Research graph
References from Reactive oxygen species define leukemia stem cell identity in pediatric acute myeloid leukemia. Local targets link to admitted publications; unresolved targets remain external evidence.
Relapsed pediatric acute myeloid leukaemia: state-of-the-art in 2023
10.3324/haematol.2022.281106 · 2023 · External reference
Implementation of mechanism of action biology-driven early drug development for children with cancer
10.1016/j.ejca.2016.04.001 · 2016 · External reference
Improved outcomes of the refined risk-stratification and risk-adapted therapy in children with acute myeloid leukemia: final results of the AIEOP AML 2013
2026 · External reference
Navigating Treatment Options and Communication in Relapsed Pediatric AML
2024 · External reference
Leukemic stem cells and therapy resistance in acute myeloid leukemia
10.3324/haematol.2022.280800 · 2023 · External reference
Leukemic stem cells as a target for eliminating acute myeloid leukemia: Gaps in translational research
10.1016/j.critrevonc.2022.103710 · 2022 · External reference
10.3389/fimmu.2021.775128
10.3389/fimmu.2021.775128 · External reference
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
10.1016/j.ccell.2018.10.005 · 2018 · External reference
Metabolic regulation in normal and leukemic stem cells
10.1016/j.tips.2024.08.004 · 2024 · External reference
Combined GLUT1 and OXPHOS inhibition eliminates acute myeloid leukemia cells by restraining their metabolic plasticity
10.1182/bloodadvances.2023009967 · 2023 · External reference
Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth
10.1038/s41467-024-45691-4 · 2024 · External reference
Molecular minimal residual disease in acute myeloid leukemia
10.1056/nejmoa1716863 · 2018 · External reference
Leukemia Stem Cell Frequency at Diagnosis Correlates With Measurable/Minimal Residual Disease and Impacts Survival in Adult Acute Myeloid Leukemia
10.3389/fonc.2022.867684 · 2022 · External reference
CD34+CD38- leukemic stem cell frequency to predict outcome in acute myeloid leukemia
10.1038/s41375-018-0326-3 · 2019 · External reference
A Functional Comparison of CD34+ CD38– Cells in Cord Blood and Bone Marrow
10.1182/blood.v86.10.3745.bloodjournal86103745 · 1995 · External reference
Biology and relevance of human acute myeloid leukemia stem cells
10.1182/blood-2016-10-696054 · 2017 · External reference
GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo
10.1182/blood-2015-11-683649 · 2016 · External reference
The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stems cells
10.1038/sj.leu.2401903 · 2000 · External reference
CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia
10.1073/pnas.0704271104 · 2007 · External reference
Single Cell Multimodal Framework Identifies CD84 As a Leukaemic Stem Cell Target in Paediatric AML
10.1182/blood-2024-204084 · 2024 · External reference
Cooperative CAR targeting to selectively eliminate AML and minimize escape
10.1016/j.ccell.2023.09.010 · 2023 · External reference
CD200 expression marks leukemia stem cells in human AML
10.1182/bloodadvances.2020001802 · 2020 · External reference
A 17-gene stemness score for rapid determination of risk in acute leukaemia
10.1038/nature20598 · 2016 · External reference
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia
2022 · External reference
Stem cell gene expression programs influence clinical outcome in human leukemia
10.1038/nm.2415 · 2011 · External reference
BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells
10.1016/j.stem.2012.12.013 · 2013 · External reference
Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid Leukemia
10.1158/2159-8290.cd-13-0609 · 2014 · External reference
Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates
10.1038/s41375-024-02510-5 · 2025 · External reference
Therapeutic targeting of leukemia stem cells in acute myeloid leukemia
10.3389/fonc.2023.1204895 · 2023 · External reference
CD123 Expression Is Associated With High-Risk Disease Characteristics in Childhood Acute Myeloid Leukemia: A Report From the Children’s Oncology Group
10.1200/jco.21.01595 · 2022 · External reference
Allogeneic TCRαβ deficient CAR T-cells targeting CD123 in acute myeloid leukemia
10.1038/s41467-022-29668-9 · 2022 · External reference
Mesothelin is a novel cell surface disease marker and potential therapeutic target in acute myeloid leukemia
10.1182/bloodadvances.2021004424 · 2021 · External reference
Dual-Targeting CD33/CD123 NANOBODY ® T Cell Engager Targeting Leukemia Blasts and Stem/Progenitor Cells in Relapsed AML
10.1182/blood-2023-186012 · 2023 · External reference
Therapeutic targeting of acute myeloid leukemia stem cells
10.1182/blood-2016-10-696039 · 2017 · External reference
Advancing precision therapy in pediatric acute myeloid leukemia through PDX models and mitochondrial targeting
10.1182/bloodadvances.2025018002 · 2026 · External reference
A low level of reactive oxygen species selects for primitive hematopoietic stem cells that may reside in the low-oxygenic niche
10.1182/blood-2007-05-087759 · 2007 · External reference
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region
10.1038/nbt1350 · 2007 · External reference
Targeting the plasticity of mesenchymal stromal cells to reroute the course of acute myeloid leukemia
2021 · External reference
A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia
10.1172/jci130809 · 2020 · External reference
Epigenetic heterogeneity affects the risk of relapse in children with t(8;21)RUNX1-RUNX1T1-rearranged AML
10.1038/s41375-017-0003-y · 2018 · External reference
Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
10.1038/nature10350 · 2011 · External reference
Mitochondrial Cristae: Where Beauty Meets Functionality
10.1016/j.tibs.2016.01.001 · 2016 · External reference
How does density of the inner mitochondrial membrane influence mitochondrial performance?
