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References from AAV-mediated delivery of CRISPR/Cas9 targeting conserved overlapping ORFs efficiently suppresses HBV replication in hepatocyte models. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanisms of HBV-induced hepatocellular carcinoma
2016 · External reference
The mechanisms of HBV-induced hepatocellular carcinoma
10.2147/jhc.s307962 · 2021 · External reference
The role of cccDNA in HBV maintenance
10.3390/v9060156 · 2017 · External reference
HBV cccDNA: viral persistence reservoir and key obstacle for a cure of chronic hepatitis B
10.1136/gutjnl-2015-309809 · 2015 · External reference
Epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection
10.1007/s41048-020-00112-z · 2020 · External reference
HBV covalently closed circular DNA minichromosomes in distinct epigenetic transcriptional states differ in their vulnerability to damage
10.1002/hep.32245 · 2022 · External reference
Hepatitis B virus genome recycling and de novo secondary infection events maintain stable cccDNA levels
10.1016/j.jhep.2018.08.012 · 2018 · External reference
HBV cccDNA and its potential as a therapeutic target
2019 · External reference
Persistence of hepatitis B virus covalently closed circular DNA in hepatocytes: molecular mechanisms and clinical significance
2014 · External reference
Present and future therapies of hepatitis B: from discovery to cure
10.1002/hep.28025 · 2015 · External reference
Genome engineering using the CRISPR-Cas9 system
10.1038/nprot.2013.143 · 2013 · External reference
Genome editing. The new frontier of genome engineering with CRISPR-Cas9
10.1126/science.1258096 · 2014 · External reference
Development and applications of CRISPR-Cas9 for genome engineering
10.1016/j.cell.2014.05.010 · 2014 · External reference
CRISPR-Cas9 structures and mechanisms
10.1146/annurev-biophys-062215-010822 · 2017 · External reference
Targeting Hepatitis B virus with CRISPR/Cas9
2014 · External reference
Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors
10.1038/sj.gt.3302233 · 2004 · External reference
In vivo delivery of CRISPR/Cas9 for therapeutic gene editing: progress and challenges
10.1021/acs.bioconjchem.7b00057 · 2017 · External reference
The role of recombinant AAV in precise genome editing
2021 · External reference
CRISPR-mediated integration of large gene cassettes using AAV donor vectors
10.1016/j.celrep.2017.06.064 · 2017 · External reference
Development of an in vivo delivery system for CRISPR/Cas9-mediated targeting of hepatitis B virus cccDNA
10.1016/j.virusres.2020.198191 · 2020 · External reference
Targeting hepatitis B virus cccDNA by CRISPR/Cas9 nuclease efficiently inhibits viral replication
10.1016/j.antiviral.2015.03.015 · 2015 · External reference
CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus
10.1038/srep10833 · 2015 · External reference
An effective molecular target site in Hepatitis B Virus S gene for Cas9 cleavage and mutational inactivation
10.7150/ijbs.16064 · 2016 · External reference
Complete spectrum of CRISPR/Cas9-induced mutations on HBV cccDNA
10.1038/mt.2016.94 · 2016 · External reference
Suppression of hepatitis B virus DNA accumulation in chronically infected cells using a bacterial CRISPR/Cas RNA-guided DNA endonuclease
10.1016/j.virol.2014.12.001 · 2015 · External reference
Orthologous CRISPR/Cas9 systems for specific and efficient degradation of covalently closed circular DNA of hepatitis B virus
10.1007/s00018-019-03021-8 · 2019 · External reference
Permanent inactivation of HBV genomes by CRISPR/Cas9-mediated non-cleavage base editing
10.1016/j.omtn.2020.03.005 · 2020 · External reference
CRISPR-Cas9 targeting of hepatitis B virus covalently closed circular DNA generates transcriptionally active episomal variants
10.1128/mbio.02888-21 · 2022 · External reference
Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9
10.1038/s41598-019-38526-6 · 2019 · External reference
Development of immortalized hepatocyte-like cells from hMSCs
10.1007/978-1-61779-468-1_7 · 2012 · External reference
Upregulation of CYP 450s expression of immortalized hepatocyte-like cells derived from mesenchymal stem cells by enzyme inducers
10.1186/1472-6750-11-89 · 2011 · External reference
