Research graph
References from Clusterin interference decreases cerebral ischemia/reperfusion injury by suppressing TFR1-dependent ferroptosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Cardioprotective effects of the extracellular chaperone clusterin in acute myocardial infarction
10.1111/eci.70076 · 2025 · External reference
Emerging Therapeutic Targets and Signaling Networks in Ischemia-Reperfusion Injury
2026 · External reference
Qingda granule alleviates cerebral ischemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 signaling in microglia
10.1016/j.jep.2024.117712 · 2024 · External reference
Neuroinflammation, Stroke, Blood-Brain Barrier Dysfunction, and Imaging Modalities
10.1161/strokeaha.122.036946 · 2022 · External reference
Piezo1 activation in endothelial cells aggravates microvascular ischemia-reperfusion injury in limbs by enhancing ferroptosis
10.1038/s12276-025-01616-9 · 2026 · External reference
Resibufogenin ameliorates cerebral ischemia-reperfusion injury by modulating microglial redox homeostasis via Keap1-Nrf2-TFR1/ARE axis
10.1038/s41401-025-01689-2 · 2026 · External reference
Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway
10.2147/dddt.s509357 · 2025 · External reference
Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway
10.1016/j.phymed.2023.155282 · 2024 · External reference
Clusterin: structure, function and roles in disease
10.7150/ijms.107159 · 2025 · External reference
Nanoparticles Designed Based on the Blood-Brain Barrier for the Treatment of Cerebral Ischemia-Reperfusion Injury
10.1002/smll.202410404 · 2025 · External reference
Transferrin Receptor Is a Specific Ferroptosis Marker
10.1016/j.celrep.2020.02.049 · 2020 · External reference
Rosmarinic acid attenuates blood-brain barrier dysfunction to improve cerebral ischemia/reperfusion injury in mice
10.1016/j.ejphar.2025.177882 · 2025 · External reference
Nanomedicine-based therapeutic strategies for cerebral ischemia-reperfusion injury: from blood-brain barrier penetration to precision targeting
2026 · External reference
Sustained astrocytic clusterin expression improves remodeling after brain ischemia
10.1016/j.nbd.2005.11.009 · 2006 · External reference
Rosmarinic acid liposomes suppress ferroptosis in ischemic brain via inhibition of TfR1 in BMECs
10.1016/j.phymed.2024.155835 · 2024 · External reference
Neutrophil Mobilization Triggers Microglial Functional Change to Exacerbate Cerebral Ischemia-Reperfusion Injury
2025 · External reference
Neuroinflammation in Cerebral Ischemia and Ischemia/Reperfusion Injuries: From Pathophysiology to Therapeutic Strategies
10.3390/ijms23010014 · 2021 · External reference
Polyphyllin I alleviates neuroinflammation after cerebral ischemia-reperfusion injury via facilitating autophagy-mediated M2 microglial polarization
10.1186/s10020-024-00828-5 · 2024 · External reference
MFSD2A: a molecular nexus linking blood-brain barrier, lipid metabolism, and ischemia-reperfusion injury
10.1186/s11658-025-00828-1 · 2025 · External reference
Silencing Hmox1 Attenuates Cerebral Ischemia/reperfusion Injury and Inhibits Inflammation and Ferroptosis Via the PPAR-γ/FABP4 Signaling Pathway
10.1007/s12035-025-04899-1 · 2025 · External reference
THBS1 in macrophage-derived exosomes exacerbates cerebral ischemia-reperfusion injury by inducing ferroptosis in endothelial cells
10.1186/s12974-025-03382-x · 2025 · External reference
Ferritinophagy and Ferroptosis in Cerebral Ischemia Reperfusion Injury
10.1007/s11064-024-04161-5 · 2024 · External reference
Pseudorabies virus induces ferroptosis by disrupting iron homeostasis through activation of TfR1 and ferritinophagy
10.1128/jvi.00974-25 · 2025 · External reference
Clusterin deficiency exacerbates cholestatic liver disease through ER stress and NLRP3 inflammasome activation
10.1186/s13578-025-01376-z · 2025 · External reference
From Analysis of Ischemic Mouse Brain Proteome to Identification of Human Serum Clusterin as a Potential Biomarker for Severity of Acute Ischemic Stroke
10.1007/s12975-018-0675-2 · 2019 · External reference
Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion
10.1038/s41392-022-00917-z · 2022 · External reference
Blood-brain barrier injury and neuroinflammation induced by SARS-CoV-2 in a lung-brain microphysiological system
10.1038/s41551-023-01141-y · 2024 · External reference
Beta-asarone alleviated cerebral ischemia/reperfusion injury by targeting PINK1/Parkin-dependent mitophagy
10.1016/j.ejphar.2025.177831 · 2025 · External reference
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway
10.1111/cns.70314 · 2025 · External reference
Ferroptosis in ischemia-reperfusion injury: molecular mechanisms and therapeutic strategies
10.62347/olgv6926 · 2025 · External reference
Clusterin-mediated polarization of M2 macrophages: a mechanism of temozolomide resistance in glioblastoma stem cells
10.1186/s13287-025-04247-z · 2025 · External reference
Lycium barbarum polysaccharide alleviates ferroptosis in Sertoli cells through NRF2/SLC7A11/GPX4 pathway and ameliorates DEHP-induced male reproductive damage in mice
2024 · External reference
Clusterin Inhibits Neuronal Ferroptosis via the PI3K-AKT-mTOR-SREBP1 Axis to Promote Functional Recovery after Spinal Cord Injury
10.7150/ijbs.124291 · 2026 · External reference
Kaempferol Ameliorates Oxygen-Glucose Deprivation/Reoxygenation-Induced Neuronal Ferroptosis by Activating Nrf2/SLC7A11/GPX4 Axis
10.3390/biom11070923 · 2021 · External reference
Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis
10.1161/circulationaha.123.066110 · 2024 · External reference
Tetrahydrocurcumin Ameliorates Cerebral Ischemia-Reperfusion Injury and Restores Blood-Brain Barrier Dysfunction by Inhibiting Ferroptosis
10.1111/cns.70662 · 2025 · External reference
SerpinA3N attenuates ischemic stroke injury by reducing apoptosis and neuroinflammation
10.1111/cns.13776 · 2022 · External reference