Research graph
References from circMTHFD1L-driven lipid metabolism in Cancer-associated fibroblasts confers oxaliplatin resistance in pancreatic cancer through O-GlcNAcylation-dependent chromatin recruitment of Ku70. Local targets link to admitted publications; unresolved targets remain external evidence.
Pancreatic cancer stroma: an update on therapeutic targeting strategies
10.1038/s41575-020-0300-1 · 2020 · External reference
Stromal reprogramming overcomes resistance to RAS-MAPK inhibition to improve pancreas cancer responses to cytotoxic and immune therapy
10.1126/scitranslmed.ado2402 · 2024 · External reference
Cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
10.1038/s41419-022-05351-1 · 2022 · External reference
Pancreatic cancer: advances and challenges
10.1016/j.cell.2023.02.014 · 2023 · External reference
Cancer-associated fibroblasts employ NUFIP1-dependent autophagy to secrete nucleosides and support pancreatic tumor growth
10.1038/s43018-022-00426-6 · 2022 · External reference
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
10.1038/nature19084 · 2016 · External reference
Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance
10.1158/0008-5472.can-19-0960 · 2019 · External reference
Metabolic reprogramming from glycolysis to fatty acid uptake and beta-oxidation in platinum-resistant cancer cells
10.1038/s41467-022-32101-w · 2022 · External reference
Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription
10.1038/s41419-024-06527-7 · 2024 · External reference
circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
10.1186/s12943-022-01501-3 · 2022 · External reference
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer
10.1186/s13046-023-02854-3 · 2023 · External reference
Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation
10.1038/s41419-025-07431-4 · 2025 · External reference
Golgi self-correction generates bioequivalent glycans to preserve cellular homeostasis
10.7554/elife.14814 · 2016 · External reference
Stabilization of fatty acid synthesis enzyme acetyl-CoA carboxylase 1 suppresses acute myeloid leukemia development
10.1172/jci141529 · 2021 · External reference
The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα
10.1186/s12964-022-00849-9 · 2022 · External reference
Nanomedicine in cancer therapy
10.1038/s41392-023-01536-y · 2023 · External reference
Pancreatic cancer
10.1016/s0140-6736(25)00261-2 · 2025 · External reference
Current and future immunotherapeutic approaches in pancreatic cancer treatment
10.1186/s13045-024-01561-6 · 2024 · External reference
Tumor microenvironment in pancreatic cancer pathogenesis and therapeutic resistance
10.1146/annurev-pathmechdis-031621-024600 · 2023 · External reference
Cancer-associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
10.1016/j.celrep.2024.114972 · 2024 · External reference
IL1-Induced JAK/STAT signaling is antagonized by TGFβ to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
10.1158/2159-8290.cd-18-0710 · 2019 · External reference
Cancer-associated fibroblasts-mediated ATF4 expression promotes malignancy and gemcitabine resistance in pancreatic cancer via the TGF-β1/SMAD2/3 pathway and ABCC1 transactivation
10.1038/s41419-021-03574-2 · 2021 · External reference
circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-κB signaling pathway
10.1186/s13046-021-02237-6 · 2022 · External reference
Metabolic interplays between the tumour and the host shape the tumour macroenvironment
10.1038/s41568-024-00786-4 · 2025 · External reference
Metabolism of pancreatic cancer: paving the way to better anticancer strategies
10.1186/s12943-020-01169-7 · 2020 · External reference
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
10.1186/s13045-023-01498-2 · 2023 · External reference
A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression
10.1158/2159-8290.cd-18-1212 · 2019 · External reference
Metabolomics reveals that CAF-derived lipids promote colorectal cancer peritoneal metastasis by enhancing membrane fluidity
10.7150/ijbs.68484 · 2022 · External reference
Oncogenic KRAS drives lipofibrogenesis to promote angiogenesis and Colon cancer progression
10.1158/2159-8290.cd-22-1467 · 2023 · External reference
Tumor cell-intrinsic epigenetic dysregulation shapes cancer-associated fibroblasts heterogeneity to metabolically support pancreatic cancer
10.1016/j.ccell.2024.03.005 · 2024 · External reference
Inhibition of Acetyl-CoA carboxylase by phosphorylation or the inhibitor ND-654 suppresses lipogenesis and hepatocellular carcinoma
10.1016/j.cmet.2018.08.020 · 2019 · External reference
Drug resistance in cancer: molecular mechanisms and emerging treatment strategies
10.1186/s43556-025-00352-w · 2025 · External reference
DNA damage repair: historical perspectives, mechanistic pathways and clinical translation for targeted cancer therapy
10.1038/s41392-021-00648-7 · 2021 · External reference
Glycosylation: mechanisms, biological functions and clinical implications
10.1038/s41392-024-01886-1 · 2024 · External reference
O-GlcNAcylation modulates expression and abundance of N-glycosylation machinery in an inherited glycosylation disorder
10.1016/j.celrep.2024.114976 · 2024 · External reference
Nutrient inputs and social metabolic control of T cell fate
10.1016/j.cmet.2023.12.009 · 2024 · External reference