An immortalized hepatocyte-like cell line (imHC) accommodated complete viral lifecycle, viral persistence form, cccDNA and eventual spreading of a clinically-isolated HBV
10.3390/v11100952 · 2019 · External reference
Curcumin inhibited hepatitis B viral entry through NTCP binding
10.1038/s41598-021-98243-x · 2021 · External reference
Immortalized hepatocyte-like cells: a competent hepatocyte model for studying clinical HCV isolate infection
10.1371/journal.pone.0303265 · 2024 · External reference
Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus
10.1002/hep.510230303 · 1996 · External reference
Dendritic cells take up viral antigens but do not support the early steps of hepatitis B virus infection
10.1002/hep.21048 · 2006 · External reference
A highly sensitive and robust method for hepatitis B virus covalently closed circular DNA detection in single cells and serum
10.1016/j.jmoldx.2018.01.010 · 2018 · External reference
Panduratin A from Boesenbergia rotunda suppresses hepatitis B virus by targeting HNF1alpha and synergizing with antiviral agents
10.1186/s13020-025-01285-w · 2026 · External reference
ExPASy: the proteomics server for in-depth protein knowledge and analysis
10.1093/nar/gkg563 · 2003 · External reference
PredictProtein—an open resource for online prediction of protein structural and functional features
10.1093/nar/gku366 · 2014 · External reference
Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA
10.1073/pnas.84.4.1005 · 1987 · External reference
Conformational control of DNA target cleavage by CRISPR–Cas9
10.1038/nature15544 · 2015 · External reference
ProNA2020 predicts protein–DNA, protein–RNA, and protein–protein binding proteins and residues from sequence
10.1016/j.jmb.2020.02.026 · 2020 · External reference
AAV-mediated liver-directed gene therapy
10.1007/978-1-61779-370-7_6 · 2011 · External reference
Advances in HBV infection and replication systems in vitro
10.1186/s12985-021-01580-6 · 2021 · External reference
Synthetic gRNA/Cas9 ribonucleoprotein targeting HBV DNA inhibits viral replication
10.1002/jmv.28952 · 2023 · External reference
Removal of integrated Hepatitis B virus DNa using CRISPR-Cas9
10.3389/fcimb.2017.00091 · 2017 · External reference
CRISPR/Cas9 produces anti-hepatitis B virus effect in hepatoma cells and transgenic mouse
10.1016/j.virusres.2016.04.003 · 2016 · External reference
Dual gRNAs guided CRISPR/Cas9 system inhibits hepatitis B virus replication
10.3748/wjg.v21.i32.9554 · 2015 · External reference
Serum hepatitis B surface antigen is correlated with intrahepatic total HBV DNA and cccDNA in treatment-naïve patients with chronic hepatitis B but not in patients with HBV related hepatocellular carcinoma
10.1002/jmv.23461 · 2013 · External reference
A novel immortalized hepatocyte-like cell line (imHC) supports in vitro liver stage development of the human malarial parasite Plasmodium vivax
10.1186/s12936-018-2198-4 · 2018 · External reference
Immortalized stem cell-derived hepatocyte-like cells: an alternative model for studying dengue pathogenesis and therapy
10.1371/journal.pntd.0008835 · 2020 · External reference
A competent hepatocyte model examining hepatitis B virus entry through sodium taurocholate cotransporting polypeptide as a therapeutic target
10.3791/63761 · 2022 · External reference
A survey of validation strategies for CRISPR-Cas9 editing
10.1038/s41598-018-19441-8 · 2018 · External reference
SUMO pathway inhibition targets an aggressive pancreatic cancer subtype
10.1136/gutjnl-2018-317856 · 2020 · External reference
Multiplex genome engineering using CRISPR/Cas systems
10.1126/science.1231143 · 2013 · External reference
Inhibition of hepatitis B virus replication via HBV DNA cleavage by Cas9 from Staphylococcus aureus
10.1016/j.antiviral.2018.02.011 · 2018 · External reference
ssAAVs containing cassettes encoding SaCas9 and guides targeting hepatitis B virus inactivate replication of the virus in cultured cells
10.1038/s41598-017-07642-6 · 2017 · External reference
DNA targeting specificity of RNA-guided Cas9 nucleases
10.1038/nbt.2647 · 2013 · External reference
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
10.1038/nbt.3437 · 2016 · External reference
