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References from Research progress on Drp1 in the pathological mechanisms and therapeutic interventions of stroke, based on the imbalance in the dynamic equilibrium of mitochondrial fission and fusion. Local targets link to admitted publications; unresolved targets remain external evidence.
Discovery of FRAG-i: a small molecule inhibitor of Drp1 that modulates mitochondrial fission
10.1016/j.mito.2026.102162 · 2026 · External reference
Current Advancement and Patient Outcomes in Reperfusion Brain Injuries After Stroke: A Comparative Analysis of Thrombolysis and Thrombectomy
10.1002/brb3.70705 · 2025 · External reference
The Putative Drp1 Inhibitor mdivi-1 Is a reversible mitochondrial complex i inhibitor that modulates reactive oxygen species
10.1016/j.devcel.2017.02.020 · 2017 · External reference
Drp1 and neuroinflammation: deciphering the interplay between mitochondrial dynamics imbalance and inflammation in neurodegenerative diseases
10.1016/j.nbd.2024.106561 · 2024 · External reference
Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
10.1111/j.1749-6632.2010.05629.x · 2010 · External reference
ROS-Drp1-mediated mitochondria fission contributes to hippocampal HT22 cell apoptosis induced by silver nanoparticles
10.1016/j.redox.2023.102739 · 2023 · External reference
Mitochondria: novel mechanisms and therapeutic targets for secondary brain injury after intracerebral hemorrhage
2020 · External reference
CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation
10.1038/emm.2014.36 · 2014 · External reference
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury
10.1126/science.1171091 · 2009 · External reference
The complement cascade as a therapeutic target in intracerebral hemorrhage
10.1016/j.expneurol.2009.07.018 · 2009 · External reference
The role of cardiolipin in mitochondrial dynamics and quality control in neuronal ischemia/reperfusion injury
10.1038/s41419-025-07786-8 · 2025 · External reference
AKAP1 protects from cerebral ischemic stroke by inhibiting Drp1-dependent mitochondrial fission
10.1523/jneurosci.0649-18.2018 · 2018 · External reference
Deletion of a Neuronal Drp1 activator protects against cerebral ischemia
10.1523/jneurosci.1926-19.2020 · 2020 · External reference
Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-I activity
10.1038/srep30127 · 2016 · External reference
Modulation of dynamin-related protein 1 (DRP1) function by increased O-linked-β-N-acetylglucosamine modification (O-GlcNAc) in cardiac myocytes
10.1074/jbc.m112.390682 · 2012 · External reference
Mitochondrial Dynamics in Neurodegenerative Diseases: Unraveling the Role of Fusion and Fission Processes
10.3390/ijms241713033 · 2023 · External reference
Iron, ferroptosis, and ischemic stroke
10.1111/jnc.15807 · 2023 · External reference
B355252 Targets UCP2 to rescue intracerebral hemorrhage-induced injury by promoting mitochondrial fusion and inhibiting ferroptosis
10.1007/s12035-025-05368-5 · 2025 · External reference
The DRP1 inhibitory peptide P110 provides neuroprotection after subarachnoid hemorrhage by suppressing neuronal apoptosis and stabilizing the blood-brain barrier
10.1016/j.freeradbiomed.2025.08.011 · 2025 · External reference
Stroke
10.1016/s0140-6736(24)00642-1 · 2024 · External reference
Targeting mitochondrial quality control: new therapeutic strategies for major diseases
2024 · External reference
The role of dynamin-related protein 1 in cerebral ischemia/hypoxia injury
10.1016/j.biopha.2023.115247 · 2023 · External reference
ATF3 knockdown exacerbates astrocyte activation by inhibiting phosphorylation of Drp1 in ischemic stroke
2025 · External reference
Drp1-dependent mitochondrial fission in cardiovascular disease
10.1038/s41401-020-00518-y · 2021 · External reference
Structural basis of mitochondrial receptor binding and constriction by DRP1
10.1038/s41586-018-0211-2 · 2018 · External reference
Mitochondrial fission - changing perspectives for future progress
10.1242/jcs.263640 · 2025 · External reference
Distinct fission signatures predict mitochondrial degradation or biogenesis
