Research graph
References from Multiscale modeling uncovers macrophage infiltration and TNF-α signaling networks for targeting in inflammatory breast cancer tumor emboli. Local targets link to admitted publications; unresolved targets remain external evidence.
Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study
10.1002/cncr.25682 · 2011 · External reference
Incidence and survival of inflammatory breast cancer between 1973 and 2015 in the SEER database
10.1007/s10549-020-05938-2 · 2021 · External reference
Pattern of distant metastases in inflammatory breast cancer - a large-cohort retrospective study
10.7150/jca.34572 · 2020 · External reference
Dermal lymphatic invasion, survival, and time to recurrence or progression in inflammatory breast cancer
10.1097/coc.0000000000000843 · 2021 · External reference
Tailoring treatment for patients with inflammatory breast cancer
10.1007/s11864-023-01077-0 · 2023 · External reference
Metastatic behavior and overall survival according to breast cancer subtypes in stage IV inflammatory breast cancer
10.1186/s13058-019-1201-5 · 2019 · External reference
Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge
10.1002/cncr.25169 · 2010 · External reference
Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies
10.18632/oncotarget.15667 · 2017 · External reference
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
10.1073/pnas.1815345116 · 2019 · External reference
Inflammatory breast cancer appearance at presentation is associated with overall survival
10.1002/cam4.4170 · 2021 · External reference
Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint
10.1093/intbio/zyaa024 · 2021 · External reference
X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor
10.1158/1535-7163.mct-10-0160 · 2010 · External reference
XIAP regulation by MNK links MAPK and NFκB signaling to determine an aggressive breast cancer phenotype
10.1158/0008-5472.can-17-1667 · 2018 · External reference
Regulation of cell death and immunity by XIAP
10.1101/cshperspect.a036426 · 2020 · External reference
Inflammatory breast cancer biology: the tumour microenvironment is key
10.1038/s41568-018-0010-y · 2018 · External reference
Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors
10.1080/2162402x.2021.1929724 · 2021 · External reference
XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant
10.1016/j.tranon.2024.101907 · 2024 · External reference
Perspectives on inflammatory breast cancer (IBC) research, clinical management and community engagement from the duke IBC consortium
10.7150/jca.31176 · 2019 · External reference
Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum
10.1016/j.tranon.2021.101026 · 2021 · External reference
Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers
10.1186/s13073-021-00879-x · 2021 · External reference
A novel human xenograft model of inflammatory breast cancer
1999 · External reference
Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model
10.1186/s13058-015-0549-4 · 2015 · External reference
Three-dimensional culture systems in cancer research: focus on tumor spheroid model
10.1016/j.pharmthera.2016.03.013 · 2016 · External reference
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells
10.1016/j.canlet.2017.09.033 · 2017 · External reference
A novel preclinical murine model to monitor inflammatory breast cancer tumor growth and lymphovascular invasion
10.3390/cancers15082261 · 2023 · External reference
Uncovering the molecular secrets of inflammatory breast cancer biology: an integrated analysis of three distinct affymetrix gene expression datasets
10.1158/1078-0432.ccr-12-2549 · 2013 · External reference
Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival
10.1093/annonc/mdt496 · 2014 · External reference
Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization
10.1016/j.canlet.2013.05.017 · 2013 · External reference
Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer
10.1038/s41523-024-00664-0 · 2024 · External reference
The spatial immune landscape predicts outcome and reveals the central role of tumor-associated macrophages in inflammatory breast cancer biology
10.1186/s13058-025-02192-6 · 2026 · External reference
