lymphoblastic leukemia predicts subsequent working memory impairment
10.1186/s10020-025-01414-z · 2025 · External reference
What is known and unknown about chemotherapy-related cognitive impairment in patients with haematological malignancies and areas of needed research
10.1111/bjh.14211 · 2016 · External reference
Methotrexate, a high-affinity pseudosubstrate of dihydrofolate reductase
10.1021/bi00579a021 · 1979 · External reference
Non-targeted lipidomics of CSF and frontal cortex grey and white matter in control, mild cognitive impairment, and Alzheimer’s disease subjects
10.1017/neu.2015.18 · 2015 · External reference
Serine ether glycerophospholipids: decrements in the frontal cortex associated with mild cognitive impairment and Alzheimer’s disease
10.3389/fnagi.2022.981868 · 2022 · External reference
Spatially and temporally probing distinctive glycerophospholipid alterations in Alzheimer’s disease mouse brain via high-resolution ion mobility-enabled sn-position resolved lipidomics
10.1038/s41467-024-50299-9 · 2024 · External reference
An animal model to detect learning deficits following treatment of the immature brain
1983 · External reference
Nicotinamide mononucleotide prevents cisplatin-induced cognitive impairments
10.1158/0008-5472.can-20-3290 · 2021 · External reference
Plasmalogens as endogenous antioxidants: somatic cell mutants reveal the importance of the vinyl ether
10.1042/bj3380769 · 1999 · External reference