10.1038/s41586-021-03510-6 · 2021 · External reference
Resveratrol reduces DRP1-mediated mitochondrial dysfunction via the SIRT1-PGC1α signaling pathway in manganese-induced nerve damage in mice
10.1002/tox.23397 · 2022 · External reference
Acetylation of α-tubulin restores endothelial cell injury and blood-brain barrier disruption after intracerebral hemorrhage in mice
10.1038/s12276-025-01454-9 · 2025 · External reference
The role of mitochondrial dynamin in stroke
2022 · External reference
Neuroprotective effects of resveratrol against oxygen glucose deprivation induced mitochondrial dysfunction by activation of AMPK in SH-SY5Y cells with 3D gelatin scaffold
10.1016/j.brainres.2019.146492 · 2020 · External reference
The mitochondrial fission receptor Mff selectively recruits oligomerized Drp1
10.1091/mbc.e15-08-0591 · 2015 · External reference
Mitochondrial fission and fusion in neurodegenerative diseases:Ca(2+) signalling
10.1016/j.mcn.2025.103992 · 2025 · External reference
Pseudolaric acid B triggers cell apoptosis by activating AMPK/JNK/DRP1/mitochondrial fission pathway in hepatocellular carcinoma
10.1016/j.tox.2023.153556 · 2023 · External reference
Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities
10.1016/j.arr.2024.102638 · 2025 · External reference
GSKIP- and GSK3-mediated anchoring strengthens cAMP/PKA/Drp1 axis signaling in the regulation of mitochondrial elongation
10.1016/j.bbamcr.2015.04.013 · 2015 · External reference
Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission
10.1091/mbc.e12-10-0721 · 2013 · External reference
Drp1 proteins released from hydrolysis-driven scaffold disassembly trigger nucleotide-dependent membrane remodeling to promote scission
10.1021/jacs.4c15836 · 2025 · External reference
Exercise as a bidirectional regulator of Drp1: a goldilocks principle for mitochondrial adaptation in skeletal muscle
10.3390/cells15121091 · 2026 · External reference
Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement
10.1038/jcbfm.2014.186 · 2015 · External reference
Dynamic mechanisms and targeted interventions in cerebral ischemia-reperfusion injury: pathological cascade from ischemia to reperfusion and promising therapeutic strategies
10.3389/fnins.2025.1649533 · 2025 · External reference
Mechanism of neuroprotective mitochondrial remodeling by PKA/AKAP1
10.1371/journal.pbio.1000612 · 2011 · External reference
Aberrant protein s-nitrosylation in neurodegenerative diseases
10.1016/j.neuron.2013.05.005 · 2013 · External reference
Effects of Mdivi-1 on neural mitochondrial dysfunction and mitochondria-mediated apoptosis in ischemia-reperfusion injury after stroke: a systematic review of preclinical studies
10.3389/fnmol.2021.778569 · 2021 · External reference
Cell-specific roles of GRK2 in onset and severity of hypoxic-ischemic brain damage in neonatal mice
10.1016/j.bbi.2009.11.009 · 2010 · External reference
Human Fis1 directly interacts with Drp1 in an evolutionarily conserved manner to promote mitochondrial fission
10.1016/j.jbc.2023.105380 · 2023 · External reference
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1
10.1242/jcs.061481 · 2010 · External reference
Mechanistic and therapeutic role of Drp1 in the pathogenesis of stroke
10.1016/j.gene.2022.147130 · 2023 · External reference
Mitochondrial fission: rings around the organelle
10.1016/j.cub.2013.02.042 · 2013 · External reference
Mitochondria as intracellular signalling organelles. An update
10.1016/j.cellsig.2023.110794 · 2023 · External reference
Five-decade mortality trends in ischemic stroke in the United States: A CDC WONDER Analysis
10.1002/brb3.71177 · 2026 · External reference
A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity
2013 · External reference
The role of mitochondrial fission in cardiovascular health and disease
10.1038/s41569-022-00703-y · 2022 · External reference
Inhibition of Drp1-dependent mitochondrial fission by natural compounds as a therapeutic strategy for organ injuries
10.1016/j.phrs.2023.106672 · 2023 · External reference