10.1152/ajpregu.00254.2022 · 2023 · External reference
Mitochondrial cristae narrowing upon higher 2-oxoglutarate load
10.1016/j.bbabio.2019.06.015 · 2019 · External reference
A phase I study of CPI-613 in combination with high-dose cytarabine and mitoxantrone for relapsed or refractory acute myeloid leukemia
10.1158/1078-0432.ccr-17-2282 · 2018 · External reference
Assessing metabolic intervention with a glutaminase inhibitor in real-time by hyperpolarized magnetic resonance in acute myeloid leukemia
10.1158/1535-7163.mct-18-0985 · 2019 · External reference
Antileukemic activity of 2-deoxy-D-glucose through inhibition of N-linked glycosylation in acute myeloid leukemia with FLT3-ITD or c-KIT mutations
10.1158/1535-7163.mct-15-0163 · 2015 · External reference
PPM1K Regulates Hematopoiesis and Leukemogenesis through CDC20-Mediated Ubiquitination of MEIS1 and p21
10.1016/j.celrep.2018.03.140 · 2018 · External reference
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia
10.1038/s41591-022-01819-x · 2022 · External reference
A longitudinal single-cell atlas of treatment response in pediatric AML
10.1016/j.ccell.2023.10.008 · 2023 · External reference
Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia
10.1038/s41587-019-0332-7 · 2019 · External reference
Evolution of acute myelogenous leukemia stem cell properties after treatment and progression
10.1182/blood-2016-02-695312 · 2016 · External reference
Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment
10.1182/blood-2010-12-327437 · 2011 · External reference
CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity
10.1038/ncomms12320 · 2016 · External reference
Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy
10.1182/blood-2015-08-665547 · 2016 · External reference
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
10.1038/367645a0 · 1994 · External reference
Hypoxia-Inducible Factors: Master Regulators of Cancer Progression
10.1016/j.trecan.2016.10.016 · 2016 · External reference
RhoB regulates cell migration through altered focal adhesion dynamics
10.1098/rsob.120076 · 2012 · External reference
CD44 engagement enhances acute myeloid leukemia cell adhesion to the bone marrow microenvironment by increasing VLA-4 avidity
10.3324/haematol.2019.231944 · 2021 · External reference
Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia
10.1038/nm909 · 2003 · External reference
CXCR4/CXCL12 axis counteracts hematopoietic stem cell exhaustion through selective protection against oxidative stress
2016 · External reference
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy
10.1016/j.cmet.2020.09.001 · 2020 · External reference
An inhibitor of oxidative phosphorylation exploits cancer vulnerability
10.1038/s41591-018-0052-4 · 2018 · External reference
Complex I inhibitor of oxidative phosphorylation in advanced solid tumors and acute myeloid leukemia: phase I trials
10.1038/s41591-022-02103-8 · 2023 · External reference
OXPHOS-targeting drugs in oncology: new perspectives
10.1080/14728222.2023.2261631 · 2023 · External reference
Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells
10.1016/j.ccell.2018.10.005 · 2018 · External reference
Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia
10.1016/j.stem.2023.04.001 · 2023 · External reference
A clinical transcriptome approach to patient stratification and therapy selection in acute myeloid leukemia
10.1038/s41467-021-22625-y · 2021 · External reference
The Crossroads of Clonal Evolution, Differentiation Hierarchy, and
2025 · External reference
Results of the AIEOP AML 2002/01 multicenter prospective trial for the treatment of children with acute myeloid leukemia
10.1182/blood-2013-03-491621 · 2013 · External reference
Screening of novel genetic aberrations in pediatric acute myeloid leukemia: A report from the AIEOP AML-2002 study group
10.1182/blood-2012-09-454454 · 2012 · External reference
CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
10.1182/blood-2012-11-469825 · 2013 · External reference
10.1038/leu.2013.339
10.1038/leu.2013.339 · External reference
Characterization of children with FLT3-ITD acute myeloid leukemia: A report from the AIEOP AML-2002 study group
10.1038/leu.2016.177 · 2017 · External reference
NUP98-fusion transcripts characterize different biological entities within acute myeloid leukemia: a report from the AIEOP-AML group
10.1038/leu.2016.361 · 2017 · External reference
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Evaluating mitochondrial length, volume, and cristae ultrastructure in rare mouse adult stem cell populations
10.1016/j.xpro.2023.102107 · 2023 · External reference
SCENITH: A Flow Cytometry-Based Method to Functionally Profile Energy Metabolism with Single-Cell Resolution
10.1016/j.cmet.2020.11.007 · 2020 · External reference
Regularization paths for Cox’s proportional hazards model via coordinate descent
10.18637/jss.v039.i05 · 2011 · External reference
The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells
10.1038/nbt.2859 · 2014 · External reference