Smac mimetic birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-alpha-independent mechanism
10.1007/s10549-012-2352-6 · 2013 · External reference
Automatic measurement of sister chromatid exchange frequency
10.1177/25.7.70454 · 1977 · External reference
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC
10.1038/s41523-021-00379-6 · 2022 · External reference
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
10.1038/s41418-020-0541-0 · 2020 · External reference
Modeling and characterization of inflammatory breast cancer emboli grown in vitro
10.1002/ijc.27928 · 2013 · External reference
The prognostic significance of lymphovascular invasion in invasive breast carcinoma
10.1002/cncr.26711 · 2012 · External reference
Molecular complexity of lymphovascular invasion: the role of cell migration in breast cancer as a prototype
10.1159/000508337 · 2020 · External reference
Geometric tumor embolic budding characterizes inflammatory breast cancer
10.1007/s10549-022-06819-6 · 2023 · External reference
E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo
10.1038/srep12599 · 2015 · External reference
Tumor-associated macrophages: an important player in breast cancer progression
10.1111/1759-7714.14268 · 2022 · External reference
Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer
10.1007/s10549-018-4835-6 · 2018 · External reference
Inflammation mediated metastasis: immune induced epithelial-to-mesenchymal transition in inflammatory breast cancer cells
10.1371/journal.pone.0132710 · 2015 · External reference
TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
10.1038/s41419-023-06122-2 · 2023 · External reference
Inflammatory breast cancer appearance at presentation is associated with overall survival
10.1002/cam4.4170 · ExternalCitation · doi-reference
Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge
10.1002/cncr.25169 · ExternalCitation · doi-reference
Differences in survival among women with stage III inflammatory and noninflammatory locally advanced breast cancer appear early: a large population-based study
10.1002/cncr.25682 · ExternalCitation · doi-reference
The prognostic significance of lymphovascular invasion in invasive breast carcinoma
10.1002/cncr.26711 · ExternalCitation · doi-reference
Modeling and characterization of inflammatory breast cancer emboli grown in vitro
10.1002/ijc.27928 · ExternalCitation · doi-reference
Smac mimetic birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-alpha-independent mechanism
10.1007/s10549-012-2352-6 · ExternalCitation · doi-reference
Mammary stem cell and macrophage markers are enriched in normal tissue adjacent to inflammatory breast cancer
10.1007/s10549-018-4835-6 · ExternalCitation · doi-reference
Incidence and survival of inflammatory breast cancer between 1973 and 2015 in the SEER database
10.1007/s10549-020-05938-2 · ExternalCitation · doi-reference
Geometric tumor embolic budding characterizes inflammatory breast cancer
10.1007/s10549-022-06819-6 · ExternalCitation · doi-reference
Tailoring treatment for patients with inflammatory breast cancer
10.1007/s11864-023-01077-0 · ExternalCitation · doi-reference
Quantitative high-throughput efficacy profiling of approved oncology drugs in inflammatory breast cancer models of acquired drug resistance and re-sensitization
10.1016/j.canlet.2013.05.017 · ExternalCitation · doi-reference
Pharmacological targeting of GLI1 inhibits proliferation, tumor emboli formation and in vivo tumor growth of inflammatory breast cancer cells
10.1016/j.canlet.2017.09.033 · ExternalCitation · doi-reference
Three-dimensional culture systems in cancer research: focus on tumor spheroid model
10.1016/j.pharmthera.2016.03.013 · ExternalCitation · doi-reference
Gene expression profiles of inflammatory breast cancer reveal high heterogeneity across the epithelial-hybrid-mesenchymal spectrum
10.1016/j.tranon.2021.101026 · ExternalCitation · doi-reference
XIAP overexpressing inflammatory breast cancer patients have high infiltration of immunosuppressive subsets and increased TNFR1 signaling targetable with Birinapant
10.1016/j.tranon.2024.101907 · ExternalCitation · doi-reference
Targeting triple-negative breast cancers with the Smac-mimetic birinapant
10.1038/s41418-020-0541-0 · ExternalCitation · doi-reference
TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs
10.1038/s41419-023-06122-2 · ExternalCitation · doi-reference
Comparative transcriptional analyses of preclinical models and patient samples reveal MYC and RELA driven expression patterns that define the molecular landscape of IBC
10.1038/s41523-021-00379-6 · ExternalCitation · doi-reference
Altered ribosomal profile in acquired resistance and reversal associates with pathological response to chemotherapy in inflammatory breast cancer
10.1038/s41523-024-00664-0 · ExternalCitation · doi-reference
Inflammatory breast cancer biology: the tumour microenvironment is key
10.1038/s41568-018-0010-y · ExternalCitation · doi-reference
E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo
10.1038/srep12599 · ExternalCitation · doi-reference
Toward understanding cancer stem cell heterogeneity in the tumor microenvironment
10.1073/pnas.1815345116 · ExternalCitation · doi-reference
Immune landscape of inflammatory breast cancer suggests vulnerability to immune checkpoint inhibitors
10.1080/2162402x.2021.1929724 · ExternalCitation · doi-reference
Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival
10.1093/annonc/mdt496 · ExternalCitation · doi-reference
Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint
10.1093/intbio/zyaa024 · ExternalCitation · doi-reference
Dermal lymphatic invasion, survival, and time to recurrence or progression in inflammatory breast cancer
10.1097/coc.0000000000000843 · ExternalCitation · doi-reference
Regulation of cell death and immunity by XIAP
10.1101/cshperspect.a036426 · ExternalCitation · doi-reference
Tumor-associated macrophages: an important player in breast cancer progression
10.1111/1759-7714.14268 · ExternalCitation · doi-reference
XIAP regulation by MNK links MAPK and NFκB signaling to determine an aggressive breast cancer phenotype
10.1158/0008-5472.can-17-1667 · ExternalCitation · doi-reference
Uncovering the molecular secrets of inflammatory breast cancer biology: an integrated analysis of three distinct affymetrix gene expression datasets
10.1158/1078-0432.ccr-12-2549 · ExternalCitation · doi-reference
X-linked inhibitor of apoptosis protein inhibits apoptosis in inflammatory breast cancer cells with acquired resistance to an ErbB1/2 tyrosine kinase inhibitor
10.1158/1535-7163.mct-10-0160 · ExternalCitation · doi-reference
Molecular complexity of lymphovascular invasion: the role of cell migration in breast cancer as a prototype
10.1159/000508337 · ExternalCitation · doi-reference
Automatic measurement of sister chromatid exchange frequency
10.1177/25.7.70454 · ExternalCitation · doi-reference
Mesenchymal stem cells mediate the clinical phenotype of inflammatory breast cancer in a preclinical model
10.1186/s13058-015-0549-4 · ExternalCitation · doi-reference
Metastatic behavior and overall survival according to breast cancer subtypes in stage IV inflammatory breast cancer
10.1186/s13058-019-1201-5 · ExternalCitation · doi-reference
The spatial immune landscape predicts outcome and reveals the central role of tumor-associated macrophages in inflammatory breast cancer biology
10.1186/s13058-025-02192-6 · ExternalCitation · doi-reference
Whole-genome sequencing of phenotypically distinct inflammatory breast cancers reveals similar genomic alterations to non-inflammatory breast cancers
10.1186/s13073-021-00879-x · ExternalCitation · doi-reference
Inflammation mediated metastasis: immune induced epithelial-to-mesenchymal transition in inflammatory breast cancer cells
10.1371/journal.pone.0132710 · ExternalCitation · doi-reference
Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies
10.18632/oncotarget.15667 · ExternalCitation · doi-reference
A novel preclinical murine model to monitor inflammatory breast cancer tumor growth and lymphovascular invasion
10.3390/cancers15082261 · ExternalCitation · doi-reference
Perspectives on inflammatory breast cancer (IBC) research, clinical management and community engagement from the duke IBC consortium
10.7150/jca.31176 · ExternalCitation · doi-reference
Pattern of distant metastases in inflammatory breast cancer - a large-cohort retrospective study
10.7150/jca.34572 · ExternalCitation · doi-reference