Melatonin regulates mitochondrial dynamics and mitophagy: cardiovascular protection
10.1111/jcmm.70074 · 2024 · External reference
MiD49 and MiD51: new mediators of mitochondrial fission and novel targets for cardioprotection
2018 · External reference
Molecular mechanisms of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive oxygen species generation
10.1007/s12035-012-8344-z · 2013 · External reference
Naotaifang formula regulates Drp1-induced remodeling of mitochondrial dynamics following cerebral ischemia-reperfusion injury
10.1016/j.freeradbiomed.2025.01.031 · 2025 · External reference
Melatonin as a neuroprotective agent in ischemic stroke: mechanistic insights centralizing mitochondria as a potential therapeutic target
10.32604/biocell.2025.072557 · 2026 · External reference
A new strategy for the treatment of intracerebral hemorrhage: ferroptosis
10.1016/j.expneurol.2024.114961 · 2024 · External reference
Molecular mechanisms of mitochondrial dynamics
10.1038/s41580-024-00785-1 · 2025 · External reference
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
10.1074/jbc.m607279200 · 2007 · External reference
Development of classification models for predicting inhibition of mitochondrial fusion and fission using machine learning methods
2020 · External reference
10.3390/ph17101302
10.3390/ph17101302 · 2024 · External reference
Blood-brain barriers and drug pharmacokinetics: mechanisms and models
10.1016/j.ejphar.2025.177872 · 2025 · External reference
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
10.1038/sj.emboj.7601963 · 2008 · External reference
Unresolved reference
2026 · External reference
DRP1, fission and apoptosis
10.1038/s41420-025-02458-0 · 2025 · External reference
Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
10.1016/j.cmet.2012.01.009 · 2012 · External reference
Identification of novel dynamin-related protein 1 (Drp1) GTPase inhibitors: therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia-reperfusion injury
10.1096/fj.201901467r · 2020 · External reference
The mystery of phospho-Drp1 with four adaptors in cell cycle: when mitochondrial fission couples to cell fate decisions
10.1080/15384101.2023.2289753 · 2023 · External reference
YiQiFuMai powder injection protects against ischemic stroke via inhibiting neuronal apoptosis and PKCδ/Drp1-Mediated Excessive Mitochondrial Fission
10.1155/2017/1832093 · 2017 · External reference
Dental pulp stem cell-derived conditioned medium alleviates subarachnoid hemorrhage-induced microcirculation impairment by promoting M2 Microglia Polarization and Reducing Astrocyte Swelling
10.1007/s12975-022-01083-8 · 2023 · External reference
Diverse roles of mitochondria in ischemic stroke
10.1016/j.redox.2018.03.002 · 2018 · External reference
Neuronal HIPK2-HDAC3 axis regulates mitochondrial fragmentation to participate in stroke injury and post-stroke anxiety like behavior
10.1016/j.expneurol.2024.114906 · 2024 · External reference
Selective cerebral hypothermia alleviates focal cerebral ischemia/reperfusion injury via enhancing SUMO2/3 modification of Drp1 in rats
10.1016/j.biocel.2025.106772 · 2025 · External reference
Targeted treatment of ischemic stroke by bioactive nanoparticle-derived reactive oxygen species responsive and inflammation-resolving nanotherapies
10.1021/acsnano.1c04753 · 2021 · External reference
Mdivi-1 alleviates brain damage and synaptic dysfunction after intracerebral hemorrhage in mice
10.1007/s00221-021-06089-6 · 2021 · External reference
Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission
10.1186/s10020-024-00948-y · 2024 · External reference
O-GlcNAc Transferase (OGT) protects cerebral neurons from death during ischemia/reperfusion (I/R) Injury by Modulating Drp1 in Mice
10.1007/s12017-021-08688-6 · 2022 · External reference
Ginkgolide K attenuates neuronal injury after ischemic stroke by inhibiting mitochondrial fission and GSK-3β-dependent increases in mitochondrial membrane permeability
10.18632/oncotarget.17967 · 2017 · External reference
Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke
10.1093/abbs/gmab092 · 2021 · External reference